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Advances in Cancer Research & Clinical Imaging最新文献

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Advances in Oral Cancer Diagnosis: Is AI the Magic Tool? 口腔癌诊断的进展:人工智能是神奇的工具吗?
Advances in Cancer Research & Clinical Imaging Pub Date : 2023-04-03 DOI: 10.33552/acrci.2023.03.000574
Amir Chater
{"title":"Advances in Oral Cancer Diagnosis: Is AI the Magic Tool?","authors":"Amir Chater","doi":"10.33552/acrci.2023.03.000574","DOIUrl":"https://doi.org/10.33552/acrci.2023.03.000574","url":null,"abstract":"Oral care diagnosis is a critical aspect of maintaining overall health and well-being. Early detection and accurate diagnosis of oral diseases can significantly improve patient outcomes and reduce healthcare costs [1]. In recent years, AI has emerged as a promising tool for enhancing diagnostic accuracy and efficiency in oral care [2].","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135718025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simple Screening Test for Cancer 一种简单的癌症筛查试验
Advances in Cancer Research & Clinical Imaging Pub Date : 2021-04-07 DOI: 10.33552/ACRCI.2021.03.000558
A. Shamsuddin
{"title":"A Simple Screening Test for Cancer","authors":"A. Shamsuddin","doi":"10.33552/ACRCI.2021.03.000558","DOIUrl":"https://doi.org/10.33552/ACRCI.2021.03.000558","url":null,"abstract":"Comparative and correlative studies of the pathology and pathogenesis of colon cancer in animal models and human disease have resulted in conceptualization of ‘field effect” theory, and identification of a simple carbohydrate marker that is expressed early during carcinogenesis. This assimilated body of knowledge has resulted in development of a simple screening test for cancers of the lung, breast, colorectum, uterus, pancreas, and prostate. The marker galactose-N acetyl-galactosamine (Gal-GalNAc) is expressed in the cell surface and secreted glycoproteins of otherwise normal appearing tissues remote from cancer or precancerous lesions and is detected by enzymatic oxidation (10 minutes) followed by color reaction (1 minute). The high sensitivity, specificity, and cost-effectiveness of this point-of-care test makes it a great tool in our strategies for early detection, hence control of cancer. It would also reduce the number of unnecessary and expensive procedures, thereby decreasing the total national health-care cost to the societies and governments, globally.","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117238346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preimplantation Genetic Testing for Inherited Cancer Predisposition 遗传癌症易感性的胚胎植入前基因检测
Advances in Cancer Research & Clinical Imaging Pub Date : 2021-03-23 DOI: 10.33552/ACRCI.2021.03.000557
A. Kuliev
{"title":"Preimplantation Genetic Testing for Inherited Cancer Predisposition","authors":"A. Kuliev","doi":"10.33552/ACRCI.2021.03.000557","DOIUrl":"https://doi.org/10.33552/ACRCI.2021.03.000557","url":null,"abstract":"Summary Inherited cancer predisposition is presently one of the major indications for preimplantation genetic testing (PGT), providing an option for couplers at risk to avoid the birth of an offspring with predisposition to cancer. We present here our experience of 874 PGT cycles for cancer, resulting in birth of 387 mutation free children, without risk of developing cancer, which is a part of our overall PGT series of 6,204 PGT cases for monogenic disorders (PGT-M), with 2,517 resulting births, free of genetic disorder. The accumulated experience demonstrates considerable progress in using PGT for avoiding the birth of children with genetic predisposition to cancer.","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"30 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121004342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ANP Family of Peptides and Cancer Treatment ANP多肽家族与癌症治疗
Advances in Cancer Research & Clinical Imaging Pub Date : 2021-02-15 DOI: 10.33552/ACRCI.2021.03.000556
Michael R. Kozlowski
{"title":"The ANP Family of Peptides and Cancer Treatment","authors":"Michael R. Kozlowski","doi":"10.33552/ACRCI.2021.03.000556","DOIUrl":"https://doi.org/10.33552/ACRCI.2021.03.000556","url":null,"abstract":"Atrial natriuretic peptide (ANP) was discovered over 40 years ago, and the other members of the ANP family of peptides nearly 30 years ago. One of the effects of these peptides was found to be inhibition of the proliferation of both normal and cancer cells in vitro as well as in vivo . For the past 20 years, numerous studies have characterized the antiproliferative effects of ANP family peptides on cancer cells and proposed a role for them in the treatment of cancer. Yet, as of 2021, no anti-cancer drugs have been developed from ANP. Recently, however, events have propelled two ANP-related agents into clinical development for treating cancer. The present mini review outlines the history of ANP, from its discovery to the recent entry of ANP-related peptides into clinical trials for cancer.","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"227 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116374015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Eosinophilia and Neutrophilia Associated with AntiPD-1 use in Metastatic Non-Small Cell Lung Cancer – A Case Report" 嗜酸性粒细胞增多和中性粒细胞增多与抗pd -1在转移性非小细胞肺癌中的应用有关-1例报告
Advances in Cancer Research & Clinical Imaging Pub Date : 2021-01-29 DOI: 10.33552/ACRCI.2021.03.000555
Y. Khan
{"title":"\"Eosinophilia and Neutrophilia Associated with AntiPD-1 use in Metastatic Non-Small Cell Lung Cancer – A Case Report\"","authors":"Y. Khan","doi":"10.33552/ACRCI.2021.03.000555","DOIUrl":"https://doi.org/10.33552/ACRCI.2021.03.000555","url":null,"abstract":"The use of immunotherapy has dramatically changed the way many cancers are treated with several studies having looked at the relationship between eosinophils and immunotherapy. This case study reports nivolumab induced eosinophilia and neutrophilia with no other systemic adverse effects in a patient with metastatic non-small cell lung cancer. A 61-year-old woman with Eastern Cooperative Oncology Group performance status 1 was diagnosed with metastatic non-small cell lung cancer without any driver mutations and was commenced on nivolumab after progressing on platinum doublet therapy. She had mild eosinophilia and neutrophilia at baseline in the context of a lower respiratory tract infection which became more pronounced with the introduction of nivolumab. Nivolumab was ceased at week-26 due to significant eosinophilia and reached peak levels at week-35. She developed postural hypotension during the course of her disease and prednisolone was commenced to treat possible adrenal insufficiency from metastasis. The introduction of steroids led to the improvement in eosinophilia and neutrophilia. She had stable disease for 8 months after commencement of immunotherapy before progression of disease leading to clinical deterioration and death. Asymptomatic eosinophilia and neutrophilia is an extremely rare toxicity of immune checkpoint inhibitors. Its significance as prognostic and predictive marker needs to be researched further.","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128735699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Saliva as a Diagnostic Tool in Oral Cancer- An Opinion 唾液作为口腔癌诊断工具的观点
Advances in Cancer Research & Clinical Imaging Pub Date : 2020-12-18 DOI: 10.33552/ACRCI.2020.03.000554
B. Syed
{"title":"Saliva as a Diagnostic Tool in Oral Cancer- An Opinion","authors":"B. Syed","doi":"10.33552/ACRCI.2020.03.000554","DOIUrl":"https://doi.org/10.33552/ACRCI.2020.03.000554","url":null,"abstract":"Testing Saliva is a novel approach and recent research trend in diagnostics of local oral and systemic diseases as liquid biopsy. In patients with oral submucous fibrosis where biopsy further raises the risk of malignant transformation, changes in the composition of saliva including electrolytes, proteins content and presence of RNAs, tumor markers and cells as a panel can potentially be used for early detection of oral cancers.","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121196734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Horizontally Oriented V-Y Flap may Diminish Lower Lid Retraction 水平方向的V-Y皮瓣可减少下眼睑收缩
Advances in Cancer Research & Clinical Imaging Pub Date : 2020-09-28 DOI: 10.33552/ACRCI.2020.03.000553
H. Molaei
{"title":"Horizontally Oriented V-Y Flap may Diminish Lower Lid Retraction","authors":"H. Molaei","doi":"10.33552/ACRCI.2020.03.000553","DOIUrl":"https://doi.org/10.33552/ACRCI.2020.03.000553","url":null,"abstract":"Introduction: lower lid malposition following malignancy surgery in infra- orbital area is often challenging and any way to reduce its chance is appreciated. Case presentation: 36 years old women with confirmed Basal Cell Carcinoma (BCC) of left cheek underwent tumor excision with free margins and remained skin defect reconstructed with adipocutaneous v-y advancement flap, which designed in a horizontally orientation. Patient had no signs of ectropion with good wound repair and obscured scar. Conclusion: v-y flaps are commonly used local flaps with minimal donor site morbidity, and if designed horizontally, not only may reduce chance of lower lid malposition, but also can remain more acceptable scars.","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131436946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing Pain in The Oncologic Patient: The Therapeutic Possibilities in The Pharmacological and Interventionist Field 解决肿瘤患者的疼痛:药理学和干预领域的治疗可能性
Advances in Cancer Research & Clinical Imaging Pub Date : 2020-09-21 DOI: 10.33552/ACRCI.2020.03.000552
D. Abdalla
{"title":"Addressing Pain in The Oncologic Patient: The Therapeutic Possibilities in The Pharmacological and Interventionist Field","authors":"D. Abdalla","doi":"10.33552/ACRCI.2020.03.000552","DOIUrl":"https://doi.org/10.33552/ACRCI.2020.03.000552","url":null,"abstract":"Cancer is the second cause of death worldwide, presenting a number of different symptoms, with pain being present in up to 66% of these patients, being characterized as one of the most invalidating symptoms, which may be present regardless of the stage of the disease, either as the first symptom, during diagnosis and treatment or in advanced stages of disease. Thus, this work aims to address the various means of analgesia for cancer patients. Among the approaches are included from the steps established by the pain scale recommended by the World Health Organization, to the approach of interventionist techniques currently in use, giving greater prominence to the use of anesthetics, by different routes of administration (oral, subcutaneous, itratectal, neuroaxial and neuronal blocks), such as safe and effective analgesia for cancer patients.","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122613120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Importance of Treating Energy Imbalances and Chakras Replenishment for Prevention and Treatment of Cancer 治疗能量失衡和补充脉轮对预防和治疗癌症的重要性
Advances in Cancer Research & Clinical Imaging Pub Date : 2020-09-08 DOI: 10.33552/ACRCI.2020.03.000551
Huang Wl
{"title":"The Importance of Treating Energy Imbalances and Chakras Replenishment for Prevention and Treatment of Cancer","authors":"Huang Wl","doi":"10.33552/ACRCI.2020.03.000551","DOIUrl":"https://doi.org/10.33552/ACRCI.2020.03.000551","url":null,"abstract":"Introduction: Western medicine’s cancer treatment focus on the destruction of the diseased cells, harming the healthy cells as well. In traditional Chinese medicine (TCM), cancer is the manifestation of the body’s energy deficiency and Heat retention. One direct way to search for the root of these energy imbalances is through the assessment of the chakra system, which offers vital information about the body’s energy levels. Purpose: To demonstrate that cancer patients have energy deficiencies and Heat retention as root and also chakra’s energy deficiencies in the lowest level. The balance of the energy deficiencies and taking out the Heat retention associated with the replenishment of these energies is important to prevent and treat cancer patients. Methods: Three clinical cases reports. All three patients with cancer diagnoses (case one: thyroid; case two: uterus; case three: lungs). All of them received treatment to reestablish the equilibrium between Yin, Yang, Qi , Blood and taking out Heat retention through Chinese dietary counselling, auricular acupuncture with apex-ear bloodletting, homeopathy according to the Constitutional Homeopathy of Five Elements Based on Traditional Chinese Medicine and crystal-based medication after chakras energy measurement through radiesthesia procedure. All three patients were found to be at their lowest level of energy, rating one out of eight. Results: Out of the three patients, the first two case reports were cured of their cancer condition without any treatment by Western medicine, only with the treatment done. The third patient, though, was already under radiotherapy and chemotherapy but through the treatment previously described the metastasis disappeared and he achieved a better physical and emotional health state. Conclusion: TCM believes that energy deficiency and Heat retention causes cancer. Treatment with Chinese dietary counseling, auricular acupuncture, apex-ear bloodletting and recharge of the Chakras energy can be a path to prevention and treatment of cancer patients.","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129001322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Clinical Significance of Molecular Biomarkers on Brain Gliomas 脑胶质瘤分子标志物的临床意义
Advances in Cancer Research & Clinical Imaging Pub Date : 2020-08-31 DOI: 10.33552/ACRCI.2020.02.000550
Shanqiang Qu
{"title":"Clinical Significance of Molecular Biomarkers on Brain Gliomas","authors":"Shanqiang Qu","doi":"10.33552/ACRCI.2020.02.000550","DOIUrl":"https://doi.org/10.33552/ACRCI.2020.02.000550","url":null,"abstract":"Gliomas are the most common primary brain tumors, and more than half of them are glioblastoma multiformes (GBMs) with the highest heterogeneity malignant degree. According to the statistical report of the Central Brain Tumor Registry of the United States, the glioma patients in the United States accounted for 26% of all intracranial tumor patients and 81% of all intracranial malignant tumor patients in 2011-2015 [1]. The overall survival (OS) of patients with gliomas has always been","PeriodicalId":413188,"journal":{"name":"Advances in Cancer Research & Clinical Imaging","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122495094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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