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ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology最新文献

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A novel UVA-labile β-adrenergic agonist allows for optical control of subcellular signaling 一种新的uva不稳定β-肾上腺素能激动剂允许亚细胞信号的光学控制
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.563170
Waruna Thotamune, Sithurandi Ubeysinghe, A. Karunarathne, K. Shrestha, M. Young, M. Tennakoon
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引用次数: 0
Enhanced cAMP-based assay for GPCR deorphanization 增强的基于camp的GPCR去孤儿化检测
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.148500
L. Franchini, Lindsay R. Watkins, C. Orlandi
{"title":"Enhanced cAMP-based assay for GPCR deorphanization","authors":"L. Franchini, Lindsay R. Watkins, C. Orlandi","doi":"10.1124/jpet.122.148500","DOIUrl":"https://doi.org/10.1124/jpet.122.148500","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126349285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designer Autocrine Signaling Networks for Discovering GPCR-modulating Nanobodies 设计自分泌信号网络发现gpcr调节纳米体
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.260740
J. Rowe, Kyu‐Sung Lee, Sam Taylor, D. Isom
{"title":"Designer Autocrine Signaling Networks for Discovering GPCR-modulating Nanobodies","authors":"J. Rowe, Kyu‐Sung Lee, Sam Taylor, D. Isom","doi":"10.1124/jpet.122.260740","DOIUrl":"https://doi.org/10.1124/jpet.122.260740","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133336659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N-cadherin Signaling via PI3Kβ-Akt3 Stabilizes Occludin Tight Junctions in the Blood-Brain Barrier 通过PI3Kβ-Akt3传导的n -钙粘蛋白信号稳定血脑屏障中的紧密连接
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.196530
Quinn Lee, K. Kruse, Shuangping Zhao, Leon Tai, Y. Komarova
{"title":"N-cadherin Signaling via PI3Kβ-Akt3 Stabilizes Occludin Tight Junctions in the Blood-Brain Barrier","authors":"Quinn Lee, K. Kruse, Shuangping Zhao, Leon Tai, Y. Komarova","doi":"10.1124/jpet.122.196530","DOIUrl":"https://doi.org/10.1124/jpet.122.196530","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"189 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131640725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic insights into Rap1A-dependent regulation of phospholipase C epsilon in the heart 心脏中依赖rap1a的磷脂酶C epsilon调控的机制见解
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.159660
Kadidia Samassekou, Elisabeth E. Garland-Kuntz, Isaac J. Fisher, Vaani Ohri, Livia M. Bogdan, S. Erramilli, A. Lyon, A. Kossiakoff
{"title":"Mechanistic insights into Rap1A-dependent regulation of phospholipase C epsilon in the heart","authors":"Kadidia Samassekou, Elisabeth E. Garland-Kuntz, Isaac J. Fisher, Vaani Ohri, Livia M. Bogdan, S. Erramilli, A. Lyon, A. Kossiakoff","doi":"10.1124/jpet.122.159660","DOIUrl":"https://doi.org/10.1124/jpet.122.159660","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123329875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Δ9-tetrahydrocannabinolic acid A (THCA-A) and Delta-9-tetrahydrocannabinol (THC) in neuronal cell functions Δ9-tetrahydrocannabinolic酸A (THCA-A)和δ -9-四氢大麻酚(THC)在神经细胞功能中的比较
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.551160
Khalil Eldeeb, S. Leone‐Kabler, Allyn C. Howlett
{"title":"Comparison of Δ9-tetrahydrocannabinolic acid A (THCA-A) and Delta-9-tetrahydrocannabinol (THC) in neuronal cell functions","authors":"Khalil Eldeeb, S. Leone‐Kabler, Allyn C. Howlett","doi":"10.1124/jpet.122.551160","DOIUrl":"https://doi.org/10.1124/jpet.122.551160","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114396347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel GαGTP Sensors to probe Subcellular signaling of Endogenous heterotrimeric G proteins 新型Gα gtp传感器探测内源性异三聚体G蛋白的亚细胞信号
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.548930
Dhanushan Wijayaratna, A. Karunarathne
{"title":"Novel GαGTP Sensors to probe Subcellular signaling of Endogenous heterotrimeric G proteins","authors":"Dhanushan Wijayaratna, A. Karunarathne","doi":"10.1124/jpet.122.548930","DOIUrl":"https://doi.org/10.1124/jpet.122.548930","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121065590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery and Validation of RGS2-FBXO44 Protein-Protein Interaction Inhibitors RGS2-FBXO44蛋白-蛋白相互作用抑制剂的发现和验证
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.164970
Sadikshya Aryal, Harrison J. McNabb, Benita Sjogren
{"title":"Discovery and Validation of RGS2-FBXO44 Protein-Protein Interaction Inhibitors","authors":"Sadikshya Aryal, Harrison J. McNabb, Benita Sjogren","doi":"10.1124/jpet.122.164970","DOIUrl":"https://doi.org/10.1124/jpet.122.164970","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129435917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcellular Optogenetic Inhibition of PLCβ-GαqGTP Interaction Sheds Light on the Molecular Regulation of Gαq-Governed Directional Cell Migration plc - β- g - α - qgtp相互作用的亚细胞光遗传抑制揭示了g - α - q调控的定向细胞迁移的分子调控
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.544610
Sithurandi Ubeysinghe, Dinesh Kankanamge, A. Karunarathne
{"title":"Subcellular Optogenetic Inhibition of PLCβ-GαqGTP Interaction Sheds Light on the Molecular Regulation of Gαq-Governed Directional Cell Migration","authors":"Sithurandi Ubeysinghe, Dinesh Kankanamge, A. Karunarathne","doi":"10.1124/jpet.122.544610","DOIUrl":"https://doi.org/10.1124/jpet.122.544610","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126331443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amyloid Beta Protein (Aβ1-42) induced Endolysosome Iron Dyshomeostasis caused increases in Reactive Oxygen Species, Mitochondrial Depolarization, and Neurotoxicity 淀粉样蛋白(a - β1-42)诱导的内溶酶体铁失衡导致活性氧增加、线粒体去极化和神经毒性
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.212100
D. Quansah, P. Halcrow, Nirmal Kumar, Braelyn Liang, J. Geiger
{"title":"Amyloid Beta Protein (Aβ1-42) induced Endolysosome Iron Dyshomeostasis caused increases in Reactive Oxygen Species, Mitochondrial Depolarization, and Neurotoxicity","authors":"D. Quansah, P. Halcrow, Nirmal Kumar, Braelyn Liang, J. Geiger","doi":"10.1124/jpet.122.212100","DOIUrl":"https://doi.org/10.1124/jpet.122.212100","url":null,"abstract":"","PeriodicalId":406842,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129816046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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