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2022-RA-945-ESGO Antitumour activity of dostarlimab by PD-L1 and tumour mutation burden in patients with mismatch repair deficient and proficient tumours in the GARNET trial GARNET试验中dostarlimumab对PD-L1的抗肿瘤活性和错配修复缺陷和精通肿瘤患者的肿瘤突变负担
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.878
Susana Banerjee, T. André, D. Berton, S. Ellard, B. Jímenez, V. Samouëlian, L. Gilbert, V. Boni, Xinwei Han, G. Antony, J. Veneris, A. Oaknin
{"title":"2022-RA-945-ESGO Antitumour activity of dostarlimab by PD-L1 and tumour mutation burden in patients with mismatch repair deficient and proficient tumours in the GARNET trial","authors":"Susana Banerjee, T. André, D. Berton, S. Ellard, B. Jímenez, V. Samouëlian, L. Gilbert, V. Boni, Xinwei Han, G. Antony, J. Veneris, A. Oaknin","doi":"10.1136/ijgc-2022-esgo.878","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.878","url":null,"abstract":"with mismatch repair deficient (dMMR) recurrent/advanced endometrial cancer (EC) that has progressed on or after platinum-based chemotherapy or solid tumours that have progressed on or after prior treatment, with no satisfactory alternative treatment options. We report a post hoc analysis of antitumour activity by PDL1 expression and tumour mutational burden (TMB) in patients with dMMR and MMR proficient (MMRp) solid tumours in the GARNET trial.","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126961304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-627-ESGO Preoperative circulating tumor DNA level is associated to poor overall survival in patients with ovarian cancer 卵巢癌患者术前循环肿瘤DNA水平与较差的总生存率相关
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.868
Arturas Dobilas, P. Leandersson, Yilun Chen, M. Alcaide, C. Brueffer, L. Saal, C. Borgfeldt
{"title":"2022-RA-627-ESGO Preoperative circulating tumor DNA level is associated to poor overall survival in patients with ovarian cancer","authors":"Arturas Dobilas, P. Leandersson, Yilun Chen, M. Alcaide, C. Brueffer, L. Saal, C. Borgfeldt","doi":"10.1136/ijgc-2022-esgo.868","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.868","url":null,"abstract":"2022-RA-627-ESGO Figure 1 Waterfall plot of validated somatic mutations in the patient tumors. Genes are indicated in rows and samples in columns. Mutated samples are show according to mutation type. Patient and tumor clinopathological variables are shown below the patient IDs Abstract 2022-RA-627-ESGO Figure 2 Plasma circulating tum or (ctDNA) mutant concentration increased with higher stage (ptrend<0.001).Concentrations of circulating tumor DNA (ctDNA) in stage III and stage IV OvCa were significantly higher compared with stage I OvCa (p=0.025 and p=0.007 respectively) Bars include highest and lowest values, except outliers (o), which are 1.5 to 3 box lengths from the end of the box, and extremes (*) which are more than 3 box lengths from the end of the box2022-RA-627-ESGO Figure 2 Plasma circulating tum or (ctDNA) mutant concentration increased with higher stage (ptrend<0.001).Concentrations of circulating tumor DNA (ctDNA) in stage III and stage IV OvCa were significantly higher compared with stage I OvCa (p=0.025 and p=0.007 respectively) Bars include highest and lowest values, except outliers (o), which are 1.5 to 3 box lengths from the end of the box, and extremes (*) which are more than 3 box lengths from the end of the box Conclusion Measuring ctDNA in pre-operative plasma may be useful as a predictive biomarker for tumor staging and prognosis in ovarian cancer patients. Abstracts Int J Gynecol Cancer 2022;32(Suppl 2):A1–A504 A405 on D ecem er 8, 2022 by gest. P rocted by coright. http/ijgc.bm jcom / nt J G ynecol C acer: frst pulished as 10.11ijgc-2022-E S G O .68 on 20 O cber 222. D ow nladed fom","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121944431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-1480-ESGO TRANSLACOL project: digital-PCR human papilloma virus (HPV) detection for recurrence prediction in early cervical cancer patients without pelvic lymph node invasion 2022-RA-1480-ESGO TRANSLACOL项目:数字pcr人乳头瘤病毒(HPV)检测用于预测无盆腔淋巴结侵袭的早期宫颈癌患者的复发
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.895
R. M. Macías, Nicolas Robillard, T. Bruneau, Coronado Pluvio, Mélanie Boulhic, M. L. Frére-Belda, I. Stanković, M. Ángeles, E. Mery, P. Rigolet, C. Badoual, P. Mathevet, A. Bats, V. Taly, D. Veyer, F. Lécuru, H. Péré
{"title":"2022-RA-1480-ESGO TRANSLACOL project: digital-PCR human papilloma virus (HPV) detection for recurrence prediction in early cervical cancer patients without pelvic lymph node invasion","authors":"R. M. Macías, Nicolas Robillard, T. Bruneau, Coronado Pluvio, Mélanie Boulhic, M. L. Frére-Belda, I. Stanković, M. Ángeles, E. Mery, P. Rigolet, C. Badoual, P. Mathevet, A. Bats, V. Taly, D. Veyer, F. Lécuru, H. Péré","doi":"10.1136/ijgc-2022-esgo.895","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.895","url":null,"abstract":"","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131956545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-1360-ESGO Circulatory HMGB-1 as a plausible diagnostic marker in liquid biopsy of cervical cancer 2022-RA-1360-ESGO循环HMGB-1在宫颈癌液体活检中的诊断价值
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.891
Alpana Sharma, N. Gupta, R. Khan, M. Sharma
{"title":"2022-RA-1360-ESGO Circulatory HMGB-1 as a plausible diagnostic marker in liquid biopsy of cervical cancer","authors":"Alpana Sharma, N. Gupta, R. Khan, M. Sharma","doi":"10.1136/ijgc-2022-esgo.891","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.891","url":null,"abstract":"","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114067186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-846-ESGO Predictive value of DNA methylation markers as an invasive diagnostic tool for pathological upgrading cervical lesions DNA甲基化标志物作为宫颈病变病理升级的侵入性诊断工具的预测价值
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.874
Yanan Kang, Yi Zhang
{"title":"2022-RA-846-ESGO Predictive value of DNA methylation markers as an invasive diagnostic tool for pathological upgrading cervical lesions","authors":"Yanan Kang, Yi Zhang","doi":"10.1136/ijgc-2022-esgo.874","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.874","url":null,"abstract":"","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116723775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-1218-ESGO Physiologically relevant treatment models to investigate epigenetic mechanisms driving platinum resistance in ovarian high grade serous carcinoma 2022-RA-1218-ESGO生理相关治疗模型探讨卵巢高级别浆液性癌铂耐药的表观遗传机制
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.888
R. Ergasti, M. Q. Lim, G. Giannone, D. Ennis, I. Dye, H. Mirza, A. Fagotti, G. Scambia, I. McNeish
{"title":"2022-RA-1218-ESGO Physiologically relevant treatment models to investigate epigenetic mechanisms driving platinum resistance in ovarian high grade serous carcinoma","authors":"R. Ergasti, M. Q. Lim, G. Giannone, D. Ennis, I. Dye, H. Mirza, A. Fagotti, G. Scambia, I. McNeish","doi":"10.1136/ijgc-2022-esgo.888","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.888","url":null,"abstract":"","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125171492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-1608-ESGO Clinical implications of genomic intratumoural heterogeneity in high grade serous ovarian cancer 高级别浆液性卵巢癌肿瘤内基因组异质性的临床意义
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.900
P. Cunnea, E. Christie, E. Curry, C. Kwok, A. Pandey, K. Nixon, J. Ploski, J. Krell, I. McNeish, D. Bowtell, C. Fotopoulou
{"title":"2022-RA-1608-ESGO Clinical implications of genomic intratumoural heterogeneity in high grade serous ovarian cancer","authors":"P. Cunnea, E. Christie, E. Curry, C. Kwok, A. Pandey, K. Nixon, J. Ploski, J. Krell, I. McNeish, D. Bowtell, C. Fotopoulou","doi":"10.1136/ijgc-2022-esgo.900","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.900","url":null,"abstract":"","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117117188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-915-ESGO STK11 adnexal tumors: challenge of a new tumor entity 附件肿瘤:一种新的肿瘤实体的挑战
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.877
F. Pagano, Flurina Anna-Carina Maria Saner, Solass Wiebke, S. Imboden, M. Mueller
{"title":"2022-RA-915-ESGO STK11 adnexal tumors: challenge of a new tumor entity","authors":"F. Pagano, Flurina Anna-Carina Maria Saner, Solass Wiebke, S. Imboden, M. Mueller","doi":"10.1136/ijgc-2022-esgo.877","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.877","url":null,"abstract":"","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131656771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-1502-ESGO Multiplexed biomarker detection using the QuantiGene assay in women living with HIV for cervical dysplasia detection 使用QuantiGene法检测2022-RA-1502-ESGO多路生物标志物检测HIV感染妇女宫颈发育不良
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.896
A. Skof, Wilbert Mbuya, R. Mcharo, L. Torres, J. France, A. Kroidl, C. Geldmacher, A. Kaufmann
{"title":"2022-RA-1502-ESGO Multiplexed biomarker detection using the QuantiGene assay in women living with HIV for cervical dysplasia detection","authors":"A. Skof, Wilbert Mbuya, R. Mcharo, L. Torres, J. France, A. Kroidl, C. Geldmacher, A. Kaufmann","doi":"10.1136/ijgc-2022-esgo.896","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.896","url":null,"abstract":"","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128928486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022-RA-1093-ESGO Validation of self-sampling use for a multiplexed biomarker assay for HPV and dysplasia detection 自采样用于HPV和非典型增生检测的多重生物标志物检测的验证
Translational research/biomarkers Pub Date : 2022-10-01 DOI: 10.1136/ijgc-2022-esgo.881
A. Skof, E. Payrich, Maja Struck, S. Thies, C. Schreckenberger, J. Sehouli, A. Kaufmann
{"title":"2022-RA-1093-ESGO Validation of self-sampling use for a multiplexed biomarker assay for HPV and dysplasia detection","authors":"A. Skof, E. Payrich, Maja Struck, S. Thies, C. Schreckenberger, J. Sehouli, A. Kaufmann","doi":"10.1136/ijgc-2022-esgo.881","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.881","url":null,"abstract":"","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129353953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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