Onkourologiya最新文献

{"title":"Nephrectomy and thrombectomy in renal cell carcinoma patients with extensive tumor venous thrombosis: how to minimize surgical risks?","authors":"V. Matveev, I. Stilidi, M. Volkova, N. Vashakmadze, A. Klimov, A. K. Begaliev, P. I. Feoktistov, K. P. Kuznetsov, M. Davydov","doi":"10.17650/1726-9776-2021-17-1-19-30","DOIUrl":"https://doi.org/10.17650/1726-9776-2021-17-1-19-30","url":null,"abstract":"Objective: to evaluate the outcomes of thrombectomy performed using different surgical techniques in renal cell carcinoma (RCC) patients with extensive tumor venous thrombosis.Materials and methods. This study included 345 RCC patients with extensive tumor venous thrombosis who underwent surgical treatment.The median age was 57 years (range: 16—79 years); the male-to-female ratio was 1:1.9. Two hundred and sixty patients (75.4 %) had their tumor thrombus originating from the right renal vein, 85 patients (24.6 %) — from the left renal vein. In 169 patients (49.0 %), the thrombus spread to the retrohepatic inferior vena cava (IVC), while in 176 patients (51.0 %), it spread above the diaphragm (to the intrapericardial IVC in 59 patients (17.1 %) and to the right heart cameras in 117 patients (33.9 %)). Regional metastases were found in 90 individuals (26.1 %), while distant metastases were observed in 124 patients (35.9 %). All patients underwent surgical treatment (radical in 251 patients (72.8 %) and cytoreductive — in 94patients (27.2 %)); the technique of vascular control and circulatory support was chosen individually. In 97 patients (28.1 %), the control over the cranial thrombus boarder did not require opening of the chest cavity; eleven patients (3.2 %) were operated on with cardiopulmonary bypass.Results. The median surgery time was 215 minutes; the median blood loss was 4500 mL. Intraoperative complications were registered in 209 patients (60.6 %) and postoperative complications were observed in 118 patients (35.1 %) (including those of grade I—II in 43 individuals (12.8 %) and grade III—V in 75 individual (22.3 %)). The in-hospital mortality rate was 10.7 % (37/345). At a median follow-up of 32.3 months, overall and diseasespecific survival rates among all patients were 51.9 % and 68.3 %, respectively; relapse-free survival rate in 226patients who have undergone radical surgeries and discharged from the hospital was 61.5 %; progression-free survival rate in 82 patients who have undergone cytoreductive surgery was 33.0 %. The method ofIVC control and circulatory support had no effect on both short-term and long-term treatment outcomes (p >0.05 for both).Conclusion. The use of minimally invasive techniques of vascular control and avoidance of cardiopulmonary bypass in carefully selected RCC patients with extensive tumor venous thrombosis do not worsen the outcomes of nephrectomy and thrombectomy.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"17 1","pages":"19-30"},"PeriodicalIF":0.1,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67764369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Past, present and future magnetic resonance diagnosis of prostate cancer","authors":"D. Goncharuk, E. Veliev, A. Mikhaylov","doi":"10.17650/1726-9776-2021-17-1-142-152","DOIUrl":"https://doi.org/10.17650/1726-9776-2021-17-1-142-152","url":null,"abstract":"After almost 40 years since the first-ever magnetic resonance imaging (MRI) of the prostate has been made the technology has made significant strides forward: dynamic contrast-enhanced imaging, diffusion weighted imaging and MR spectroscopy being a few among the others. Moreover, the development of high power magnets and phased array coils had contributed to the drastically improved quality of the imaging. These improvements have increased the detection quality for the clinically significant prostate cancer (PCa) and early recurrences, enabling physicians to create a more personalized treatment plan easier and quicker. PROMIS (the Patient-Reported Outcome Measurement Information System) 2017 and PRECISION (Prostate Evaluation for Clinically Important Disease: Sampling Using Image Guidance or Not) 2018 studies underline the importance of MRI in detecting clinically significant PCa and avoiding overly aggressive diagnostic of clinically insignificant PCa. A large number of articles devoted to analyzing the role of MRI in diagnosing PCa (localization and staging) do not come to a uniform conclusion. This can be, in part, explained by the different study designs and protocols, as well as other controllable factors in the MRI studies themselves. The goal of this article is to attempt to analyze the role of MRI in diagnosing PCa since its advent, through its' current stage of development, as well as to explore the forward looking scenarios and opportunities for this extremely useful imaging modality.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"22 1","pages":"142-152"},"PeriodicalIF":0.1,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67764604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of lenvatinib and everolimus combination in patients with metastatic renal cell carcinoma progression following targeted antiangiogenic therapy: secondary analysis of data obtained in the Russian multicenter observational study","authors":"M. Volkova, A. Kalpinskiy, P. Borisov, O. Evsyukova, A. Olshanskaya, V. Matveev, B. Alekseev, E. V. Peganova, A. Nasretdinov, E. V. Lymar, E. Ovchinnikova, T. A. Sveklina, E. Usynin, A. Abdelgafur, E. Tararova, L. Shumova, A. S. Belenkov, I. Dolgov, N. Ponomareva, I. Evstigneeva, A. N. Ivanov, A. R. Isaev, R. Leonenkov, A. V. Meskikh, M. R. Mukhitova, S. Orlova, I. V. Teslenok, M. Shegurova, M. Aivazov, Z. Amoev, K. Babina, A. Vorontsova, E. Karabina, N. Kirdakova, I. Shumskaya, G. P. Kolesnikov, E. Kuzmina, D. Latipova, E. Lyutova, M. Fael, A. N. Chugarova, A. Antipin","doi":"10.17650/1726-9776-2021-17-1-31-44","DOIUrl":"https://doi.org/10.17650/1726-9776-2021-17-1-31-44","url":null,"abstract":"Objective. The primary endpoint was progression-free survival; secondary endpoints included overall survival, objective response rate and duration, tumor control rate and duration, as well as safety profile of lenvatinib with everolimus in consecutive patients with advanced renal cell carcinoma who had disease progression after targeted antiangiogenic therapy.Materials and methods. This observational study included 129 consecutive patients with metastatic renal cell carcinoma resistant to targeted antiangiogenic therapy. The median age was 60 years; a male to female ratio was 3.1:1. Twenty-seven patients (20.9 %) had ECOG performance status of 2—4. The majority of study participants (n = 127; 98.4 %) had multiple metastases. Tumor lesions were located in >1 organ in 104 cases (80.6 %). The primary tumor was removed in 110 (85.3 %), including 39 (30.2 %) patients undergone cytoreductive surgery. Seventy patients (54.2 %) had earlier received more than one line of therapy. Upon enrollment, there were 13 IMDC favourable-risk patients (10.1 %), 86 IMDC intermediate-risk patients (66.6 %), and 29 IMDC poor-risk patients (22.5 %). In one patient (0.8 %), the IMDC risk was not estimated. All patients received lenvatinib at a dose of 18 mg/day and everolimus at a dose of 5 mg/day. The median follow-up was 10.5 (1—30) months.Results. Median progression-free survival was 14.9 (11.9—17.9) months; overall survival was 19.9 (15.2—24.6) months. The objective response rate was 17.0 % (median duration 9.7 (2.8—16.5) months); tumor control rate was 72.9 % (median duration 10.0 (2.5—17.5) months). Adverse events were observed in 112patients (86.8 %) with grade III—IVadverse events registered in 27participants (20.9 %). Five participants (3.9 %) needed inpatient treatment of adverse events; one patient (0.8 %) died due to adverse events. Adverse events required treatment discontinuation in 4 patients (3.1 %), treatment interruption in 35 patients (27.1 %), and dose reduction in 33 patients (25.6 %).Conclusion. The results of the secondary analysis in the ROSLERCM observational study confirmed the results obtained earlier on the efficacy and safety of the lenvatinib plus everolimus combination in the second- and subsequent-line therapy for advanced renal cell carcinoma resistant to targeted antiangiogenic therapy in consecutive Russian patients.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"17 1","pages":"31-44"},"PeriodicalIF":0.1,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67765313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charles Brenton Huggins. Francis Peyton Rous","authors":"O. Karyakin","doi":"10.17650/1726-9776-2021-17-1-185-188","DOIUrl":"https://doi.org/10.17650/1726-9776-2021-17-1-185-188","url":null,"abstract":"The article is dedicated to two Nobel laureates Charles Brenton Huggins and Francis Peyton Rous.Charles Huggins research on prostate cancer has changed the attitude of scientists to understanding the development of all malignant cells and for the first time gave hope for the prospect of treating advanced forms of cancer. Dr. Huggins' was a pioneer in the understanding of the physiology and biochemistry of the male urinary tract and was able to extend his discoveries from this area to many other areas. In 1966, Dr. Huggins received the Nobel Prize for his research on the relationship between hormones and prostate cancer.Francis Peyton Rous discovered that sarcomas in chickens can be transmitted by birds of the same inbred population not only by inoculating tumor cells, but also by injecting a submicroscopic agent extracted from them. This discovery gave rise to the viral theory of cancer causality. He was able to prove that some “spontaneous” chicken tumors, apparently classic neoplasms, are actually triggered and controlled by viruses that also determine their shape.In 1966, Dr. Huggins received the Nobel Prize (with virologist Peyton Rous) for his research on the relationship between hormones and prostate cancer. The Nobel Committee cited his fundamental discoveries concerning the hormonal dependence of normal and neoplastic cells in experimental animals and their immediate practical application for the treatment of human prostate and breast cancer. In 1966, Peyton Rose was awarded the Nobel Prize.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"17 1","pages":"185-188"},"PeriodicalIF":0.1,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67764248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the article “Complications after radical cystoprostatectomy with various variants of the heterotopic ureteroneocystostomy”","authors":"S. Darenkov","doi":"10.17650/1726-9776-2021-17-1-107","DOIUrl":"https://doi.org/10.17650/1726-9776-2021-17-1-107","url":null,"abstract":"На сегодняшний день существует не так много тем в урологии, которые порождают среди отечественных и иностранных специалистов столь же много оживленных споров и дискуссий, как вопрос выбора метода отведения мочи после цистэктомии.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"17 1","pages":"107"},"PeriodicalIF":0.1,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67764544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the article “An original surgical method for the formation of fascial duplication in the elimination of damage to the anterior rectal wall during prostatectomy”","authors":"P. A. Karnauh","doi":"10.17650/1726-9776-2021-17-1-62","DOIUrl":"https://doi.org/10.17650/1726-9776-2021-17-1-62","url":null,"abstract":"Радикальная простатэктомия, широко используется в лечебных учреждениях для лечения локализованного рака предстательной железы. С накоплением хирургического опыта закономерно происходит расширение показаний для этого метода лечения. Неизбежно увеличение осложнений хирургического лечения, в том числе и такого грозного, как ранение прямой кишки. Комбинированные операции являются уделом онкологов, однако, в последнее время радикальную простатэктомию выполняют и врачи-урологи, не имеющие регулярной практики работы на кишечнике. В этом случае предложенный метод ушивания дефекта прямой кишки во время простатэктомии очень актуален.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"17 1","pages":"62"},"PeriodicalIF":0.1,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49557603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and morphological features of non-muscle invasive bladder cancer: implications for treatment, prognosis and relapse of the disease (literature review)","authors":"A. Pshikhachev, L. Mikhaleva, M. A. Gusniev, V. Pechnikova, N. I. Polyanko, N. Sorokin, A. Kamalov","doi":"10.17650/1726-9776-2021-17-1-134-141","DOIUrl":"https://doi.org/10.17650/1726-9776-2021-17-1-134-141","url":null,"abstract":"This review of bladder cancer describes modern clinical and pathologic features of the neoplasm, reports new data about treatment and prognosis of this disease.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"17 1","pages":"134-141"},"PeriodicalIF":0.1,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48886219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An original surgical method for the formation of fascial duplication in the elimination of damage to the anterior rectal wall during prostatectomy","authors":"Yu. N. Yurgel, B. Alekseev, E. Kopyltsov, O. Leonov, I. A. Sikhvardt, A. O. Leonova, V. A. Vodolazskiy, I. A. Durnev, N. Y. Yurgel","doi":"10.17650/1726-9776-2021-17-1-54-61","DOIUrl":"https://doi.org/10.17650/1726-9776-2021-17-1-54-61","url":null,"abstract":"Background. Intraoperative rectal injury in patients undergoing prostatectomy is a severe complication, worsens the quality of life and leads to social maladjustment.Objective. To develop, substantiate the reproducibility and safety of the technique for the formation of fascial duplication in the elimination of damage to the anterior rectal wall during prostatectomy.Materials and methods. The authors present a description of the technique and their own experience of retropubic prostatectomy with the formation of fascial duplication in the elimination of damage to the anterior rectal wall in 2 patients with prostate cancer. Patients with intermediate risk of recurrence and progression according to the D'Amico index. The observation period is 6 and 11 months.Results. Prostatectomy revealed damage to the anterior rectal wall and destruction of the external longitudinal muscular layer of the rectum. The rectal defect was eliminated according to the original method. The duration of the operation is 160 and 140 min. Intraoperative blood loss 350 and 150 ml. The first bowel movement on the 5th day. Removal of the urethral catheter on day 10. The period of hospitalization was 11 and 14 days, no postoperative mortality was noted. No lethal outcomes were noted.Conclusion. A constructively simple surgical technique for the formation of fascial duplication by local tissues in case of intraoperative injury of the rectum during prostatectomy has been developed and implemented into clinical practice.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"17 1","pages":"54-61"},"PeriodicalIF":0.1,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67765589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the article “Resection of a kidney tumor with superselective targeted balloon-occluded chemoembolization”","authors":"A. Popov","doi":"10.17650/1726-9776-2020-16-4-59-60","DOIUrl":"https://doi.org/10.17650/1726-9776-2020-16-4-59-60","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"16 1","pages":"59-60"},"PeriodicalIF":0.1,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67764234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Function of the orthotopic urinary reservoir formed from the ileocecal angle in the long term after radical cystectomy in women","authors":"V. Atduev, Z. K. Kushaev, D. Ledyaev, Y. Lyubarskaya, Z. Amoev, V. E. Gasrataliev, G. I. Shejyhov, I. S. Shevelev","doi":"10.17650/1726-9776-2020-16-4-136-146","DOIUrl":"https://doi.org/10.17650/1726-9776-2020-16-4-136-146","url":null,"abstract":"Objective: to study the long-term functional results of creating an orthotopic urinary reservoir from the ileocecal angle in comparison with the Studer technique of creating a urinary reservoir after radical cystectomy in women. angle plastic surgery, higher values of the maximum pressure of the reservoir wall, “leakage pressure” and maximum expulsion pressure are observed, possibly associated with a more pronounced muscle layer of the intestinal segment used. Conclusion. The functional results of the orthotopic reservoir formed from the ileocecal angle are comparable to the results of urine derivation using the classical Studer method. Complex urodynamic study showed a direct influence of various characteristics of the reservoir on the nature and degree of urination disorders in patients.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67762301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}