Journal of Drugs and Pharmaceutical Science最新文献

Quality assessment of five pharmaceutical products of different brands marketed in Nigeria 在尼日利亚销售的五种不同品牌药品的质量评价

Journal of Drugs and Pharmaceutical Science Pub Date : 2021-08-30 DOI: 10.31248/JDPS2019.028

A. Adegbuyi, J. Orege, A. Adepoju, R. Akinyeye

{"title":"Quality assessment of five pharmaceutical products of different brands marketed in Nigeria","authors":"A. Adegbuyi, J. Orege, A. Adepoju, R. Akinyeye","doi":"10.31248/JDPS2019.028","DOIUrl":"https://doi.org/10.31248/JDPS2019.028","url":null,"abstract":"Many pharmaceutical products have been reported to be substandard and counterfeit. About 15% of all drugs circulating in some parts of Africa and Asia are believed to be counterfeit, with figures rising to as high as 50%. This study was therefore carried out to assess the quality of five groups of drugs of different brands manufactured by pharmaceutical companies in Nigeria. Qualitative and quantitative analysis were carried out on the drugs using United States, British and Indian Pharmacopoeias. Qualitative analysis investigated includes: friability test, hardness test, disintegration test, dissolution test, pH, and weight uniformity for tablets; specific gravity, flow rate, pH and weight per ml of syrups. The quantitative analysis includes percentage purity and drug assay determination for different constituents using titrimetric, spectrophotometric and high performance liquid chromatographic (HPLC) methods. From the study, it was established that the Nigeria brands of pharmaceutical products sampled generally conformed to the established qualitative and quantitative specifications. There was however a short slight fall in the chromatographic assay for vitamin B6 in the Blood tonic from one company and similarly, the vitamin B1 in the Blood tonic of one company were at variance to those from other companies. The result for the statistical analysis shows that there is uniformity in weight of all tablets analysed and it complies with the specification. Standard pharmaceutical analysis must therefore be regularly carried out on pharmaceutical products before marketing so as to ensure good health, safety, elimination of sub-standard drugs and prevention of over- or under-dosage, which may further affect or cause damage to the health of the users. Consumer’s choice of generics should therefore be based on the analytical results (assay results, bio-pharmaceutical results, and statistical results) of the product and the projected bioequivalence.","PeriodicalId":413294,"journal":{"name":"Journal of Drugs and Pharmaceutical Science","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114759526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative QSAR analysis, 3D-QSAR, molecular docking and molecular design of iminoguanidine-based inhibitors of HemO: A rational approach to antibacterial drug design 基于亚氨基胍的HemO抑制剂的比较QSAR分析、3D-QSAR、分子对接和分子设计:抗菌药物设计的合理途径

Journal of Drugs and Pharmaceutical Science Pub Date : 2020-08-30 DOI: 10.31248/JDPS2020.036

E. Edache, A. Uzairu, P. Mamza, Gideon Adamu Shallangwa

{"title":"A comparative QSAR analysis, 3D-QSAR, molecular docking and molecular design of iminoguanidine-based inhibitors of HemO: A rational approach to antibacterial drug design","authors":"E. Edache, A. Uzairu, P. Mamza, Gideon Adamu Shallangwa","doi":"10.31248/JDPS2020.036","DOIUrl":"https://doi.org/10.31248/JDPS2020.036","url":null,"abstract":"QSAR models of 25 iminoguanidine derivatives with inhibitory HemO were developed. The QSAR model was built by using DFT-MLR and the best QSAR model has R2, Q2 values of 0.6569 and 0.5493 for cross-validated and non-cross-validated. The predictive ability of QSAR model was further validated by a test set of 7 compounds, giving R2pred value of 0.7123. 3D-QSAR and docking studies were used to find the actual conformations of chemicals in active site of HemO, as well as the binding mode pattern to the binding site in HemO enzyme. Molecular dynamics and simulations study revealed that A-chain of HemO protein was stable at and above 100ps with respect to temperature (at and above 298 K), electrostatic (at and above 57500 kJ/mol), kinetic energy (at and above 12200 kJ/mol) and total energy (at and above 30500 kJ/mol). The information provided by QSAR, 3D-QSAR and molecular docking may provide a better understanding of the structural requirements of iminoguanidine-based inhibitors of HemO and help to design potential antibacterial molecules. Four (4) new compounds (4A, 5A, 6A, and 7A) with high predicted antibacterial activities have been theoretically designed and they are expected to be confirmed experimentally.","PeriodicalId":413294,"journal":{"name":"Journal of Drugs and Pharmaceutical Science","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122136145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Phytochemicals, acute toxicity and in-vitro antioxidant activity of ethanol extract of Sphenocentrum jollyanum leaves 山参叶乙醇提取物的植物化学成分、急性毒性及体外抗氧化活性研究

Journal of Drugs and Pharmaceutical Science Pub Date : 2020-06-30 DOI: 10.31248/jdps2020.035

Emmanuel Uka, O. E. Etim, Akaninyene O. Effiong, Imo Jacobs

{"title":"Phytochemicals, acute toxicity and in-vitro antioxidant activity of ethanol extract of Sphenocentrum jollyanum leaves","authors":"Emmanuel Uka, O. E. Etim, Akaninyene O. Effiong, Imo Jacobs","doi":"10.31248/jdps2020.035","DOIUrl":"https://doi.org/10.31248/jdps2020.035","url":null,"abstract":"Medicinal plants possess strong antioxidants that help to scavenge and protect the human health against several diseases caused by free radicals. This study was carried out to evaluate the phytochemical constituents, acute toxicity and antioxidant activity of the ethanol extract of Sphenocentrum jollyanum leaves in order to validate the medicinal potential of this herb. The antioxidant activity was evaluated using different in vitro models such as total phenolic, flavonoid content, DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP) and Iron chelating activity. Phytochemical constituents included alkaloids, saponins, tannins, flavonoids and cardiac glycosides while total phenolic, flavonoid and gallic acid equivalent were 31.49, 29.98 and 1215.80 mg/mL respectively. The acute toxicity revealed that the oral lethal dose of the ethanol extract of S. jollyanum leaves is non-toxic and safe for consumption. The leaf extract of S. jollyanum exhibited scavenging activity with IC50 of 164.214, 72.410 and 167.202 mg/mL for DPPH, FRAP and Iron chelating activity respectively. The results obtained from this study reveal that the extract is rich in antioxidant components with several mechanisms of eliciting antioxidant actions which provide a scientific basis for its use in traditional system of medicine.","PeriodicalId":413294,"journal":{"name":"Journal of Drugs and Pharmaceutical Science","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114500950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Gas Chromatography Mass Spectrometry and Fourier transform Infrared Spectroscopy analysis of methanolic extract of Mimosa pudica L. leaves 含羞草叶甲醇提取物的气相色谱-质谱及傅里叶变换红外光谱分析

Journal of Drugs and Pharmaceutical Science Pub Date : 2020-04-30 DOI: 10.31248/JDPS2020.031

A. Ahuchaogu, I. Otuokere, P. Ukaogo, G. I. Ogbuehi

{"title":"Gas Chromatography Mass Spectrometry and Fourier transform Infrared Spectroscopy analysis of methanolic extract of Mimosa pudica L. leaves","authors":"A. Ahuchaogu, I. Otuokere, P. Ukaogo, G. I. Ogbuehi","doi":"10.31248/JDPS2020.031","DOIUrl":"https://doi.org/10.31248/JDPS2020.031","url":null,"abstract":"The present study investigates the chemical constituents of a traditionally used ethno-medicinal plant Mimosa pudica Linn using Gas Chromatography Mass Spectrometry (GC/MS) and Fourier Transform Infrared Spectroscopy (FTIR). The identification of phytochemical compounds was based on the peak area, retention time, molecular weight, molecular formula, MS fragment ions. Thirteen phytochemical compounds were identified in the methanolic extract of leaves Mimosa pudica. The GC-MS analysis provide the existence of N, N'-Bis (Carbobenzyloxy)-lysine methyl(ester, Acetamide, N-methyl-N-[4-[4-fluoro-1-hexahydropyridyl]-2-butynyl]-, o-Ethylhydroxylamine, Propanamide, 2-hydroxy-, 1-Allyl-4-(4-methoxyphenyl)-1H-pyrimidin-2-thion, Gentamicin a, Mannosamine, 1H-Indole, 4-(3-methyl-2-butenyl)-. The FT-IR analysis revealed the presence of carbonyl (C=O) at 1705.3 Cm-1 , aliphatic stretching (C-H) at 2978.8 Cm-1 and 2944 Cm-1 and hydroxyl functional group (O-H) at 3313.6 Cm-1 These chemical compounds may exhibit various therapeutic properties such as antifungal, antibacterial, anti- inflammatory, anti-oxidant and others.","PeriodicalId":413294,"journal":{"name":"Journal of Drugs and Pharmaceutical Science","volume":"379 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116576711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Affordability issues of biotech drugs in low- and middle-income countries 中低收入国家生物技术药物的可负担性问题

Journal of Drugs and Pharmaceutical Science Pub Date : 2019-08-30 DOI: 10.31248/JDPS2019.025

Abdul Kader Mohiuddin

引用次数: 0

Neurobehavioural effects of Vigna unguiculata spp Dekindtiana (L.) Walp in mice 蜈蚣蜈蚣的神经行为效应小鼠Walp

Journal of Drugs and Pharmaceutical Science Pub Date : 2019-08-30 DOI: 10.31248/jdps2019.021

A. Adegbuyi, M. Akanmu, G. Olayiwola

{"title":"Neurobehavioural effects of Vigna unguiculata spp Dekindtiana (L.) Walp in mice","authors":"A. Adegbuyi, M. Akanmu, G. Olayiwola","doi":"10.31248/jdps2019.021","DOIUrl":"https://doi.org/10.31248/jdps2019.021","url":null,"abstract":"The study investigated the pharmacological effects of the extract and fractions of Vigna unguiculata spp dekindtiana. The neurobehavioural parameters investigated in this study include: rearing, grooming and locomotion as well as pentobarbital-induced sleeping time model as a measure of the sedative effect of the plant. The neuropharmacological profile of the plant was determined in mice. The extract and fractions were administered orally at doses of 100, 200, 400 and 800 mg/kg for novelty-induced behavior while phenobarbital-induced sleeping time was assessed at the doses of 100, 200 and 400 mg/kg. The result obtained showed significant decrease in rearing, grooming and locomotion with increase in the dose of the extract and the fractions indicating the central inhibitory effect of the plant extract. The possible mechanism of action of the novelty-induced behaviours was investigated by using picrotoxin (GABAA antagonist), cyproheptadine (5HT2 antagonist), yohimbine (alpha2 adrenergic antagonist). The result of the study showed the reversal of the novelty-induced rearing and locomotion with picrotoxin while the reduction in novelty-induced behaviour (rearing and locomotion) was potentiated by both cyproheptadine and yohimbine. This shows the possibility of GABAergic, serotonergic and adrenergic involvement in the behavioural effects of the extract and its fractions. Also, the methanol extract and ethyl acetate fraction showed dose-dependent increase in sleeping time and dose-dependent decrease in sleep latency indicating the hypnotic effect of the extract of the plant. The possible mechanism of action of the phenobarbital-induced sleeping time was investigated using flumazenil (an antagonist of GABA), where a reversal was obtained suggesting the possible involvement of GABAergic receptor. In conclusion, the result showed that methanol extract and its fractions exhibited both central inhibitory effect and hypnotic effect in mice.","PeriodicalId":413294,"journal":{"name":"Journal of Drugs and Pharmaceutical Science","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127792207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The perception of healthcare providers on the quality of locally made drugs and imported drugs 医疗服务提供者对本地药品和进口药品质量的看法

Journal of Drugs and Pharmaceutical Science Pub Date : 2019-04-30 DOI: 10.31248/JDPS2019.018

Linda Iliya, P. Builders, M. Builders

{"title":"The perception of healthcare providers on the quality of locally made drugs and imported drugs","authors":"Linda Iliya, P. Builders, M. Builders","doi":"10.31248/JDPS2019.018","DOIUrl":"https://doi.org/10.31248/JDPS2019.018","url":null,"abstract":"Locally made drugs are an important policy way of reducing out-of-pocket expenditure on medicines. Therefore, negative perceptions of their quality affect utilization and raise issues of confidence and trust in medicines and health services. This study examines the perception of healthcare professionals to locally made drugs in relation to their understanding and opinions of generic and brand name drugs with the use of administering questionnaires to pharmacists, doctors, and nurses in tertiary hospitals in Kaduna State, Nigeria. Majority of the respondents were nurses (58.1%), 50.1% of the participant were females, they were in the age range of 20 to 30 years (37.8%). 46.4% of the nurses strongly agreed that locally manufactured medicines are more affordable than the foreign made, 15.9% of the nurses strongly agreed that locally manufactured medicines produce more side effects/adverse events than the foreign made while 19.6% of the pharmacists strongly agreed that prescribing decision is influenced by medical representatives of foreign made medicines. The lack of consensus in the perceptions of locally made drugs and foreign drugs may result in friction among health professionals as well as discrimination in patronage of foreign and locally made drugs.","PeriodicalId":413294,"journal":{"name":"Journal of Drugs and Pharmaceutical Science","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121184887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antidepressant effects of the hydro-alcoholic extract and fractions of Anchomanes difformis (Blume) Engler rhizome (family Araceae) in mice 天南星科天南星根水醇提取物及部分对小鼠的抗抑郁作用

Journal of Drugs and Pharmaceutical Science Pub Date : 2019-04-30 DOI: 10.31248/JDPS2019.019

O. Ilesanmi, M. Akanmu, S. Agboola

{"title":"Antidepressant effects of the hydro-alcoholic extract and fractions of Anchomanes difformis (Blume) Engler rhizome (family Araceae) in mice","authors":"O. Ilesanmi, M. Akanmu, S. Agboola","doi":"10.31248/JDPS2019.019","DOIUrl":"https://doi.org/10.31248/JDPS2019.019","url":null,"abstract":"In ethno-medicinal practice in the South-western part of Nigeria, the rhizome of Anchomanes difformis is claimed to be effective in the management of mental illness. This study determined the antidepressant effects of hydro-alcoholic extract and fractions of Anchomanes difformis rhizome and the likely mechanisms of action of the extract and the most active fraction in mice. The extract was partitioned into n-hexane, ethylacetate, butanol and distilled water to obtain n-hexane, ethylacetate, butanol and residual aqueous fractions, respectively. The extract and fractions were administered to mice of both sexes (18 to 25 g) at 60, 125, 250, 500, and 1000 mg/kg, orally. Tail suspension and forced swimming anti-depressant animal models were used. The likely mechanism of anti-depressant action was assessed using yohimbine and cyproheptadine. The data were analyzed using one-way ANOVA followed by Student-Newman-Keul’s post hoc test with the level of significance taken as p<0.05. The extract and ethylacetate fraction at 60 to 250 mg/kg significantly (p<0.05) reduced the period of immobility in both the tail suspension and forced swimming tests without significantly impairing the locomotor activity, suggesting an anti-depressant effect. This effect was reversed by yohimbine (1 mg/kg, i.p.), an α2-adrenergic receptor antagonist, yohimbine and also by cyproheptadine (0.5 mg/kg, i.p.), a serotonergic receptor antagonist. The study concluded that the extract and ethylacetate fraction of A. difformis rhizome possessed an anti-depressant effect in mice which was probably mediated through α2-adrenergic and serotonergic pathways.","PeriodicalId":413294,"journal":{"name":"Journal of Drugs and Pharmaceutical Science","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130506118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Determination of antibacterial activity of essential oils from mint (Mentha spicata) leaves on selected pathogenic bacteria 薄荷叶精油对病原菌抑菌活性的测定

Journal of Drugs and Pharmaceutical Science Pub Date : 2018-10-30 DOI: 10.31248/JDPS2018.015

Lucy W. Kiarie, P. Waithaka, E. M. Gathuru, B. Githaiga

{"title":"Determination of antibacterial activity of essential oils from mint (Mentha spicata) leaves on selected pathogenic bacteria","authors":"Lucy W. Kiarie, P. Waithaka, E. M. Gathuru, B. Githaiga","doi":"10.31248/JDPS2018.015","DOIUrl":"https://doi.org/10.31248/JDPS2018.015","url":null,"abstract":"Drug resistant pathogenic microorganisms account for the highest proportion of death today. This study was aimed at extracting essential oils (EOS) from mint. Sensitivity tests of selected pathogenic microorganism were also carried out. EOS were extracted using distillation method. Phytochemical screening of the essential oils for the presence of tannins, alkaloids, glycosides, flavonoids, resins, phenols and steroids was carried out using standard procedures. Sensitivity test of Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (clinical isolate), Escherichia coli ((ATCC 25922), Erwinia carotovora (ATCC 33244), Xanthomonas campestris (ATCC 33913) and Bacillus subtilis (ATCC 6633) to the EOS was carried out using agar well diffusion technique. The minimum inhibitory concentration of the test pathogens by the essential oils was carried out using two-fold serial dilution. The yield of essential oils varied from 1.0±0.01% in first replicate to 3.0±0.03% in the fourth replicate. All the tested phytochemical compounds were present in the EOS of mint. There was no significant difference between the zones of inhibition of the three replicates (F=0.34 P=0.74). In addition, there was no significant difference between the MIC’s of the three replicates (F=0.33 P=0.72). Mint from Egerton University has EOS that can be extracted using distillation method. The EOS were bioactive against the selected bacterial pathogens which creates a need for their mass production.","PeriodicalId":413294,"journal":{"name":"Journal of Drugs and Pharmaceutical Science","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132141241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Bryophyllum pinnatum: A mini review on Ethnobotany and Phytochemistry 红藓:民族植物学与植物化学综述

Journal of Drugs and Pharmaceutical Science Pub Date : 2018-04-30 DOI: 10.31248/JDPS2017.011

O. Idowu, E. T. Ayodele, S. Oladoye

引用次数: 0