What goes down, must come up: oscillation, obstruction and lung physiology最新文献

S44 Bronchodilator response for airway oscillometry in severe eosinophilic asthma 支气管扩张剂对重度嗜酸性哮喘气道振荡测量的影响

What goes down, must come up: oscillation, obstruction and lung physiology Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.50

R. Chan, C. Kuo, B. Lipworth

引用次数: 0

S43 Repeatability of impulse oscillometry in patients with severe asthma 重度哮喘患者脉冲振荡测量的重复性

What goes down, must come up: oscillation, obstruction and lung physiology Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.49

R. Chan, B. Lipworth

引用次数: 0

S46 Lung function and pulmonary symptoms in classical and late-onset fabry disease 经典和迟发性法布里病的肺功能和肺部症状

What goes down, must come up: oscillation, obstruction and lung physiology Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.52

A. Shah, N. Shafi, A. Saigal, S. Mandal, M. Lipman, D. Hughes

{"title":"S46 Lung function and pulmonary symptoms in classical and late-onset fabry disease","authors":"A. Shah, N. Shafi, A. Saigal, S. Mandal, M. Lipman, D. Hughes","doi":"10.1136/thorax-2021-btsabstracts.52","DOIUrl":"https://doi.org/10.1136/thorax-2021-btsabstracts.52","url":null,"abstract":"IP-10) and cytokines (IL-6, IL-1). CS leads to fever, hypotension, coagulopathy, respiratory failure, ARDS, and death. Lenzilumab is a novel Humaneered ® anti-human GM-CSF monoclonal antibody that binds GM-CSF and prevents signaling through its receptor. The LIVE-AIR Phase 3 randomized, double-blind, placebo-controlled trial investigated the efficacy and safety of lenzilumab to improve the likelihood of ventilator-free survival (referred to herein as survival without ventilation, SWOV), beyond standard suppor-tive care, in hospitalized subjects with severe COVID-19. Background The hyperinflammatory cytokine storm (CS) of COVID-19 is mediated by GM-CSF leading to release of downstream inflammatory chemokines, cytokines, and markers of systemic inflammation (C-reactive protein, CRP). The LIVE-AIR study demonstrated that lenzilumab, an anti-GM-CSF monoclonal antibody in patients hospitalized with COVID-19, safely improved the likelihood of achieving the primary endpoint, survival without ventilation (SWOV) by 1.54-fold (HR: 1.54; 95%CI: 1.02 – 2.32, p=0.0403) compared with placebo. An exploratory analysis in patients with CRP<150 mg/L and age<85 years was conducted to deter-mine lenzilumab efficacy when administered prior to advanced inflammation.","PeriodicalId":413592,"journal":{"name":"What goes down, must come up: oscillation, obstruction and lung physiology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130954516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S42 Correlation of measurement of small airways indices in a population of firefighters 消防人员小气道指数测量的相关性

What goes down, must come up: oscillation, obstruction and lung physiology Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.48

J. Feary, T. Kabir, S. Schofield, P. Cullinan

引用次数: 0

S45 A puff of sugar and a pinch of (speech & language therapy) SALT: is the mannitol challenge test a useful ingredient in the assessment of inducible laryngeal obstruction?

What goes down, must come up: oscillation, obstruction and lung physiology Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.51

C. Slinger, A. Vyas, H. Lever, R. Slinger, J. Silva, C. Prior

{"title":"S45 A puff of sugar and a pinch of (speech & language therapy) SALT: is the mannitol challenge test a useful ingredient in the assessment of inducible laryngeal obstruction?","authors":"C. Slinger, A. Vyas, H. Lever, R. Slinger, J. Silva, C. Prior","doi":"10.1136/thorax-2021-btsabstracts.51","DOIUrl":"https://doi.org/10.1136/thorax-2021-btsabstracts.51","url":null,"abstract":"S44 Figure 1 Spoken sessions A32 Thorax 2021;76(Suppl 2):A1–A205 on A ril 2, 2022 by gest. P rocted by coright. httphorax.bm jcom / T hrax: frst pulished as 10.113orax-2021-B T S absacts.51 on 8 N ovem er 221. D ow nladed fom Conclusions In assessment for causation of breathlessness, observations of the inspiratory arm of the FVL during MCT may provide clues to the experienced clinician. MCT has potential to be a useful adjunct in the assessment for ILO. However, due to poor inter-rater reliability, further studies are needed to improve our understanding. Further prospective studies are needed, ideally with MCT and concurrent laryngoscopy to further investigate the utility in assessment for ILO. S46 LUNG FUNCTION AND PULMONARY SYMPTOMS IN CLASSICAL AND LATE-ONSET FABRY DISEASE AJ Shah, N Shafi, A Saigal, S Mandal, M Lipman, DA Hughes. Thoracic Department, Royal Free London Foundation NHS Trust, London, UK; UCL Respiratory, London, UK; Haematology Department, Royal Free London NHS Foundation Trust, London,","PeriodicalId":413592,"journal":{"name":"What goes down, must come up: oscillation, obstruction and lung physiology","volume":"227 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125792120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S47 Hard to swallow; incidence of oropharyngeal dysphagia in inducible laryngeal obstruction (ILO) 难以下咽;诱导性喉梗阻患者口咽吞咽困难的发生率

What goes down, must come up: oscillation, obstruction and lung physiology Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.53

H. Lever, K. Prior, A. Vyas, C. Slinger

引用次数: 0