Iranian Quarterly Journal of Breast Diseases最新文献

Effectiveness of Transpersonal Therapy (Spiritual Therapy, Yoga-Meditation) in Reducing Fear of Cancer Recurrence in Breast Cancer Survivors: A Randomized Controlled Trial 超个人疗法(精神疗法，瑜伽冥想)在减少乳腺癌幸存者癌症复发恐惧中的有效性:一项随机对照试验

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-08-01 DOI: 10.30699/ijbd.14.2.50

A. Sajadian, K. Zahrakar, E. Asadpour

{"title":"Effectiveness of Transpersonal Therapy (Spiritual Therapy, Yoga-Meditation) in Reducing Fear of Cancer Recurrence in Breast Cancer Survivors: A Randomized Controlled Trial","authors":"A. Sajadian, K. Zahrakar, E. Asadpour","doi":"10.30699/ijbd.14.2.50","DOIUrl":"https://doi.org/10.30699/ijbd.14.2.50","url":null,"abstract":"Introduction: Psycho-spiritual therapy (mind-body spirituality) is a multidimensional, transpersonal, and integrative intervention for breast cancer survivors. This study aimed to determine the effectiveness of counseling based on transpersonal psychotherapy (spirituality therapy, mind and body) in reducing the fear of recurrence in breast cancer survivors. Methods: This was a randomized controlled clinical trial with a pretest-posttest design conducted in Motamed cancer clinic, Tehran. Iran. Thirty breast cancer patients who had finished their treatment were randomly allocated to either an experimental or a control group, 15 patients each. Both groups completed the Persian version Fear of Cancer Recurrence Inventory. Then, the experimental group participated in transpersonal therapy for 14 sessions, a 2-hour session every week. Both groups completed the aforementioned questionnaire again immediately and two months after the intervention. The data were analyzed with an independent t test and the analysis of variance for repeated measures. Results: all components of fear of recurrence, including triggers, severity, psychological distress, coping strategies, functioning impairments, and insight ( P < 0.001), except for reassurance. Conclusion: Based on the findings of the present study, counseling based on transpersonal psychotherapy can reduce the fear of recurrence and stress and increase adaptation and insight in cancer patients. This method increases relaxation, reduces stress, contributing to improved quality of life.","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"253 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129788236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of Serum Cystatin C Levels in Women with Breast Cancer Compared to the Control Group 乳腺癌妇女血清胱抑素C水平与对照组的比较

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-08-01 DOI: 10.30699/ijbd.14.2.16

F. Esmaeili, Vahid Pouresmaeil, Amir Amirabad

{"title":"Assessment of Serum Cystatin C Levels in Women with Breast Cancer Compared to the Control Group","authors":"F. Esmaeili, Vahid Pouresmaeil, Amir Amirabad","doi":"10.30699/ijbd.14.2.16","DOIUrl":"https://doi.org/10.30699/ijbd.14.2.16","url":null,"abstract":"Introduction: Breast cancer is the most common type of cancer in Iranian women, detected in 70% of cases when the disease has reached an advanced stage. The discovery of new diagnostic biomarkers is essential for the early detection of the disease. Cystatin C is a member of the cystatin family and a non-glycosylated, cysteine protease inhibitor that is also used as a functional marker of the kidney. To evaluate the serum cystatin C level in women with breast cancer compared with a control group and to verify this in the pathophysiological data of the patients. Methods: This study was carried out on 88 women (44 patients with breast cancer and 44 healthy controls) referred to Reza radiotherapy and oncology center, Mashhad, Iran, in 2020. After recording demographic information and clinical studies, the serum cystatin C level was measured using an ELISA kit, and the data were analyzed with SPSS version 22. Results: The mean age of healthy controls was 48.48 years and patients 52.32 years. The patients had a mean BMI of 29.52 m 2 /kg, while the mean BMI for the controls was 24.37 m 2 /kg. Our results showed that the mean serum cystatin C level (ng/ml) in breast cancer patients was 0.555±0.413 versus 0.258±0.291 in the control group (P<0.001). Serum cystatin C levels was correlated with cancer stage (P = 0.029), tumor size (P = 0.002), tumor grade (P = 0.001). In the analysis by BMI, serum cystatin C level was significantly higher for both BMI>25 (P < 0.001) and BMI≤25 (P = 0.017) in breast cancer patients compared with the controls. Cystatin C also increases significantly in patients over 50 years (P < 0.001). No significant association was found between serum cystatin C level and lymph node involvement, estrogen receptor, progesterone receptor, or HER2. In the study of the ROC curve, sensitivity was equal to 65.9%, specificity 86.4%, positive predictive value 82.8% and negative predictive value 71.6%. Conclusion: Cystatin C plays an important role in the pathophysiology of breast cancer and can be used as a diagnostic biomarker.","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131926119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participation Rate, Family Histories, Symptoms, and Incidence of Breast Cancer in the Screening Program for Breast Cancer in the Population Covered by Arak Health Centers 阿拉克保健中心所覆盖人口乳腺癌筛查方案的参与率、家族史、症状和乳腺癌发病率

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-08-01 DOI: 10.30699/ijbd.14.2.41

P. Mohaghegh, M. Farahani, A. Moslemi, F. Ahmadi, J. Nazari

{"title":"Participation Rate, Family Histories, Symptoms, and Incidence of Breast Cancer in the Screening Program for Breast Cancer in the Population Covered by Arak Health Centers","authors":"P. Mohaghegh, M. Farahani, A. Moslemi, F. Ahmadi, J. Nazari","doi":"10.30699/ijbd.14.2.41","DOIUrl":"https://doi.org/10.30699/ijbd.14.2.41","url":null,"abstract":"Introduction: Breast cancer is the most common cancer in women. The present study aimed to assess the incidence, family histories, and symptoms of breast cancer among the 30–70-year-old women under the coverage of the health centers of Arak city, as well as evaluating the rate of participation in breast cancer screening. Methods: The present cross-sectional study was conducted during 2016-2019 among all the 30- to 70-year-old women who were under the coverage of health centers in Arak and attended rural, urban, or suburban health centers for breast cancer screening and whose data were recorded in the Sib system. Family histories, signs and symptoms reported, rate of participation in the screening program, and incidence of breast cancer were calculated. Results: The population of women aged 30 to 70 years who were under the coverage of health centers in Arak was 145,743 persons, 56,168 (38.5%) of which participated in the breast cancer screening program. The participation rate was greater in villagers (71.3%) than in the city (33.9%) and the suburb (35.1%). Family history of breast cancer and breast mass were the most frequently reported issues. The mean (SD) age of the breast cancer diagnosis was 49.49 (9.53) years, and breast cancer incidence rates in 2016, 2017, 2018, and 2019 were 7.85, 8.61, 10.26, and 10.70 (per 10,000 people), respectively, which made an increasing trend. Also, the highest incidence was observed in the age group of 46-59 years. Conclusion: The rates of participation in the breast cancer screening program in the city and suburb were low, and the trend of the cancer incidence was increasing. Finally, awareness-raising about breast cancer risk factors and symptoms, as well as regular participation in screening, is considered essential.","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123245128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mental Health and Quality of Life of Breast Cancer Patients During the COVID-19 Pandemic COVID-19大流行期间乳腺癌患者的心理健康和生活质量

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-08-01 DOI: 10.30699/ijbd.14.2.76

F. B. Sheykhangafshe

引用次数: 0

Barriers to Participation of Breast Cancer Patients’ Relatives in Mammographic Screening 乳腺癌患者亲属参与乳腺x线摄影筛查的障碍

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-08-01 DOI: 10.30699/ijbd.14.2.26

Kobra Noori, Parvaneh Sahraee, N. K. Mohammadi

{"title":"Barriers to Participation of Breast Cancer Patients’ Relatives in Mammographic Screening","authors":"Kobra Noori, Parvaneh Sahraee, N. K. Mohammadi","doi":"10.30699/ijbd.14.2.26","DOIUrl":"https://doi.org/10.30699/ijbd.14.2.26","url":null,"abstract":"Introduction: Breast cancer is the most common female cancer in the world and Iran and the leading cause of cancer death among Iranian women. One way to control this cancer is to get screened and diagnosed early. Given that screening in the general population is not possible, early detection of this cancer in high-risk women is one way to control it. Mammography is one way to diagnose breast cancer, but unfortunately, most people do not want to have a mammogram. This is an important issue for women with a family history of breast cancer, which constitutes one of the most high-risk groups for the disease. Therefore, the present study aimed to identify the views of relatives of patients with breast cancer about the reasons for unwillingness to perform mammography. Methods: The present study was a qualitative study performed on 160 first-degree relatives and 118 second-degree relatives of breast cancer patients who were selected by purposive sampling to discover the reasons for not performing mammography. In-depth semi-structured interviews were used to collect data. All data were recorded and handwritten and analyzed using structural methods. Results: In the content analysis of the interviews, 5 themes, 14 main categories, and 73 subcategories were extracted. Preoccupation with daily life matters and lack of knowledge were the most common barriers to participation in screening among 1st-degree relatives, while wrong beliefs and attitudes constituted the most common barriers contributing to the unwillingness to getting mammography screening among 2nd-degree relatives. Conclusion: Relatives of women with breast cancer are neglected despite facing a high probability of developing this cancer. It is suggested that the country’s health system provide comprehensive and effective education for relatives of women with breast cancer to raise awareness and eliminate misconceptions.","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116300622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect of 12 Weeks of Interval and Continuous Training on Serum Levels of Interleukin-17 and Interleukin-10 in Postmenopausal Breast Cancer Survivors: A Clinical Trial 12周间隔和持续训练对绝经后乳腺癌幸存者血清白细胞介素-17和白细胞介素-10水平的影响:一项临床试验

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-08-01 DOI: 10.30699/ijbd.14.2.4

P. Pournemati, Babak Hooshmand Moghadam

{"title":"The Effect of 12 Weeks of Interval and Continuous Training on Serum Levels of Interleukin-17 and Interleukin-10 in Postmenopausal Breast Cancer Survivors: A Clinical Trial","authors":"P. Pournemati, Babak Hooshmand Moghadam","doi":"10.30699/ijbd.14.2.4","DOIUrl":"https://doi.org/10.30699/ijbd.14.2.4","url":null,"abstract":"Introduction: Breast cancer is one of the inflammatory diseases, and physical inactivity is one of the risk factors. It has been suggested that exercise training can improve breast cancer outcomes by modulating inflammation. The aim of this study was to determine the effect of 12 weeks of high-intensity interval training and moderate- intensity continuous training on serum levels of IL-17 and IL-10 in breast cancer survivors. Methods: In this quasi-experimental study, 45 postmenopausal women (age:57.25± 3.91) who after the termination of breast cancer treatments, were randomly divided into three groups of 15 individuals each: (1) a high-intensity interval training (HIIT) group, (2) a moderate-intensity continuous training (MOD) group, and (3) a control group. HIIT and MOD were performed for 12 weeks, three days a week, using a cycle ergometer. Body composition and biochemical indices were evaluated 48 hours before and after the interventions. Data were analyzed using one- way ANOVA and the Tukey post hoc test at a significance level of 0.05. Results: The results showed that 12 weeks of HIIT and MOD significantly decreased IL-17 (P< 0.001 and P= 0.004, respectively) and significantly increased IL-10 (P= 0.005, P= 0.027, respectively). However, a significant difference (P= 0.004) was observed between the training group and the control group only in the levels of IL-17. In addition, no significant difference was observed between the two training groups in IL-17 or IL-10 (P> 0.05). Conclusion: It seems that HIIT and MOD can be incorporated in breast cancer treatment plans as effective strategies for modulating inflammatory and anti-inflammatory factors.","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127072872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Group Counseling Based on Reality Therapy on Women's Self Efficacy in Breast Self-examination: An Educational Intervention 基于现实治疗的团体咨询对女性乳房自检自我效能感的影响:教育干预

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-08-01 DOI: 10.30699/ijbd.14.2.64

R. Mirsafi, Naimeh Akbari Torkestani, Efat Noroozi

{"title":"The Effect of Group Counseling Based on Reality Therapy on Women's Self Efficacy in Breast Self-examination: An Educational Intervention","authors":"R. Mirsafi, Naimeh Akbari Torkestani, Efat Noroozi","doi":"10.30699/ijbd.14.2.64","DOIUrl":"https://doi.org/10.30699/ijbd.14.2.64","url":null,"abstract":"Introduction: The most appropriate and effective method of breast cancer screening is breast self-examination. The aim of this study was to determine the effect of group counseling based on reality therapy on women’s self-efficacy of breast self-examination. Methods: This was an educational trial with a pretest-posttest design that was conducted in Shazand city in 2020. The study sample consisted of 30 women who were recruited from five health centers via available sampling. Participants were randomized into two groups of intervention (14 people) and control (16 people). Both groups completed personal, demographic, and self-efficacy of breast self-examination questionnaires. The intervention group received 8 sessions (two 90-min sessions per week) of group counseling based on reality therapy. One month after the intervention, both groups completed the self-efficacy of breast self-examination questionnaire again, and changes in the mean scores were examined. Results: There was no statistically significant difference between the groups in terms of demographic characteristics such as age, level of education, marital status, menstrual age, age at marriage, and gestational age. The mean score of female self-efficacy of breast self-examination before intervention was 58.9 ± 19.8 in the control group and 58.4 ± 21.2 in the intervention group (no difference). After the intervention, the mean score of female self-efficacy in breast self-examination was 59.9 ± 18.8 in the control group and 85.7 ± 9.7 in the intervention group (P < 0.05). Using analysis of covariance (ANCOVA), the effect size of counseling was calculated at 46%. Conclusion: The results of the study indicate that group counseling based on reality therapy can improve women’s self-efficacy of breast self-examination. Since this approach can be achieved in a shorter time than other types of counseling, the use of this method in important health behaviors such as breast self-examination is recommended.","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132673417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Predicting the Incidence and Trend of Breast Cancer Using Time Series Analysis for 2007-2016 in Qazvin 用时间序列分析预测2007-2016年Qazvin地区乳腺癌发病率及趋势

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-05-10 DOI: 10.30699/ijbd.14.1.11

F. Hajiabadi, H. Bagheri, Nasrin Tonokaboni, M. Zamanian, Z. Hosseinkhani

{"title":"Predicting the Incidence and Trend of Breast Cancer Using Time Series Analysis for 2007-2016 in Qazvin","authors":"F. Hajiabadi, H. Bagheri, Nasrin Tonokaboni, M. Zamanian, Z. Hosseinkhani","doi":"10.30699/ijbd.14.1.11","DOIUrl":"https://doi.org/10.30699/ijbd.14.1.11","url":null,"abstract":"Introduction: Breast cancer is the most common cancer and the second leading cause of death in women worldwide. The aim of this study was to analyze the trend and predict the incidence of breast cancer using time series analysis. Methods: In this study, data on breast cancer incidence in Qazvin province between 2007 and 2016 were analyzed using time series analysis with autoregressive integrated moving average (ARIMA) modeling to forecast the future pattern. The Box-Jenkins time series model and its diagnosis and evaluation methods were used to show the trend and forecasting the next year new cancers. To describe and fit the appropriate models, R statistical software version 3.6.3 was used. Results: Between 2007 and 2016, a total number of 1229 new patients had been registered (monthly mean [SD]: 10.24 [1.03]). Although the overall trend in the raw number of new breast cancer cases has been increasing over time, the change in observations over time has been increasing and decreasing. According to Bartlett test results, the variances of the data were not constant. Also, according to the results of Kolmogorov-Smirnov test, breast cancer series data were not normal. Among the studied models, ARIMA (1, 1, 1) was selected due to lower AIC criteria than other models, and this model was selected as the final model for predicting breast cancer for the next year. The confidence interval of the predicted values was relatively narrow, which indicates the appropriateness of the final model in the prediction. Conclusion: Time series analysis is an efficient tool to model the past and future data on the raw number of new cancer cases, and the goodness-of-fit indicators of the model showed that the Box-Jenkins model is a reliable model for fitting similar data.","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115162043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison of Random Survival Forests for Competing Risks and Regression Models in Determining Mortality Risk Factors in Breast Cancer Patients in Mahdieh Center, Hamedan, Iran 在伊朗哈马丹Mahdieh中心确定乳腺癌患者死亡危险因素的随机生存森林竞争风险和回归模型的比较

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-05-10 DOI: 10.30699/ijbd.14.1.21

Azadeh Yaghoubi, M. Rafiei, Ghodratallah Roshanaei, A. S. Pashaki

{"title":"Comparison of Random Survival Forests for Competing Risks and Regression Models in Determining Mortality Risk Factors in Breast Cancer Patients in Mahdieh Center, Hamedan, Iran","authors":"Azadeh Yaghoubi, M. Rafiei, Ghodratallah Roshanaei, A. S. Pashaki","doi":"10.30699/ijbd.14.1.21","DOIUrl":"https://doi.org/10.30699/ijbd.14.1.21","url":null,"abstract":"Introduction : Breast cancer is one of the most common cancers among women worldwide. Patients with cancer may die due to disease progression or other types of events. These different event types are called competing risks. This study aimed to determine the factors affecting the survival of patients with breast cancer using three different approaches: cause-specific hazards regression, subdistribution hazards regression, and the random survival forest for competing risks. Methods: A historical cohort study was conducted on 527 breast cancer patients diagnosed in Mahdieh Medical Center, Hamadan, between 2004 and 2015. To determine risk factors for death due to cancer progression or other competing risks, cause-specific hazards and substandard hazards models and a random survival forest for competing risk were fitted. Data analysis was performed with R 3.4.3. Results : Findings showed that for death from the progression of breast cancer, age and number of involved lymph nodes were significant in both models (P < 0.05), and in the random survival forest model for death due to cancer progression, tumor size, number of involved lymph nodes, progesterone, estrogen, and family history were the important identified variables. Conclusion : In the presence of competing risks, when the underlying assumptions of cause-specific and subdistribution hazard regression models are not established, the use of random survival forest for competing events data to determine the risk factors affecting survival according to the coordination index and Brier score is more appropriate .","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"21 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130870868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and characterization of liposomal nanoparticles containing hydroalcoholic extract of Artemisia absintium and its toxicity on MCF-7 breast cancer cell line 艾草水醇提取物纳米脂质体的制备、表征及其对MCF-7乳腺癌细胞系的毒性

Iranian Quarterly Journal of Breast Diseases Pub Date : 2021-05-01 DOI: 10.30699/ijbd.14.1.64

Mohammad Taebpour, M. Majdizadeh, B. Haghiralsadat, Medical Nanotechnology

{"title":"Fabrication and characterization of liposomal nanoparticles containing hydroalcoholic extract of Artemisia absintium and its toxicity on MCF-7 breast cancer cell line","authors":"Mohammad Taebpour, M. Majdizadeh, B. Haghiralsadat, Medical Nanotechnology","doi":"10.30699/ijbd.14.1.64","DOIUrl":"https://doi.org/10.30699/ijbd.14.1.64","url":null,"abstract":"Introduction: The use of chemotherapy drugs has side effects, and the use of herbal compounds in the treatment of cancer faces challenges. Nanoparticles, especially liposomes, with appropriate properties in drug delivery, such as slow drug release and low toxicity at the target cell site, can solve some of these problems. Therefore, the aim of the present study was to develop a liposomal system containing Artemisia absinthium extract and to investigate its toxicity against the MCF-7 cell line. Methods: Three liposomal systems containing extracts with different molar percentages of soybean phosphatidylcholine (80% and 60%) along with cholesterol were prepared using the thin-film hydration method. The most suitable formulation was selected according to the loading percentage and release rate. Extract release from the selected formulation, particle size, and zeta potential were investigated. Finally, the toxicity of the extractloaded system, the free extract, and the unloaded system against the MCF-7 cell line was measured. Results: Extract loading, particle size, dispersion index, and zeta potential for the selected formulation are 49.2% ± 0.4%, 121.9 nm, 0.129, and −10.6 mV. The system showed a slow release at temperatures similar to healthy and cancer cells. Also, the liposome-encapsulated extract was more toxic against MCF-7 cells compared with the free extract, and extract-free liposomes had little toxicity against MCF-7 cells. Conclusion: The liposomal system containing Artemisia absinthium extract has a higher toxicity than the free extract against breast cancer cells, which can be due to the physicochemical properties of the system, including targeted release.","PeriodicalId":405995,"journal":{"name":"Iranian Quarterly Journal of Breast Diseases","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133700405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1