Cardiovascular Innovations and Applications最新文献_第2页

Inhibition of Stimulator of Interferon Genes Protects Against Myocardial Ischemia-Reperfusion Injury in Diabetic Mice 抑制干扰素刺激因子对糖尿病小鼠心肌缺血再灌注损伤的保护作用

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-05-04 DOI: 10.15212/cvia.2023.0020

Yuce Peng, Guo-can Zhou, Mingyu Guo, Zhe Cheng, Suxin Luo, Yongzheng Guo

{"title":"Inhibition of Stimulator of Interferon Genes Protects Against Myocardial Ischemia-Reperfusion Injury in Diabetic Mice","authors":"Yuce Peng, Guo-can Zhou, Mingyu Guo, Zhe Cheng, Suxin Luo, Yongzheng Guo","doi":"10.15212/cvia.2023.0020","DOIUrl":"https://doi.org/10.15212/cvia.2023.0020","url":null,"abstract":"\u0000Background: Although the past decade has witnessed substantial scientific progress with the advent of cardioprotective pharmacological agents, most have failed to protect against myocardial ischemia/reperfusion (I/R) injury in diabetic hearts. This study was aimed at investigating the role of stimulator of interferon genes (STING) in I/R injury in diabetic mice and further exploring the underlying mechanisms.\u0000\u0000Methods: Type 2 diabetic mice were subjected to I/R or sham operation to investigate the role of STING. STING knockout mice were subjected to 30 minutes of ischemia followed by reperfusion for 24 hours. Finally, myocardial injury, cardiac function, and inflammation levels were assessed.\u0000\u0000Results: STING pathway activation was observed in diabetic I/R hearts, as evidenced by increased p-TBK and p-IRF3 expression. STING knockout significantly decreased the ischemic area and improved cardiac function after I/R in diabetic mice. STING knockout also elicited cardio-protective effects by decreasing serum cardiac troponin T and lactate dehydrogenase levels, thus diminishing the inflammatory response in the heart after I/R in diabetic mice. In vitro, STING inhibition decreased the expression of hypoxia-re-oxygenation-induced inflammatory cytokines.\u0000\u0000Conclusions: Targeting STING inhibits inflammation and prevents I/R injury in diabetic mice. Thus, STING may be a potential novel therapeutic target against myocardial I/R injury in diabetes.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43450065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression Patterns and Functions of Cardiac Pigment Epithelium-Derived Factor During Cardiac Development 心脏色素上皮衍生因子在心脏发育过程中的表达模式和功能

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-04-28 DOI: 10.15212/cvia.2023.0015

Xing-hui Li, Yandi Wu, Tong-sheng Huang, Teng Wu, Xin-lu Fu, Jiang Qian, Yan Zou, Cong-hui Shen, Shiquin Xiong, Zi-qi Feng, Hui-ting Zheng, Yuan-jun Ji, W. Cai

{"title":"Expression Patterns and Functions of Cardiac Pigment Epithelium-Derived Factor During Cardiac Development","authors":"Xing-hui Li, Yandi Wu, Tong-sheng Huang, Teng Wu, Xin-lu Fu, Jiang Qian, Yan Zou, Cong-hui Shen, Shiquin Xiong, Zi-qi Feng, Hui-ting Zheng, Yuan-jun Ji, W. Cai","doi":"10.15212/cvia.2023.0015","DOIUrl":"https://doi.org/10.15212/cvia.2023.0015","url":null,"abstract":"\u0000Objective: This study describes the expression profiles and roles of cardiac pigment epithelium-derived factor (PEDF) during cardiac development.\u0000\u0000Methods: Gene datasets from the Gene Expression Omnibus (GEO) database were used to analyze the correlation between cardiac PEDF expression and heart disease. Western blotting, immunohistochemistry, histological staining and echocardiography were used to assess the expression patterns and functions of PEDF during cardiac development.\u0000\u0000Results: Analysis of GEO data sets indicated that the expression of cardiac PEDF correlated with the occurrence and development of various heart diseases. Western blotting of various tissues in mice at 30 postnatal days of age indicated higher PEDF expression in the heart and aorta than the liver. Immunohistochemical results demonstrated that the expression of cardiac PEDF significantly decreased after birth, mainly because of a significant decrease in PEDF expression in the cytoplasm. Histological staining and echocardiography indicated that PEDF deficiency had no significant effects on cardiac structure, cardiac function and vascular hemodynamics in 8-week-old mice.\u0000\u0000Conclusion: Cardiac PEDF shows high expression and dynamic changes during cardiac development, but has no effects on cardiac structure, function and vascular hemodynamics.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43170021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Quality of Life and their Explanatory Variables in Patients with Non-Valvular Atrial Fibrillation 非瓣膜性心房颤动患者生活质量的性别差异及其解释变量

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-04-27 DOI: 10.15212/cvia.2023.0017

Qing Li, Yinong Chen, Lu Yu, Long-yang Zhu, Zhe Wang, Si-qi Jiao, Shuwen Zheng, Yihong Sun

{"title":"Sex Differences in Quality of Life and their Explanatory Variables in Patients with Non-Valvular Atrial Fibrillation","authors":"Qing Li, Yinong Chen, Lu Yu, Long-yang Zhu, Zhe Wang, Si-qi Jiao, Shuwen Zheng, Yihong Sun","doi":"10.15212/cvia.2023.0017","DOIUrl":"https://doi.org/10.15212/cvia.2023.0017","url":null,"abstract":"\u0000Background: Women with atrial fibrillation (AF) have poorer quality of life (QoL) than men; however, the factors contributing to the poorer QoL in women is unclear.\u0000\u0000Methods: We analyzed data for 3562 patients with non-valvular AF enrolled in the China Registry of Atrial Fibrillation. The Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) was used to evaluate QoL, which was compared between women and men. A multivariate logistic regression analysis model was used to explore factors potentially explaining the sex difference in QoL.\u0000\u0000Results: Overall, 43.3% of the cohort comprised women (n=1541) who were older than their male counterparts (72 ± 9.8 vs. 68 ± 11.9 years, P<0.001). Compared with men, women were more likely to have more symptoms, hypertension, diabetes mellitus, and heart failure. Women were less likely than men to receive catheter ablation (4.5% vs. 6.1%, P=0.044). Women also had lower physical component summary (PCS) scores (48 ± 9 vs. 51 ± 9, P<0.001) and mental component summary (MCS) scores (49 ± 10 vs. 51 ± 10, P<0.001) than men. In the multivariable analysis of the poorer PCS scores in women, patient age explained 32.9%, low socioeconomic status explained 20.0%, lifestyle explained 14.3%, cardiovascular comorbidities explained 15.7%, the presence of more symptoms explained 5.7%, and less catheter ablation explained 1.4%. These factors also explained similar proportions of the sex difference in MCS scores. Together, these factors explained 54.3% of the poorer physical function status and 46.8% of the poorer mental function status in women than men.\u0000\u0000Conclusions: Women with AF had poorer QoL than men. The following factors partly explained the poorer QoL in women: older age, low level of socioeconomic status, more cardiovascular comorbidities, less smoking and drinking, more symptoms, and less catheter ablation.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44135092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Key Genes and Related Molecules as Potential Biomarkers in Human Dilated Cardiomyopathy by Comprehensive Bioinformatics Analysis 综合生物信息学分析确定扩张型心肌病关键基因及相关分子的潜在生物标志物

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-04-27 DOI: 10.15212/cvia.2023.0018

Yingrui Li, Jianlin Du, Bin Liu, Q. She

{"title":"Identifying Key Genes and Related Molecules as Potential Biomarkers in Human Dilated Cardiomyopathy by Comprehensive Bioinformatics Analysis","authors":"Yingrui Li, Jianlin Du, Bin Liu, Q. She","doi":"10.15212/cvia.2023.0018","DOIUrl":"https://doi.org/10.15212/cvia.2023.0018","url":null,"abstract":"\u0000Background: Dilated cardiomyopathy (DCM) is a non-ischemic heart disease that poses a substantial global health burden, but its underlying molecular mechanisms remain poorly understood.\u0000\u0000Methods: Weighted gene co-expression network analysis, differential expression analysis of genes, enriched analysis and LASSO model construction were performed in R software. miRWalk 2.0 and StarBase v2.0 were used to predict the target miRNAs and circRNAs of hub genes, respectively.\u0000\u0000Results: Four hub genes (COL3A1, COL1A2, LUM and THBS4) were identified, which were significantly enriched in fibrosis pathways, including extracellular matrix, biological process, and the TGF beta signaling and focal adhesion pathways. The LASSO model accurately predicted the occurrence of DCM. Additionally, three miRNAs (hsa-let-7b-5p, hsa-let-7c-5p and hsa-miR-29b-3p) and 30 circRNAs (including GIT2_hsa_circRNA10114, ANKRD52_hsa_circRNA9983 and JARID2_hsa_circRNA6618) were found to be associated with DCM.\u0000\u0000Conclusion: Bioinformatics analysis identified hub genes and related molecules that may be highly associated with DCM. These findings provide insights into potential targets for improving diagnosis and pharmacological therapies to prevent DCM progression.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49074718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the Application of Pulsed Field Ablation for Arrhythmia Treatment 脉冲场消融治疗心律失常的应用进展

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-04-22 DOI: 10.15212/cvia.2023.0019

Fuding Guo, Jun Wang, Liping Zhou, Yue Wang, Hong Jiang, Lilei Yu

引用次数: 0

Five-Year Clinical Outcomes After XIENCE PRIME Everolimus Elution Coronary Stent System (EECSS) Implantation XIENCE PRIME依维莫司洗脱冠状动脉支架系统（EECSS）植入术后五年的临床结果

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-04-20 DOI: 10.15212/cvia.2023.0013

Rongrong Shen, Peiyu Zhang, Jing Liu, Rong Guo, Yawei Xu

{"title":"Five-Year Clinical Outcomes After XIENCE PRIME Everolimus Elution Coronary Stent System (EECSS) Implantation","authors":"Rongrong Shen, Peiyu Zhang, Jing Liu, Rong Guo, Yawei Xu","doi":"10.15212/cvia.2023.0013","DOIUrl":"https://doi.org/10.15212/cvia.2023.0013","url":null,"abstract":"\u0000Background/aim: This study was aimed at evaluating 5-year effectiveness and safety in participants after XIENCE PRIME Everolimus Elution Coronary Stent System (EECSS) implantation.\u0000\u0000Materials and methods: From December 2013 to May 2014, 108 patients (127 lesions) were treated with the XIENCE PRIME EECSS. The entire follow-up included annual assessments for 5 years after treatment or until one of the clinical endpoints was reached. We evaluated the 5-year clinical outcomes with Kaplan-Meier analysis and the Cox regression model.\u0000\u0000Results: Nearly three-quarters of the participants were men (76.8%), and the average age was 65.6 ± 10.8 years. Bifurcation lesions accounted for 96.1% (122 lesions), and left main lesions accounted for 3.9% (five lesions), with a total count of 127 lesions. The cumulative rate of major adverse cardiac events was as follows: 1 year, 1.9%; 2 year, 4.0%; and 5 year, 10.0%. No definite or probable stent thrombosis was observed, and the rate of target lesion failure was only 3.3% over 5 years. The cumulative rate of major bleeding eventually increased to only 4.4%.\u0000\u0000Conclusions: The 5-year clinical outcomes were favorable in patients treated with XIENCE PRIME EECSS, and the incidence of stent thrombosis and target lesion failure was relatively low. The incidence of major bleeding gradually increased but remained moderate.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42667400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience in Application of a Three-Dimensional Pulsed Field Ablation System Integrating Mapping and Ablation 集测绘和烧蚀于一体的三维脉冲场烧蚀系统的应用经验

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-04-01 DOI: 10.15212/cvia.2023.0009

Yan Wang, Jie Qiu, Daowen Wang

引用次数: 0

Advances in Renal Denervation in the Treatment of Hypertension 肾去神经治疗高血压的研究进展

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-03-30 DOI: 10.15212/cvia.2023.0014

Bin Xiong, Shaojie Chen, Weijie Chen, Y. Yin, Zhiyu Ling

引用次数: 0

Machine Learning Methods in Real-World Studies of Cardiovascular Disease 真实世界心血管疾病研究中的机器学习方法

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-03-24 DOI: 10.15212/cvia.2023.0011

Jiawei Zhou, Dongfang You, Jianling Bai, Xin Chen, Yaqian Wu, Zhongtian Wang, Yingdan Tang, Yang Zhao, G. Feng

{"title":"Machine Learning Methods in Real-World Studies of Cardiovascular Disease","authors":"Jiawei Zhou, Dongfang You, Jianling Bai, Xin Chen, Yaqian Wu, Zhongtian Wang, Yingdan Tang, Yang Zhao, G. Feng","doi":"10.15212/cvia.2023.0011","DOIUrl":"https://doi.org/10.15212/cvia.2023.0011","url":null,"abstract":"\u0000Objective: Cardiovascular disease (CVD) is one of the leading causes of death worldwide, and answers are urgently needed regarding many aspects, particularly risk identification and prognosis prediction. Real-world studies with large numbers of observations provide an important basis for CVD research but are constrained by high dimensionality, and missing or unstructured data. Machine learning (ML) methods, including a variety of supervised and unsupervised algorithms, are useful for data governance, and are effective for high dimensional data analysis and imputation in real-world studies. This article reviews the theory, strengths and limitations, and applications of several commonly used ML methods in the CVD field, to provide a reference for further application.\u0000\u0000Methods: This article introduces the origin, purpose, theory, advantages and limitations, and applications of multiple commonly used ML algorithms, including hierarchical and k-means clustering, principal component analysis, random forest, support vector machine, and neural networks. An example uses a random forest on the Systolic Blood Pressure Intervention Trial (SPRINT) data to demonstrate the process and main results of ML application in CVD.\u0000\u0000Conclusion: ML methods are effective tools for producing real-world evidence to support clinical decisions and meet clinical needs. This review explains the principles of multiple ML methods in plain language, to provide a reference for further application. Future research is warranted to develop accurate ensemble learning methods for wide application in the medical field.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46885057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated Monocyte to High-density Lipoprotein Ratio Is a Risk Factor for New-onset Atrial Fibrillation after Off-pump Coronary Revascularization 单核细胞与高密度脂蛋白比值升高是非体外循环冠状动脉血运重建术后新发心房颤动的危险因素

IF 0.5 4区医学

Cardiovascular Innovations and Applications Pub Date : 2023-03-23 DOI: 10.15212/cvia.2023.0012

Yameng Mu, Jiayin Niu, Min Zhang, Pengfei Liu, Cuncun Hua, Yulin Guo, Guangzhen Zhong

{"title":"Elevated Monocyte to High-density Lipoprotein Ratio Is a Risk Factor for New-onset Atrial Fibrillation after Off-pump Coronary Revascularization","authors":"Yameng Mu, Jiayin Niu, Min Zhang, Pengfei Liu, Cuncun Hua, Yulin Guo, Guangzhen Zhong","doi":"10.15212/cvia.2023.0012","DOIUrl":"https://doi.org/10.15212/cvia.2023.0012","url":null,"abstract":"Atrial fibrillation (AF) is a common complication of coronary revascularization. Currently, the mechanisms of postoperative AF are unclear. This study was aimed at investigating the risk factors for new-onset AF (NOAF) after coronary revascularization and exploring the early warning effects of clinical inflammatory markers. A retrospective analysis was conducted on 293 patients with unstable angina pectoris who underwent coronary artery revascularization in Beijing Chao-Yang Hospital, Capital Medical University, between April 2018 and June 2021, including 224 patients who underwent coronary artery bypass grafting and 69 patients who underwent one-step hybrid coronary revascularization. Baseline data, clinical data, blood indicators and AF episodes within 7 days after the surgery were collected. Participants were divided into two groups according to whether AF occurred, and the data were analyzed between groups. In addition, multivariate logistic regression was used to explore the independent risk factors for developing AF post coronary revascularization. Aging, a larger left atrial inferior-superior diameter, use of an intra-aortic balloon pump, a greater blood volume transfused during perioperative period and a higher monocyte to high-density lipoprotein ratios on postoperative day 1 were independent risk factors for NOAF after coronary artery surgery.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47394704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1