K. Ponnuvelu, J. Saniasiaya, I. Mohamad, N. Abdul Gani
{"title":"Oral ulcer and skin lesions: a tell-tale sign of pemphigus vulgaris","authors":"K. Ponnuvelu, J. Saniasiaya, I. Mohamad, N. Abdul Gani","doi":"10.15557/pimr.2023.0008","DOIUrl":"https://doi.org/10.15557/pimr.2023.0008","url":null,"abstract":"Aim: The aim of this case presentation was to highlight the importance of the awareness of two different coexisting pathologies, as well as emphasise that early diagnosis and prompt management are essential to manage pemphigus vulgaris. Pemphigus vulgaris is a rare, life-threatening autoimmune disease characterised by the presence of blisters on the surface of oral mucosa caused by antibodies against adhesion molecules on the cell surface of keratinocytes. Coexistence with various conditions, notably herpes simplex virus, is noteworthy. Case report: We report a case of a middle-aged female who presented with non-healing oral ulceration that turned out to be herpes simplex virus, consequently triggering pemphigus vulgaris. Histopathology and immunofluorescence were suggestive of pemphigus vulgaris, but immunohistochemistry and polymerase chain reaction were indicative of herpes simplex virus infection. Conclusion: The coexistence of a viral infection with pemphigus vulgaris poses a therapeutic challenge.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":"1 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41743290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siri Kavita Nalathamby, J. Saniasiaya, J. Kulasegarah
{"title":"Sudden onset of double vision in a child","authors":"Siri Kavita Nalathamby, J. Saniasiaya, J. Kulasegarah","doi":"10.15557/pimr.2023.0010","DOIUrl":"https://doi.org/10.15557/pimr.2023.0010","url":null,"abstract":"Introduction: The abducens nerve, or cranial nerve six (CN VI), is the most common nerve involved in cranial nerve palsy. Various causes have been identified as the aetiology, but no association has been made with monoclonal gammopathy. We aim to describe isolated cranial nerve palsy in a child with monoclonal gammopathy. Case report: We report a case of a healthy 6-year-old girl who presented with sudden onset binocular diplopia, headache, and unsteady gait. Further investigation revealed isolated left sixth cranial nerve neuritis with monoclonal gammopathy, which was treated with steroids. Discussion: Cranial nerve palsy is an alarming sign, especially in children, and is almost always related to intracranial pathologies such as a tumour, hydrocephalus, and meningitis. Conclusion: Prompt investigations alongside relevant management result in a good prognosis.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43746798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Brychcy, Ewa Kopaczewska, P. Kolodziejski, Krzysztof Bryłka
{"title":"Ingrown toenail – an update of knowledge and a proposal of a novel treatment approach","authors":"A. Brychcy, Ewa Kopaczewska, P. Kolodziejski, Krzysztof Bryłka","doi":"10.15557/pimr.2023.0003","DOIUrl":"https://doi.org/10.15557/pimr.2023.0003","url":null,"abstract":"Ingrown toenail is one of the most common foot health problems, which is the reason for frequent paediatric, surgical, family medicine and podology appointments. The problem most often affects schoolchildren and young adults, with incorrect hygiene habits and improper care typically considered its causes. The disorder is usually managed in a surgical clinic, with a wedge-shaped undercutting of the nail plate or, in advanced cases, total nail avulsion, being the most common treatment approaches. However, these techniques are characterised by poor efficacy and high recurrence rates, and often lead to further complications, as well as permanent deformations of the nail plate. Therefore, we propose an alternative approach to the problem of ingrown toenails and present a causative surgical method. This technique consists in soft tissue plasty to reduce the prominence of nail folds followed by adaptation of healthy tissues with the use of skin sutures to the shape and dimensions of the nail plate. Since the procedure is performed under local anaesthesia, the treatment can be performed in an outpatient setting. Nail fold plasty allows for effective and permanent resolution of ingrown toenail symptoms, however, it requires strict compliance with postoperative recommendations, which mainly focus on proper care. The lack of interference in the structure of the nail matrix and plate minimises the risk of complications, permanent deformations of the nail apparatus and allows for maintaining the full width of the nail plate.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43352300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of seizures in children in primary health care","authors":"Jakub Zachaj, Zuzanna Tomczewska, Marta Rybińska","doi":"10.15557/pimr.2023.0002","DOIUrl":"https://doi.org/10.15557/pimr.2023.0002","url":null,"abstract":"Sudden health states accompanied by seizures require proper diagnosis and appropriate treatment. A seizure in the paediatric population may turn into a life-threatening condition, especially when it is misdiagnosed and appropriate management is initiated too late. The article presents the classification of seizures proposed by the International League Against Epilepsy and seizure time intervals when appropriate treatment should be implemented. The main part of this work is the description of non-pharmacological treatment. In this paper, the management of seizures in the paediatric population was based on the guidelines proposed by several recognised organisations. The American Epilepsy Foundation is one of the bodies publishing guidelines for the management of seizures in the paediatric population. This organisation recommends treatment based on the STAY-SAFE-SIDE strategy. According to these guidelines, the patient should not be left alone, all objects that may injure the patient during the seizure should be moved away, and the patient should be placed on their side. An important element of these activities is also recording seizure duration, which is associated with appropriate pharmacological treatment. Pharmacological management of seizures is based on benzodiazepines. The type of drug, dosage and route of administration are described in detail. The article also mentions guidelines explaining in which cases it is advisable to continue diagnosis and treatment in an Emergency Department setting, and which cases require calling the Emergency Medical Services.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44734541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Saniasiaya, Jasintha Vani Raja Sekaran, P. Narayanan
{"title":"Impact of COVID-19 among otorhinolaryngologists in Malaysia: a cross-sectional online survey","authors":"J. Saniasiaya, Jasintha Vani Raja Sekaran, P. Narayanan","doi":"10.15557/pimr.2023.0005","DOIUrl":"https://doi.org/10.15557/pimr.2023.0005","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) has changed the lives of millions of people worldwide, including the lives of healthcare workers. The aim of this study was to determine the impact of COVID-19 on the quality of life, financial implications, and fear of COVID-19 among otorhinolaryngologists in Malaysia at the peak of the COVID-19 pandemic. Methods: A cross-sectional online survey was conducted for a period of one week from 1 to 7 June 2021 using the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF) and the Consumer Financial Protection Bureau (CFPB) Financial Well-Being Scale and Fear of COVID-19 Scale (FCV-19S) available at a link sent to potential participants. The study’s target participants were otorhinolaryngology specialists residing and working in Malaysia. Results: A total of 115 participants completed the survey. The majority of them were of the Malay (51.3%) race, of Malaysian (99.1%) nationality, and predominantly female. Most of the respondents were 20–40 years old, working in public hospitals (46.1%). The mean WHOQOL-BREF scores for the physical domain, psychological domain, social domain, and environmental domain were 54.64 ± 12.93, 53.79 ± 11.09, 72.70 ± 20.74, and 67.22 ± 16.32, respectively. The mean CFPB and FVC-19S scores were 54.57 ± 8.47 and 19.13 ± 6.04, respectively. A significant difference between the participants with different lengths of professional experience was observed in the social relationship domain (p = 0.011) and the financial well-being score (p = 0.004). Participants with more than ten years of professional experience had the highest CFPD score (mean ± SD: 58.07 ± 8.65). Conclusion: COVID-19 has affected various domains of the quality of life, financial stability, and fear of COVID-19 across the various groups of otorhinolaryngologists in Malaysia. The findings of this survey identify negative effects and help to plan various strategies to address the issue.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49204627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Sim, Thevagi Maruthamuthu, Chenthilnathan Periasamy, Zahirrudin Zakaria, I. Mohamad
{"title":"Inverted papilloma masquerading as juvenile nasopharyngeal angiofibroma in a young adolescent male","authors":"L. Sim, Thevagi Maruthamuthu, Chenthilnathan Periasamy, Zahirrudin Zakaria, I. Mohamad","doi":"10.15557/pimr.2023.0009","DOIUrl":"https://doi.org/10.15557/pimr.2023.0009","url":null,"abstract":"Inverted papilloma is a benign sinonasal epithelial tumour that mainly occurs in the fifth to sixth decades of life, with male predominance. The incidence in the young adolescent population is comparatively lower. The clinical and radiological findings may mimic other benign sinonasal tumours, so the diagnosis can only be confirmed by histopathological examination. Consequently, precise diagnostic and therapeutic planning is recommended to achieve the optimal result. We describe a case of unilateral sinonasal tumour in a young adolescent male who showed clinical and radiological features of juvenile nasopharyngeal angiofibroma, such as widening of the sphenopalatine foramen, extension of the mass posteriorly towards the nasopharynx, and presence of flow voids that suggested highly vascular nature of the mass. However, a postoperative histopathological examination showed a diagnosis of inverted papilloma.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43007793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnieszka Byrwa, Ewa Łuczak, Izabela Górzyńska, Katarzyna Serwan, E. Jakubowska-Pietkiewicz
{"title":"Bruck syndrome – description of the first Polish infant with FKBP10 gene mutation","authors":"Agnieszka Byrwa, Ewa Łuczak, Izabela Górzyńska, Katarzyna Serwan, E. Jakubowska-Pietkiewicz","doi":"10.15557/pimr.2023.0007","DOIUrl":"https://doi.org/10.15557/pimr.2023.0007","url":null,"abstract":"Background: Bruck syndrome is a very rare genetic disorder that combines features of congenital bone fragility and arthrogryposis. It is characterised by osteoporosis, increased susceptibility to bone fractures, progressive joint contractures, and short stature, among other features. Bruck syndrome is inherited in an autosomal recessive manner, and the mutation affects mainly the gene located on chromosome 17p12 (FKBP10 gene). Case presentation: The authors present the first description of an 18-month-old Polish boy diagnosed with Bruck syndrome. The management includes making a correct diagnosis based on the clinical picture, phenotypic features, and additional laboratory and imaging examinations. In the discussion, the authors touched upon the available treatment modalities and the differentiation of Bruck syndrome with similar diseases. Conclusions: Understanding the clinical spectrum of Bruck syndrome and providing appropriate medical interventions in the early stages of the disease enables the implementation of appropriate treatment and rehabilitation.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43300554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of phototherapy on neonatal calcium and bilirubin levels: a comparison between patients with low and normal G6PD levels","authors":"M. Sheikh, P. Ostadrahimi","doi":"10.15557/pimr.2023.0004","DOIUrl":"https://doi.org/10.15557/pimr.2023.0004","url":null,"abstract":"Introduction: Iran is among countries that report a higher prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency, ranging from 2.28% to 30.80%. This study aimed to estimate the general prevalence of G6PD deficiency in newborns with jaundice who were hospitalised in southeast Iran. Methods: This was a prospective study. A total of 100 newborns (boys and girls) with hyperbilirubinaemia, presented to Amir Al-Mo’menin Hospital in 2006 and 2007, were selected for the study. Age, gender, weight, time of jaundice, the maximum level of direct bilirubin, and the total level of bilirubin among the newborns were recorded, and the data were analysed by SPSS. Results: A total of 100 jaundice neonates, including 46 girls and 54 boys, were enrolled. Twenty-two percent of these patients, including 18 (82%) boys and 4 (18%) girls, showed low levels of G6PD. The overall mean bilirubin level was 15.45 ± 3.43 mg/dL among neonates with low G6PD levels, while it was 19.21 ± 3.34 mg/dL in patients with normal G6PD levels, which showed a significant difference (p < 0.05). Conclusion: The prevalence of G6PD deficiency in neonates with jaundice in our study was 22%, which was higher compared to other regions. We propose G6PD deficiency screening for the prevention of its complications. We also suggest assessing calcium levels following phototherapy, given the higher prevalence of hypocalcaemia.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47910207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vaccination against COVID-19 – historical foundations","authors":"Kamil Faltin, M. Figlerowicz","doi":"10.15557/pimr.2023.0001","DOIUrl":"https://doi.org/10.15557/pimr.2023.0001","url":null,"abstract":"Vaccinations are a relatively recent development in human history. Variolation, i.e. contacting healthy persons with biological material from mildly ill individuals was the prototype of a vaccine. Although used for centuries, it was only at the end of the 19th century that Louis Pasteur developed the first successful vaccines (including against rabies). Over the years, new preparations against many diseases were developed and improved by modifying, among others, route of administration or antigen vector. The general mechanism of action, i.e. preparing the immune system to fight off a given pathogen, remained unchanged. Vaccination has contributed to the reduced spread of multiple infectious diseases, and even complete elimination of some of them. The discovery of vaccination had a significant impact on reducing mortality, extending lifespan and improving the quality of life. We are again facing the threat of infectious epidemics in this era of advancing globalisation, climate crisis and population migratory movements. These predictions were confirmed by the COVID-19 pandemic. Intensive work of many research centres has led to a rapid development of an innovative mRNA vaccine against this clinical entity. These vaccines act by introducing an mRNA template into the host cell to stimulate antigen synthesis in vivo. Once again, science has succeeded in limiting the spread of a disease, which was a historic breakthrough. This paper presents a historical outline of the stages of the development of vaccinology leading to the modern concept and technology of vaccine production.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49391937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jakub Milczarek, Anita Kurlenda, Katarzyna Ziobro, B. Ostrowski
{"title":"Eosinophilic oesophagitis – symptoms, diagnosis and treatment","authors":"Jakub Milczarek, Anita Kurlenda, Katarzyna Ziobro, B. Ostrowski","doi":"10.15557/pimr.2022.0046","DOIUrl":"https://doi.org/10.15557/pimr.2022.0046","url":null,"abstract":"Eosinophilic oesophagitis is a complex multifactorial disorder and one of the leading causes of dysphagia in children and adults. An allergen-mediated inflammatory response is the underlying cause of this disease. Allergen-activated Th2 cells, eosinophils and interleukins 4, 5 and 13 play a major role in the pathogenesis of eosinophilic oesophagitis. Difficulties swallowing, especially dry food, and the related increase in chewing time, as well as episodes of oesophageal food impaction, often requiring endoscopic treatment, are the leading symptoms. Children develop nausea, vomiting, abdominal pain, irritability and reluctance to consume foods. The incidence of eosinophilic oesophagitis has increased dramatically in recent years and is now estimated at approximately 42.2/100,000 per year in adults. Endoscopy followed by histopathological examination of at least six biopsy specimens taken from two different sections of the oesophagus is the gold diagnostic standard. The eosinophilic oesophagitis endoscopic reference score (EREFS) is used for endoscopy and the eosinophilic oesophagitis histologic scoring system (EoE HSS) is used for histopathology to objectify the assessment. Pharmacological and dietary therapies are of primary importance in eosinophilic oesophagitis. Proton pump inhibitors and glucocorticoids are most commonly used. Allergen-free diets significantly contribute to the achievement of permanent histological and clinical remission. In the case of permanent oesophageal remodelling, endoscopic and/or surgical treatment should be considered.","PeriodicalId":42380,"journal":{"name":"Pediatria i Medycyna Rodzinna-Paediatrics and Family Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45535276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}