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Demographic Characteristics and Transmission Risk Factors of Patients with Hepatitis C Virus in Turkey: The EPI-C, A Multicenter and Cross-sectional Trial 土耳其丙型肝炎病毒患者的人口统计学特征和传播危险因素:EPI-C，一项多中心横断面试验
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-12-23 DOI: 10.4274/vhd.galenos.2021.2021-1-3
F. Tabak, G. Sirin, M. Demir, M. Aladağ, Ş. Sümer, B. Kurtaran, S. Tosun, T. Yamazhan, İlkay Bozkurt, Yunus Gürbüz, A. Batırel, E. Şenateş, F. O. Kandemir, Firdevs Topal, H. Doğanay, O. Sezgin, R. Mıstık, Ş. Köse, Y. Yılmaz, D. Inan, İ. Köksal, E. Parlak, M. Akdoğan, Rahmet Güner
{"title":"Demographic Characteristics and Transmission Risk Factors of Patients with Hepatitis C Virus in Turkey: The EPI-C, A Multicenter and Cross-sectional Trial","authors":"F. Tabak, G. Sirin, M. Demir, M. Aladağ, Ş. Sümer, B. Kurtaran, S. Tosun, T. Yamazhan, İlkay Bozkurt, Yunus Gürbüz, A. Batırel, E. Şenateş, F. O. Kandemir, Firdevs Topal, H. Doğanay, O. Sezgin, R. Mıstık, Ş. Köse, Y. Yılmaz, D. Inan, İ. Köksal, E. Parlak, M. Akdoğan, Rahmet Güner","doi":"10.4274/vhd.galenos.2021.2021-1-3","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2021-1-3","url":null,"abstract":"ÖZ Objectives: To describe the prevalence of risk factors in patients infected with hepatitis C virus (HCV). Materials and Methods: Patients who were aged >18 years visiting outpatient clinics and diagnosed as having HCV infection were enrolled in this cross-sectional, multicenter study conducted in 71 cities. Patient data on socio-demographic and clinical characteristics and pre-defined risk factors were collected. Results: Among 1,018 patients, 53.0% were women. The mean age was 57.2±14.3 years and 34.8% had been diagnosed as having HCV infection >10 years before enrollment. Almost half of the patients (45.5%) were diagnosed during their regular check-up visits, and only 16.8% were diagnosed because of signs or symptoms of HCV. Genotype 1 and sub-genotype 1 b were detected in 87.9% and 73.7% of the patients, respectively. At least one risk factor was present in 94.8% of the patients. The most frequently reported risk factor was major dental procedures (79.2%), followed by major surgical operations (56.9%) and minor surgical interventions (42.3%). Conclusion: Our results revealed that most of the patients with HCV infection underwent major dental procedures.","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48341537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Treatment of Ledipasvir/Sofosbuvir in Patients with Chronic Hepatitis C Virus: The Results of Five-year Follow-up Ledipasvir/Sofosbuvir治疗慢性丙型肝炎患者的5年随访结果
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-12-23 DOI: 10.4274/vhd.galenos.2021.2021-6-1
M. Pekgöz, N. Ince
{"title":"The Treatment of Ledipasvir/Sofosbuvir in Patients with Chronic Hepatitis C Virus: The Results of Five-year Follow-up","authors":"M. Pekgöz, N. Ince","doi":"10.4274/vhd.galenos.2021.2021-6-1","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2021-6-1","url":null,"abstract":"Objectives: Chronic hepatitis C virus (HCV) is a fundamental worldwide health challenge. We assessed the treatment outcomes of ledipasvir (LDV) and sofosbuvir (SOF) with and without ribavirin (RBV) for 12 and 24 weeks in pre-treated and treatment-naive patients with chronic HCV. Materials and Methods: Totally 65 patients were included in the present study. Patients were divided in two groups. In the first group, LDV and SOF with RBV were administered to 12 patients for 12 weeks. In the second group, LDV and SOF without RBV were administered to 53 patients for 24 weeks. Results: Sustained virological response (SVR) rates were 100% for the both groups included in the study. The adverse events were weakness (15.39%), pruritus (6.15%), myalgia (4.62%) nausea (3.08%), dry mouth (1.54%) and anorexia (1.54%) in all patients. HCV-RNA was also negative in all patients 48 weeks after the beginning of the treatment. At the end of the fifth year of treatment, all the patients still had SVR and no recurrence was detected. Conclusion: In the treatment of patients with chronic HCV, LDV and SOF with and without RBV were highly effective. SVR rate of 100% was achieved in all pre-treated or treatment naive patients with or without cirrhosis regardless of genotype of HCV.","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47011319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Hepatitis B Virus Genotypes and Viral Load on the Response of Patients Treated with Peginterferon-αα-2a 乙型肝炎病毒基因型和病毒载量对聚乙二醇干扰素-αα-2a治疗患者疗效的影响
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-12-23 DOI: 10.4274/vhd.galenos.2021.2021-5-6
M. Mahmood, M. A. Anwar, Muhammad Naseem Hasrat, Zahid Azam
{"title":"Effect of Hepatitis B Virus Genotypes and Viral Load on the Response of Patients Treated with Peginterferon-αα-2a","authors":"M. Mahmood, M. A. Anwar, Muhammad Naseem Hasrat, Zahid Azam","doi":"10.4274/vhd.galenos.2021.2021-5-6","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2021-5-6","url":null,"abstract":"","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43504725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge Level of Physicians in Turkey about Hepatitis C and New Treatments 土耳其医生对丙型肝炎和新疗法的知识水平
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-12-23 DOI: 10.4274/vhd.galenos.2021.2021-5-2
A. Sezen, K. Kart Yaşar
{"title":"Knowledge Level of Physicians in Turkey about Hepatitis C and New Treatments","authors":"A. Sezen, K. Kart Yaşar","doi":"10.4274/vhd.galenos.2021.2021-5-2","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2021-5-2","url":null,"abstract":"Ad dress for Cor res pon den ce: Ayşegül İnci Sezen MD, University of Health Sciences Turkey, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, İstanbul, Turkey Phone: +90 212 414 71 71 E-mail: incinarin@hotmail.com ORCID ID: orcid.org/0000-0001-8920-9019 Re cei ved: 07.05.2021 Ac cep ted: 14.09.2021 ©Copyright 2021 by Viral Hepatitis Society / Viral Hepatitis Journal published by Galenos Publishing House. ABSTRACT ÖZ","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41370603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Analysis of Hepatitis B Virus Reverse Transcriptase Domain for Mutations Associated with Viral Resistance in Pakistani Patients 巴基斯坦患者乙型肝炎病毒逆转录酶结构域与病毒耐药性相关突变的分子分析
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-12-23 DOI: 10.4274/vhd.galenos.2021.2021-5-5
M. Mahmood, Sdia Jameel, Z. Rahman, M. A. Anwar
{"title":"Molecular Analysis of Hepatitis B Virus Reverse Transcriptase Domain for Mutations Associated with Viral Resistance in Pakistani Patients","authors":"M. Mahmood, Sdia Jameel, Z. Rahman, M. A. Anwar","doi":"10.4274/vhd.galenos.2021.2021-5-5","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2021-5-5","url":null,"abstract":"Objectives: Current study was designed to screen out the resistant mutations in reverse transcriptase (RT) domain of hepatitis B virus (HBV) genome from non-responder Pakistani patients. Materials and Methods: A total of 22 patients, receiving different nucleot(s)ide analogues were included in the study. RT domain of the virus from samples of non-responder patients was amplified and sequenced. Sequences were aligned and analyzed for RT domain mutations. Results: After 18 months, 18 patients were responder and 4 were non-responder. Mean alanine aminotransferase (ALT) and viral load of responder patients decreased significantly as compared to those of non-responder patients. Two of the 4 samples from nonresponders were successfully sequenced. Mutations rtY135S, rtI169P, rtV173P, rtL180I, rtA181V, rtT184Y and rtM204V were identified from the sample of patient 1, while rtL80V/rtL80G and rtY135S were identified from the sample of patient 2. Conclusion: Mutations rtY135S, rtI169P, rtV173P, rtL180I, rtA181V, rtT184Y, rtM204V, rtL80V/rtL80G, and rtY135S are present in genome of HBV circulating in Pakistani patients. These mutations give resistance to virus against lamivudine, telbivudine, adefovir, and partially resistance against entecavir. However, no mutation was found to be associated with the viral resistance against tenofovir.","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49029935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of HBsAg, Anti-HCV, Anti-HIV Seroprevalence and Perinatal Outcomes in Pregnant Women 孕妇HBsAg、抗- hcv、抗- hiv血清阳性率及围产期结局的评价
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-08-01 DOI: 10.4274/vhd.galenos.2021.2020-12-2
Kazım Uçkan, İzzet Çeleğen, T. Uçkan
{"title":"Evaluation of HBsAg, Anti-HCV, Anti-HIV Seroprevalence and Perinatal Outcomes in Pregnant Women","authors":"Kazım Uçkan, İzzet Çeleğen, T. Uçkan","doi":"10.4274/vhd.galenos.2021.2020-12-2","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2020-12-2","url":null,"abstract":"","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45768381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin Resistance in Patients with Chronic Hepatitis B Virus Infection: A Case-control Study 慢性乙型肝炎病毒感染患者的胰岛素抵抗:一项病例对照研究
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-08-01 DOI: 10.4274/vhd.galenos.2021.2021-2-6
A. Kaya, S. Kaya, B. Mete, I. Balkan, N. Saltoğlu, Ö. Tabak
{"title":"Insulin Resistance in Patients with Chronic Hepatitis B Virus Infection: A Case-control Study","authors":"A. Kaya, S. Kaya, B. Mete, I. Balkan, N. Saltoğlu, Ö. Tabak","doi":"10.4274/vhd.galenos.2021.2021-2-6","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2021-2-6","url":null,"abstract":"","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47892069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Etiology and Clinical Follow-up of Patients with Acute Viral Hepatitis in an Adult Population: A Prospective Multicenter Study 成人急性病毒性肝炎的病因学和临床随访:一项前瞻性多中心研究
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-08-01 DOI: 10.4274/vhd.galenos.2021.2021-3-1
S. Tosun, Ayşe Albayrak, G. Durmus, İrem Çetin Altaş, Ayşegül Özel, N. Tülek, A. Kadanalı, S. Erol, Arzu Altunçekiç Yıldırım, N. Ceran, Ö. Dağlı, A. Olut
{"title":"The Etiology and Clinical Follow-up of Patients with Acute Viral Hepatitis in an Adult Population: A Prospective Multicenter Study","authors":"S. Tosun, Ayşe Albayrak, G. Durmus, İrem Çetin Altaş, Ayşegül Özel, N. Tülek, A. Kadanalı, S. Erol, Arzu Altunçekiç Yıldırım, N. Ceran, Ö. Dağlı, A. Olut","doi":"10.4274/vhd.galenos.2021.2021-3-1","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2021-3-1","url":null,"abstract":"","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44241217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of Viral Hepatitis and Human Immunodeficiency Virus Screening in Afghan Irregular Migrants: A Crosssectional Study (2011-2019) 阿富汗非正规移民病毒性肝炎和人类免疫缺陷病毒筛查结果:横断面研究(2011-2019)
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-08-01 DOI: 10.4274/vhd.galenos.2021.2020-12-8
Emine Füsun Karaşahin1, Ömer Karaşahin, İ. Akdemir Kalkan
{"title":"Results of Viral Hepatitis and Human Immunodeficiency Virus Screening in Afghan Irregular Migrants: A Crosssectional Study (2011-2019)","authors":"Emine Füsun Karaşahin1, Ömer Karaşahin, İ. Akdemir Kalkan","doi":"10.4274/vhd.galenos.2021.2020-12-8","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2020-12-8","url":null,"abstract":"","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47546800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Evaluation of Knowledge Levels, Attitudes and Behaviors Among the Relatives of Patients Infected with Hepatitis B 乙型肝炎患者亲属知识水平、态度和行为的评价
IF 0.1
Viral Hepatit Dergisi-Viral Hepatitis Journal Pub Date : 2021-08-01 DOI: 10.4274/vhd.galenos.2021.2020-12-4
A. Kaya Kalem, Rahmet Güner, F. Eser, I. Hasanoğlu, G. Yılmaz, Mehmet Akın Taşyaran
{"title":"Evaluation of Knowledge Levels, Attitudes and Behaviors Among the Relatives of Patients Infected with Hepatitis B","authors":"A. Kaya Kalem, Rahmet Güner, F. Eser, I. Hasanoğlu, G. Yılmaz, Mehmet Akın Taşyaran","doi":"10.4274/vhd.galenos.2021.2020-12-4","DOIUrl":"https://doi.org/10.4274/vhd.galenos.2021.2020-12-4","url":null,"abstract":"","PeriodicalId":42346,"journal":{"name":"Viral Hepatit Dergisi-Viral Hepatitis Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44223096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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