Medical Journal of Bakirkoy最新文献_第9页

The Potential Protective Effects of Ginkgo Biloba on Bilirubin Cytotoxicity in Newborn Rat 银杏叶对新生大鼠胆红素细胞毒性的潜在保护作用

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Medical Journal of Bakirkoy Pub Date : 2022-06-01 DOI: 10.4274/bmj.galenos.2022.2022.2-22

Ö. Şahin, H. Ergin, Aydın Demiray, M. B. Özdemir, H. Akça, Ç. Yenisey

引用次数: 0

Is There a Relation Between Pretreatment CONUT Score and Neoadjuvant Chemotherapy Response in Breast Cancer Patients? 乳腺癌患者预处理CONUT评分与新辅助化疗反应有关系吗?

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Medical Journal of Bakirkoy Pub Date : 2022-06-01 DOI: 10.4274/bmj.galenos.2022.2022.2-8

A. I. Yasin, A. Topçu

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Protective Effects of Hesperetin Against Lipopolysaccharide-induced Acute Renal Injury in Rat 橙皮素对脂多糖所致大鼠急性肾损伤的保护作用

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Medical Journal of Bakirkoy Pub Date : 2022-06-01 DOI: 10.4274/bmj.galenos.2022.2022.2-16

Serkan Kaya, I. Karaboğa

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The Comparison of TOAST, CCS, and ASCO Etiological Classifications in Ischemic Stroke Patients 缺血性脑卒中患者TOAST、CCS和ASCO病因分类的比较

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Medical Journal of Bakirkoy Pub Date : 2022-06-01 DOI: 10.4274/bmj.galenos.2022.2021.12-16

Anıl Özkaya, H. Erdoğan, Ibrahim Acir, M. Çabalar, V. Yayla

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The Role of Neutrophil Gelatinase-associated Lipocalin as a Predictive Biomarker of Acute Kidney Injury in Patients Undergoing Major Abdominal Surgery 中性粒细胞明胶酶相关脂钙蛋白作为大腹部手术患者急性肾损伤的预测性生物标志物的作用

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Medical Journal of Bakirkoy Pub Date : 2022-06-01 DOI: 10.4274/bmj.galenos.2022.2021.12-17

A. Mustafayeva, Meliha Orhon Ergün, Seniyye Ülgen Zengin

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Evaluation of White Blood-cell-based Inflammatory Markers in Gestational Diabetes Mellitus 基于白细胞的炎症标志物在妊娠糖尿病中的评价

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Medical Journal of Bakirkoy Pub Date : 2022-06-01 DOI: 10.4274/bmj.galenos.2022.2021.12-10

Zeynep Levent Cirakli, Nuray Gulec

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Impact of Malnutrition on Prognosis in Patients with HER2-negative Metastatic Gastric Cancer 营养不良对her2阴性转移性胃癌患者预后的影响

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Medical Journal of Bakirkoy Pub Date : 2022-06-01 DOI: 10.4274/bmj.galenos.2022.2022.4-7

A. Topçu, A. I. Yasin

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Outcomes of Pediatric Liver Transplantation in Inherited Metabolic Diseases: A Single-center’s Experience 儿童肝脏移植治疗遗传性代谢性疾病的疗效：单一中心的经验

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Medical Journal of Bakirkoy Pub Date : 2022-03-25 DOI: 10.4274/bmj.galenos.2022.2022.1-4

Melike Ersoy, V. Ertekin, G. Şık, A. Çıtak, Selim Keçeoğlu, R. Emiroğlu

引用次数: 0

The Relationship of Elevated Hepatic Fibrosis-4 Index Score with Pneumonia Severity Index and in Hospital Mortality Among COVID-19 Patients Admitted to Intensive Care Unit 重症监护病房新冠肺炎患者肝纤维化-4指数评分升高与肺炎严重程度指数及住院死亡率的关系

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Medical Journal of Bakirkoy Pub Date : 2022-03-25 DOI: 10.4274/bmj.galenos.2022.2021.12-5

E. Demir, Hande Güngör, Cem Erdoğan, O. Olmuşçelik, Rumeysa Çakmak, Ayşegül Yıldırım

{"title":"The Relationship of Elevated Hepatic Fibrosis-4 Index Score with Pneumonia Severity Index and in Hospital Mortality Among COVID-19 Patients Admitted to Intensive Care Unit","authors":"E. Demir, Hande Güngör, Cem Erdoğan, O. Olmuşçelik, Rumeysa Çakmak, Ayşegül Yıldırım","doi":"10.4274/bmj.galenos.2022.2021.12-5","DOIUrl":"https://doi.org/10.4274/bmj.galenos.2022.2021.12-5","url":null,"abstract":"Objective: We investigated the relationship hepatic fibrosis-4 (FIB-4) index score calculated in the early period and pneumonia severity index (PSI) and in-hospital mortality in patients hospitalized in the intensive care unit (ICU) due to new severe acute respiratory syndrome coronavirus-2 infection. Methods: Seventy six consecutive patients diagnosed with coronavirus disease-2019 (COVID-19), hospitalized in the ICU due to hypoxemia, and selected consecutively were included. COVID-19 infection was diagnosed using real-time reverse transcription-polymerase chain reaction (RT-PCR) in nose and throat swab samples. The diagnosis of pneumonia was confirmed by showing typical ground-glass opacities and areas of subsegmental consolidation in lung computed tomography examinations of patients previously diagnosed with COVID-19 by RT-PCR. Hepatic FIB-4 index score and PSI score was calculated separately for each patient. In the statistical method, the independent samples t-test and Mann-Whitney U test were used to compare quantitative data. A chi-square test was used to compare qualitative data. Results: The FIB-4 value and PSI value were significantly higher (p<0.05) in the mortality group than in the non-mortality group. Also, there was no significant statistical difference between the two groups in terms of the other laboratory parameters (p>0.05) FIB-4 value was significantly predictive [under the curve 0.835 (0.742-0.929)] in differentiating patients with and without mortality. For a cut-off value of 5.4, FIB-4 had a sensitivity of 60.6%, positive predictive of 95.2%, specificity of 97.6%, and negative predictive value of 75.9% Conclusion: High FIB-4 index and PSI score detected in the early period in patients admitted to the ICU due to COVID-19 seem to be predictors of in-hospital mortality.","PeriodicalId":42529,"journal":{"name":"Medical Journal of Bakirkoy","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45653673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Coronary Artery Disease Due to Acetylsalicylic Acid Resistance May Be Related to COX-1 and COX-2 Mutations 乙酰水杨酸耐药所致冠状动脉疾病复发可能与COX-1和COX-2突变有关

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Medical Journal of Bakirkoy Pub Date : 2022-03-25 DOI: 10.4274/bmj.galenos.2022.2021.10-20

D. Kıraç, Emrah Bayram, Tansu Doran, E. Keleş

{"title":"Recurrent Coronary Artery Disease Due to Acetylsalicylic Acid Resistance May Be Related to COX-1 and COX-2 Mutations","authors":"D. Kıraç, Emrah Bayram, Tansu Doran, E. Keleş","doi":"10.4274/bmj.galenos.2022.2021.10-20","DOIUrl":"https://doi.org/10.4274/bmj.galenos.2022.2021.10-20","url":null,"abstract":"Objective: Acetylsalicylic acid (ASA) is a commonly used antiplatelet drug for the treatment of coronary artery disease (CAD). However, in some patients recurrent CAD occurs due to ASA resistance (AR). This condition may be related to some genetic factors. Therefore, this study aims to investigate the effects of cyclooxygenase (COX)-1 and COX-2 mutations on recurrent CAD due to AR. Methods: Hundred CAD patients taking 100 mg ASA daily for 2 years were enrolled to the study. The patients were divided into two groups according to their recurrent CAD status. Forty-eight patients with recurrent CAD due to AR and 52 patients without recurrent CAD were selected to ASA resistant (AR+) and ASA non-resistant (AR-) group, respectively. AR was confirmed by platelet aggregation testing. Risk factors related to recurrent CAD were also obtained. After DNA was isolated from peripheral blood, rs1330344 variation in COX-1 and rs20417 variation in COX-2 were determined using real-time polymerase chain reaction. Results were evaluated statistically. Results: COX-1 and COX-2 mutations were mostly detected in the AR+ group however these data were not found statistically significant. Nevertheless, C allele of COX-2 was found statistically high in the AR+ group (67.9%) (p=0.023). Additionally statistically significant associations were found between high total cholesterol and low density lipoprotein cholesterol levels with the GC genotype of COX-2. Conclusion: It was suggested a relation between COX-2 mutations and recurrent CAD due to AR. Similar studies with a large population must explain the mechanisms governing the association of COX-1 and COX-2 genotypes and response to ASA in recurrent CAD patients.","PeriodicalId":42529,"journal":{"name":"Medical Journal of Bakirkoy","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45439830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0