The Open Drug Delivery Journal最新文献

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Rationally Designed Synthetic Vectors for Gene Delivery 合理设计基因传递合成载体

The Open Drug Delivery Journal Pub Date : 2007-07-12 DOI: 10.2174/1874126600701010007

Gururaj A. Rao, Preeti Yadava, J. Hughes

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引用次数: 9

Effect of Insulin and Losartan on Modulation of Insulin-Like Growth Factor 1 Receptor at Heart Level in Diabetic Rats 胰岛素和氯沙坦对糖尿病大鼠心脏水平胰岛素样生长因子1受体调节的影响

The Open Drug Delivery Journal Pub Date : 2007-07-12 DOI: 10.2174/1874126600701010001

A. Bikhazi, Wael M Maharsy, Lina N. Kadi, N. Issa, Ghinwa M. Barakat, N. Nuwayri-Salti, G. Karam, O. Batal, K. Bitar

{"title":"Effect of Insulin and Losartan on Modulation of Insulin-Like Growth Factor 1 Receptor at Heart Level in Diabetic Rats","authors":"A. Bikhazi, Wael M Maharsy, Lina N. Kadi, N. Issa, Ghinwa M. Barakat, N. Nuwayri-Salti, G. Karam, O. Batal, K. Bitar","doi":"10.2174/1874126600701010001","DOIUrl":"https://doi.org/10.2174/1874126600701010001","url":null,"abstract":"This study investigates insulin-like growth factor-1 receptor (IGF-1R) modulation in hearts of streptozotocin- induced diabetic rats treated with insulin/angiotensin-II receptor subtype-1 blocker (AR1B), losartan. Male rats were di- vided into: normal (N), losartan-treated normal (NL), diabetic (D), insulin-treated diabetic (DI), losartan-treated diabetic (DL), and insulin/losartan co-treated diabetic (DIL) groups. Thirty days post-treatment, rats underwent heart perfusion us- ing (I 125 )-labeled IGF-1 to assess receptor-binding affinity on coronary endothelial cells (CE) and cardiomyocytes (CM). This revealed an increase in binding affinity of IGF-1 to its receptor on CE in all groups compared to N. On CM, binding affinity increased in D, DI, and DL compared to N, but was almost normalized in DIL. Western blot analyses and immu- nohistochemistry done on heart tissues showed decrease in IGF-1R density in DIL versus remaining groups. These results demonstrate a complex interaction between insulin, angiotensin-II, and IGF-1, and mass blockade of myocardial remodel- ing by AR1B treatment in diabetic state.","PeriodicalId":421840,"journal":{"name":"The Open Drug Delivery Journal","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123202419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

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