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Effects of 3,5-diiodo-L-thyronine on the liver of high fat diet fed rats 3,5-二碘- l -甲状腺原氨酸对高脂饲料喂养大鼠肝脏的影响
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2016-06-27 DOI: 10.4081/JBR.2016.5667
M. Giammanco, S. Aiello, A. Casuccio, M. Guardia, L. Cicero, R. Puleio, I. Vazzana, G. Tomasello, G. Cassata, G. Leto, D. Majo
{"title":"Effects of 3,5-diiodo-L-thyronine on the liver of high fat diet fed rats","authors":"M. Giammanco, S. Aiello, A. Casuccio, M. Guardia, L. Cicero, R. Puleio, I. Vazzana, G. Tomasello, G. Cassata, G. Leto, D. Majo","doi":"10.4081/JBR.2016.5667","DOIUrl":"https://doi.org/10.4081/JBR.2016.5667","url":null,"abstract":"Experimental studies have highlighted that the administration of 3,5-diiodo-L-thyronine (T2) to rats fed diets rich in lipids induces a decrease of cholesterol and triglycerides plasma levels and body weight (BW) without inducing liver steatosis. On the basis of these observations we carried out some experimental in vivo studies to assess the effects of multiple high doses of T2 on the pituitary thyroid axis of rats fed diet rich in lipids. Fifteen male Wistar rats were divided into three groups of five animals each. The first group (N group) received standard diet, the second group was fed with a high fat diet (HFD group), while the third group (HFDT2 group) was additionally given T2 intraperitoneally at a dose level of 70 µg/100 g of BW three times a week up to four weeks. At the end of the treatment, blood sample from each animal was collected, centrifuged and the serum was stored at -20°C. The serum concentrations of thyroidstimulating hormone (TSH), triiodothyronine, thyroxine, adrenocorticotropic hormone, triglycerides, cholesterol, glucose, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase were then determined. In addition, liver of rats was examined by histology in order to assess the presence and degree of steatosis. The administration of T2 to rats fed with a high fat diet suppressed TSH secretion (P=0.013) while no steatosis was observed in the liver of these animals. Our data show that multiple administrations of high doses of T2 to rats fed diets rich in lipid inhibit TSH secretion and prevent the onset of liver steatosis in these animals.","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/JBR.2016.5667","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70232865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Monitoring and use of antimycotic (micafungin) for systemic use provided by the pharmacy of Marsala Hospital, Italy 意大利Marsala医院药房提供的抗真菌药(micafungin)系统用药的监测和使用情况
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2016-06-08 DOI: 10.4081/JBR.2016.5113
F. Venturella, M. Tumbarello, L. Navarra, S. Martorana
{"title":"Monitoring and use of antimycotic (micafungin) for systemic use provided by the pharmacy of Marsala Hospital, Italy","authors":"F. Venturella, M. Tumbarello, L. Navarra, S. Martorana","doi":"10.4081/JBR.2016.5113","DOIUrl":"https://doi.org/10.4081/JBR.2016.5113","url":null,"abstract":"Micafungin is an antimycotic drug and represents an important addition to the available therapies for the treatment of systemic fungal infections. Micafungin is used: in the treatment of invasive candidiasis, oesophageal and prophylaxis of Candida infections. It inhibits, in a non-competitive way, the synthesis of 1,3-β-D-glucan, a component of fungal cell wall and is rapidly distributed into the tissues. It has a high-rate respectful bond with plasma protein, which is independent from the concentration of the drug. It is metabolized through the liver, being not subject to intense metabolic transformations until the excretion. There is no evidence of systemic accumulation after repeated use. The steady-state is reached in 4-5 days. Medical records examined at the pharmacy of Marsala Hospital highlight that, from 01/06/2014 to 01/08/2014, in this hospital 12 vials were used by the hospitalized patients in the Department of Intensive Care: 8 patients between 75 and 83 years old had a body weight (BW) higher than 40 kg; 3 patients between 40 and 60 years of age had a BW higher than 40 kg, and one 17 year-old patient had a BW of 40 kg. Two patients needed a dose increase, while for the other 10 patients the first dose resulted sufficient. Mycamine ® was used for the treatment of hypovolemic post-operative shock. The most recorded adverse reactions were anemia, hypokalemia, hypomagnesemia, phlebitis, nausea, liver problems. Given the different weight of the subjects, the dosage was different.","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2016-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/JBR.2016.5113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70232776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ZmRCP-1 promoter of maize provides root tip specific expression of transgenes in plantain 玉米ZmRCP-1启动子在车前草中提供根尖特异性表达
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2016-03-29 DOI: 10.1186/s40709-016-0041-z
S. Onyango, H. Roderick, Jaindra Nath Tripathi, R. Collins, H. Atkinson, Richard O. Oduor, L. Tripathi
{"title":"The ZmRCP-1 promoter of maize provides root tip specific expression of transgenes in plantain","authors":"S. Onyango, H. Roderick, Jaindra Nath Tripathi, R. Collins, H. Atkinson, Richard O. Oduor, L. Tripathi","doi":"10.1186/s40709-016-0041-z","DOIUrl":"https://doi.org/10.1186/s40709-016-0041-z","url":null,"abstract":"","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2016-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40709-016-0041-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65745355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Gram-negative and -positive bacteria differentiation in blood culture samples by headspace volatile compound analysis 用顶空挥发性化合物分析血液培养样品中革兰氏阴性和阳性细菌的分化
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2016-03-12 DOI: 10.1186/s40709-016-0040-0
M. Dolch, Silke Janitza, A. Boulesteix, Carola Graßmann-Lichtenauer, S. Praun, W. Denzer, G. Schelling, S. Schubert
{"title":"Gram-negative and -positive bacteria differentiation in blood culture samples by headspace volatile compound analysis","authors":"M. Dolch, Silke Janitza, A. Boulesteix, Carola Graßmann-Lichtenauer, S. Praun, W. Denzer, G. Schelling, S. Schubert","doi":"10.1186/s40709-016-0040-0","DOIUrl":"https://doi.org/10.1186/s40709-016-0040-0","url":null,"abstract":"","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2016-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40709-016-0040-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65745344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Addressing huge spatial heterogeneity induced by virus infections in lentil breeding trials 解决小扁豆育种试验中病毒感染诱导的巨大空间异质性
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2016-03-01 DOI: 10.1186/s40709-016-0039-6
A. Kargiotidou, D. Vlachostergios, C. Tzantarmas, I. Mylonas, C. Foti, G. Menexes, A. Polidoros, I. Tokatlidis
{"title":"Addressing huge spatial heterogeneity induced by virus infections in lentil breeding trials","authors":"A. Kargiotidou, D. Vlachostergios, C. Tzantarmas, I. Mylonas, C. Foti, G. Menexes, A. Polidoros, I. Tokatlidis","doi":"10.1186/s40709-016-0039-6","DOIUrl":"https://doi.org/10.1186/s40709-016-0039-6","url":null,"abstract":"","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40709-016-0039-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65745328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
NaCl stress-induced transcriptomics analysis of Salix linearistipularis (syn. Salix mongolica) 盐胁迫诱导Salix linearistipularis (syn. Salix mongolica)转录组学分析
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2016-02-29 DOI: 10.1186/s40709-016-0038-7
Guixian Nan, Yan Zhang, Song Li, Imshik Lee, T. Takano, Shenkui Liu
{"title":"NaCl stress-induced transcriptomics analysis of Salix linearistipularis (syn. Salix mongolica)","authors":"Guixian Nan, Yan Zhang, Song Li, Imshik Lee, T. Takano, Shenkui Liu","doi":"10.1186/s40709-016-0038-7","DOIUrl":"https://doi.org/10.1186/s40709-016-0038-7","url":null,"abstract":"","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40709-016-0038-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65745319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Climate change and food safety: citizen science for monitoring the presence of toxic alien fish species in Italian waters 气候变化和食品安全:监测意大利水域有毒外来鱼类存在的公民科学
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2016-01-01 DOI: 10.4081/jbr.2016.6432
L. Guardone, M. Guarducci, L. Gasperetti, F. Susini, Martina Longo, A. Maneschi, Nadav Davidovich, A. Guidi, A. Armani
{"title":"Climate change and food safety: citizen science for monitoring the presence of toxic alien fish species in Italian waters","authors":"L. Guardone, M. Guarducci, L. Gasperetti, F. Susini, Martina Longo, A. Maneschi, Nadav Davidovich, A. Guidi, A. Armani","doi":"10.4081/jbr.2016.6432","DOIUrl":"https://doi.org/10.4081/jbr.2016.6432","url":null,"abstract":"","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/jbr.2016.6432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70232917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Gluten sensitivity and neurological manifestations 麸质敏感性和神经系统表现
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2015-12-17 DOI: 10.4081/JBR.2015.5405
A. Berio, G. Mangiante, G. Mariottini, A. Piazzi
{"title":"Gluten sensitivity and neurological manifestations","authors":"A. Berio, G. Mangiante, G. Mariottini, A. Piazzi","doi":"10.4081/JBR.2015.5405","DOIUrl":"https://doi.org/10.4081/JBR.2015.5405","url":null,"abstract":"The authors report on six cases of gluten-sensitivity, also defined non-celiac gluten sensitivity, characterized by abdominal features (diarrhea, bloating, pain), genetic positivity for predisposition to celiac disease (DQB1* 02 in all cases; DQA1*05 in three; DQA1*02 in two, DQB1*03 in two), negative anti-t-Transglutaminase antibodies, normal mucosa on biopsy in four cases, type 1 of Marsh in one case. The subjects presented frequent central nervous system (CNS) symptoms: headache in three patients, somnolence in one, electroencephalogram aspecific alterations in three (in two of them with previous seizures), leptomeningeal cyst in one, intracranial calcification in one, cerebral gliosis in two. After a gluten-free diet, all intestinal and clinical CNS features remitted, but re-appeared after gluten reintroduction. On the basis of the neurological signs, the authors stress the relevance of immune innate system in the pathogenesis of these cases with possible subsequent evolution on immune adaptive system involvement.","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2015-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/JBR.2015.5405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70233030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases BIM交互组的识别与功能分析它可能与eb病毒相关疾病有关的新线索
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2015-12-01 DOI: 10.1186/s40709-015-0037-0
E. Rouka, D. Kyriakou
{"title":"Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases","authors":"E. Rouka, D. Kyriakou","doi":"10.1186/s40709-015-0037-0","DOIUrl":"https://doi.org/10.1186/s40709-015-0037-0","url":null,"abstract":"","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40709-015-0037-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65745307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of melatonin in oral health and as dental premedication 褪黑素在口腔健康和牙科前用药中的应用
IF 0.5
Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale Pub Date : 2015-11-19 DOI: 10.1186/s40709-015-0036-1
Mercedes Pérez-Heredia, J. Clavero-González, Leticia Marchena-Rodríguez
{"title":"Use of melatonin in oral health and as dental premedication","authors":"Mercedes Pérez-Heredia, J. Clavero-González, Leticia Marchena-Rodríguez","doi":"10.1186/s40709-015-0036-1","DOIUrl":"https://doi.org/10.1186/s40709-015-0036-1","url":null,"abstract":"","PeriodicalId":42615,"journal":{"name":"Journal of Biological Research-Bollettino della Societa Italiana di Biologia Sperimentale","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40709-015-0036-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65745295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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