Gazi Medical Journal最新文献_第4页

Anti-diabetic Properties of Melissa officinalis and Saffron: Recent Advances and Discoveries 厚朴和藏红花抗糖尿病作用的研究进展

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Gazi Medical Journal Pub Date : 2023-10-01 DOI: 10.12996/gmj.2023.93

S. Sanaie, Behnam Sadigi, Reza Yarani, Nikolaj Travica, Zahra Yousefi, S. Shakouri, Alireza Ostadrahimi, M. Mobasseri, Fateme Tahmasbi, Mostafa Araj-khodaei

{"title":"Anti-diabetic Properties of Melissa officinalis and Saffron: Recent Advances and Discoveries","authors":"S. Sanaie, Behnam Sadigi, Reza Yarani, Nikolaj Travica, Zahra Yousefi, S. Shakouri, Alireza Ostadrahimi, M. Mobasseri, Fateme Tahmasbi, Mostafa Araj-khodaei","doi":"10.12996/gmj.2023.93","DOIUrl":"https://doi.org/10.12996/gmj.2023.93","url":null,"abstract":"Aim: Diabetes mellitus is a chronic medical condition characterized by an accumulation of glucose in the bloodstream. Specifically, type 2 diabetes occurs when the body’s cells are unable to efficiently respond to insulin, the hormone responsible for transporting circulatory glucose into cells. In the advanced stages of the disease, the body may also not produce sufficient amounts of insulin. As the disease progresses, the symptoms become more severe and potentially lead to a series of comorbidities. Although several medications are used to treat and control type 2 diabetes, these medications may have serious side effects. Hence, the use of herbal medicine to alleviate type 2 diabetes has been studied and has attracted widespread interest. Our major goal is to examine these herbs' effectiveness and related mechanisms of action in treating type 2 diabetes. Method : We studied worldwide traditional medicines, old texts, and published literature for anti-diabetic effect of Melissa officinalis and saffron. Electronic databases comprising PubMed, Web of Science, Science Direct, Scopus and Google Scholar were searched to collect articles published between 1990 and 2022 years. Results : We confirmed that a variety of herbal therapies, including saffron and lemon balm (Melissa officinalis), had anti-diabetic activities based on the findings of various research. Conclusion: Saffron and Melissa officinalis have anti-diabetic properties.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47195144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Interobserver and Intraobserver Differences of Graf Method in Developmental Hip Dysplasia Graf方法在发育性髋关节发育不良中观察者间和观察者内差异的评价

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Gazi Medical Journal Pub Date : 2023-10-01 DOI: 10.12996/gmj.2023.86

Gelişimsel Kalça, Displazisinde Graf, Yönteminin Gözlemciler, Arası ve, Gözlemci İçi, Farklılıklarının Değerlendirilmesi, H. Doğruel, A. C. Baymurat, Ismail Cengiz Tuncay, Hakan Atalar

{"title":"Evaluation of Interobserver and Intraobserver Differences of Graf Method in Developmental Hip Dysplasia","authors":"Gelişimsel Kalça, Displazisinde Graf, Yönteminin Gözlemciler, Arası ve, Gözlemci İçi, Farklılıklarının Değerlendirilmesi, H. Doğruel, A. C. Baymurat, Ismail Cengiz Tuncay, Hakan Atalar","doi":"10.12996/gmj.2023.86","DOIUrl":"https://doi.org/10.12996/gmj.2023.86","url":null,"abstract":"Purpose: The aim of this study was to evaluate possible differences in hip ultrasonography (US) results between physicians working in different medical centers. Method: In this study, a total of 117 horizontal US images representing all sonographic types of developmental dysplasia of the hip (DDH) were utilized. Four experienced researchers independently measured the 117 US images at different times. The results obtained by each researcher were documented separately, including alpha and beta angles, Graf types. All of the collected data were analyzed statistically to assess for interobserver and intraobserver variability. Results: The study found that the average change between the alpha angles ranged from a minimum of 1 to a maximum of 4. The mean change between the beta angles was wider, ranging from a minimum of 1.8 to a maximum of 8.2. To evaluate the differences between the Graf hip typologies, paired groups were formed and Cohen's Kappa method was used. For the first group k= 0.661, for the second group k= 0.671, for the third group K= 0.647, for the fourth group k= 0, 718, k= 0.717 for the fifth group and k= 0.637 for the sixth group. Interobserver Kappa evaluation results (k=0.647) showed moderate and significant agreement. Conclusion: The results revealed a moderate to substantial level of agreement between the researchers. Based on these findings, it was concluded that the use of US for screening and follow-up of the Graf hip typing method should be performed by experienced professionals.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42356479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do Routine Laboratory Parameters Predict the Disease Activity in Children with Behçet’s Disease? 常规实验室参数能预测behaperet病患儿的疾病活动性吗?

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Gazi Medical Journal Pub Date : 2023-10-01 DOI: 10.12996/gmj.2023.76

Deniz Gezgin, Sevcan A Yildirim¹, Bakkaloglu, Rutin Laboratuvar, Parametreleri Behçet, Hastalığı olan, Çocuklarda Hastalık, Aktivitesini Öngörüyor

{"title":"Do Routine Laboratory Parameters Predict the Disease Activity in Children with Behçet’s Disease?","authors":"Deniz Gezgin, Sevcan A Yildirim¹, Bakkaloglu, Rutin Laboratuvar, Parametreleri Behçet, Hastalığı olan, Çocuklarda Hastalık, Aktivitesini Öngörüyor","doi":"10.12996/gmj.2023.76","DOIUrl":"https://doi.org/10.12996/gmj.2023.76","url":null,"abstract":"Objective. Juvenile Behçet’s disease (jBD) is a multi-systemic inflammatory disorder characterized by recurrent episodes of oral and genital aphthae, and cutaneous, gastrointestinal, neurological, articular, ocular and vascular manifestations. The main aim of this study was to assess the value of routine laboratory parameters for predicting disease activity in children with jBD. Methods. The demographic features and laboratory findings, including white blood cell, neutrophil (NEU), lymphocyte (LYM) and platelet (PLT) counts, neutrophil/ lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPR) values were retrospectively evaluated between jBD patients with active and inactive, and compared with those in healthy peers. Inactive jBD was accepted as the absence of any clinical symptoms, while active jBD was accepted as presence of at least two clinical symptoms related with jBD. Results. Thirty six patients with jBD, and 58 sex-and age-matched healthy children were enrolled into this study. Median age at diagnosis of jBD was 13 (min – max: 5-17) years. 12 patients had active and remaining 24 inactive disease at enrollment. Active jBD group had significantly higher mean values for NLR, PLR, and lower MPV compared to inactive patients (p= 0.026, p= 0.039, and p= 0.07, respectively). PLR was revealed as an independent factor for predicting disease activity in jBD patients (p= 0.035, OR [95% Cl] = 0.988 [0.978-0.999]). Conclusion. This study has shown that active jBD patients had increased values of NLR and PLR. Among them PLR was the possible risk predictor for disease activity. These parameters are easily accessible inflammatory markers that may help detecting active disease in the early phase to prevent complications and to guide the therapy.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45112304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid Tumors other than Breast Cancer are Associated with Germ-line ATM Heterozygosity 癌症以外的实体瘤与种系ATM杂合性相关

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Gazi Medical Journal Pub Date : 2023-10-01 DOI: 10.12996/gmj.2023.87

MD Oktay Ünsal, O. Yazıcı, N. Özdemir, Büşra Güvercin, A. Özet, Mehmet Ali Ergün

{"title":"Solid Tumors other than Breast Cancer are Associated with Germ-line ATM Heterozygosity","authors":"MD Oktay Ünsal, O. Yazıcı, N. Özdemir, Büşra Güvercin, A. Özet, Mehmet Ali Ergün","doi":"10.12996/gmj.2023.87","DOIUrl":"https://doi.org/10.12996/gmj.2023.87","url":null,"abstract":"Objective: It is known that ATM heterozygosity is associated with increased risk of cancer, especially for breast cancer. This report reveals the characteristics of the patients with solid tumors other than breast cancer, associated with Germ-line ATM heterozygosity. Methods: Patients with germline ATM heterozygous mutation, admitted to the Department of Medical Genetics between January 2020 to 2023 were evaluated retrospectively. Patients with a diagnosis of solid tumors other than breast cancer, being followed up for at least 6 months were included in the study. Data of the patients were examinated using the SPSS software version 23. Results: Median aged at cancer diagnosis of 36 patients were 52.5 (23-65) years. The median follow-up period was 29.5 (11-283) months. Colorectal cancer was the most common diagnosis (30.6%). At follow-up, second primary solid malignancy was diagnosed in 27.8% (10 patients) of the patients. The median time for development of second primary malignancy were 9 (3-156) months. Most common diagnosis of these 10 patients were breast cancer (80%-8 patients). Conclusion: Development of various solid tumors other than breast cancer related to Germ-line ATM heterozygosity highlights the importance of ATM linked to cancer susceptibility.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43925757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Factors for Survival in Pediatric Diffuse Midline Gliomas: The Importance of T2 FLAIR Missmatch Sign and Nimotuzumab Therapy 影响儿童弥漫性中线胶质瘤生存的预后因素：T2 FLAIR不匹配征和尼莫单抗治疗的重要性

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Gazi Medical Journal Pub Date : 2023-10-01 DOI: 10.12996/gmj.2023.84

MD Arzu Okur, Ozge Vural, Merve Yazol, Büşra Topuz Turkcan, A. Börcek, F. Pınarlı, C. Karadeniz

{"title":"Prognostic Factors for Survival in Pediatric Diffuse Midline Gliomas: The Importance of T2 FLAIR Missmatch Sign and Nimotuzumab Therapy","authors":"MD Arzu Okur, Ozge Vural, Merve Yazol, Büşra Topuz Turkcan, A. Börcek, F. Pınarlı, C. Karadeniz","doi":"10.12996/gmj.2023.84","DOIUrl":"https://doi.org/10.12996/gmj.2023.84","url":null,"abstract":"Purpose: The aim of this study is to investigate the clinical and radiological features, especially the importance of the T2-FLAIR mismatch sign and the response to treatment of patients diagnosed with diffuse midline gliomas (DMG) in our center. Methods: Eighteen patients treated with a diagnosis of DMG between January 2008 and January 2021 in Gazi University Medical Faculty, Department of Pediatric Oncology were retrospectively evaluated. The radiologycal evaluation was made as T2-FLAIR mismatch sign positive or negative. After a tumor board review, the diagnosis of DMG was made clinically and radiologically and all patients received local radiotherapy. Nimotuzumab was given as monotherapy or in combination with other medications Results: T2-FLAIR mismatch sign was positive for twelve patients and median OS for patients with T2-FLAIR mismatch positive and negative were 12.5 months and 9.2 months respectively (p=0.77). Median PFS for patients with T2-FLAIR mismatch sign positive and negative were 10.6 months and 4.8 months respectively (p=0.84). After nimotuzumab therapy, there was 4 cases with PR (44.4%), and 1 patient with SD (11.1%). Median OS for patients who were treated with and without nimotuzumab were 16.5 and 6.2 months respectively (p<0.05). Median PFS for patients who were treated with and without nimotuzumab were 13.3 and 3.7 months respectively (p<0.05). Conclusion: In conclusion, DMGs have poor prognosis. In our study patients with T2-FLAIR mismatch sign positive had better prognosis so it can be used as an imaging marker for prognosis. Nimotuzumab therapy may be a promising treatment option for DMG.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45381334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laryngeal Amyloidosis Case Series: Rare Cause of Hoarseness 喉淀粉样变病例系列:罕见的声音嘶哑原因

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Gazi Medical Journal Pub Date : 2023-07-01 DOI: 10.12996/gmj.2023.72

Bao Ling Wong, P. S. Heng, Chian Ling Tang, Nik Fariza Husna Nik Hassan

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Managing a Ruptured Giant Abdominal Aortic Aneurysm with Aortocaval Fistula 主动脉腔瘘治疗破裂的巨大腹主动脉瘤

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Gazi Medical Journal Pub Date : 2023-07-01 DOI: 10.12996/gmj.2023.74

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The Effects of Cerium Oxide on Sevoflurane Anesthesia and its Relationship to Renal Injury in Rats 氧化铈对七氟醚麻醉大鼠的影响及其与肾损伤的关系

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Gazi Medical Journal Pub Date : 2023-07-01 DOI: 10.12996/gmj.2023.59

引用次数: 0

The Evaluation of the Prevalence of Improper Medication Use in Patients Age of 65 and over in Internal Diseases and Neurology Intensive Care Units in Terms of Stopp-Start Criteria 基于停止-开始标准的内科及神经内科重症监护病房65岁及以上患者不当用药发生率评估

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Gazi Medical Journal Pub Date : 2023-07-01 DOI: 10.12996/gmj.2023.62

Özdağ Erdil, H. Z. Güney

{"title":"The Evaluation of the Prevalence of Improper Medication Use in Patients Age of 65 and over in Internal Diseases and Neurology Intensive Care Units in Terms of Stopp-Start Criteria","authors":"Özdağ Erdil, H. Z. Güney","doi":"10.12996/gmj.2023.62","DOIUrl":"https://doi.org/10.12996/gmj.2023.62","url":null,"abstract":"Introduction: Physiological changes are seen in many systems in the body related to aging. Treatment modalities and drug prescribing processes need to be re-evaluated in the geriatric population. To elaborate on polypharmacy, the number of drugs the individual should use must also be defined effectively. Various criteria have been developed for prescribing and using drugs for elderly individuals. The most used of these criteria is called the Beers criteria. STOPP and START criteria are other criteria used. Material and Method: Our study aimed to retrospectively evaluate the prevalence of inappropriate drug use in patients aged 65 and over who were hospitalized in the Internal Medicine and Neurology Intensive Care Units of Ankara Atatürk Training and Research Hospital in terms of STOPP-START criteria. Results: Study group consists of 168 (58,3%) female and 120 (41,7%) male. A total of 727 diseases were diagnosed in 288 patients. 201 of these were \"Cerebrovascular Diseases,” 153 were \"Hypertension.” While the most common STOPP criterion main group and single criterion were antiplatelet anticoagulant agent group (35,7%), “Presence of a drug class causing duplication (Aiming optimum level with a single drug before adding a new agent) (23,2%)”, respectively. At the same time, the most common START criterion main group and single criterion were cardiovascular system group (94,5%), and “Statin therapy in patients who are near the end of life or who are not older than 85 years of age, with a history of coronary, cerebral or peripheral vascular disease”, respectively (70,2%). Conclusion: It is seen that the study results are generally similar to the national literature. There are partisan differences between the study results and the international literature. It is anticipated that these differences can be attributed to the diagnostic criteria used, study group selection, and study design differences.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46011422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Microsatellite Instability in Lung Adenocarcinoma 肺腺癌的微卫星不稳定性

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Gazi Medical Journal Pub Date : 2023-07-01 DOI: 10.12996/gmj.2023.70

引用次数: 0