Fyodorov journal of ophthalmic surgery最新文献

{"title":"Refractive results of cataract surgery with posterior capsulorhexis and optic capture","authors":"E. V. Egorova, A. Biryukova, V. V. Dulidova, M. A. Talalaev","doi":"10.25276/0235-4160-2022-3-13-19","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-13-19","url":null,"abstract":"Purpose. To compare refractive results in the following groups: after standard cataract surgery (1), standard cataract surgery supplemented with primary posterior capsulorhexis (2) and supplemented with a posterior capture of the IOL optics (3). Material and methods. This study included 32 patients (40 eyes) aged 52 to 68 years after uncomplicated phacoemulsification of age-related cataract with implantation of several models of monolithic flexible hydrophobic IOLs: Tecnis (J&J), enVista (B&L), RPR-2 (Reper-NN). The axial length of the eyes varied from 22.2 to 25,25 mm. The exclusion criteria were pseudoexfoliation syndrome and concomitant ophthalmopathology. Results. There were no intra- and postoperative complications in all studied groups. OCT monitoring showed the intactness of the anterior hyaloid in the second and third groups, the centered IOL position and the location of the capsular sheets according to the applied technology. The obtained refractive results were compared with the target refraction when calculating the IOL. The emmetropia was planned in all cases. However, because the strength of the lenses has discrete values with a step of 0.5 diopters, the closest value with a shift towards myopia was chosen. No statistically significant differences were found in the first and second compared groups when evaluating the refractive Results. However, the postoperative parameters were statistically significantly different in the third group with posterior optic capture. In this group a hyperopic shift of about 0,5 diopters was always observed. Conclusion. Primary posterior capsulorhexis with posterior optics capture provides a stable centered IOL position. The axial displacement of the IOL and the hypermetropic shift of the refractive results should be considered when planning posterior optical capture. Key words: posterior capsulorhexis, posterior optic capture, optic buttonholing","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123975634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular correction of presbyopia after laser keratorefractive surgery","authors":"A. Doga, E. V. Kechin, A. Golovin, A. N. Karimova, N. Tsikarishvili, A.N. Dzhaber","doi":"10.25276/0235-4160-2022-3-98-104","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-98-104","url":null,"abstract":"Purpose. To present the results of research on modern aspects of intraocular correction of presbyopia after laser keratorefractive surgery. Material and methods. A literature search was performed to identify studies on databases eLibrary, PubMed and Scopus, using the keywords «calculation of multifocal lenses», «multifocal IOLs after refractive surgery», «correction of presbyopia after refractive surgery» (in the eLibrary database), «multifocal IOL» and «multifocal lenses calculation» (in the PubMed and Scopus databases). Thirty related articles were identified. In addition, seven clinical studies in which different groups of patients with a history of refractive surgery underwent correction of presbyopia with multifocal intraocular lenses (IOL) were identified. Results. In this article, there are examples of recent research of information about the intricacies of calculating refractive power of multifocal lenses after refractive surgery. Every year the number of people with a history of laser vision correction is growing, which means that for surgeons arises question about correct calculation of keratometric parameters. To date, the calculation of the value of the optical power of an implantable multifocal IOL after laser refractive surgery is complex and individual for each patient. Most people in this category are still not ready to wear glasses. Recent studies confirm the success of calculating implantable multifocal IOL, and ways to minimize inaccuracies in hitting the refraction of the target lie both in the approach to calculating the optical power of an implanted multifocal lens, and in choosing the optimal method for assessing artificially modified cornea keratometry. Conclusion. The results of clinical studies presented in the review allow us to conclude that the results of calculating the optical power of implanted multifocal IOLs are quite successful and, in turn, clinical and functional results in patients with a history of laser refractive surgery. However, further research is required. Key words: presbyopia correction, multifocal IOL, IOL calculation formulas, laser correction, LASIK, FemtoLASIK, SMILE.","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116921324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of Blefarovit cosmetic product usage in patients with chronic blepharoconjunctivitis and «dry eye» syndrome, combined with an active demodicosis component","authors":"D. Maychuk, А.О. Loshkareva","doi":"10.25276/0235-4160-2022-3-41-49","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-41-49","url":null,"abstract":"Purpose. Comparative analysis of the efficacy and safety of Blefarovit product in the complex therapy of chronical blepharoconjunctivitis and «dry eye» syndrome with a pronounced demodicosis component in patients, previously received standard treatment with or without short-term positive effect. Material and methods. The present study included 60 patients (120 eyes) with chronical blepharoconjunctivitis, «dry eye» syndrome and demodicosis component. The patients, involved in the study had pronounced thickening of the eyelid margin, scabs and «clutches» in the eyelashes, meibomeitis, hyperemia, follicular reaction of the tarsal and bulbar conjunctiva. This study was devoted to finding a new approach for the demodecosis component therapy, using staged eyelid hygiene technology with the multicomponent product Blefarovit. The purpose of this study was to estimate efficacy and safety in isolated Blefarovit usage (1st stage of therapy) and Blefarovit in the combination with anti-inflammatory and artificial tears therapy (2nd stage of therapy). Results. The results of the study were increasing of the TBUT test and decreasing the ofDemodex Folliculorumnumber. Conclusion. The usage of Blefarovit product made possible to show significant decreasing in the severity of the demodectic component without increasing the toxicoallergic background. Key words: blepharitis, conjunctivitis, «dry eye» syndrome, meibomian gland dysfunction, eyelid hygiene, demodex","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117116438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crucial fluorescent angiographic features of favorable and unfavorable course of active retinopathy of prematurity","authors":"I. G. Trifanenkova, A. V. Tereshchenko","doi":"10.25276/0235-4160-2022-3-57-67","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-57-67","url":null,"abstract":"Purpose. To determine the crucial fluorescence-angiographic features of favorable and unfavorable types of active retinopathy of prematurity and evaluate their prognostic informational value. Material and methods. Fundus fluorescence angiography (FFA) was performed by 180 premature infants (180 eyes). The children had 1st–3rd stage of active ROP. The age of gestation of the children was 24–34 weeks. A birth weight of the children was 560–2150 g. By the time of the study the age of the children was 3–14 weeks. This age corresponded to 30–38 weeks of postconceptual age (PCA). The stage and type of the pathological process was determined by using a comprehensive ophthalmological examination, which included reverse ophthalmoscopy, digital retinoscopy and morphometry. Children were admitted to FFA procedure in a stable somatic state, without pathology of renal and hepatic metabolism, after setting a test to determine the sensitivity to the drug. The evaluation of the prognostic information content of the revealed features of FFA in relation to the type of disease course was performed. Statistical processing of the research results was carried out by using the Statistica 13.3 program (Tibco Software Inc., USA). Results. During of the study, pathological fluorescence-angiographic features were identified and studied. These features were conditionally divided into 3 groups depending on the location on the fundus: near the border with the avascular retina, in the avascular retina, in the vascularized retina. It has been shown that the unfavorable course of the 1st–3rd stage of active ROP is distinguished by a much wider variety of fluorescence-angiographic phenomena and their more pronounced intensity (frequency of occurrence) in comparison with the favorable course of active ROP. On the basis of a comprehensive statistical analysis, the most informative fluorescence-angiographic features for the prognosis of the type of active ROP were determined: increased vascular tortuosity near the border with the avascular retina, zones of capillary nonperfusion in the vascularized retina, multiple foci of local neovascularization in the vascularized retina. Conclusion. Clinical use of a fluorescence angiographic study of the fundus of patients with ROP with the determination of crucial prognostic features of favorable and unfavorable types in the early stages of the disease will contribute to early treatment of this severe retinal pathology in premature infants and consequently, its favorable outcome. Key words: fluorescence angiography, retinopathy of prematurity, prognosis","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128376210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience with the use of glucocorticosteroid implants in patients with macular edema associated with sarcoidosis.","authors":"V. A. Pavlov, E. Kryukov, D. Davydov, A. Zaytsev, V. E. Kurnosov, A. Kapatsina","doi":"10.25276/0235-4160-2022-3-28-33","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-28-33","url":null,"abstract":"Purpose. To evaluate the results of treatment of patients with sarcoidosis with chronic non-infectious uveitis complicated by macular edema by intravitreal injection of a glucocorticosteroid implant with previously used methods. Material and methods. The study performed a comparative analysis of data from patients with cystic macular edema against the background of chronic non-infectious uveitis associated with sarcoidosis, with corrected visual acuity of more than 0.05 (according to the Golovin-Sivtsev table). Group 1 (prospective analysis) included the results of treatment of patients with sarcoidosis with corticosteroid implants (4 eyes, 4 patients). In the 2nd group (retrospective analysis of the medical history), patients underwent peribulbar administration of betamethasone (9 eyes, 7 patients). The parameters were analyzed after 2.0±0.5, 4.0±0.5 and 6.0±0.5 months with assessment of maximally corrected visual acuity (BCVA), OCT, color photography, and IOP control. The risk of recurrence of macular edema when comparing groups was assessed over a 6-month follow-up period. Results. During the observed period in both groups, no complications were detected in any case. According to visometry and OCT, the best functional results were obtained in group 1. Average visual acuity after 6 months. was 0.7±0.1, the thickness of the retina in the central zone was 331±15µm. Conclusion. According to the results of the study, it was found that intravitreal injection of dexamethasone implant in its effectiveness surpasses the previously used peribulbar injections of betamethasone in terms of the quality of restoration of visual functions, the effectiveness of reducing macular edema and the duration of remission of the chronic inflammatory process. Key words: sarcoidosis, chronic uveitis, macular edema, dexamethasone implant, surgical treatment","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134274832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limbal stem cell deficiency diagnostics","authors":"B. Malyugin, S. Borzenok, S. Kalinnikova, M. Gerasimov","doi":"10.25276/0235-4160-2022-3-82-97","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-82-97","url":null,"abstract":"Relevance. Limbal stem cell deficiency (LSCD) is a pathology that leads to substantial vision decrease, corneal neovascularization, corneal epithelial persistent erosions and have a negative impact on patient's the quality of life. It is known that the efficiency of corneal transplantation in LSCD patients is low and requires repeated interventions. One of the important problems is the lack of a clear diagnostic algorithm and a standardized set of diagnostic techniques for this condition. Purpose. Systematically analyze domestic and foreign literature on the currently existing methods for diagnosing LSCD. Material and methods. A systematic analysis of scientific publications from 1992 to 2021 was carried out. Its included domestic and foreign authors on the resources of PubMed, Medline, eLibrary, as well as dissertations and textbooks devoted to currently existing methods for diagnosing LSCD. Results. In addition to biomicroscopy, the main in vivomethods for diagnosing LSCD are staining of the ocular surface, impression cytology with the detection of specific cytokeratins, confocal microscopy, optical coherence tomography of the anterior segment (OST) and OST-angiography. Conclusion. Physician awareness and vigilance are required for the diagnosis of LSCD, especially in patients with conjunctivalization and corneal neovascularization. It is impossible to use only biomicroscopy and the patient's complaints, since LSCD is not always obvious. That is why diagnostics should include an integrated approach, including all available research methods, which are briefly described in Table No. 1 with their disadvantages and advantages. Key words: limbal stem cell deficiency, impression cytology, laser confocal scanning microscopy, goblet cells, cytokeratin, penetrating keratoplasty, cytokines","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115463000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study psychoemotional status in patients planning keratorefractive surgery using SMILE procedure","authors":"I. V. Dutchin, O. V. Kolenko, O.B. Dutchina, E. L. Sorokin, Y. Kutuzova","doi":"10.25276/0235-4160-2022-3-20-27","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-20-27","url":null,"abstract":"Purpose. To study frequency and degree of mental stress among patients with myopia planning to keratorefractive surgery using SMILE procedure. Material and methods. In-depth psychological study was carried out in 145 patients planning for keratorefractive surgery. The average age of the patients is 37 years. At the first stage, patients with an increased level of psychological anxiety were identified using the «Unfinished sentences» method. At the second stage, among the selected patients, we studied the degree of their mental stress using stress scale with the Psychological Stress Measure (PSM-25) questionnaire. Results. At the first stage, 42 patients (29%) were identified with increased level of psychological anxiety: 20 men and 22 women. Their average age was 35 years. At the second stage, it turned out that 9 patients had high level mental stress; in 13 – average and in 20 people – low (the latter are psychologically stable). During routine external examination and interview with ophthalmologist, patients with average and high-level mental stress indicator did not have any characteristic differences both from patients with low level mental stress indicator and from the rest of patients in general population. Conclusion. At conducting screening psychological test among the surveyed large population of patients with myopia planning to keratorefractive surgery, 29% patients with unstable psychoemotional status were identified. Among the selected patients with unstable psychoemotional status, 21.5% had a high level of mental stress; 31% have average level and 47.5% have low level. Key words: patient anxiety, preoperative stress, psychological stress diagnosis","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"299 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116581778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glial cell line-derived neurotrophic factor in patients with age-related cataract","authors":"A. Shpak, A. Guekht, T. Druzhkova, A. Troshina, N. Gulyaeva","doi":"10.25276/0235-4160-2022-3-8-12","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-3-8-12","url":null,"abstract":"Purpose. To study the content of glial cell line-derived neurotrophic factor (GDNF) in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract. Material and methods. The content of GDNF in the LF, AH and BS was studied in 47 patients (47 eyes) with age-related cataract. Collection of stimulated LF was performed with a pipette on the day preceding surgery; the AH and BS were sampled during the phacoemulsification of a cataract. The concentration of GDNF was measured using an enzyme immunoassay. Results. The concentration of GDNF in the AH was 88.9±46.9 (2.0–212.5) pg/ml, in the BS – 201.1±44.6 (103.2–287.2) pg/ml, in the LF – 343.6±133.7 (172.8– 683.0) pg/ml. The levels of GDNF in the studied biological fluids did not show any significant correlations with each other. Conclusion. In patients with age-related cataract, the level of GDNF in the AH was relatively low: the concentration of GDNF in the AH was more than 2 times lower than in the BS and almost 4 times lower than in the LF. No significant correlations were found between the concentrations of GDNF in LF, AH and BS. Key words: glial cell line-derived neurotrophic factor, lacrimal fluid, aqueous humor, blood serum, age-related cataract","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130908954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the effectiveness of surgical treatment of macular hole with and without postoperative gas tamponade of the vitreal cavity","authors":"A. Y. Kleymenov, V. Kazaykin, M. A. Lipina","doi":"10.25276/0235-4160-2022-2-6-14","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-2-6-14","url":null,"abstract":"Fyodorov Eye Microsurgery Federal State Institution, Ekaterinburg Branch, Ekaterinburg, Russian Federation","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129373885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmic products with extracellular matrix components. Their effectiveness in the process of corneal repair in neurotrophic, herpetic, recurrent keratitis and erosions","authors":"D. Maychuk, A. A. Tarkhanova, I. Pronkin, Д.Ю. Майчук, А.А. Тарханова, И.А. Пронкин","doi":"10.25276/0235-4160-2022-2-91-100","DOIUrl":"https://doi.org/10.25276/0235-4160-2022-2-91-100","url":null,"abstract":"Introduction. One of the topical issues of modern ophthalmology is the widespread prevalence of corneal blindness among the working-age population. The cause of this condition in most cases are infectious and inflammatory diseases of the anterior segment of the eye, the outcome of which is a violation of the architectonics of the extracellular matrix (ECM) of the cornea, clinically manifested by edema of the stroma, its fibrosis. Purpose. Comparative analysis of the effectiveness of existing ophthalmic agents based on biomimetics of ECM to stimulate the processes of reparative regeneration in neurotrophic, herpetic, recurrent keratitis and corneal erosions. Material and methods. Our literature review has shown the great importance of the components in maintaining corneal homeostasis, its transparency, strength, shape stability, as well as differentiation, proliferation, migration and growth of cellular structures of the ECM, and therefore the need to maintain its physiological architectonics in the treatment of infectious and inflammatory pathology. Results. The range of ophthalmic medicines and medical devices based on biomimetics of ECM is quite diverse. The active substances of such ophthalmic agents are the main components of the ECM, namely, glycosaminoglycans (GAG), glycoproteins, collagen, hyaluronic acid, heparin. Conclusion. Among the many biomimetics, we can single out the multicomponent hydrogel composition «Corneal Epithelium gel Protector (CEGP) SPHERO ® oko (JSC «BIOMIR Service», Russia), designed to restore the corneal epithelium, which includes both the main components of ECM and other biologically active substances, including peptides, amino acids, uronic acids, monosaccharides, growth factors, etc. The multicomponent composition of SPHERO ® oko provides the microenvironment necessary for the cells of the eye tissues, contributing to the processes of their proliferation and differentiation and, as a final result, to the acceleration of reparative regeneration of tissues damaged as a result of injury or infectious-inflammatory process. And also SPHERO ® oko demonstrates anti-inflammatory, decongestant, tear-substituting action, contributes to reducing neovascularization. Key words: SPHERO ® oko, extracellular matrix, keratitis, erosion, herpes, dry eye disease, cornea","PeriodicalId":424200,"journal":{"name":"Fyodorov journal of ophthalmic surgery","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133248651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}