Elena Manferlotti, M. Vissani, A. Mazzoni, Arvind Kumar
{"title":"Correlated inputs to striatal population drive subthalamic nucleus hyper-synchronization","authors":"Elena Manferlotti, M. Vissani, A. Mazzoni, Arvind Kumar","doi":"10.1109/NER49283.2021.9441370","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441370","url":null,"abstract":"Movement disorders such as Parkinson's disease (PD) are often associated with hyper-synchronization in basal ganglia (BG) activity. The origins of the hyper-synchronization and its interaction with deep brain stimulations (DBS) of BG nuclei are still debated. The structure of the BG suggests that strong neuronal correlations cannot arise within the BG but should rather be inherited from cortical or thalamic inputs. However, this is inconsistent with the hypothesized decorrelating role of the striatal network. Here we investigate to what extent striatum can decorrelate correlated inputs, and the consequences of correlations in striatal activity on the dynamics of the BG; especially, the beta-band oscillations, which are the cardinal symptom of PD. We developed a BG network model with spiking neurons and analyzed the effects on input correlation on BG activity. We found that striatum does not completely decorrelate the inputs and that the residual correlations can synchronize the whole BG. These results provide new insights into the origin of BG hyper-synchronization and pave the way to understand DBS induced disruption of synchrony and ensuing therapeutical effects.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124861918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Yuditskaya, J. Williamson, G. Ciccarelli, Kara J. Blacker, M. Funke, B. Telfer
{"title":"Quantifying Neural Processing Changes During an Auditory Oddball Task Under Hypoxia Using Electroencephalography","authors":"S. Yuditskaya, J. Williamson, G. Ciccarelli, Kara J. Blacker, M. Funke, B. Telfer","doi":"10.1109/NER49283.2021.9441116","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441116","url":null,"abstract":"To investigate neural phenotypes specific to hypoxia’ we quantify the capability of electroencephalography (EEG) dynamics to determine if an individual is in a normoxic or hypoxic state during a passive auditory task and identify EEG-based features that provide maximal discriminability. Two distinct modeling approaches are explored, each intended to capture contrasting aspects of the relationship between neural activity and the hypoxic physiological state. With an analysis that exploits Auditory Deviance Response landmarks to characterize cognitive-neurophysiological changes during hypoxia, we achieve a receiver operating characteristic area under the curve (AUC) of 0.76 using only two fronto-temporal channels, on par with larger EEG channel set benchmarks. With a novel EEG correlation structure approach that examines finer neural coordination patterns across a spatially diverse channel set, we achieve an AUC of 0.85. Our methods of EEG analysis may find applications in understanding and detecting environmental impact on neural health.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132097289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tao Xie, Zehan Wu, Liang Chen, Xiangyang Zhu, X. Sheng, P. Brunner
{"title":"Phase-Amplitude Coupling between Neuronal Wideband Low-Frequency Oscillations and Broadband Gamma Activity","authors":"Tao Xie, Zehan Wu, Liang Chen, Xiangyang Zhu, X. Sheng, P. Brunner","doi":"10.1109/NER49283.2021.9441250","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441250","url":null,"abstract":"Phase-amplitude coupling (PAC) between the phase of low-frequency oscillations and the power of high-frequency activity plays a functional role in neuronal computation and information transfer. Traditional Hilbert transform-based PAC methods assume that neuronal activity is narrowband, sinusoidal, and sustained. However, natural neuronal signals often violate these three assumptions, creating a potential confound for the interpretation of PAC results. In this study, we present a new method, called Tau-Modulation, that does not require these assumptions to be met. We use this method to identify task-relevant neuronal networks in human electrocorticographic signals. Our results show that Tau-Modulation can identify these networks and characterize the strength and frequency of wideband low-frequency coupling with broadband gamma activity. Thus, Tau-Modulation might provide for a robust approach to analyzing neuronal signals and pave the way for new insights on brain functions.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128852517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A programmable, multichannel, miniature stimulator for electrotactile feedback of neural hand prostheses","authors":"Han Wang, G. Chai, X. Sheng, Xiangyang Zhu","doi":"10.1109/NER49283.2021.9441192","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441192","url":null,"abstract":"In this paper, a wearable, battery-powered, multichannel miniature electrical stimulator is developed. The stimulator consists of power module, controller module, bidirectional constant-current module and channel multiplexing module. The stimulator circuit can output maximum ±10 mA constant-current stimulation with a compliance voltage of 80 V, at a 5 V supply voltage. The size of the prototype is 35 × 35 × 22 mm3 and can be easily integrated into the socket of a prosthetic hand. The system is capable of providing biphasic pulse stimulation to six channels simultaneously with programmable amplitude, pulse width and frequency or outputting arbitrary continuous waveform on a single channel. The comparable performance of our stimulator to similar commercially available and developed devices is proposed. The stimulator can be used for providing the sensory feedback of neural hand prostheses as well as electrical functional stimulation for kinds of sensorimotor rehabilitation.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121628359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Technical Note: A Low-Cost Research Platform for Brain-Computer-Interface Applications in Mixed Reality","authors":"Griffin W. Milsap, Preston Peranich","doi":"10.1109/NER49283.2021.9441260","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441260","url":null,"abstract":"Many brain-computer-interface (BCI) approaches, such as the steady-state-visually-evoked-potential (SSVEP) and BCI speller paradigms, rely on evoking neural signals using presentation of audiovisual stimuli. These exogenous BCIs typically involve the user staring at a physical stimulus presentation apparatus resulting in prolonged system setup and degraded portability. We present a research platform for BCI implementations in mixed reality (XR) environments, enabling less-invasive holographic stimulus presentation and greatly enhanced portability at low-cost. The platform consists of a 3D-printable electroencephalography (EEG) attachment for the Microsoft HoloLens, firmware for the OpenBCI Cyton EEG amplifier evaluation kit, and Unity software supporting direct Bluetooth low-energy communication between the EEG device and the HoloLens. The platform allows researchers and hobbyists to prototype BCIs with an easy to don/doff EEG attachment for the HoloLens that is capable of recording high-quality EEG using dry electrodes in an untethered XR environment without the need for external compute resources.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122198558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vahan Babushkin, Wanjoo Park, Muhammad Hassan Jamil, Haneen Alsuradi, M. Eid
{"title":"EEG-based Classification of the Intensity of Emotional Responses","authors":"Vahan Babushkin, Wanjoo Park, Muhammad Hassan Jamil, Haneen Alsuradi, M. Eid","doi":"10.1109/NER49283.2021.9441371","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441371","url":null,"abstract":"Considering the fact that emotional experiences are stored in the brain, classifying emotion from brain activity measured using electroencephalography has become a trend. In most of the previous studies, the user's emotions were classified based on a stimulus. In this paper, we present a model that can classify the emotion intensity by the participants' self-report. Two machine learning classifiers are considered: support vector machine (SVM) and convolutional neural networks (CNN). Results demonstrated that both SVM and CNN models perform well with four classes of emotions (positive/negative valence high/low arousal combination) where SVM achieved an accuracy of 85% whereas CNN achieved 81%. Considering 12 classes of emotional responses (low, medium, and high intensity for positive/negative valence high/low arousal combination) by the participants' self report resulted in an accuracy of 70% for SVM and 69% for CNN. The proposed model excels in classifying emotional intensity and provides superior performance compared to the state-of-the-art emotion classification systems.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"439 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116639685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Cortical Extracellular Simulation Model to Create Synthetic Neural Recordings","authors":"Kyle Gherardi, H. Töreyin","doi":"10.1109/NER49283.2021.9441104","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441104","url":null,"abstract":"Synthetic extracellular neural recordings allow precise knowledge of when and which neuron spikes in a recording, and therefore are important to assess and refine spike detection and sorting algorithms. Such algorithms are strongly dependent on the spike waveform shapes. Therefore, it is critical for a model that generates synthetic recordings to incorporate the factors changing the waveform shape in the neural environment. In this paper, we present a simulation tool that models frequency-filtering and layer-inhomogeneity of cortical layers, where most actual extracellular recordings are performed. The tool uses simulated transmembrane currents of neurons from NEURON, and implements line-source-approximation, method-of-images, and low-pass filtering to calculate the potentials on MATLAB.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":" 100","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113947427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Population Activity in Motor Cortex is Influenced by the Contexts of the Motor Behavior","authors":"Xuan Ma, Kevin L. Bodkin, L. Miller","doi":"10.1109/NER49283.2021.9441430","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441430","url":null,"abstract":"Most sensorimotor studies investigating the covariation of populations of neurons in primary motor cortex (M1) have considered only a few trained movements made under highly constrained conditions. However, motor behaviors in daily living happen in a far more complex and varied contexts. It is unclear whether M1 neurons would have different population responses in a more naturalistic, unconstrained setting, including requirements to accommodate multiple limbs and body posture, and more extensive proprioceptive inputs. Here, we recorded M1 spiking signals while a monkey performed hand grasp movements in two different contexts: one in the typical constrained lab setting, and the other while moving freely in a large plastic cage. We compared the covariance patterns of the neural activity during movements across the two contexts. We found that the neural covariation patterns accompanying two different hand grasps in the unconstrained context were largely preserved, while they differed across contexts, even for the same type of grasp. We also found that the M1 population activity was confined to context-dependent neural manifolds, but these manifolds were not completely independent, as some dimensions appeared to be shared across the contexts. These results suggest that the coordinated activity of M1 neurons is strongly dependent on behavioral context, in ways that were not entirely anticipated.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132568112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Adversarial Variational Autoencoder Approach Toward Transfer Learning for mTBI Identification","authors":"Shiva Salsabilian, L. Najafizadeh","doi":"10.1109/NER49283.2021.9441372","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441372","url":null,"abstract":"Subject variability in mild traumatic brain injury (mTBI) data has often been an obstacle in accurate injury-related feature extraction and biomarker identification for successful mTBI diagnosis. To address this issue, we propose an adversarial variational autoencoder model as a novel regularization approach to extract subject-invariant representations for transfer learning in mTBI identification. The proposed method consists of a variational autoencoder with an attached adversarial network. The autoencoder attempts to learn the latent space mappings from neural activity, while the adversary network is used in a discriminative setting to detach the subject individuality from the representations. The trained encoder is then transferred to extract the representations from new subject's data. Several classifiers are utilized to classify the extracted representations into two categories of normal and mTBI. To evaluate the performance of the proposed method, recorded cortical activity of GCaMP6s transgenic calcium reporter mice before and after inducing an injury is used. Experimental results on cross-subject transfer learning exhibit the efficiency of the proposed framework by achieving 89.7% classification accuracy, suggesting the feasibility of the proposed method in learning invariant representations in mTBI data.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133226609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher C. Cline, Molly V. Lucas, Yinming Sun, Matthew Menezes, A. Etkin
{"title":"Advanced Artifact Removal for Automated TMS-EEG Data Processing","authors":"Christopher C. Cline, Molly V. Lucas, Yinming Sun, Matthew Menezes, A. Etkin","doi":"10.1109/NER49283.2021.9441147","DOIUrl":"https://doi.org/10.1109/NER49283.2021.9441147","url":null,"abstract":"Transcranial magnetic stimulation (TMS) with concurrent electroencephalography (EEG) is a key tool towards non-invasively characterizing causal circuits in humans. However, the recorded data is highly noisy due to a variety of stimulation-induced artifacts and other noise sources. While many TMS-EEG processing pipelines require manual intervention, the pipeline described here is fully automated. As part of this pipeline, we introduce several novel approaches specifically designed to mitigate TMS-induced artifacts to produce cleaner and more reliable TMS-evoked EEG responses.","PeriodicalId":413977,"journal":{"name":"2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133923072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}