OBM Integrative and Complementary Medicine最新文献

{"title":"Efficacy and Safety of Andrographolide and Favipiravir Versus Favipiravir Monotherapy in Patients with Mild COVID-19 Infection: A Multicenter Randomized Controlled Trial","authors":"Thaninee Prasoppokakorn, Supachaya Sriphoosanaphan, Nutbordee Nalinthassanai, Thitaporn Roongrawee, P. Hanboonkunupakarn, P. Tangkijvanich, R. Rerknimitr","doi":"10.21926/obm.icm.2401013","DOIUrl":"https://doi.org/10.21926/obm.icm.2401013","url":null,"abstract":"Reports indicate that Andrographolide inhibits viral replication and reduces COVID-19 symptoms. This study aimed to determine Andrographolide's additional effect and safety in mild COVID-19 patients treated with favipiravir. A multicenter, open-labeled, randomized controlled trial was conducted from October 2021 to February 2022. The patients were randomized to receive a combination of Andrographolide and favipiravir or favipiravir monotherapy. The primary outcome was the occurrence rate of severe pneumonia. The secondary outcomes were symptom improvement, inflammatory biomarkers, and adverse events on days 7 and 14. 82 mild COVID-19 patients were enrolled; 43 and 39 patients received either combination therapy or favipiravir alone. Baseline characteristics were comparable. None developed severe pneumonia, requiring a mechanical ventilator. The Andrographolide group had a significant reduction of cough compared to the controlled group; 13 (30.2%) vs. 22 (56.4%), p = 0.017 on day 7 and 4 (9.3%) vs. 7 (17.9%), p = 0.025 on day 14. Moreover, the Andrographolide group had significantly lower levels of inflammatory markers on day 7, CRP (5.8 vs. 18.4 mg/L; p = 0.019) and IL-6 (2.0 vs. 21.8 pg/mL; p = 0.001) but not on day 14. Regarding safety outcomes, the Andrographolide group had significantly higher AST levels on day 7 (40.3 vs. 32.2 U/L; p = 0.030) and both AST and ALT levels on day 14 (55.3 vs. 32.0; p = 0.014 and 63.8 vs. 40.0; p = 0.022, respectively). In mild COVID-19 patients, the combination of Andrographolide and favipiravir did not demonstrate additional benefits over favipiravir alone in preventing severe pneumonia. However, Andrographolide significantly reduced cough symptoms, especially during the first week. Furthermore, despite mild transaminitis, patients treated with Andrographolide showed improvements in inflammatory markers.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Andrographolide and Favipiravir Versus Favipiravir Monotherapy in Patients with Mild COVID-19 Infection: A Multicenter Randomized Controlled Trial","authors":"Thaninee Prasoppokakorn, Supachaya Sriphoosanaphan, Nutbordee Nalinthassanai, Thitaporn Roongrawee, P. Hanboonkunupakarn, P. Tangkijvanich, R. Rerknimitr","doi":"10.21926/obm.icm.2401013","DOIUrl":"https://doi.org/10.21926/obm.icm.2401013","url":null,"abstract":"Reports indicate that Andrographolide inhibits viral replication and reduces COVID-19 symptoms. This study aimed to determine Andrographolide's additional effect and safety in mild COVID-19 patients treated with favipiravir. A multicenter, open-labeled, randomized controlled trial was conducted from October 2021 to February 2022. The patients were randomized to receive a combination of Andrographolide and favipiravir or favipiravir monotherapy. The primary outcome was the occurrence rate of severe pneumonia. The secondary outcomes were symptom improvement, inflammatory biomarkers, and adverse events on days 7 and 14. 82 mild COVID-19 patients were enrolled; 43 and 39 patients received either combination therapy or favipiravir alone. Baseline characteristics were comparable. None developed severe pneumonia, requiring a mechanical ventilator. The Andrographolide group had a significant reduction of cough compared to the controlled group; 13 (30.2%) vs. 22 (56.4%), p = 0.017 on day 7 and 4 (9.3%) vs. 7 (17.9%), p = 0.025 on day 14. Moreover, the Andrographolide group had significantly lower levels of inflammatory markers on day 7, CRP (5.8 vs. 18.4 mg/L; p = 0.019) and IL-6 (2.0 vs. 21.8 pg/mL; p = 0.001) but not on day 14. Regarding safety outcomes, the Andrographolide group had significantly higher AST levels on day 7 (40.3 vs. 32.2 U/L; p = 0.030) and both AST and ALT levels on day 14 (55.3 vs. 32.0; p = 0.014 and 63.8 vs. 40.0; p = 0.022, respectively). In mild COVID-19 patients, the combination of Andrographolide and favipiravir did not demonstrate additional benefits over favipiravir alone in preventing severe pneumonia. However, Andrographolide significantly reduced cough symptoms, especially during the first week. Furthermore, despite mild transaminitis, patients treated with Andrographolide showed improvements in inflammatory markers.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":"24 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Attitudes Towards Use of Complementary and Integrative Health Therapies for Veterans with Opioid Use Disorder in the Veterans Health Administration","authors":"Adam Resnick, Alicia Bergman, Rebecca Oberman, Stephanie Taylor, Emmeline Chuang, Kelsey Cummings, Evelyn Chang","doi":"10.21926/obm.icm.2401012","DOIUrl":"https://doi.org/10.21926/obm.icm.2401012","url":null,"abstract":"The Veterans Health Administration (VA) offers complementary and integrative health (CIH) therapies to Veterans with chronic pain and opioid use disorder (OUD). While CIH therapies have known benefits for chronic pain, less research exists on its use for patients with OUD. In this qualitative study, we aimed to assess provider and patient perceptions of CIH therapies for Veterans with OUD. We interviewed 45 providers involved in OUD care and 17 Veterans with OUD from five VA medical centers as part of a larger mixed-methods evaluation. Interviewees were identified through a snowball sampling strategy. The interview guide used the Practical Robust Implementation and Sustainability Model to explore contextual factors influencing CIH therapy adoption (i.e., patient perspectives, provider perspectives, external environment). Most Veterans and providers were knowledgeable about CIH therapies and had positive experiences with them. Providers and Veterans said it was important to offer non-pharmacologic options for OUD. Some providers, however, felt that Veterans with OUD may be less likely than those with only chronic pain to consider CIH therapies due to more reported patient resistance and other barriers. Veterans with OUD and their providers were enthusiastic about integrating CIH therapies into treatment plans as a non-pharmacologic option for chronic pain and OUD. However, providers noted unique challenges impacting use of CIH therapies for Veterans with OUD. Providers may benefit from learning patient-centered approaches to offering CIH therapies to Veterans with OUD as part of a comprehensive pain treatment plan.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":"146 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140472401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplifying the Understanding and Measurement of Mental Disorders Thru a Comprehensive Framework of Psychosocial Health","authors":"Waqar Husain, Farrukh Ijaz, Muhammad Ahmad Husain, Marwa Zulfiqar, Javeria Khalique","doi":"10.21926/obm.icm.2401011","DOIUrl":"https://doi.org/10.21926/obm.icm.2401011","url":null,"abstract":"The assessment of mental health and mental disorders has undergone extensive exploration within the field of psychology, resulting in various models and approaches. In addition to traditional ways like the Diagnostic and Statistical Manual of Mental Disorders, psychologists have proposed alternative perspectives for evaluating mental health. One such innovative approach is the psychosocial health model, which defines mental well-being as sexual, emotional, social, environmental, cognitive, religious, moral, and spiritual satisfaction. This paper presents four consecutive studies aimed at developing and validating a new scale, Sukoon Psychosocial Illness Scale (SPIS), to measure psychosocial illness and its sub-factors based on the model of psychosocial health. SPIS was developed and validated through four sequential studies involving 684 participants. Rigorous exploratory and confirmatory factor analyses were employed to establish content and construct validity. Convergent and discriminant validity were assessed by examining associations with psychological distress and overall psychosocial health. Reliability was evaluated using internal consistency, test-retest reliability, and item-total and item-scale correlations. The results of the study confirm the high reliability and validity of SPIS. This refined instrument consists of 21 items presented in English, employing a 7-point Likert scale for responses. The scale comprises six distinct sub-scales, namely emotional problems, sexual problems, religious and moral problems, social problems, spiritual problems, and professional problems. SPIS emerges as a promising tool for future researchers and clinicians, offering a fresh perspective on mental disorders through the comprehensive lens of psychosocial health. This instrument contributes to the evolving landscape of mental health assessment and underscores the importance of considering diverse dimensions for a holistic understanding of psychosocial well-being.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":"118 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139605387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicament Testing in the Diagnosis of Long COVID Syndrome","authors":"N. Djumaeva, Gulnara Akhundjanova, Leyla Djumaeva, Dilbar Urunova","doi":"10.21926/obm.icm.2401010","DOIUrl":"https://doi.org/10.21926/obm.icm.2401010","url":null,"abstract":"Long COVID syndrome resulting from SARS-CoV-2 infection has a prevalence of 10%-35% in the population. Numerous studies of the disease are currently being conducted concerning the manifestations of long COVID syndrome; however, there are no data on the use of electroacupuncture diagnosis (EAV) and medicament testing (MT) in assessing this condition. The purpose of the study was to study the possibilities of diagnosing EAV to determine changes in the electrodermal activity of acupuncture points of the meridian test system - EAV in patients with long COVID syndrome, as well as to identify drugs that can influence the altered electrodermal impedance at these acupuncture points based on the results of MT. At present, the physiological basis of this phenomenon is still unknown. This blind, randomized, placebo-controlled trial included 89 patients (aged from 16 to 50) with long COVID syndrome, who were examined with EAV based on measuring the electrodermal impedance of acupuncture points (APs), followed by testing the RNA polymerase nosode, ribavirin, and dexamethasone at those acupuncture points where a decrease in electrodermal activity was recorded. A reduction of electrodermal activity was observed in APs of various meridians of Voll diagnosis, with this phenomenon being more pronounced in the Nervous Degeneration and Circulation (Voll). The use of RNA polymerase nosode, ribavirin (tablets), and dexamethasone (pills) in the process of MT with positive reaction to testing drugs in specified APs with decreased levels of electrodermal activity in some patients has led to the normalization of indexes of electrodermal impedance in the studied APs. The results of the research suggested the feasibility of using EAV diagnostics to identify the APs of meridians with a decreased level of electrodermal activity, followed by MT using an RNA polymerase nosode, ribavirin, and dexamethasone as drugs, that contribute to the restoration of electrodermal impedance at the APs of the identified meridians in some patients with long COVID syndrome. Further clinical and instrumental studies are needed to evaluate the clinical application of medication testing in assessing long COVID syndrome further.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139619501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There Hope for Chronic Pain Patients?","authors":"James David Adams","doi":"10.21926/obm.icm.2401009","DOIUrl":"https://doi.org/10.21926/obm.icm.2401009","url":null,"abstract":"Many websites are dedicated to educating the public about chronic pain and its management. The majority of these websites say there is no cure for chronic pain, but encourage patients to try exercise, diet, stress reduction and other techniques to decrease the severity of chronic pain. Patients are also taught to use oral or injected drugs to treat their chronic pain. This can be dangerous and leads to adverse events and death in some patients. The majority of these websites teach patients that chronic pain comes from the brain and brain stem. This teaching is incorrect, since chronic pain is generated in the skin and can best be treated and cured with topical medicines.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139627051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Gratitude as a Mind-Body-Spirit Practice in Optimizing Health and Human Functioning","authors":"Stephanie Bryan, Maryellen Hamilton","doi":"10.21926/obm.icm.2401008","DOIUrl":"https://doi.org/10.21926/obm.icm.2401008","url":null,"abstract":"This paper provides an overview of gratitude as a concept and as a mind-body-spirit practice, impacting health and human functioning throughout the lifespan, that can be integrated into daily life to great benefit at no cost. Current society is rife with increases in stress, anxiety, depression, lifestyle-related diseases, and social isolation. The practice of gratitude and its interrelated pro-social, health-enhancing, resilience-building effects suggest that promoting gratitude from childhood through adulthood may provide much-needed, accessible reinforcement towards optimal health and wellbeing.KeywordGratitude; health; resilience","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":"10 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Compassion-Based Interventions in Oncology: A Review of Current Practices","authors":"Charlotte Grégoire, Alexandra Paye, Audrey Vanhaudenhuyse","doi":"10.21926/obm.icm.2401007","DOIUrl":"https://doi.org/10.21926/obm.icm.2401007","url":null,"abstract":"Self-compassion consists of an attitude of self-support and self-benevolence. In the general population, increased self-compassion has been associated with well-being and decreased psychopathology. In oncology, higher self-compassion has also been linked with various benefits, such as lower emotional distress, fatigue, body-image disturbances, and sleep difficulties. Self-compassion also seems to foster treatment adherence. Various interventions based on self-compassion have recently been designed and tested in different clinical and non-clinical populations. They are particularly relevant in oncology, as patients are increasingly interested in complementary approaches to help them manage their symptoms and difficulties benevolently and without judgment. In this review, we described various self-compassion-based interventions that have been or will be proposed to patients with cancer, as well as their first results. The main interventions that have been tested are compassion-focused therapy, the combination of self-hypnosis and self-compassion learning, mindful self-compassion training, cognitively-based compassion training, and loving-kindness meditation. Other interventions include a self-compassion-focused writing activity, a mobile self-compassion application, and a self-compassion group therapy focused on the fear of cancer recurrence. Many of these studies were quasi-experimental or protocols. However, existing results tend to suggest the benefits of these interventions to improve different symptoms often endured by patients with cancer. Further research is needed to conduct rigorous studies on these approaches and to determine how and for whom they are efficient.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":"42 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Insecurity, Cardiometabolic Risk and Cardiovascular Disease: A Narrative Review and Call for Action","authors":"Satchit Anand Saha, Katelyn Ann Williams, George Murphy, Sandeep Ajoy Saha","doi":"10.21926/obm.icm.2401006","DOIUrl":"https://doi.org/10.21926/obm.icm.2401006","url":null,"abstract":"Food insecurity and insufficient access to affordable nutrition have been associated with increased risk for the development of multiple chronic medical conditions, including cardiovascular disease. In this narrative review, we explore the association between food insecurity and the development of chronic medical conditions that confer increased cardiometabolic risk, cardiovascular disease, and mortality. We also identify the various barriers leading to food insecurity and lack of food literacy, with an emphasis on patients with high blood pressure, diabetes mellitus, stroke, congestive heart failure, and coronary heart disease. We discuss recent developments in legislation and public policies and programs designed to expand our understanding and reduce food insecurity at the local, regional, national, and international levels, and identify opportunities for future research and innovation.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":"37 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment to Reviewers of OBM Integrative and Complementary Medicine in 2023","authors":"Ellen Zhang","doi":"10.21926/obm.icm.2401005","DOIUrl":"https://doi.org/10.21926/obm.icm.2401005","url":null,"abstract":"The editors of OBM Integrative and Complementary Medicine would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web of Science Reviewer Recognition Service (formerly Publons) (https://webofscience.com/wos/) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.","PeriodicalId":413918,"journal":{"name":"OBM Integrative and Complementary Medicine","volume":"57 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139382008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}