Haseki TIp Bulteni-Medical Bulletin of Haseki最新文献

{"title":"Association Between Thyroid Antibodies and Ultrasonic Imaging in Patients with Hashimoto’s Thyroiditis","authors":"M. Unal, Iffet Dagdelen Duran, E. Karakiliç, Mehtap Navdar Başaran, S. Guler","doi":"10.4274/haseki.galenos.2022.8177","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8177","url":null,"abstract":"Aim: The association between high levels of anti-thyroid antibodies and the extent of destruction of thyroid tissue is well documented. The aim of the present study was to analyze the relationship between anti-thyroid antibodies, thyroid hormones, and sonographic parenchymal changes. Methods: The study was designed as a case-control study. Four hundred and seventy-five patients with HT and 98 healthy subjects were included in the study. Serum levels of free thyroxine (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone, and anti-thyroid antibodies (anti-thyroid peroxidase antibodies and anti-thyroglobulin antibodies) were measured. The ultrasonographic results of the patients were also recorded. Results: Serum levels of anti-TPO and anti-Tg were significantly associated with hypoechogenicity, heterogeneity, and pseudonodulation (p<0.001). There was no significant difference between the two groups in terms of cyst and nodule formation, however, a significant difference was found in terms of thyroid volume (p<0.001). Thyroid volumes were higher in the HT group. As serum anti-TPO levels increased in the HT group, parenchymal hypoechogenicity increased (p<0.001). Conclusion: Ultrasonography is a non-invasive method that provides information about the inflammatory activity of the thyroid gland. Significantly reduced echogenicity, heterogeneity, and multifocal pseudonodular infiltration were indicators of inflammatory activity and were associated with higher anti-TPO levels. Anti-TPO and ultrasonographical changes may be useful in the follow-up of Hashimoto’s thyroiditis.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"63 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84795319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Analysis of the Blood Products used in the Emergency Room and other Clinics with the Pre-pandemic Period","authors":"Attila Beştemir, Alpay Tuncar","doi":"10.4274/haseki.galenos.2022.8469","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8469","url":null,"abstract":"Aim: In this study, we evaluated the blood transfusion statistics by determining the frequency of blood component transfusions by year and the total number of transfusions administered in emergency departments (EDs) and all inpatient clinics across Turkey, to provide a foresight of the future and to guide planning. Method(s): The study was conducted retrospectively, covering the period between January 1, 2016, and January 1, 2022. The numerical data of the blood transfusions applied in the 2nd and 3rd level public hospitals in Turkey were collected as the number of units, and the data were used by obtaining the necessary permissions from the Ministry of Health. The most frequently used blood components in EDsand inpatient clinics in our country were examined. The total number of transfusions in EDs and all inpatient clinics was calculated, and the frequency changes over time were investigated. In the study, the 4-year period of 2016-2019 was specified as the prepandemic period. The 2-year data for 2020 and 2021 are also stated as the pandemic period. The mean values of the data belonging to both periods were taken, and their significance was evaluated with Fisher's exact test. Blood transfusion statistics for each year were recorded on the tabulation software, and the frequency changes were calculated using the statistical formulas of the tabulation software. Patient consent was waived because of the study. Result(s): The most common types of blood components transfused in Turkey were packed red blood cell (PRBC), fresh frozen plasma (FFP), platelet concentrate, whole blood, and cryoprecipitate. When the blood component transfusion rates in the EDs were evaluated, the most frequently transfused blood component was found to be PRBC, followed by FFP (64.4% and 29.8%, respectively). Platelet concentrate, cryoprecipitate, and whole blood transfusion rates were found to be 5.5%, 0.17%, and 0.13%, respectively. 6.6% of all blood transfusions were administered in EDs. The use of all blood and blood products, except PRBC, has decreased in the ED. In all departments, there was a decrease in the use of platelets and whole blood and an increase in the use of cryoprecipitate. Conclusion(s): Since the current study shows blood and blood product replacement and includes a broad comparison with the pandemic and pre-pandemic periods, it can guide the blood replacement strategies of the ED and all departments. Copyright © 2022 by The Medical Bulletin of Istanbul Haseki Training and Research Hospital The Medical Bulletin of Haseki published by Galenos Yayinevi.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"4 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91004537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Dietary Intakes and Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease Dietary Intake and Polycystic Kidney Volume","authors":"Yonca Sevim, E. Cebeci, Ozlem Persil Ozkan, Y. Savaş, S. Ozturk, G. Kiziltan","doi":"10.4274/haseki.galenos.2022.8019","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8019","url":null,"abstract":"Aim: There is a need to understand autosomal dominant polycystic kidney disease (ADPKD) patients’ dietary habits since dietary interventions may have potential effects on ADPKD. In this study, we aimed to analyze the relationship between dietary nutrient intake and total kidney volume (TKV). Methods: This cross-sectional study was conducted on 54 ADPKD patients recruited from the Nephrology outpatient clinic between June and July 2014. TKV was determined by magnetic-resonance imaging and general characteristics, biochemical and urinary parameters were determined. The nutrient intakes of patients were calculated using the three-day dietary records obtained on three consecutive days. Results: The total kidney-volume median was found to be 1407 mL. Patients’ total dietary energy and protein intakes were 25.8±9.4 kcal/kg, 0.9±0.3 g/kg, respectively. The percentage of carbohydrates, protein, and fat in energy was 49±7%, 14±3%, 37±7%, respectively. The mean intakes of thiamin, riboflavin, B6, calcium, magnesium, and zinc were sufficient, the mean dietary potassium intake was insufficient; and sodium intake was excessive in both sexes. In females, there was a negative but weak correlation between dietary vitamin C intake and TKV. In males, a negative but weak correlation was found between TKV and dietary intake of fiber, water, vitamin B6, vitamin K, magnesium, and iron. Conclusions: Dietary micronutrient intake may affect TKV according to sex.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"54 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90965572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Literacy and Cyberchondria Levels in Healthcare Workers and Their Relationship with Body Awareness and Physical Activity","authors":"R. Şavkın, Izgi Guven, Nihal Buker","doi":"10.4274/haseki.galenos.2022.8258","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8258","url":null,"abstract":"Aim: The level of health literacy and cyberchondria of healthcare providers can affect service beneficiaries, and the influence of health literacy and cyberchondria on physical activity and body awareness remains unclear. The aim of this study was to determine the health literacy and cyberchondria levels of healthcare workers and examine their relationship with physical activity level and body awareness. Methods: This cross-sectional study was conducted between August and November 2021 on 168 healthcare professionals working at the university hospital. The Turkish Health Literacy scale (TSOY-32), Cyberchondria scale, Body Awareness Questionnaire (BAQ), and International Physical Activity Questionnaire-Short Form (IPAQ-SF) were used for outcome measurements. Results: The TSOY-32 and Cyberchondria scale total scores were 37.76±7.98 and 63.83±19.45, respectively. There were low positive and significant correlations with TSOY-32, BAQ (r=0.213, p=0.006) and IPAQ-SF (r=0.162, p=0.036), while a low negative correlation was found between cyberchondria level and BAQ (r=-0.179, p=0.022) and IPAQ-SF (r=-0.193, p=0.013). Conclusion: This study shows that, unlike predicted, health professionals did not have perfect health literacy and were found to have moderate cyberchondria. Physical activity and body awareness may affect increasing health literacy and reducing cyberchondria, which will empower individuals to make beneficial health decisions.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"49 17","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72390796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Change in the Incidence of Neural Tube Defects in the Eastern Black Sea Region of Turkey by Years and its Relationship with Folic Acid Use: A Case-control Study","authors":"Omer Demir, H. Şal, Mirac Ozalp, M. Topbaş","doi":"10.4274/haseki.galenos.2022.8245","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8245","url":null,"abstract":"","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"14 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73828714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bell’s Palsy and COVID-19 Infection: A Comparative Analysis with the Pre-pandemic Period","authors":"G. Gursoy, Ayla Culha Oktar, A. Çokar","doi":"10.4274/haseki.galenos.2022.8235","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8235","url":null,"abstract":"Aim: Bell's palsy is an acute peripheral facial nerve paralysis affecting one side of the face and can be associated with various causes, such as infectious and autoimmune conditions. In line with this, an increase has been observed in the incidence of peripheral facial paralysis during the coronavirus disease-2019 (COVID-19) infection pandemic. We aimed to investigate whether the incidence of Bell's palsy increased before and after the COVID-19 in the pre-vaccine period. Method(s): All cases diagnosed with Bell's palsy in a tertiary hospital aged 18 and up in 2020 were analyzed, and to compare these numbers to pre-pandemic numbers, patients' data from 2019 was accessed. Excluding those who had recurrent facial palsy, those whose conditions were due to central causes, and those who were misdiagnosed, the frequency of the disease was calculated by proportioning it to the total number of patients presenting to Neurology, and Ear, Nose, and Throat Diseases Outpatient Clinics and the Green Zone of the Emergency Department at that time;and the Bell's palsy distribution within three-month periods and whether this distribution is correlated with the distribution of COVID-19 infection were examined. Result(s): Three hundred twenty five cases from 2019 and 291 cases from 2020 were included in the study. No significant difference was detected between those years in terms of age and sex. The frequency of Bell's palsy in 2019 was 0.059% while it was 0.071% in 2020, which suggested a significant difference between the years. The significant difference could be clearly observed in the second and fourth quarters when the cases of COVID-19 infection were at their peak. Conclusion(s): This study suggests that patients with complaints of peripheral facial paralysis should also be examined for COVID-19 infection. Copyright © 2022, Galenos Publishing House. All rights reserved.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"40 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89160512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Protective Effect of Resveratrol on Cisplatin Induced Damage in Rat Liver","authors":"Ozlem Kara, A. Kilitçi","doi":"10.4274/haseki.galenos.2022.8098","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8098","url":null,"abstract":"Aim: One of the underlying causes of cisplatin-induced hepatotoxicity is oxidative stress. We assessed the effect of an antioxidant, resveratrol, on cisplatin-induced damage in the rat liver. Methods: The project-starting date was designed as 01.10.2020 and the project-ending date was planned as 01.04.2021. Three groups were created with 30 female Wistar-Albino rats: In group 1 (control group), 1 mL of 0.9% NaCl (saline) was administered intraperitoneally for 3 days. In group 2 (cisplatin group), 7.5 mg/kg intraperitoneal cisplatin was given for 3 days. In group 3 (cisplatin + resveratrol group), 7.5 mg/kg cisplatin and 10 mg/kg resveratrol were given via the intraperitoneal route. The livers were surgically extirpated in all the groups. In both blood and tissues, malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured. Also, toxicity markers such as hepatocyte damage (cellular changes), inflammation, hemorrhage, congestion, fibrosis, disorganization of the hepatic cords, and necrosis were assessed by examining the preparations prepared from hepatic tissue with light microscopy and immunohistochemistry. Results: Histopathological tissue damage was significantly higher in group 2 than in other groups (p 0.03). MDA levels were significantly higher and the activities of SOD and CAT were lower in group 2 than in the other groups (p=0.04 and p=0.01, respectively). Conclusion: According to our short-term findings, resveratrol might be an effective molecule for preventing the harmful effects of cisplatin in the rat liver.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"10 5","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72413558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study","authors":"S. Surme, B. Copur, O. Bayramlar, G. Tuncer, Y. Ozdemir, F. Pehlivanoğlu, G. Sengoz","doi":"10.4274/haseki.galenos.2022.8505","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8505","url":null,"abstract":"Aim: Real-life data on the effect of coronavirus disease-2019 (COVID-19) vaccination is limited. We aimed to compare the incidence of COVID-19 among healthcare workers (HCWs) in the pre-vaccination and post-vaccination periods during the COVID-19 pandemic and identify associated factors for COVID-19 development. Method(s): In this single-center and cross-sectional study, HCWs employed in a tertiary care hospital were included. Pre-vaccination (14 October, 2020 and 14 January, 2021) and post-vaccination periods (1 March, 2021 and 1 June, 2021) were compared. A subgroup analysis was performed on HCWs without a previous history of COVID-19. Additionally, univariate regression analysis of COVID-19 development in the post-vaccination period was performed. Result(s): Of 2,922 HCWs, 2,096 (71.7%) were vaccinated. The incidence of COVID-19 was higher in the pre-vaccination period (16.3%) than in the post-vaccination (6.6%) (p<0.01). In the subgroup analysis, the incidence of COVID-19 was 16.6% in the pre-vaccination period and 8.1% in the post-vaccination period (p<0.01). Previous history of COVID-19 (p<0.01) and double-dose vaccination (p<0.01) were associated with a decreased risk of COVID-19 development. Conclusion(s): This study demonstrates the real-life impact of COVID-19 vaccination in reducing disease development and preventing poor clinical outcomes in a setting where the vaccination rate among HCWs was fairly low. Copyright © 2022 by The Medical Bulletin of Istanbul Haseki Training and Research Hospital The Medical Bulletin of Haseki published by Galenos Yayinevi.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"6 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86873714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Long-term Outcomes of Completion Pneumonectomy from a Tertiary Center","authors":"Y. Aksoy, Ozkan Saydam, N. Çıtak, C. Sezen, V. Erdoğu, L. Cansever, M. Bedirhan, M. Metin, A. Kutluk, A. Pekçolaklar","doi":"10.4274/haseki.galenos.2022.8372","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8372","url":null,"abstract":"","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"68 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86658538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can We Use Inflammation Biomarkers Based on Complete Blood Cell Count in the Follow-up of COVID-19 in Hemodialysis Patients?","authors":"Kubra Aydin Bahat, Tugba Tahtali","doi":"10.4274/haseki.galenos.2022.8694","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8694","url":null,"abstract":"Aim: Coronavirus disease-2019 (COVID-19) is more severe in hemodialysis patients than in the average population and causes much higher mortality. This study investigated the effect of inflammation parameters obtained from complete blood count on the prognosis of COVID-19 in hemodialysis patients with COVID-19. Method(s): Hemodialysis patients admitted to our hospital between 11.03.2020 and 01.12.2020 with the diagnosis of COVID-19 were included in this study. The relationship between the oxygen requirement, intensive care requirements, and mortality development of the patients and the parameters obtained from the complete blood count, C-reactive protein (CRP), secondary infection, and demographic characteristics of the patients were investigated. Result(s): A total of 94 hemodialysis patients were included in the study. There was a correlation between secondary infections and the need for oxygen and intensive care (p=0.001 and p<0.001, respectively). CRP levels were associated with mortality, need for intensive care and oxygen demand (p=0.031, p=0.019 and p=0.014, respectively). Systemic inflammation index, derived neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio were associated with oxygen demand (p=0.002, p=0.009 and p=0.044, respectively). The systemic inflammation index, platelet-lymphocyte ratio, and derived neutrophil-lymphocyte ratio exhibited the highest specificity (19.4% vs 26.9% vs 16.4%) and sensitivity (96.7% vs 92.6% vs 96.7%) and the largest areas under the curve of 0.672 vs 0.652 vs 0.666, respectively. Conclusion(s): Systemic inflammation index, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio obtained from complete blood count parameters in hemodialysis patients are functional parameters that can be used to predict the course of COVID-19. Copyright © 2022 by The Medical Bulletin of Istanbul Haseki Training and Research Hospital The Medical Bulletin of Haseki published by Galenos Yayinevi.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"22 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89704535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}