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International Journal of Endocrine Oncology最新文献

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The role of theragnostics in oncology: an interview with Stefano Buono 诊断学在肿瘤学中的作用：Stefano Buono访谈
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-06-09 DOI: 10.2217/ije-2017-0014
S. Buono
{"title":"The role of theragnostics in oncology: an interview with Stefano Buono","authors":"S. Buono","doi":"10.2217/ije-2017-0014","DOIUrl":"https://doi.org/10.2217/ije-2017-0014","url":null,"abstract":"Stefano Buono* speaks to Commissioning Editor, Sebastian Dennis-Beron: Stefano Buono is the Chief Executive Officer, a member of the board of directors, and a founder of Advanced Accelerator Applications (AAA). He has been responsible for overseeing AAA operations, including the development and commercialization of the current portfolio of diagnostic and therapeutic molecular nuclear medicine products, and listing AAA on Nasdaq (stock symbol: AAAP). Prior to founding the company in 2002, he worked as a physicist at the Centre for Advanced Studies, Research and Development, or CRS4, in Italy. During his 6-year tenure with CRS4, he headed a team of engineers working on different international research projects in the field of energy production and nuclear waste transmutation. Before working at CRS4, and alongside his appointment at CRS4, he worked with Physics Nobel Laureate Carlo Rubbia at The European Organization for Nuclear Research (CERN), the world’s largest research laboratory for particle physics, i...","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/ije-2017-0014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48708771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The evolving landscape of systemic therapy for well-differentiated neuroendocrine tumors of the lung 分化良好的肺神经内分泌肿瘤系统治疗的发展前景
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-05-15 DOI: 10.2217/IJE-2017-0003
James C. Yao
{"title":"The evolving landscape of systemic therapy for well-differentiated neuroendocrine tumors of the lung","authors":"James C. Yao","doi":"10.2217/IJE-2017-0003","DOIUrl":"https://doi.org/10.2217/IJE-2017-0003","url":null,"abstract":"James Yao*, MD, is professor and chairman of gastrointestinal medical oncology at the MD Anderson Cancer Center (TX, USA). He is the chair emeritus of the North American Neuroendocrine Tumor Society (NANETS). He has numerous awards including the American Society of Clinical Oncology Career Development Award 2003, and the Carcinoid Cancer Foundation Research Award 2006, MD Anderson Distinguished Alumni Award 2009, Irwin H. Krakoff Excellence in Clinical Research Award 2011, and The Murray Brennan Distinguished Lecturer, Memorial Sloan-Kettering Cancer Center, 2012. In 1995, Dr. Yao received his doctorate of medicine at Baylor College of Medicine (TX, USA). His credentials include board of certification in internal medicine (ABIM) in 1999 and board of certification in medical oncology (ABIM) in 2003. Dr. Yao has special interests in neuroendocrine tumors and gastric cancer and has authored over 100 manuscripts including practice-changing articles in New England Journal of Medicine and The Lancet. He has als...","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42624252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics of human parathyroid tumors 人类甲状旁腺肿瘤的表观遗传学
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-05-08 DOI: 10.2217/IJE-2017-0002
V. Chiara, Corbetta Sabrina
{"title":"Epigenetics of human parathyroid tumors","authors":"V. Chiara, Corbetta Sabrina","doi":"10.2217/IJE-2017-0002","DOIUrl":"https://doi.org/10.2217/IJE-2017-0002","url":null,"abstract":"Parathyroid tumors are common endocrine neoplasia associated with primary hyperparathyroidism, a metabolic disorder sustained by parathormone hypersecretion. The epigenetic scenario in parathyroid tumors is beginning to be decoded. Here, main findings are reviewed: hypermethylation of specific DNA CpG islands has been described, despite global DNA promoter hypomethylation was not detectable; embryonic-related miRNAs, belonging to the C19MC and miR‐371-373 clusters, and miR‐296, are deregulated; expression of histone H1.2 and H2B is increased; expression of histone methyltransferase EZH2, BMI1 and RIZ1 is impaired; the tumor suppressor HIC1, MEN1 and CDC73 gene products, key molecules in parathyroid tumorigenesis, may be involved in epigenetic aberrant changes. Epigenetic changes are more frequent and more consistent in parathyroid malignancies, and positively correlated with severity of primary hyperparathyroidism.","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44712861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Using genetics to develop new treatment possibilities for ovarian cancer 利用遗传学为卵巢癌开发新的治疗方法
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-05-08 DOI: 10.2217/IJE-2017-0006
J. Delaney, D. Stupack
{"title":"Using genetics to develop new treatment possibilities for ovarian cancer","authors":"J. Delaney, D. Stupack","doi":"10.2217/IJE-2017-0006","DOIUrl":"https://doi.org/10.2217/IJE-2017-0006","url":null,"abstract":"","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45147955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral extramedullary adrenal plasmacytoma: case report and review of the literature. 双侧髓外肾上腺浆细胞瘤：病例报告和文献综述。
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-05-01 Epub Date: 2017-05-03 DOI: 10.2217/ije-2016-0023
Philip J Townend, Gabriel Kraus, Luke Coyle, David Nevell, Anton Engelsman, Stan B Sidhu
{"title":"Bilateral extramedullary adrenal plasmacytoma: case report and review of the literature.","authors":"Philip J Townend, Gabriel Kraus, Luke Coyle, David Nevell, Anton Engelsman, Stan B Sidhu","doi":"10.2217/ije-2016-0023","DOIUrl":"10.2217/ije-2016-0023","url":null,"abstract":"<p><p>Extramedullary plasmacytoma (EMP) accounts for only 3% of plasma cell malignancies; others include multiple myeloma, plasma cell leukemia and solitary plasmacytoma of bone. The majority of EMPs are found in the upper respiratory tract. Other sites include the GI tract, bladder, CNS, thyroid, breast, testes, parotid gland, lymph nodes and skin. There are eight cases in the literature of adrenal plasmacytoma, however, only two were bilateral. We describe our recent experience of bilateral adrenal plasmacytoma and review of the literature. While EMP may present as aggressive locally destructive lesions, excellent local control can be achieved in a majority of cases. Follow-up should be lifelong due to risk of progression to multiple myeloma.</p>","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480130/pdf/ije-04-67.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35279244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
11-Deoxycortisol may be superior to cortisol in confirming a successful adrenal vein catheterization without cosyntropin: a pilot study. 一项初步研究表明，去氧皮质醇可能优于皮质醇，可证实无共syntropin的肾上腺静脉导管置入术成功。
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-05-01 Epub Date: 2017-04-27 DOI: 10.2217/ije-2016-0020
Naris Nilubol, Steven J Soldin, Dhaval Patel, Muthoni Rwenji, Jianghong Gu, Likhona S Masika, Richard Chang, Constantine A Stratakis, Electron Kebebew
{"title":"11-Deoxycortisol may be superior to cortisol in confirming a successful adrenal vein catheterization without cosyntropin: a pilot study.","authors":"Naris Nilubol,&nbsp;Steven J Soldin,&nbsp;Dhaval Patel,&nbsp;Muthoni Rwenji,&nbsp;Jianghong Gu,&nbsp;Likhona S Masika,&nbsp;Richard Chang,&nbsp;Constantine A Stratakis,&nbsp;Electron Kebebew","doi":"10.2217/ije-2016-0020","DOIUrl":"https://doi.org/10.2217/ije-2016-0020","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to compare the performance of nine adrenal steroids in confirming the correct catheter position during adrenal venous sampling (AVS) without cosyntropin in patients with primary hyperaldosteronism.</p><p><strong>Materials & methods: </strong>A successful adrenal vein catheterization without cosyntropin was defined as the ratio of steroids from adrenal to peripheral veins being >3:1. AVS samples from four patients with primary hyperaldosteronism were analyzed.</p><p><strong>Results: </strong>Compared with the mean ratio of cortisol without cosyntropin, the ratios of 11-deoxycortisol (p = 0.008), dehydroepiandrosterone (p = 0.01) and androstenedione (p = 0.008) were significantly higher. None of the ratios (n = 8) of cortisol from adrenal to peripheral veins exceeded 3:1, while all ratios of 11-deoxycortisol (p < 0.001) were >3.</p><p><strong>Conclusion: </strong>Cosyntropin infusion during AVS may not be necessary if 11-deoxycortisol is used to confirm catheter position.</p>","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/ije-2016-0020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35279245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Recent advances in the management of endocrine malignancies associated with hereditary hyperparathyroidism syndromes 遗传性甲状旁腺功能亢进综合征相关内分泌恶性肿瘤的治疗进展
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-04-27 DOI: 10.2217/IJE-2016-0018
Yulong Li, W. Simonds
{"title":"Recent advances in the management of endocrine malignancies associated with hereditary hyperparathyroidism syndromes","authors":"Yulong Li, W. Simonds","doi":"10.2217/IJE-2016-0018","DOIUrl":"https://doi.org/10.2217/IJE-2016-0018","url":null,"abstract":"Hereditary hyperparathyroidism syndromes, such as multiple endocrine neoplasm type 1, type 2A and the hyperparathyroidism-jaw tumor syndrome, are associated with an increased incidence of malignancies involving the neuroendocrine tissue of the pancreas and thymus, parathyroid and thyroid glands. The natural history of these endocrine tumors can differ from nonhereditary malignancies. The surgical approach, the only potentially curative treatment option for these endocrine malignancies, has evolved considerably in recent years. Newer targeted therapies, such as small molecule kinase inhibitors, somatostatin analogs and peptide receptor radionuclide therapy, are being developed. We provide here a comprehensive review of the current standards of treatment and emerging novel therapies for the endocrine malignancies commonly associated with hereditary hyperparathyroidism syndromes.","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2016-0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43985893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Von Hippel-Lindau disease: a multidisciplinary neoplasia syndrome Von Hippel-Lindau病：一种多学科肿瘤综合征
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-04-03 DOI: 10.2217/IJE-2016-0021
K. Dreijerink, A. N. Horst-Schrivers, T. Links, R. Giles
{"title":"Von Hippel-Lindau disease: a multidisciplinary neoplasia syndrome","authors":"K. Dreijerink, A. N. Horst-Schrivers, T. Links, R. Giles","doi":"10.2217/IJE-2016-0021","DOIUrl":"https://doi.org/10.2217/IJE-2016-0021","url":null,"abstract":"","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2016-0021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46681749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel targets in the treatment of neuroendocrine tumors: RBP2 治疗神经内分泌肿瘤的新靶点：RBP2
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-03-23 DOI: 10.2217/IJE-2016-0022
E. Maggi, J. Crabtree
{"title":"Novel targets in the treatment of neuroendocrine tumors: RBP2","authors":"E. Maggi, J. Crabtree","doi":"10.2217/IJE-2016-0022","DOIUrl":"https://doi.org/10.2217/IJE-2016-0022","url":null,"abstract":"Retinoblastoma binding protein 2, also known as RBP2, JARID1A or KDM5A, is an H3K4 demethylase implicated in a variety of non-neuroendocrine, and more recently, neuroendocrine tumors (NETs). NETs are tumors that form from neuroendocrine cells in tissues of the GI tract, endocrine pancreas, lung, skin and other tissues. RBP2 is expressed at abnormally high levels in NETs and recent work demonstrates that modulation of RBP2 in vitro and in vivo impacts end points of tumorigenesis. Interestingly, the demethylase activity of RBP2 is not exclusively responsible for these changes, as RBP2's binding partners may mediate its activity in a tissue- or context-dependent manner. Here, we discuss the features of RBP2 and its role in cell cycle regulation, angiogenesis and drug resistance in cancer.","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2016-0022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44912816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Factors influencing Ki67 calculation in neuroendocrine neoplasia 影响神经内分泌肿瘤Ki67计算的因素
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2017-03-23 DOI: 10.2217/IJE-2016-0011
C. Castañeda, Miluska Castillo, Juvenal Sanchez, S. Casavilca, C. Gonzalez, C. Flores, Luis Cano, Carolina Belmar-López, Rosario Villa-Robles, Gabriela Rios-Martini, Yun Wu
{"title":"Factors influencing Ki67 calculation in neuroendocrine neoplasia","authors":"C. Castañeda, Miluska Castillo, Juvenal Sanchez, S. Casavilca, C. Gonzalez, C. Flores, Luis Cano, Carolina Belmar-López, Rosario Villa-Robles, Gabriela Rios-Martini, Yun Wu","doi":"10.2217/IJE-2016-0011","DOIUrl":"https://doi.org/10.2217/IJE-2016-0011","url":null,"abstract":"Aim: We compared different methodologies to evaluate Ki67 in neuroendocrine neoplasia (NEN). Patients & methods: ki67 was evaluated using three methods in 70 NEN cases: manual-count, eyeballed estimate made by three pathologists and ImmunoRatio-software. Manual-count was the standard method and agreement with it was evaluated through intraclass correlation (ICC). Results: Agreement between manual-count and eyeballed estimate had ICC: 0.887–0.929. Eyeballed estimate by three pathologists produced upgradation in 5.7–32.9% and downgradation in 5.7% of NEN cases. Agreement for ImmunoRatio-count had ICC: 0.989. Immunoratio produced upgradation in 17.1% and downgradation in 8.5% cases. Agreement between all methods was higher at low-Ki67. Cellularity, immune-cell infiltration, staining and sample quality did not affect agreement. Conclusion: Eyeballed estimate and ImmunoRatio showed good accuracy, especially at low-Ki67.","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2016-0011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46927337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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