International Journal Of Health & Medical Research最新文献

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Implementation Of The 5 M And Health Protocol Determinants Of Vaccination Covid-19 Events In The Region Central City Health Center 在区域中心城市卫生中心实施Covid-19疫苗接种事件的5m和卫生协议决定因素
International Journal Of Health & Medical Research Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n06
Herni Alwin Pakaja, Irwan Irwan, Herlina Jusuf
{"title":"Implementation Of The 5 M And Health Protocol Determinants Of Vaccination Covid-19 Events In The Region Central City Health Center","authors":"Herni Alwin Pakaja, Irwan Irwan, Herlina Jusuf","doi":"10.58806/ijhmr.2023.v2i8n06","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n06","url":null,"abstract":"The Indonesian government through the Ministry of Health has made various preventive efforts to reduce the transmission rate of COVID-19 in Indonesia, including implementing the 5M health protocol and promoting the COVID-19 vaccination program for all levels of society. This research was conducted to determine the effect of implementing the 5M health protocol and the determinants of vaccination on the incidence of COVID-19 in the Kota Tengah Public Health Center area, Gorontalo City. This type of research is an analytic survey, cross sectional design, with Chi-Square test and logistic regression test. The independent variables are the 5M Health protocol (Wearing Masks, Washing hands, Keeping distance, Avoiding crowds, Reducing mobility) and the determinants of vaccination (age, sex, education level, occupation, comorbidities, completeness of vaccinations), while the dependent variable is the incidence of COVID-19 . The research was conducted in November and December 2022 with a total sample of 392 people. The sampling technique used was proportional stratified random sampling. The results of the analysis found that of the 11 variables that had been tested, all of them had a significant relationship with the incidence of COVID-19, but only 5 variables had a significant influence on the incidence of COVID-19 in the Kota Tengah Public Health Center area with a P-value = < 0.05 , namely wearing a mask (0.000), keeping a distance (0.000), reducing mobility (0.000), gender (0.012) and completeness of vaccination (0.000). The conclusion from this study I that the variable that has the most influence on the incidence of COVID-19 in the Kota Tengah Public Health Center area is reduced mobility (p-value 0.000; OR 9.560; CI = 4.657-19.626), which means that respondents who never or occasionally reduce their mobility have a 9.6 times risk of being infected with COVID-19. The community should self-awarely adhere to the 5M health protocol and vaccinate so that it can prevent the spread of COVID-19.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121027045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment Of The Effect Of Menopause On Thyroid Function In South East,Nigeria 尼日利亚东南部更年期对甲状腺功能影响的评估
International Journal Of Health &amp; Medical Research Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n05
Ogochukwu A Duru, Kelechi R Onyenemezu, Chukwuemelie D Okeke, John C Ubah, Nneoma R Ubah
{"title":"Assessment Of The Effect Of Menopause On Thyroid Function In South East,Nigeria","authors":"Ogochukwu A Duru, Kelechi R Onyenemezu, Chukwuemelie D Okeke, John C Ubah, Nneoma R Ubah","doi":"10.58806/ijhmr.2023.v2i8n05","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n05","url":null,"abstract":"Menopause marks the end of a woman’s reproductive life and is associated with significant physiological changes. The thyroid gland plays an important role in regulating overall body metabolism including sexual development and reproductive function. Worldwide, thyroid gland diseases are among the most common endocrine disorders in females, especially those in menopause. This study evaluated the effect of menopause on thyroid function. Methodology: It was a case-control study among post-menopausal women in Nnewi, Anambra, Nigeria with pre-menopausal women serving as controls. Sampling was by simple random method and comprised 45 post-menopausal women matched with 45 premenopausal women in a ratio of 1:1. Data was obtained with the use of a semi-structured questionnaire. The subjects’ blood samples were taken and assayed for thyroid stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) by ELISA technique. Their body mass index (BMI) and blood pressure were obtained using standard procedures. Result: The mean serum levels of free T4 and TSH in the menopausal individuals were significantly higher compared to the premenopausal group. Following linear regression analyses with adjustment for age and BMI, the the average level of TSH and free T4 were higher in the study group, while free T3 level was lower. Also, systolic and diastolic blood pressure was significantly higher in the study group than in the control group. Conclusion: The findings suggest that menopause is associated with reduced thyroid function and could as a result play a role in cardiovascular disease play a role in cardiovascular dysfunction among women","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133597658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect Of Short Message Service Reminders On Self-Management Of Type 2 Diabetes Mellitus Patients 短信服务提醒对2型糖尿病患者自我管理的影响
International Journal Of Health &amp; Medical Research Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n07
Olivia Maharani Mohamad
{"title":"The Effect Of Short Message Service Reminders On Self-Management Of Type 2 Diabetes Mellitus Patients","authors":"Olivia Maharani Mohamad","doi":"10.58806/ijhmr.2023.v2i8n07","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n07","url":null,"abstract":"Background: Short Message Service (SMS) can be used to increase knowledge of diabetes patients and improve adherence to recommended therapy. Methodology: The study used a Quasi-Experimental method with a Pretest-Posttest Nonequivalent Control Group design involving 40 Prolanis Diabetes Mellitus Type 2 patients, which were divided into a control group and an intervention group. Data collection used a questionnaire which was analyzed by the Mann Whitney test. Results: The results showed that there were differences in self-management in dietary adherence (p=0.008 <0.05) and medication adherence (p=0.031<0.05) before and after being given a short message reminder to patients with type 2 diabetes mellitus at the Kabila Health Center. Conclusion: There is an effect of short message service reminders on the self-management of type 2 diabetes mellitus patients at Kabila Health Center.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124065602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary Use Of Topical Decongestants: An Indian Perspective 局部减充血剂的当代使用:印度人的观点
International Journal Of Health &amp; Medical Research Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n04
Samir Bhargava, Atul Sharma
{"title":"Contemporary Use Of Topical Decongestants: An Indian Perspective","authors":"Samir Bhargava, Atul Sharma","doi":"10.58806/ijhmr.2023.v2i8n04","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n04","url":null,"abstract":"Background: Allergic rhinitis and sinusitis are commonly encountered in primary practice, and nasal congestion is a common symptom experienced by these patients. Thus, it is important to address nasal congestion when treating these conditions. Despite the availability of several treatment options, therapy is impacted by adverse effects and patient dissatisfaction. We conducted a survey to evaluate the prescribing practices of physicians treating allergic rhinitis and sinusitis, with a focus on the formulation of topical xylometazoline with moisturizers (hypromellose and sorbitol). Methods: We surveyed the prescribing practices of 545 Indian ear, nose and throat (ENT) physicians for rhinitis and sinusitis to understand the place of the formulation containing xylometazoline and moisturizer (sorbitol, hypromellose) in clinical practice. Towards this, physicians provided their response to a 10-item questionnaire covering prescribing practice and patient satisfaction. Results: Overall, 91% of doctors reported that a decongestant along with a moisturizer would be beneficial to patients with nasal congestion due to allergic rhinitis and sinusitis, and a majority of doctors (89.5%) preferred prescribing xylometazoline with sorbitol and hypromellose. A majority of doctors reported high patient satisfaction with this formulation. Additionally, 78.35% of doctors reported high ratings for the reduction of nasal dryness. Conclusion: The overall satisfaction of doctors and patients is high, indicating that this formulation is an ideal choice for achieving relief from nasal congestion due to AR and sinusitis.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"427 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122821230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Of Physical Activity, Gadget Use, And Sleep Time To Adolescent Obesity 体育活动、电子设备使用和睡眠时间与青少年肥胖的关系
International Journal Of Health &amp; Medical Research Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n08
Anwar Pasaribu, Sunarto Kadir, Sylva Flora Ninta Tarigan, Irwan Irwan
{"title":"The Relationship Of Physical Activity, Gadget Use, And Sleep Time To Adolescent Obesity","authors":"Anwar Pasaribu, Sunarto Kadir, Sylva Flora Ninta Tarigan, Irwan Irwan","doi":"10.58806/ijhmr.2023.v2i8n08","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n08","url":null,"abstract":"Overweight and obesity are a global health problem for both children and adults. The highest number of overweight and obese people in Gorontalo Province in 2017, in all age groups, was highest in Gorontalo City. This study aims to determine the relationship between physical activity, gadget use, and sleep time. This type of research uses a quantitative method with Observational analysis with a Cross-Sectional research design using the Spearman test. The population included in the study were all SMA Negeri 2 Kota Gorontalo students, totaling 1149 students. Sampling was carried out non-randomly using a purposive sampling technique determined using the Slovin formula. So, the sample size for this study was 92 students. The research showed an influence between physical activity and obesity in adolescents with a P-value = 0.010 (<0.05). Based on the results of the study at SMA N 2 Gorontalo City, it was found that there was an influence between playing gadgets and the incidence of obesity in adolescents with a P-value = 0.009 (<0.05). Based on the results of research at SMA N 2 Gorontalo City, it was found that there was an influence between sleep time and the incidence of obesity in adolescents with a P-value = 0.000 (<0.05). The conclusion is that physical activity, use of gadgets, and sleep time are related to obesity in adolescents.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131500984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Assessment Of Job Satisfaction Among Frontline Health Care Workers In A Tertiary Hospital In South East Nigeria 尼日利亚东南部某三级医院一线医护人员工作满意度比较评估
International Journal Of Health &amp; Medical Research Pub Date : 2023-08-21 DOI: 10.58806/ijhmr.2023.v2i8n03
Justice Mgbecheta, Kelechi R Onyenemezu, Chukwuemelie D Okeke, John C Ubah, T. Ezike, Queeneth Edwards
{"title":"Comparative Assessment Of Job Satisfaction Among Frontline Health Care Workers In A Tertiary Hospital In South East Nigeria","authors":"Justice Mgbecheta, Kelechi R Onyenemezu, Chukwuemelie D Okeke, John C Ubah, T. Ezike, Queeneth Edwards","doi":"10.58806/ijhmr.2023.v2i8n03","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n03","url":null,"abstract":"Background: Job satisfaction cuts across facets of mental perception and responses individuals make towards their jobs. They include cognitive, affective, and behavioral components. In light of reducing workforce in the Nigerian healthcare, this study was aimed at comparing the outlook of job satisfaction among healthcare workers in Nnamdi Azikiwe University teaching Hospital, Nnewi, Nigeria. Methods: It was a cross-sectional study design with a sample size of 281 healthcare personnel consisting of doctors, nurses, medical laboratory scientists, pharmacists, physiotherapists, and radiographers using a structured, self-administered questionnaire. The data was analyzed using SPSS version 20. Statistical significance was set at p≤0.05. Results: The study showed that Radiographers and Physiotherapists averagely had the best job satisfaction scores in comparison to other healthcare personnel. Doctors and Nurses were noted to have the worst average scores in relation to other personnel. Conclusion: The disparity in job satisfaction among different professional cadres may be a reflection of disproportionate work expectations, outlooks, and rewards experienced by different professionals in the course of their duties. Favorable and unfavorable work environments and policies may be weighted differently in the work experience of different professionals.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130938897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Crucial Roles of Geospatial Techniques in The COVID-19 Fight : A Systematic Review 地理空间技术在抗击COVID-19中的关键作用:系统综述
International Journal Of Health &amp; Medical Research Pub Date : 2023-08-18 DOI: 10.58806/ijhmr.2023.v2i8n01
Thi-Quynh Nguyen, Huong Giang Nguyen, Thi Tuyet Mai Nguyen
{"title":"The Crucial Roles of Geospatial Techniques in The COVID-19 Fight : A Systematic Review","authors":"Thi-Quynh Nguyen, Huong Giang Nguyen, Thi Tuyet Mai Nguyen","doi":"10.58806/ijhmr.2023.v2i8n01","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n01","url":null,"abstract":"The Corona Virus Disease 2019 (COVID-19) appeared in Wuhan, China, at the end of 2019, spreading from there across China and the whole world. Such advanced technologies as geospatial techniques have been applied to fight the rapid spread of SARS-CoV-2. This paper aims to review and synthesize the types of applications offered through geospatial techniques to help address different issues related to the fight of the COVID-19 pandemic. The content is presented under four sub-sections; namely the roles of GIS, Remote Sensing, Global Positioning System and Internet Mapping Technologies in the fight of the COVID-19 pandemic. It was found from summarising 73 scientific papers, geospatial techniques have been proven their effectiveness not only in the study of COVID-19 in general, but also in the fight of the pandemic in particular. The wide range of applications offered by geospatial techniques affirms the value of this technique to the COVID-19 fight.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115893409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report Of Isolated Left Zygomatic Arch Fracture: Successful Management By Yoga Prana Vidya (YPV) Healing Protocols 孤立性左颧弓骨折1例:瑜伽Prana Vidya (YPV)治疗方案的成功治疗
International Journal Of Health &amp; Medical Research Pub Date : 2023-08-18 DOI: 10.58806/ijhmr.2023.v2i8n02
Leelavathi Nayak, Venkata Satyanarayana Nanduri
{"title":"A Case Report Of Isolated Left Zygomatic Arch Fracture: Successful Management By Yoga Prana Vidya (YPV) Healing Protocols","authors":"Leelavathi Nayak, Venkata Satyanarayana Nanduri","doi":"10.58806/ijhmr.2023.v2i8n02","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n02","url":null,"abstract":"Introduction: Fractures of the zygomatic bone can present with complicated aesthetic and neurological pathology. Isolated, nondisplaced fractures may be treated without surgery, whereas displaced zygomatic arch fractures are usually treated with surgical reduction this paper presents a case of Zygomatic arch fracture healed successfully without surgical intervention. Method: Case study method is used in this paper, by collecting case data from patient’s medical records, YPV healer’s records, and patient feedback. Results: The redness in the eye and pain in all affected parts reduced within a week of YPV healing. The injury and its effects were fully healed within 1 month of YPV healing without any recurrence of pain or swelling. Conclusions: Yoga Prana Vidya system, which is integrated and holistic, has been found to be successful in the treatment of many types of illnesses. Further research is recommended using appropriate sample and methodology. Practicing doctors and nurses will find it beneficial to receive training in the application of YPV healing protocols to complement their respective professional practices.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129108291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, Attitude, and Perception of Common Skin Health Problems among Secondary Schools Students in Anaocha Local Government Area, Southeast Nigeria 尼日利亚东南部阿纳奥查地方政府区中学生常见皮肤健康问题的知识、态度和认知
International Journal Of Health &amp; Medical Research Pub Date : 2023-07-30 DOI: 10.58806/ijhmr.2023.v2i7n06
Afamefuna Obumneme Onyeogulu, Kelechi R Onyenemezu, Chukwuemelie Darlington Okeke, John Chiedu Ubah, Tobechukwu Chinenye Ezike, Theophilus Nwanyigor Agbo
{"title":"Knowledge, Attitude, and Perception of Common Skin Health Problems among Secondary Schools Students in Anaocha Local Government Area, Southeast Nigeria","authors":"Afamefuna Obumneme Onyeogulu, Kelechi R Onyenemezu, Chukwuemelie Darlington Okeke, John Chiedu Ubah, Tobechukwu Chinenye Ezike, Theophilus Nwanyigor Agbo","doi":"10.58806/ijhmr.2023.v2i7n06","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i7n06","url":null,"abstract":"Background: Dermatological conditions are commonly associated with low mortality rates, but they significantly contribute to morbidity globally. The burden of certain common skin diseases is remarkably higher among adolescents, and associated with psychosocial and physical impacts. This study was aimed at assessing the knowledge, attitude, and perception of common skin diseases among secondary school students in Anaocha. Methodology: It was a descriptive cross-sectional study among 395 secondary school students in Anaocha Local Government Area of Anambra state using a multistage stratified sampling technique with an interviewer-administered, semi-structured questionnaire. Data analysis was done using SPSS version 25. Results: There were 178 (45.1%) males and 217 (54.9%) females with an average age of 14.27 years ± 1.52. The respondents’ knowledge of acne, tinea capitis, and scabies was found to have an overall score of 43.29% ± 13.26. 78.2% of respondents showed a strong perception of common skin health challenges, and 84.3% showed a decisive attitude toward them. The level of knowledge was significantly associated with the student’s academic class and gender. Conclusion: Overall knowledge of common skin conditions was poor and there was a high rate of misconceptions along with the tendency for self-medication. Though most respondents showed a decisive attitude towards these conditions, there is a high potential for neglect of care for skin diseases in general including sinister ones. Therefore, health education on common skin conditions should be intensified within all secondary schools in Anambra state to improve the knowledge of students on these important conditions.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130121379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-Drug Interaction Between Amlodipine And Clarithromycin In Hypertension Rabbits 氨氯地平与克拉霉素在家兔高血压中的相互作用
International Journal Of Health &amp; Medical Research Pub Date : 2023-07-28 DOI: 10.58806/ijhmr.2023.v2i7n05
Rana Mahmood Ahmad,, Zahraa Kadhim Lafi,, H. Alshaikhli
{"title":"Drug-Drug Interaction Between Amlodipine And Clarithromycin In Hypertension Rabbits","authors":"Rana Mahmood Ahmad,, Zahraa Kadhim Lafi,, H. Alshaikhli","doi":"10.58806/ijhmr.2023.v2i7n05","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i7n05","url":null,"abstract":"This study is the first to examine the possibility of pharmacokinetic interaction in blood circulation using amlodipine and clarithromycin as representatives in hypertension rabbits and identify changes. The current study design required rabbits (n=6) for Pharmacokinetics. In group A, rabbits without treatment were used as control. In group B, were administration of a single dose of amlodipine (0.21mg/kg.BW) for 24 hours. Group C, were administered with a single dose of amlodipine (0.21mg/kg/BW.) and clarithromycin (22 mg/kg/BW.) each 6 hr. for 24 hour. The blood samples were collected from (B and C) groups at time intervals of zero, 1, 2, 3, 4, 6, 8, 12, 24, 36, 48, 60, 72, 96, 120, 144 hours and the drug concentrations were estimated using a spectrophotometer and estimated blood pressure using blood pressure cuff with Doppler ultrasound transducer. An increase in C max and AUC in group C (3.52 μg/ml and 130 μg/ml*h) respectively, indicates the improved bioavailability of amlodipine in the presence of clarithromycin compared with group B (2.03 μg/ml and 96.10 μg/ml*h) respectively. Furthermore, reduction in (CL) with an elevation of (Vd) in the presence of clarithromycin (54.94 L/kg/hr. and 4994 L/kg) in group C respectively, compared with group B (74.31 L/kg/hr and 3715 L/kg) respectively. We studied the influence of clarithromycin on the pharmacodynamics of amlodipine in hypertension rabbits. Interaction of amlodipine with multiple doses of clarithromycin produced a high reduction in blood pressure at 9 after administration and the blood pressure continues redaction. In conclusion, the combination of amlodipine with clarithromycin led to the enhancement of the bioavailability of amlodipine by inhibiting the CYP3A4 enzyme leading to producing a hypotension effect with peak plasma concentration effect in hypertension rabbits.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126600489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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