Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)最新文献_第2页

Breaking the Chains of Tuberculosis: Quantifying the Effects of Literacy, Population Density, and Access to Improve Sanitation to Support Defense Health and Security in Indonesia 打破结核病链:量化识字、人口密度和获得改善卫生设施的影响，以支持印度尼西亚的国防卫生和安全

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.40353

Reinpal Falefi, Hikmat Zakky Almubaraq, Nora Lelyana, Makmur Supriyatno

{"title":"Breaking the Chains of Tuberculosis: Quantifying the Effects of Literacy, Population Density, and Access to Improve Sanitation to Support Defense Health and Security in Indonesia","authors":"Reinpal Falefi, Hikmat Zakky Almubaraq, Nora Lelyana, Makmur Supriyatno","doi":"10.14710/dmj.v12i5.40353","DOIUrl":"https://doi.org/10.14710/dmj.v12i5.40353","url":null,"abstract":"Background: Tuberculosis (TB) is a global health problem. It poses a significant burden worldwide, requiring urgent control measures and research for effective reduction especially in Indonesia.Objective: Investigating the effects of literacy, population density, and access to improved sanitation on TB incidence can provide insights into the relationship between these factors.Methods: This study was conducted in Jakarta, Indonesia from June to July 2023, using secondary data from 2005 to 2021. It employed a quantitative cross-sectional design to examine the relationship between variables. Data were collected from the ASEAN database and analyzed using descriptive and path analysis techniques to determine variable effects and significance. The study found that the incidence of tuberculosis in Indonesia initially decreased from 2005 to 2020 but significantly increased in 2021.Results: Population density, adult literacy rate, and access to improved sanitation all showed positive trends. Significant direct effects were observed among most variables, and indirect effects of population density on tuberculosis incidence were also identified through literacy and sanitation. The final model showed that higher population density correlated with increased access to sanitation and literacy rate, while access to improved sanitation was associated with reduced tuberculosis incidence. Overall, the model had a very good fit based on the indicators.Conclusion: Priority investments in sanitation infrastructure, especially in densely populated areas, along with improved access to sanitation facilities, combined with targeted health education campaigns and collaboration across defense, health, and education sectors, are recommended to enhance tuberculosis prevention and control","PeriodicalId":426927,"journal":{"name":"Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125582692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemicals as a potential inhibitor of Spike Protein of SARS-CoV-2 Omicron Variant 植物化学物质作为SARS-CoV-2组粒变异穗蛋白的潜在抑制剂

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.39577

Tuti Ratnasari, F. Fulyani, Endang Mahati

{"title":"Phytochemicals as a potential inhibitor of Spike Protein of SARS-CoV-2 Omicron Variant","authors":"Tuti Ratnasari, F. Fulyani, Endang Mahati","doi":"10.14710/dmj.v12i5.39577","DOIUrl":"https://doi.org/10.14710/dmj.v12i5.39577","url":null,"abstract":"Background: More than 50 mutations have been found in Omicron SARS-CoV-2. Most Omicron mutations are located in the spike protein, which plays a pivotal role in virus infection. The mutated spike protein in the Omicron variant increases virus transmissibility and potentially threatens the effectiveness of COVID-19 vaccines and antibody therapies. Herbal plants, such as Indian Ayurveda, African herbal plants, and Traditional Chinese Medicines (TCM), have been studied as SARS-CoV-2 potential therapy in several countries.Objective: This review explores potential phytochemical herbals that target spike protein omicron based on the available molecular docking studies.Methods: We collected research articles on the molecular docking of phytochemicals that target spike protein omicron. Combination of several keywords: in silico OR molecular docking AND spike omicron, were used as input for Google search. Out of 83 articles from Google search, eight articles matched the inclusion criteria and were selected in this review.Result: Protodioscin from Carica papaya and Landomycin A from Aloe vera are the most potential phytochemical inhibitors against spike protein with the free binding energy of -10.77 kcal/mol and -10kcal/mol, respectively. ","PeriodicalId":426927,"journal":{"name":"Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116727447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 56 Years Old Female with Uncontrolled Diabetes Mellitus Type II, Pneumonia, and Suspect With Lung Abscess: a Case Report 56岁女性，合并未控制的2型糖尿病、肺炎及疑似肺脓肿1例

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.38079

Fahreza Fahreza, Diana Novita, Sri Meutia

{"title":"A 56 Years Old Female with Uncontrolled Diabetes Mellitus Type II, Pneumonia, and Suspect With Lung Abscess: a Case Report","authors":"Fahreza Fahreza, Diana Novita, Sri Meutia","doi":"10.14710/dmj.v12i5.38079","DOIUrl":"https://doi.org/10.14710/dmj.v12i5.38079","url":null,"abstract":"Background:Diabetes mellitus is a group of metabolic diseases with characteristic hyperglycemia. Proper management of DM patients is essential, and this is useful for controlling appropriate blood glucose levels. If blood glucose levels are uncontrolled, this lead to other complications in other organs, like interference with the immune system. Disruption of the immune system causes the risk of infectious diseases, such as pneumonia and lung abscess.Case Presentation:We report a female patient with a history of type 2 diabetes mellitus, complaining of dyspnea, cough with sputum, high fever, and headache. On chest examination showed left chest movement in the right lung, increased stem fremitus in all right lung fields, dullness in the right upper lung field, and amphoric sound, coarse and wet crackles heard in the right upper lung. Several supporting examinations, including laboratory and radiological examinations were carried out.Conclusion: The patient was diagnosed with uncontrolled type 2 diabetes mellitus, pneumonia, and a suspected lung abscess. The patient was given several treatments and showed clinical improvement on the fifth day of treatment.","PeriodicalId":426927,"journal":{"name":"Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125352708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morbus Hansen

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.39371

Fitriah Idris, Wizar Putri Mellaratna

引用次数: 0

The Effect of Cervical Cancer Counseling on Cervical Cancer Prevention Behavior in Women of Childbearing Age: A Literature Study 宫颈癌咨询对育龄妇女宫颈癌预防行为影响的文献研究

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.38759

Miranti Puteri Aulia, M. Hartanti

{"title":"The Effect of Cervical Cancer Counseling on Cervical Cancer Prevention Behavior in Women of Childbearing Age: A Literature Study","authors":"Miranti Puteri Aulia, M. Hartanti","doi":"10.14710/dmj.v12i5.38759","DOIUrl":"https://doi.org/10.14710/dmj.v12i5.38759","url":null,"abstract":"Background: : According to World Health Organization (WHO) data, cervical cancer is the second leading cause of death worldwide . In 2020 the worldwide burden of cervical cancer is significant, there are an estimated 604,000 new infections and 342,000 deaths in 2020. Based on Riskesdas data, the prevalence of tumor/cancer, especially cervical cancer, in Indonesia ranks second with 36,633 cases, accounting for 9.2% of all cancer cases. Effective interventions at various life stages could significantly reduce global mortality from cervical cancer. Objective: This study was conducted to examine the impact of cervical cancer counseling on cervical cancer prevention behavior in women of reproductive age. Methods: Conducting a literature review of previous journal articles related to the effects of cervical cancer counseling on cervical cancer prevention behavior in women of childbearing age. Results: The results of this study indicate that cervical cancer is a significant reproductive health issue in Indonesia due to low screening coverage and lack of knowledge, resulting in late diagnosis. However, education and counseling can play a vital role in increasing awareness and promoting preventive behavior towards cervical cancer. Conclusion: Education and counseling interventions can effectively increase awareness and promote preventive behavior, this promotive and preventive behavior greatly reduces the burden of cervical cancer. ","PeriodicalId":426927,"journal":{"name":"Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126557163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical and Professional Dilemmas encountered by Doctors in the National Health Insurance System 国民健康保险制度下医生面临的伦理与职业困境

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.40503

T. Dhanardhono, Wian Pisia Anggreliana, Intarniati Nur Rohmah, S.K.L. Bhima

{"title":"Ethical and Professional Dilemmas encountered by Doctors in the National Health Insurance System","authors":"T. Dhanardhono, Wian Pisia Anggreliana, Intarniati Nur Rohmah, S.K.L. Bhima","doi":"10.14710/dmj.v12i5.40503","DOIUrl":"https://doi.org/10.14710/dmj.v12i5.40503","url":null,"abstract":"Background: The implementation of the National Health Insurance System in Indonesia has not only increased access to medical services but also raised various dilemmas among doctors. Objective: This study aims to analyse various ethical and professional dilemmas among physicians in the National Health Insurance System (NHIS).Methods: This is a cross-sectional descriptive study with a purposive sampling method. A questionnaire was distributed online between June to December 2019 to physicians practicing in Indonesia.Results: Of the 87 doctors who participated in this study, 60.92% were general practitioners and 39.08% were specialists. The inability to maintain professional independence (63.41%) is the most common ethical dilemma faced by doctors with 65.38% of them experienced in advanced level health facilities. Meanwhile, the limitation of adequate medical care in an emergency (25.45%) is the most dilemmatic situation experienced in terms of professionalism with 85.71% occurring in advanced level health facilities.Conclusion: Physicians in Indonesia were deal with various dilemmas while practicing in the NHIS. The high rate of dissatisfaction and the various ethical problems and professional disciplines require a review of the health system to improve the quality of services and maintain the professionalism of doctors.","PeriodicalId":426927,"journal":{"name":"Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132707998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of the Neutrophil-to-Lymphocytes Ratio with Serum Urea and Creatinine Levels in Leptospirosis Patients 钩端螺旋体病患者中性粒细胞与淋巴细胞比值与血清尿素和肌酐水平的相关性

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.37592

D. Retnoningrum, Teddy Dharmawan

{"title":"Correlation of the Neutrophil-to-Lymphocytes Ratio with Serum Urea and Creatinine Levels in Leptospirosis Patients","authors":"D. Retnoningrum, Teddy Dharmawan","doi":"10.14710/dmj.v12i5.37592","DOIUrl":"https://doi.org/10.14710/dmj.v12i5.37592","url":null,"abstract":"Background: Leptospirosis is a zoonosis that is still a problem in Indonesia. The kidneys are often the target organs in leptospirosis. The outer membrane of Leptospira Sp contains antigenic components and toxins that stimulate the inflammatory process in the kidneys. The neutrophil-to-lymphocyte ratio (NLR) is used as a marker of the inflammatory process, while urea creatinine is a sign of kidney damage. Objective: To prove the correlation between NLR and serum urea and creatinine levels in leptospirosis patients. Methods: This study was carried out retrospectively on the medical records of patients with confirmed leptospirosis by Microscopic Agglutination Test (MAT) at Dr. Kariadi Semarang between January 2020 and July 2022. NLR examination was obtained by dividing the number of neutrophils by the number of lymphocytes in the leukocyte count, urea, and creatinine levels from the patient's medical record. Statistical analysis using the Spearman correlation test, with a significance level of p <0.05. Results: From 33 samples, the median NLR was 10.75 (2.19-47,5), the median urea level was 131.0 mg/dL (15–467 mg/dL) creatinine 2.0 mg/dL (0.7-11.9 mg/dL). The correlation between NLR with urea (p=0.001 and r=0.561) and creatinine (p=0.003 and r=0.501). Increased NLR, urea, and creatinine were found in leptospirosis patients. Conclusion: There is a moderate positive correlation between NLR and urea and creatinine. An increase in NLR is a sign of an inflammatory process from leptospirosis. An increase in NLR correlates with an increase in urea and creatinine","PeriodicalId":426927,"journal":{"name":"Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116857263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between HbA1c Levels with Several Methods of estimated Glomerular Filtration Rate Calculation : Study in type-2 diabetes mellitus patients HbA1c水平与几种估算肾小球滤过率计算方法的相关性:2型糖尿病患者的研究

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.38564

M. Hendrianingtyas

{"title":"Correlation between HbA1c Levels with Several Methods of estimated Glomerular Filtration Rate Calculation : Study in type-2 diabetes mellitus patients","authors":"M. Hendrianingtyas","doi":"10.14710/dmj.v12i5.38564","DOIUrl":"https://doi.org/10.14710/dmj.v12i5.38564","url":null,"abstract":"ABSTRACTBackground: Diabetes Mellitus is a long-term chronic disease characterized by blood glucose levels enhancement (hyperglycemia). Diabetes is closely related to hyperglycemia conditions. Prolonged hyperglycemic conditions can initiate abnormal interactions of metabolic and hemodynamic factors and stimulate the establishment of fibronectin and collagen, including affecting eGFR values. This study analyzed the correlation between HbA1c level and several methods of calculating eGFR in patients with type-2 diabetes mellitus.Objective: Analyzing the correlation between HbA1c levels and several methods of calculating eGFR (CKD-EPI, MDRD, and CG) in patients with type-2 diabetes mellitus.Method: This study was a cross-sectional observational study on 85 research subjects aged over 18 in February to November 2021. The data were taken from medical records of type-2 diabetes mellitus patients at RSND Semarang. The statistical analysis used the Pearson test.Results: The Pearson results showed that there was a significant correlation between HbA1c levels and several methods of calculating eGFR in patients with type-2 diabetes mellitus (p=0,000; r=0,430 in the CKD-EPI method, p=0,000; r=0,384 in the MDRD method, p=0,001; r=0,361 in the CG method).Conclusion: There was a significant positive correlation between HbA1c levels and eGFR CG, MDRD, and CKD-EPI methods in patients with type-2 diabetes mellitus, characterized by increased HbA1c levels and still high eGFR values.Keywords: Diabetes mellitus, HbA1c, eGFR, CKD-EPI, MDRD, CG","PeriodicalId":426927,"journal":{"name":"Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)","volume":"237 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115176025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Level Of Patient Satisfaction With Pharmaceutical Services In The Outpatient Pharmaceutical Room, Mandiraja Community Health Center 1 Mandiraja社区卫生中心门诊药房患者对药学服务的满意度

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.39231

Novita Endang Fitriyani, Iva Rinia Dewi, Dian Novita Octavia

{"title":"Level Of Patient Satisfaction With Pharmaceutical Services In The Outpatient Pharmaceutical Room, Mandiraja Community Health Center 1","authors":"Novita Endang Fitriyani, Iva Rinia Dewi, Dian Novita Octavia","doi":"10.14710/dmj.v12i5.39231","DOIUrl":"https://doi.org/10.14710/dmj.v12i5.39231","url":null,"abstract":"Background: Pharmaceutical services are direct and responsible services to patients with the aim of improving the patient's quality of life. Satisfaction is a feeling of pleasure or disappointment that arises after comparing product performance with expected performance. Satisfaction and service are two things that cannot be separated, with the satisfaction of related parties, they can correct each other how far the improvement in the services that have been provided. Measurement of satisfaction uses five dimensions of service quality, namely tangible evidence (Tangible), responsiveness (responsiveness), assurance (assurance), empathy (Emphaty) and reliability (Reliability). Objective: This study was to describe the level of patient satisfaction with pharmaceutical services in the outpatient pharmacy room at Puskesmas Mandiraja 1. Methods: The type of research was descriptive using a cross sectional approach with the sampling technique of accidental sampling and data collection using questionnaires. Results: Based on the results of calculations on each research indicator the level of patient satisfaction with pharmaceutical services in the outpatient pharmacy room at Mandiraja 1 Health Center is generally categorized as satisfied with the percentage of 75%. The real evidence dimension is 74.15%, the responsiveness dimension is 75.01 %, assurance dimension of 77.44%, the empathy dimension is 75.15% and reliability dimension of 71.07%. Conclusion: Based on the results of the study, the level of patient satisfaction with pharmaceutial services in the outpatient pharmacy room at Puskesmas Mandiraja 1 was in the satisfed category","PeriodicalId":426927,"journal":{"name":"Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132969922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Hyperglycemia in Pregnancy and The Impacts on Fetal Welfare 病例报告:妊娠期高血糖及其对胎儿福利的影响

Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Pub Date : 2023-08-31 DOI: 10.14710/dmj.v12i5.37831

Stella Andani

引用次数: 0