Immunology and Genetics Journal最新文献_第2页

Association Study of Interleukin 23 Receptor (IL-23R) Polymorphisms with Inflammatory Bowel Disease (IBD) in Khuzestan Province of Iran 伊朗胡齐斯坦省白介素23受体(IL-23R)多态性与炎症性肠病(IBD)的相关性研究

Immunology and Genetics Journal Pub Date : 2023-05-22 DOI: 10.18502/igj.v4i4.12756

H. Esmaeili, P. Ghandil, A. Ghadiri, M. Ghafourian, Seyed jalal Hashem

{"title":"Association Study of Interleukin 23 Receptor (IL-23R) Polymorphisms with Inflammatory Bowel Disease (IBD) in Khuzestan Province of Iran","authors":"H. Esmaeili, P. Ghandil, A. Ghadiri, M. Ghafourian, Seyed jalal Hashem","doi":"10.18502/igj.v4i4.12756","DOIUrl":"https://doi.org/10.18502/igj.v4i4.12756","url":null,"abstract":"Both innate and adaptive arms of immune system play role in tumor development. Moreover, genetic and epigenetic alterations, widely demonstrated in cancer cells, result in disturbances in molecular pathways regulating cell growth, survival, and metastasis. Knowledge of molecular and cellular mechanisms involved in carcinogenesis leads to improvement of targeted treatments for cancers. Similarly, allergies are immune related entities and are treated according to the molecular mechanisms of hypersensitivity reactions. Some studies support the hypothesis of inverse association between cancer and susceptibility for allergies but the correlation is not simple and some demonstrate positive relation. For example, in some studies histamine released in response to allergens plays a role in tumor progression, probably through maintaining survival of myeloid derived suppressor cells (MDSCs). However, in other studies, the protective role of IgE against carcinogenesis have been reported. In this review, the role of immune system and specific molecular mechanisms in cancer and allergy will be discussed. Based on separately mentioned factors, interactions between these two seemingly disparate entities will also be presented. We conducted this review to illustrate potential molecular and cellular mechanisms underlying the association of cancer and allergy and make a basis for future interventions.","PeriodicalId":406184,"journal":{"name":"Immunology and Genetics Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127520280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel RAG2 Mutation in a Patient with Leaky Severe Combined Immunodeficiency 漏性严重联合免疫缺陷患者的新型RAG2突变

Immunology and Genetics Journal Pub Date : 2023-05-22 DOI: 10.18502/igj.v4i4.12758

S. Pashangzadeh, R. Yazdani, S. Delavari, Hassan Abolhassani, N. Parvaneh

引用次数: 0

Case-Based Learning of Primary Immunodeficiency: A Pilot Gamification for Education 基于案例的初级免疫缺陷学习:教育游戏化的试点

Immunology and Genetics Journal Pub Date : 2023-05-22 DOI: 10.18502/igj.v4i4.12762

S. Hanaei

{"title":"Case-Based Learning of Primary Immunodeficiency: A Pilot Gamification for Education","authors":"S. Hanaei","doi":"10.18502/igj.v4i4.12762","DOIUrl":"https://doi.org/10.18502/igj.v4i4.12762","url":null,"abstract":"Objectives: Proper knowledge transfer to medical students would be highly important in training future generation of physicians and scientists. the current pilot study was designed to determine a model of gamification would be efficient in education of primary immunodeficiency diseases (PIDs) in medical students. Results: 15 PIDs were selected among the most common PIDs, and were described as an infographic case-problem. The cases were distributed among the students via emails and social media. Generally, we received 125 answers (102 correct and 23 incorrect). For each correct answer, the student was rewarded with a grant. In case of an incorrect answer, the student was encouraged to continue efforts on providing the most accurate answer. The immediate feed-backs encouraged some students to more precisely seek for the correct answer. The pattern of received answers, could provide a clue for the trainer regarding which PIDs have been more commonly learnt and established in minds, and which ones may need more practice and explanation in classes. It is proposed that not only such methods would make the teaching-learning process more exciting, but also, they may lead to more permanent establishment of an educational concept in the students’ minds.","PeriodicalId":406184,"journal":{"name":"Immunology and Genetics Journal","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124943800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer and Allergy; Molecular Association and Integrated Therapies 癌症和过敏;分子关联与综合治疗

Immunology and Genetics Journal Pub Date : 2023-05-22 DOI: 10.18502/igj.v4i4.12754

Sara Hemmati, Behnoud Baradaran Noveiry, Mahsa Keshavarz-Fathi

{"title":"Cancer and Allergy; Molecular Association and Integrated Therapies","authors":"Sara Hemmati, Behnoud Baradaran Noveiry, Mahsa Keshavarz-Fathi","doi":"10.18502/igj.v4i4.12754","DOIUrl":"https://doi.org/10.18502/igj.v4i4.12754","url":null,"abstract":"Both innate and adaptive arms of immune system play role in tumor development. Moreover, genetic and epigenetic alterations, widely demonstrated in cancer cells, result in disturbances in molecular pathways regulating cell growth, survival, and metastasis. Knowledge of molecular and cellular mechanisms involved in carcinogenesis leads to improvement of targeted treatments for cancers. Similarly, allergies are immune related entities and are treated according to the molecular mechanisms of hypersensitivity reactions. Some studies support the hypothesis of inverse association between cancer and susceptibility for allergies but the correlation is not simple and some demonstrate positive relation. For example, in some studies histamine released in response to allergens plays a role in tumor progression, probably through maintaining survival of myeloid derived suppressor cells (MDSCs). However, in other studies, the protective role of IgE against carcinogenesis have been reported. In this review, the role of immune system and specific molecular mechanisms in cancer and allergy will be discussed. Based on separately mentioned factors, interactions between these two seemingly disparate entities will also be presented. We conducted this review to illustrate potential molecular and cellular mechanisms underlying the association of cancer and allergy and make a basis for future interventions.","PeriodicalId":406184,"journal":{"name":"Immunology and Genetics Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131443601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Evaluation of NOD2 Promoter Methylation Profiling in Colon Biopsy Samples from Ulcerative Colitis Patients and Non-Colitis Controls 溃疡性结肠炎患者和非结肠炎对照组结肠活检样本中NOD2启动子甲基化谱的定量评估

Immunology and Genetics Journal Pub Date : 2023-05-22 DOI: 10.18502/igj.v4i4.12757

G. Sanati, M. Noruzinia, D. Jafari, M. Ahmadvand, S. Teimourian, N. Daryani, S. Hanaei, N. Rezaei

{"title":"Quantitative Evaluation of NOD2 Promoter Methylation Profiling in Colon Biopsy Samples from Ulcerative Colitis Patients and Non-Colitis Controls","authors":"G. Sanati, M. Noruzinia, D. Jafari, M. Ahmadvand, S. Teimourian, N. Daryani, S. Hanaei, N. Rezaei","doi":"10.18502/igj.v4i4.12757","DOIUrl":"https://doi.org/10.18502/igj.v4i4.12757","url":null,"abstract":"Background: Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the colon with evidence addressing the role of epigenetic changes. The intention of this study was to detect the association of DNA methylation levels of NOD2 gene with UC and to evaluate whether any of these changes might be a useful biomarker for detecting patients with UC. \u0000Methods: The methylation status of the promoter CpG islands (CGIs) of NOD2 gene was examined in the colonic mucosae of 15 cancer-free patients with UC and 15 age- and sex-matched healthy controls by the real-time quantitative multiplex-methylation specific PCR (QM-MSP) assay. Methylation-specific melting curve analysis (MS-MCA) were used to analyze the data. \u0000Results: The median unmethylated DNA index was significantly higher in cases compared to controls, and hypormethylation of NOD2 gene was significantly correlated with UC (Unmethylated DNA in UC vs. HC; 0.102±0.055 vs. 0.025±0.016, P = 0.000). \u0000Conclusion: The NOD2 gene that was differentially methylated in UC patients, providing new insights into the pathogenesis of UC, with a view to making steps toward the development of accurate biomarkers for diagnostic tools in UC.","PeriodicalId":406184,"journal":{"name":"Immunology and Genetics Journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114450044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omenn Syndrome Caused by A Novel Mutation of the DCLRE1C Gene: Case Report and Review of Literature 由DCLRE1C基因突变引起的Omenn综合征:病例报告及文献复习

Immunology and Genetics Journal Pub Date : 2023-03-07 DOI: 10.18502/igj.v4i3.12113

T. Cheraghi, Afshin Safaee, E. Esmaili, Kiomars Golshekan, Maryam x Maryam Ghavideldarestani

引用次数: 0

Bacteriophage Therapy as an Alternative to Antibiotics: A Dead End or A Solution? 噬菌体治疗作为抗生素的替代品:死胡同还是解决方案?

Immunology and Genetics Journal Pub Date : 2023-03-07 DOI: 10.18502/igj.v4i3.12114

Amirhossein Rismanbaf

{"title":"Bacteriophage Therapy as an Alternative to Antibiotics: A Dead End or A Solution?","authors":"Amirhossein Rismanbaf","doi":"10.18502/igj.v4i3.12114","DOIUrl":"https://doi.org/10.18502/igj.v4i3.12114","url":null,"abstract":"Antibiotic resistance has been around for years and could lead to a serious crisis in the near future. If the problem of antibiotic resistance is not solved, antimicrobial resistance is predicted to increase, killing 10 million people annually by 2050 (more than the number of cancer deaths), and costing the global economy approximately $100 trillion USD, because of this, it will need the rapid development of alternative therapies. This issue prompted scientists to find a solution; the use of bacteriophages as an alternative to antibiotics is one of these tactics. In this review article, I will first focus on bacteriophages from various aspects and then, by analyzing the available information, I will try to answer the following questions: \u0000 \u0000Given the meager standard clinical data and characteristics of bacteriophages, is bacteriophage therapy a safe and reliable method? \u0000Given the short time left before the antibiotic resistance crisis, is it cost-effective to invest in bacteriophage? \u0000Are bacteriophages a double-edged sword? (Besides being used to treat bacterial diseases in the future, do bacteriophages have the potential to become a human virus in the future?) \u0000","PeriodicalId":406184,"journal":{"name":"Immunology and Genetics Journal","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131400539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA Methylation of JAK2 Gene in Intestinal Biopsy and Peripheral Blood Samples of Patients with Ulcerative Colitis 溃疡性结肠炎患者肠道活检和外周血样本中JAK2基因的DNA甲基化

Immunology and Genetics Journal Pub Date : 2023-03-07 DOI: 10.18502/igj.v4i3.12115

S. Hanaei, G. Sanati, M. Sadr, S. Gharibzadeh, Roham Salmanroghani, Hassan Salmanroghani, N. Rezaei

引用次数: 0

The Role of Intranasal Corticosteroid Therapy in Pediatric Adenoidal Hypertrophy: A Randomized Clinical Trial Study 鼻内皮质类固醇治疗在儿童腺样体肥大中的作用:一项随机临床试验研究

Immunology and Genetics Journal Pub Date : 2023-03-07 DOI: 10.18502/igj.v4i3.12116

M. Sadeghi-shabestari, Masoud Naderpoor, Samira Farzipour, Azar Dastranji

{"title":"The Role of Intranasal Corticosteroid Therapy in Pediatric Adenoidal Hypertrophy: A Randomized Clinical Trial Study","authors":"M. Sadeghi-shabestari, Masoud Naderpoor, Samira Farzipour, Azar Dastranji","doi":"10.18502/igj.v4i3.12116","DOIUrl":"https://doi.org/10.18502/igj.v4i3.12116","url":null,"abstract":"Background: Adenoidal hypertrophy (AH) is a common disorder in pediatric population with severe complications due to nasal air way obstruction. Adenoidectomy is a choice treatment for children with severe symptoms due to AH; however, it is accompanied by several side effects such as complication of surgery and emotional distress. We evaluated the efficacy of intranasal corticosteroid therapy in size and symptoms of Adenoid Hypertrophy especially in atopic patients. \u0000Methods: In this clinical trial 45 children aged 2 to 14 years old with AH were enrolled. All of them underwent 8-week course of intranasal Fluticasone therapy and their symptoms before and after treatment were scored and compared by questionnaires. Also they were divided into Atopic and non- Atopic groups based on history, physical examination and positive skin prick test. Then the two groups were compared after the treatment according to their response to therapy. \u0000Results: After 8 weeks’ treatment with intranasal corticosteroid, improvement in all symptoms score of AH including (Snoring, Sleep Apnea, Mouth breathing and Nasal congestion) was statistically significant (P = 0.000). The improvement in clinical symptoms of AH after treatment was observed in 92% of atopic patients in comparison with non-atopic patients was 50%, which was also statistically significant (P = 0.024). \u0000Conclusion: Our study demonstrated that 8-week intranasal corticosteroid was associated with a decrease in size of AH and all symptoms of obstruction. As a result, it can be suggested that intranasal corticosteroid therapy can prevent adenoidectomy especially in atopic patients.","PeriodicalId":406184,"journal":{"name":"Immunology and Genetics Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122885009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Novel ZBTB24 Mutation Identified in an Iranian Patient with Type 2 ICF Syndrome 在伊朗2型ICF综合征患者中发现的新型ZBTB24突变

Immunology and Genetics Journal Pub Date : 2023-03-07 DOI: 10.18502/igj.v4i3.12117

S. Arshi, M. Nabavi, M. Bemanian, M. Fallahpour, S. Delavari, N. Rezaei, S. Shokri

引用次数: 0