Transplant Research and Risk Management最新文献

{"title":"Knowledge, Attitude, and Willingness Towards Organ Donation Among Medical and Health Sciences Students in Central Region, Saudi Arabia","authors":"S. Almutairi","doi":"10.2147/trrm.s264872","DOIUrl":"https://doi.org/10.2147/trrm.s264872","url":null,"abstract":"Purpose: In this modern era, organ transplantation has become an important treatment method for certain diseases. Doctors and allied health professionals play important roles in continuing its advocacy and sharing knowledge within the community; thus, educating the public on organ donation is paramount. The present study aimed to understand the knowledge, attitude, and willingness toward organ donation of medical and health sciences students. Materials and Methods: We conducted a cross-sectional questionnaire-based study from January to March 2020. The pretested questionnaire was prepared on Google Forms, and the link was shared with 467 students graduating in medicine, dentistry, nursing, physiotherapy, and paramedical studies to analyze their knowledge, attitudes, and willingness towards organ donation. Of 467 students, 425 students provided complete answers and were included in data analysis. Results: We found that knowledge scores were uniformly low among students in all specialties except for those studying medicine and physiotherapy (p = 0.001). Moreover, female students scored higher than male students in all the three domains of knowledge, attitude, and willingness toward organ donation, and such was statistically significant (p = 0.001). Conclusion: Since final-year medical and health sciences students will soon graduate and join their respective professions, we recommend the integration of the topic of organ donation into their final-year curriculum to provide them with adequate knowledge so that they can provide proper guidance to the general public. Similarly, the advocacy in promoting organ donation should be increased through the use of appropriate mediums to change the attitudes and enhance the willingness of people.","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/trrm.s264872","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48433184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Coronary Angiographic Findings in Potential Renal Transplant Recipients in a Tertiary Care Center of Nepal","authors":"V. Yadav, S. Jha, R. Gajurel, C. Poudel, Ravi Sahi, Manju Sharma, S. Adhikari","doi":"10.2147/trrm.s261084","DOIUrl":"https://doi.org/10.2147/trrm.s261084","url":null,"abstract":"","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46638108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Supplement Use in Live Kidney Donors and Recipients","authors":"Nicole Persun, David Johnson, Amanda K. Leonberg-Yoo, Jehan Z. Bahrainwala, P. Reese, Brendan Steiner, Brooke Witmer, J. Rashid, A. Naji, J. Trofe‐Clark","doi":"10.2147/trrm.s235488","DOIUrl":"https://doi.org/10.2147/trrm.s235488","url":null,"abstract":"Background: Dietary supplement use in living kidney donors (LKDs) and kidney transplant recipients (KTRs) provides care challenges due to drug interactions, limited data, and lack of management guidelines. The study purposes were to describe supplement use patterns and intra/postoperative complications in these populations. Methods: A single-center retrospective review of LKDs and KTRs from September 2016 – 2018 was conducted. Supplement information was collected at evaluation and preoperative visits. Supplement relationship to intra/postoperative complications was graded by Naranjo Adverse Drug Reaction Probability Scale. Results: One hundred and fi fty-seven LKDs met inclusion with an average age of 45 (SD 11) years. Thirty-seven LKDs (24%) reported supplement use pre-donation. One hundred and eleven KTRs met inclusion with an average age of 46 (SD 13) years and 21 (19%) reported supplement use pre-transplant. No signi fi cant differences in sex, ethnicity, or education were found between LKDs or KTRs using supplements vs none. One complication in an LKD was “ possibly ” related to supplement use vs none in KTRs. Conclusion: Transplant providers should screen for supplement use in LKDs and KTRs at both the evaluation and pre-operative visits and review perioperative management. The low dietary supplement-related intra/post complication rate may be due to discontinuation of supplements preoperatively. administered herbal or complementary nutritional products (including botanicals, microbial additives, and amino acids), excluding micronutrients (vitamins/minerals), and foods/drinks.","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/trrm.s235488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47127312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Health Sciences Students Have the Appropriate Knowledge and Attitude to Advance Organ Donation in Ethiopia? Cross-Sectional Study","authors":"A. Wolide, K. K. Goro, Fantu Kerga Dibaba, Serkadis Debalke, Meskerem Seboka, Birtukan Edilu Tufa, F. G. Fufa, E. Bobasa","doi":"10.2147/trrm.s226492","DOIUrl":"https://doi.org/10.2147/trrm.s226492","url":null,"abstract":"Background: Donated organs and tissues are necessary for transplantation to treat irrepar-able organ failure. This study aimed to assess the knowledge and attitude of undergraduate health science students ’ toward organ donation at Jimma University. Methods: The study was conducted in Jimma University, College of Health Sciences from February 1, 2018 to April 25, 2018, Gregorian calendar. Data was entered into Epi-Data version 3.1 and exported to SPSS version 23 for analysis. A descriptive and generalized linear model was applied to present the results. Results: The overall knowledge and attitude scores of the students were 3.844 (2.98, 4.712) and 6.3914 (5.93, 6.85) respectively. The results showed that students had good knowledge of and a positive attitude toward organ donation. Male students had a higher mean knowledge score than female students, however, the difference was not signi fi cant. Dental medicine and medicine students had a higher mean knowledge score than any other health science students in the faculty. Students showed knowledge difference yearly. A signi fi cant number of students 290 (73.4%) and 313 (79.2%) knew the importance of live and cadaveric organ donation to treat permanently failed organs, respectively. Also, about 238 (60.3%) students had the awareness of disease transmission and 358 (90.6%) of them knew the involvement of tissue rejection when inappropriate organ transplantation is done to the recipients. Furthermore, likewise, more than half of the students expressed positive beliefs toward the different questions of organ donation-ethics, religion, and willingness for organ donation. Conclusion: Students showed good knowledge and a positive attitude toward organ donation and this should be translated to the public to increase the rate of organ donations.","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/trrm.s226492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47998691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ Donation In Bahrain","authors":"M. Khder, Latifa Khalid Alnoaimi","doi":"10.2147/trrm.s207628","DOIUrl":"https://doi.org/10.2147/trrm.s207628","url":null,"abstract":"Results: Quantitative parameters were extracted from responses and participants' views. The results showed that Bahrain has few people on the organ-donor register, few waiting for transplant surgery, and few who had undergone transplant surgery, in addition to very different responses regarding willingness to donate organs: many were not willing to donate their organs or not sure. Few knew about laws and regulations in Bahrain, which might have been the reason for the low numbers on the organ-donor register. Also, those willing to donate their organs were aged 18 – 24 years, but despite that, most would donate an organ for their loved ones, while on the other hand most would not donate family member ’ s organs. The results also showed that most would not donate for money. Conclusion: The data extracted from this study can be used in a quantitative description of organ donation in Bahrain in many aspects. Overall results show how to prevent the problem of organ failure by lessening prevalence its main factors and to spread awareness of donating organs.","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/trrm.s207628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45515967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Patient Outcomes Following Pediatric Liver Transplant: Current Perspectives","authors":"A. Cuenca, H. Yeh","doi":"10.2147/trrm.s183382","DOIUrl":"https://doi.org/10.2147/trrm.s183382","url":null,"abstract":": Over the last 50 years, considerable advances have been made in pediatric liver transplantation. The long-term 10-year patient and graft survival following pediatric liver transplant have improved considerably to greater than 90% and 75%, respectively. With longer living grafts, patients are now struggling with different issues, such as the consequences and morbidity of immunosuppression and/or chronic hospitalization. This review will discuss some of the current outcomes and obstacles in pediatric liver transplantation, such as sequelae of long-term maintenance immunosuppression, worsened neurocognitive development, and shortages in allografts that lead to waitlist mortality. Though the future is bright and certainly better than it once was, there are clearly areas of in the long-term clinical care of these patients that deserve focus and attention. This review will highlight some of these concepts, as well as novel strategies to treat and address some of these issues in this complex and fragile patient population.","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/trrm.s183382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47041969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BK virus in transplant recipients: current perspectives","authors":"S. Muhsin, D. Wojciechowski","doi":"10.2147/trrm.s188021","DOIUrl":"https://doi.org/10.2147/trrm.s188021","url":null,"abstract":"","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/trrm.s188021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46138557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public attitudes toward vascularized composite allograft donation: a literature review","authors":"Manraj N. Kaur, A. Thoma","doi":"10.2147/trrm.s161961","DOIUrl":"https://doi.org/10.2147/trrm.s161961","url":null,"abstract":": Vascularized composite allotransplantation (VCA) is the transplantation of anatomical or functional structures composed of multiple types of tissues. The technical advancement of solid organ transplantation and replantation instigated the development of the skills required for successful VCA several years ago; however, the recent advancements in immunosuppression therapy have renewed the interest in this fi eld. As VCAs are primarily life-enhancing procedures, the perception and attitudes of the general public (i.e. potential donors and candidates) and the health care professionals is extremely relevant in terms of health policy and funding decision allocations, availability of donor tissue and ethical and legal implications. In this article, we review the current evidence to assess the sociocultural and demographic factors that in fl uence the growth and success of VCA procedures.","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/trrm.s161961","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47747170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy in heart transplant recipients – current perspectives","authors":"W. Watson, S. Bhagra, C. Bhagra","doi":"10.2147/TRRM.S188281","DOIUrl":"https://doi.org/10.2147/TRRM.S188281","url":null,"abstract":"William D Watson 1 Sai K Bhagra 2 Catriona J Bhagra 3,4 1Division of Cardiovascular Medicine, University of Oxford, Oxford, UK; 2Transplant Unit, Royal Papworth Hospital, Cambridge, UK; 3Department of Cardiology, Addenbrooke’s Hospital, Cambridge, UK; 4Department of Cardiology, Royal Papworth Hospital, Cambridge, UK Abstract: Successful pregnancy with a live birth and preserved graft function is possible in women following cardiac transplantation but requires careful assessment and planning in conjunction with the co-ordinated care of a specialist multidisciplinary team. Pregnancy poses significant risks to the mother, graft and foetus; these include the challenges of managing immunosuppression to avoid rejection whilst balancing the risks to the foetus from potentially teratogenic medication. This article aims to provide a contemporary perspective on the issues pertaining to pregnancy in heart transplant recipients; describing the pre-conception, pre-partum, intrapartum and postpartum management in this unique group of women.","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/TRRM.S188281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46849315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating nucleic acids as biomarkers for allograft injury after solid organ transplantation: current state-of-the-art","authors":"S. Pattar, S. Greenway","doi":"10.2147/TRRM.S204233","DOIUrl":"https://doi.org/10.2147/TRRM.S204233","url":null,"abstract":"Sabrina K Pattar Steven C Greenway 1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; 2Department of Pediatrics and Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; 3Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Abstract: Immune-mediated injury of a transplanted organ can lead to allograft dysfunction and even patient death. Acute cellular rejection typically occurs within the first months post-transplantation but patients are at life-time risk, particularly if there is medication non-compliance or reduction of immunosuppression due to complications. Therefore, safe and accurate monitoring of the donated organ for signs of rejection is essential for long-term survival of the transplanted organ and recipient. The current gold standard for rejection surveillance is through tissue biopsy and histology, which is costly, invasive, and subjective. Thus, efforts to develop non-invasive methods for the detection of rejection post-transplantation are a priority in the field. The first FDA-approved noninvasive assay, AlloMap, was developed in 2006 and monitored the peripheral expression of 11 genes associated with immune system activation. More recently, there has been a shift towards interrogating the status of the transplanted organ directly. Fragments of genomic DNA are released into the blood during cellular apoptosis and levels of cell-free DNA (cfDNA) have been shown to be elevated in the presence of organ injury, including after transplantation. Since the genomic characteristics of DNA are maintained in cfDNA (eg, sequence variants), this circulating molecule represents a promising organ-specific biomarker for allograft injury. DNA sequence variants have been used to distinguish donor and recipient cfDNA with or without a priori donor genotyping in a variety of solid organs post-transplant. Current research has established the groundwork and future multicenter trials will determine if this novel molecular diagnostic tool represents a viable alternative to tissue biopsy. Other nucleic acid molecules released from the transplanted organ (eg, microRNAs) are presently less well developed in comparison to cfDNA but may also represent potential novel biomarkers. This review summarizes current literature and evaluates the promises and pitfalls of circulating nucleic acids as biomarkers for allograft injury post-transplant.","PeriodicalId":41597,"journal":{"name":"Transplant Research and Risk Management","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/TRRM.S204233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49641163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}