Pain Research最新文献_第3页

Mechanism of neural circuit reorganization in the brain that produces ectopic pain 脑内神经回路重组产生异位痛的机制

Pain Research Pub Date : 2022-07-15 DOI: 10.11154/pain.37.97

M. Miyata

引用次数: 0

Neurorehabilitation for pain 神经康复治疗疼痛

Pain Research Pub Date : 2022-07-15 DOI: 10.11154/pain.37.75

M. Osumi, M. Sumitani

引用次数: 0

Effects of acetaminophen on neuronal activity in the mouse locus coeruleus 对乙酰氨基酚对小鼠蓝斑区神经元活动的影响

Pain Research Pub Date : 2022-03-30 DOI: 10.11154/pain.37.16

Iwao Seki, Ayumi Nakamura, Keisuke Koga, Hiroyuki Aono, H. Furue

引用次数: 0

Chronic pain and opioids —how to control proper prescribing ? 慢性疼痛和阿片类药物——如何控制正确的处方？

Pain Research Pub Date : 2022-03-30 DOI: 10.11154/pain.37.1

E. Kalso, M. Iseki

引用次数: 0

Effect of Pulse Irradiation with a 10–W Semiconductor Laser on pressure pain threshold and temporal summation 10W半导体激光器脉冲辐照对压痛阈值和时间总和的影响

Pain Research Pub Date : 2022-03-30 DOI: 10.11154/pain.37.26

Nobuyuki Takeuchi, M. Matsumoto

引用次数: 0

Pharmacotherapy: Exploring an individualized therapy for neuropathic pain 药物治疗：探索神经性疼痛的个体化治疗

Pain Research Pub Date : 2021-09-30 DOI: 10.11154/pain.36.173

Munetaka Hirose

引用次数: 0

Brain imaging study for central sensitization 中枢致敏的脑成像研究

Pain Research Pub Date : 2021-09-30 DOI: 10.11154/pain.36.180

K. Wakaizumi

引用次数: 0

Analgesic mechanism of Goshajinkigan for neuropathic pain Goshajinkigan治疗神经性疼痛的镇痛机制

Pain Research Pub Date : 2021-09-30 DOI: 10.11154/pain.36.154

Miho Nakanishi, S. Fukui, H. Kitagawa

引用次数: 0

Expression of TrkA and GFRα1, and their coexpression in muscle innervating primary afferent neurons in rats TrkA和GFRα1在大鼠肌肉神经原代传入神经元中的表达及其共表达

Pain Research Pub Date : 2021-09-30 DOI: 10.11154/pain.36.147

K. Mizumura, Kimiko Kobayashi, S. Murase

{"title":"Expression of TrkA and GFRα1, and their coexpression in muscle innervating primary afferent neurons in rats","authors":"K. Mizumura, Kimiko Kobayashi, S. Murase","doi":"10.11154/pain.36.147","DOIUrl":"https://doi.org/10.11154/pain.36.147","url":null,"abstract":"On the way of analyzing the mechanism of delayed onset muscle soreness, author’s group found that nerve growth factor (NGF) and glial cell line derived neurotrophic factor (GDNF) synergistically interact to induce muscular mechanical hyperalgesia. However, it is believed that NGF and GDNF work on different sets of DRG neurons that express NGF receptor, TrkA or GDNF receptor, GFR α 1–RET. However, this result was obtained from skin–innervating neurons or whole DRG neurons. It is not known whether muscle innervating DRGs are similar. In this experiment we examined whether it is also true for muscle innervating DRG neurons. We identified muscle innervating DRG neurons using retrograde tracing with Fluoro–Gold. Under anesthesia FG (4%, 10 μl) was injected to 10 points each of medial and lateral head of gastrocnemius muscle (GC). Ten to eleven days later rats were perfused and fixed under deep anesthesia. Using serial sections immunohistochemistry for FG and double in situ hybridization for TrkA and GFR α 1 were performed. As a result 39%–50% of FG+ DRG neurons were TrkA+, and 69–77% were GFR α 1+. Co–expression of TrkA and GFR α 1 was observed in 24%–29% DRG neurons innervating GC. The size distribution of FG + DRG neurons did not show a skewness in small size range (< 600 μm 2 ), rather distributed equally in small to large cell ranges. Size distribution of TrkA+ neurons and double positive (TrkA+ and GFR α 1+) also showed no skewness in small size range and distributed widely from small to large size. A part of these TrkA+ ⁄ GFR α 1+ coexpressing neurons might be the site of synergistic interaction of NGF and GDNF.","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47625483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of TRP channels in analgesic action of Kampo medicine TRP通道参与汉布药的镇痛作用

Pain Research Pub Date : 2021-09-30 DOI: 10.11154/pain.36.163

Yi Dai

引用次数: 0