{"title":"Introduction: History and Poetry in Ennius’Annals","authors":"J. Farrell, C. Damon","doi":"10.1017/9781108650908.001","DOIUrl":"https://doi.org/10.1017/9781108650908.001","url":null,"abstract":"Studies of Ennius’ Annals have grown frequent in recent years, but they are not so common that a new contribution should require any special apology. At the same time, the range of topics and approaches found in recent studies has become much wider than before, so that a new intervention does perhaps require an explanation of its basic assumptions, methods, perspective, and goals, beyond what might be expected of any work of scholarship. That is particularly true at the present moment. Most scholarship on the Annals prior to was principally concerned with establishing the text of this highly fragmentary work and, in a more general sense, with understanding its original form. In that year the appearance of Otto Skutsch’s edition, which is concerned with these matters to a very high degree, perhaps unexpectedly made possible a change of direction. It took some time for the impact of Skutsch’s work to be felt, but the existence of an authoritative text equipped with a copious commentary eventually proved useful to scholars interested in literary, historical, and cultural interpretation. Many of these scholars either endorsed the assumptions on which Skutsch’s edition is based or simply took them for granted, and a few have taken them even further. In short, however widely or explicitly shared the basic assumptions of Skutsch’s work may be, the work itself has to be seen as the one indispensable prerequisite for the boom in Ennian studies that has occurred in these last few decades. Now the situation has changed again. Just a few years ago the assumptions on which Skutsch’s edition and its main predecessors are based were fundamentally questioned by Jackie Elliott, one of the contributors to this volume. It is not yet entirely clear what this will mean over the long run.","PeriodicalId":427672,"journal":{"name":"Ennius' <I>Annals</I>","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130769380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence","authors":"Gary Peltz","doi":"10.1017/9781108650908.011","DOIUrl":"https://doi.org/10.1017/9781108650908.011","url":null,"abstract":"which analyzes whole genome sequence data for 20 inbred strains. This method has been used to analyze the genetic basis for 16 different biomedical traits. Clinical trials are currently underway that test the efficacy of 2 therapies that were generated by these genetic discoveries: a pilot study at Stanford to alleviate incisional pain after surgery and a multi-center NIH funded trial for preventing narcotic drug withdrawal in infants born to narcotic consuming mothers was begun in 2012. Metabolomic analysis: We are developing novel methods for analyzing changes in cellular metabolites caused by drug treatment or in disease. The metabolomic results are integrated with the genetic data to identify new disease mechanisms and to develop new diagnostics. Mice with human LIvers: This is a novel experimental in vivo platform that replaces mouse liver with functioning human liver tissue. The reconstituted liver was shown to be a mature and functioning “human organ.” It had zonal position-specific enzyme expression and bile duct function representative of mature human liver, and could generate a human-specific profile of drug metabolism. These features make this chimeric mouse the preferred experimental platform for in vivo analysis of drug metabolism or liver regeneration. The mice are maintained in a specialized barrier facility that was designed for housing these mice.The humanized mice are being used to: develop a novel platform for predicting human drug metabolism and human drug responses; for understanding stem cell development; and to develop a new method for liver transplantation that uses autologous cells without immunosuppression.","PeriodicalId":427672,"journal":{"name":"Ennius' <I>Annals</I>","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123939123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
求助内容：
应助结果提醒方式：