ASPET 2023 Annual Meeting Abstract - Toxicology最新文献

{"title":"Beta-Catenin Mediates PKM2’s Role in LPS-induced Renal Injury","authors":"Katelin Hubbard, Mohammed Alquraishi, Samah L. Chahed, Dina S. Alani, Dexter L. Puckett, Presley D Dowker-Key, Yi Zhao, Ji Yeon Kim, L. Nodit, Huma Fatima, Dallas R. Donohoe, B. Voy, Jay N. Whelan, Winyoo Chowanadisai, Ahmed Bettaieb","doi":"10.1124/jpet.122.237500","DOIUrl":"https://doi.org/10.1124/jpet.122.237500","url":null,"abstract":"","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115157131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nrf2-dependent and independent effects of tBHQ on dendritic cell function","authors":"Saamera Awali, Yining Jin, C. Rockwell","doi":"10.1124/jpet.122.138180","DOIUrl":"https://doi.org/10.1124/jpet.122.138180","url":null,"abstract":"","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116907176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocyte Senescence is Initiated through a Klf6-p21 Mechanism which mediates the Production of Cxcl14, a Novel Prognostic Biomarker of Acute Liver Failure","authors":"David S. Umbaugh, Nga T Nguyen, Giselle Sanchez Guerrero, Cecilia E Villanueva, B. Hagenbuch, A. Ramachandran, H. Jaeschke","doi":"10.1124/jpet.122.294240","DOIUrl":"https://doi.org/10.1124/jpet.122.294240","url":null,"abstract":"","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122140631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Immunomodulators as Therapeutic Treatments for Sulfur Mustard-Induced Ocular Injury","authors":"Ki H. Ma, Bailey T. Chalmers, A. Ruff","doi":"10.1124/jpet.122.544580","DOIUrl":"https://doi.org/10.1124/jpet.122.544580","url":null,"abstract":"","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127626226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyrrolizidine alkaloids induced obstructive pulmonary disease more than pulmonary vascular diseases","authors":"Zijing Song, Yisheng He, Ge Lin","doi":"10.1124/jpet.122.539980","DOIUrl":"https://doi.org/10.1124/jpet.122.539980","url":null,"abstract":"","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133811754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eugenol Protects Against Diclofenac-Induced Hepatocellular Injury in an In Vitro Mouse Model","authors":"Jaiden Martin, B. Stamper, Jon Taylor","doi":"10.1124/jpet.122.149070","DOIUrl":"https://doi.org/10.1124/jpet.122.149070","url":null,"abstract":"","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117346024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Electronic Cigarette Exposure Induces Inflammation, Oxidative Stress and Alters Mitochondrial Function in Postnatal Brain","authors":"S. Archie, A. Sifat, David Mara, Yong Zhang, T. Abbruscato","doi":"10.1124/jpet.122.224900","DOIUrl":"https://doi.org/10.1124/jpet.122.224900","url":null,"abstract":"Purpose: Electronic nicotine delivery systems (ENDS), also commonly known as cigarettes (e-Cig) are often considered as a safer alternative to tobacco smoke and therefore have become extremely popular among all age groups and sex. Around 15% of pregnant women are now using e-Cigs in the US which keeps increasing at an alarming rate. Harmful effects of tobacco smoking during pregnancy are well documented for both pregnant and postnatal health, however a lack of preclinical and clinical studies exist to evaluate the long-term effects of prenatal e-Cig exposure on postnatal health. In our previous study, we have observed disruption of blood-brain barrier integrity and deteriorated motor, learning and memory function in prenatally e-Cig exposed offspring. In this study, we have evaluated the consequences of maternal e-Cig use on postnatal neuro-inflammation, oxidative stress, hypoxia and mitochondrial function at different age including evaluation of both male and female offspring. Method: In our study, pregnant CD1 mice (E5) were exposed to e-Cig vapor (2.4% nicotine) till postnatal day (PD) 7. Body and brain weight were measured at PD7, PD23, PD45 and PD90. Immunobead assay was performed to measure the level of pro-inflammatory cytokines at PD7, PD23, PD45 and PD90. The expression level of oxidative phosphorylation or OXPHOS Complex (I, II, III, IV and V), hypoxia inducible factor (HIF-1 a ), antioxidant glutathione (GSH), mitochondrial protein TOM20, Manganese superoxide dismutase (MnSOD), EGRI and NRF2 were analyzed in offspring brain using western blot at PD7 and PD23. Results: Significantly reduced brain to body weight ratio was observed at PD7 in prenatally e-Cig exposed offspring. Significantly increased expression of OXPHOS complexes and HIF-1 a and reduced expression of MnSOD, GSH and NRF2 were observed in prenatally e-Cig exposed offspring compared to control (P < 0.05). However, no difference was observed in expression level of TOM20 and EGR1. Additionally, prenatally e-Cig exposed offspring had higher level of pro-inflammatory cytokines (IL-6, TNF-a ) at PD7, PD45 and PD90 (P < 0.05). Conclusions: Our findings suggest that prenatal e-Cig exposure induces neuroinflammation and oxidative stress on neonatal brain by increasing cytokines level, oxidative stress and disrupting mitochondrial function which may alter fetal brain immune function and mitochondrial activity that make such offspring more vulnerable to brain insults. Currently, we are evaluating mitochondrial activity in primary neuron from prenatally e-Cig exposed offspring. Support: NIH R01DA049737 and R01DA02912.","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125830882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 3,3’-Dichlorobiphenyl (PCB-11) on the expression of CYP2A, 2B, and 2F enzymes in the liver and brain of CYP2A6-humanized, CYP2B6-humanized, or wild-type mice","authors":"Weiguo Han, Weizhu Yang, Xueshu Li, Lehmler Hans-Joachim, Qing-Yu Zhang, P. Lein, Xinxin Ding","doi":"10.1124/jpet.122.283890","DOIUrl":"https://doi.org/10.1124/jpet.122.283890","url":null,"abstract":"","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128365559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common Pathways in Human Proximal Tubular Cells Altered by Exposures to Diverse Environmental Agents and Nephrotoxic Therapeutic Drugs","authors":"L. Lash, P. Mathieu, R. Rosati, P. Stemmer, Xin Hu, Dean P. Jones","doi":"10.1124/jpet.122.150610","DOIUrl":"https://doi.org/10.1124/jpet.122.150610","url":null,"abstract":"Abstract","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114164546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of hepatotoxicity of structurally diverse pyrrolizidine alkaloids in zebrafish model","authors":"Yueyang Pan, Jiang Ma, Ge Lin","doi":"10.1124/jpet.122.536800","DOIUrl":"https://doi.org/10.1124/jpet.122.536800","url":null,"abstract":"Abstract","PeriodicalId":405653,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Toxicology","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114204060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}