The Onco Fertility Journal最新文献_第7页

Why results of endometrial receptivity assay testing should not be discounted in recurrent implantation failure? 为什么子宫内膜容受性试验的结果不应该在反复植入失败中被忽视?

The Onco Fertility Journal Pub Date : 1900-01-01 DOI: 10.4103/tofj.tofj_9_19

Simrandeep Kaur, Padmaja Naidu

{"title":"Why results of endometrial receptivity assay testing should not be discounted in recurrent implantation failure?","authors":"Simrandeep Kaur, Padmaja Naidu","doi":"10.4103/tofj.tofj_9_19","DOIUrl":"https://doi.org/10.4103/tofj.tofj_9_19","url":null,"abstract":"Recurrent implantation failure (RIF) is often encountered in patients undergoing ART leading to severe emotional, financial and physical distress. Thorough investigations should be carried out to ascertain whether there is any underlying cause of the condition. Endometrial receptivity (ER) remains a major stumbling block in IVF success as most available tests for diagnosis lack accuracy and predictive value. Microarray technology allows identification of the transcriptomic signature of the window of implantation, hence the development of an ER assay (ERA) for the diagnosis of an altered ER. ERA evaluates 238 genes expressed during WOI using RNA sequencing. Use of ERA test in patients with RIF has shown that window of implantation (WOI) is displaced in a quarter of these patients and use of a personalized embryo transfer (pET) significantly improves reproductive performance. We report three cases of RIF all of whom had failed IVF cycles despite good quality blastocysts transfer with apparently, no identifiable cause of implantation failure (uterine factores, embryonic, immunological factors ruled out). Two patients though had ERA testing done outside which showed displaced WOI, but however pET was not carried out leading to RIF. Subsequently pET carried out at our centre led to successful implantation and clinical pregnancy in both the patients.","PeriodicalId":425762,"journal":{"name":"The Onco Fertility Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129066669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Fertility preservation for patients on gonadotoxic treatment recommendations for clinical practice by Fertility Preservation Society (India) 生殖力保存学会(印度)对促性腺毒素治疗患者的临床实践建议

The Onco Fertility Journal Pub Date : 1900-01-01 DOI: 10.4103/2589-9597.315958

Nalini Kaul Mahajan

引用次数: 0

Sexual health of breast cancer survivors 乳腺癌幸存者的性健康

The Onco Fertility Journal Pub Date : 1900-01-01 DOI: 10.4103/tofj.tofj_11_19

Nalini Mahajan

引用次数: 0

Choosing wisely between oocyte versus embryo cryopreservation: A clinical vignette 明智地选择卵母细胞与胚胎冷冻保存:临床小插曲

The Onco Fertility Journal Pub Date : 1900-01-01 DOI: 10.4103/tofj.tofj_1_21

Puneet Arora, M. Jaffar, S. Andrabi

引用次数: 0

Distribution of anthropometric, clinical, and metabolic profiles of women with polycystic ovary syndrome across the four regions of India 印度四个地区多囊卵巢综合征妇女的人体测量、临床和代谢特征分布

The Onco Fertility Journal Pub Date : 1900-01-01 DOI: 10.4103/tofj.tofj_7_19

J. Kaur, M. Patil, S. Kar, P. Jirge, Nalini Mahajan

{"title":"Distribution of anthropometric, clinical, and metabolic profiles of women with polycystic ovary syndrome across the four regions of India","authors":"J. Kaur, M. Patil, S. Kar, P. Jirge, Nalini Mahajan","doi":"10.4103/tofj.tofj_7_19","DOIUrl":"https://doi.org/10.4103/tofj.tofj_7_19","url":null,"abstract":"Context: Polycystic ovary syndrome (PCOS), one of the most common endocrine disorders encountered in women of reproductive age, is associated with an increased prevalence of metabolic syndrome (MetS). Development of PCOS and its phenotypic expressions is influenced by genetic, ethnic and environmental factors. Due to the vast cultural diversity in our country, differences in the prevalence of MetS may exist across different regions. Aims and Objectives: To study the distribution of anthropometric, clinical, and metabolic profiles of women with PCOS across the four regions of India. Materials and Methods: A multicentric prospective study using data collected from four tertiary Assisted Reproductive Centres across four different regions of India was carried out between January 2017 and December 2017. A total of 651 women were diagnosed with PCOS, with 178 belonging to North, 209 to East, 115 to West and 149 to South India. A comparison of the metabolic and anthropometric profiles of women with PCOS was made across the four different ethnic regions of India. Statistical Analysis: Quantitative variables were compared using the Mann–Whitney test and qualitative variables using the Chi-square test.P < 0.05 was considered statistically significant. Results: North Indian women had the highest mean body mass index (BMI) – 27.53 ± 4.55 kg/m2 and a higher waist circumference (89.93 ± 14.53 cm) compared to women from South and West India (P = 0.0001). The prevalence of MetS (41.98%) and impaired glucose tolerance (IGT) (37.04%) was also highest in North India followed by East India. PCOS women from East India were lean but had the highest waist-to-hip ratio (WHR) 0.9 ± 0.05 (P = 0.0001) and dyslipidemia. Using multivariate logistical regression analysis, age >25 years, BMI >25 kg/m2, and WHR >0.8 had a strong association with MetS. Conclusion: Prevalence of MetS is high among Indian PCOS women, with women from the North and East India having the worst metabolic profiles. IGT is the main driver for MetS.","PeriodicalId":425762,"journal":{"name":"The Onco Fertility Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130349938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Oocyte vitrification as a choice of fertility preservation and its role in endometriosis cohort 卵母细胞玻璃化作为保存生育能力的选择及其在子宫内膜异位症队列中的作用

The Onco Fertility Journal Pub Date : 1900-01-01 DOI: 10.4103/tofj.tofj_3_21

P. Selvaraj, Kamala Selvaraj, Hamini Chandrasekar

引用次数: 0

In vitro activation of ovary 卵巢的体外活化

The Onco Fertility Journal Pub Date : 1900-01-01 DOI: 10.4103/tofj.tofj_4_19

Nalini Mahajan, J. Kaur, Bithika Bhattacharya, Padmaja Naidu, Shalu Gupta

引用次数: 5