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Clinical Management Issues最新文献

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Iatrogenic Hypoglycemia Induced by Valproic Acid in an Adult Patient 成人丙戊酸致医源性低血糖1例
IF 0.3
Clinical Management Issues Pub Date : 2021-04-23 DOI: 10.7175/CMI.V15I1.1487
E. Rota, P. Varese, L. Arena, L. Celli, I. Pappalardo, N. Morelli
{"title":"Iatrogenic Hypoglycemia Induced by Valproic Acid in an Adult Patient","authors":"E. Rota, P. Varese, L. Arena, L. Celli, I. Pappalardo, N. Morelli","doi":"10.7175/CMI.V15I1.1487","DOIUrl":"https://doi.org/10.7175/CMI.V15I1.1487","url":null,"abstract":"Literature on antiepileptic induced iatrogenic hypoglycemia is scanty. Due to its broad spectrum of activity and mechanisms of action, valproic acid (VPA), a fatty acid, is the most widely prescribed epilepsy treatment worldwide. Herein, we describe an adult epileptic patient, where persistent, otherwise unexplained hypoglycemia, was most likely induced by VPA, as suggested by the VPA time course and glucose blood levels. Indeed, no further hypoglycemic episodes occurred after VPA discontinuation and the diagnostic work-up ruled out other possible causes of hypoglycemia. This case supports the hypothesis that VPA may induce hypoglycemia, due to still not well-defined metabolic mechanisms of action. Moreover, it emphasizes the fact that an iatrogenic pathogenesis should be considered if an apparently unexplained hypoglycemia occurs in a patient on chronic therapy with antiepileptics, even at a therapeutical dosage.","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42635065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Familial Gullo’s Syndrome: a clinical case report 家族性古洛氏综合征1例临床报告
IF 0.3
Clinical Management Issues Pub Date : 2021-03-30 DOI: 10.7175/CMI.V15I1.1493
M. Turrin, L. Fornasiero
{"title":"Familial Gullo’s Syndrome: a clinical case report","authors":"M. Turrin, L. Fornasiero","doi":"10.7175/CMI.V15I1.1493","DOIUrl":"https://doi.org/10.7175/CMI.V15I1.1493","url":null,"abstract":"This case report describes a male patient born in 1953 presenting an occasional increase in serum amylase and lipase forty years ago. The monitoring of enzymes was accompanied by radiological investigations, which did not reveal pancreatic pathology. In his family, including 10 siblings, half were carriers of this isolated anomaly; multiple cysts in pancreas, kidneys, and liver were present in some family members, in addition to a pancreatic neoplasia in a sister who did not carry the enzymatic abnormality. Our patient developed colon adenocarcinoma at the age of 67. Here we examine the characteristics of non-pathological chronic pancreatic hyperenzymemia defined as such by the main Italian pioneer Professor Gullo.","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48571833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Risk of Colorectal Cancer in Inflammatory Bowel Disease: Prevention and Monitoring Strategies According With Risk Factors 炎症性肠病的结直肠癌风险:根据危险因素的预防和监测策略
IF 0.3
Clinical Management Issues Pub Date : 2021-02-05 DOI: 10.7175/CMI.V15I1.1464
E. Giuffrida, M. Mangia, A. Lavagna, E. Morello, M. Cosimato, R. Rocca, M. Daperno
{"title":"Risk of Colorectal Cancer in Inflammatory Bowel Disease: Prevention and Monitoring Strategies According With Risk Factors","authors":"E. Giuffrida, M. Mangia, A. Lavagna, E. Morello, M. Cosimato, R. Rocca, M. Daperno","doi":"10.7175/CMI.V15I1.1464","DOIUrl":"https://doi.org/10.7175/CMI.V15I1.1464","url":null,"abstract":"Colorectal cancer (CRC) is slightly increased in inflammatory bowel disease (IBD) patients, with roughly a 2.5-fold increase compared to the general population. Clinical features associated to CRC risks are extent and severity of colonic involvement, disease duration, concomitant primary sclerosing cholangitis (PSC) and/or familial history of CRC in first-degree relatives. Colonic Crohn’s disease (CD) and ulcerative colitis (UC) share similar risks when similar colonic extent is affected. Risk stratification affects outcomes and surveillance programs. Newer endoscopic techniques substantially ameliorated diagnostic performance of endoscopy, and nowadays the standard for CRC surveillance in IBD patients is high-definition endoscopy, with dye-spray or virtual colonoscopy, oriented at targeted (+ random) colonic biopsies. Visible dysplastic lesions should be considered for endoscopic resection, while invisible dysplasia is still a mandatory proctocolectomy indication. Newer endoscopic interventional techniques (endoscopic mucosa resection, EMR, and endoscopic submucosal dissection, ESD) are appropriate therapeutic techniques to be delivered, but long-term risks of cancer should be balanced towards proctocolectomy.","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46237842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Rates, dynamics, and factors of absolute and relative poverty: regional aspect 绝对和相对贫困的比率、动态和因素:区域方面
IF 0.3
Clinical Management Issues Pub Date : 2021-01-01 DOI: 10.22394/2304-3369-2021-3-80-92
E. Pastukhova, A. Mukhachyova, O. Kochneva
{"title":"Rates, dynamics, and factors of absolute and relative poverty: regional aspect","authors":"E. Pastukhova, A. Mukhachyova, O. Kochneva","doi":"10.22394/2304-3369-2021-3-80-92","DOIUrl":"https://doi.org/10.22394/2304-3369-2021-3-80-92","url":null,"abstract":"","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73461752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Classification of the factors of an enterprise innovation ecosystem development 企业创新生态系统发展要素分类
IF 0.3
Clinical Management Issues Pub Date : 2021-01-01 DOI: 10.22394/2304-3369-2021-4-151-165
E. Popov, V. Simonova, I. Chelak
{"title":"Classification of the factors of an enterprise innovation ecosystem development","authors":"E. Popov, V. Simonova, I. Chelak","doi":"10.22394/2304-3369-2021-4-151-165","DOIUrl":"https://doi.org/10.22394/2304-3369-2021-4-151-165","url":null,"abstract":"","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84378845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target management map as an instrument of strategic development of regional economy 目标管理地图作为区域经济战略发展的工具
IF 0.3
Clinical Management Issues Pub Date : 2021-01-01 DOI: 10.22394/2304-3369-2021-5-37-50
I. Ushakov, D. Skopich
{"title":"Target management map as an instrument of strategic development of regional economy","authors":"I. Ushakov, D. Skopich","doi":"10.22394/2304-3369-2021-5-37-50","DOIUrl":"https://doi.org/10.22394/2304-3369-2021-5-37-50","url":null,"abstract":"","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85197915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of university personnel capacity: competitive procedure for a faculty staff 高校人员能力管理:教师队伍的竞争过程
IF 0.3
Clinical Management Issues Pub Date : 2021-01-01 DOI: 10.22394/2304-3369-2021-4-166-178
A. Fedorova, E.B. Vlasova
{"title":"Management of university personnel capacity: competitive procedure for a faculty staff","authors":"A. Fedorova, E.B. Vlasova","doi":"10.22394/2304-3369-2021-4-166-178","DOIUrl":"https://doi.org/10.22394/2304-3369-2021-4-166-178","url":null,"abstract":"","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88352100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Great Depression of 1929–1933: development of approaches to macroeconomic regulation during crisis 1929-1933年的大萧条:危机期间宏观经济调控方法的发展
IF 0.3
Clinical Management Issues Pub Date : 2021-01-01 DOI: 10.22394/2304-3369-2021-3-49-60
E. Sandoyan, A. B. Egiazaryan, M. Voskanyan, A. Galstyan, G. Grigoryan, Grigoryan, Partners Llc
{"title":"The Great Depression of 1929–1933: development of approaches to macroeconomic regulation during crisis","authors":"E. Sandoyan, A. B. Egiazaryan, M. Voskanyan, A. Galstyan, G. Grigoryan, Grigoryan, Partners Llc","doi":"10.22394/2304-3369-2021-3-49-60","DOIUrl":"https://doi.org/10.22394/2304-3369-2021-3-49-60","url":null,"abstract":"","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86666491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ways to improve the balanced scorecard system applied to the evaluation of management effectiveness in small and medium-sized businesses 如何改进平衡计分卡系统在中小企业管理有效性评价中的应用
IF 0.3
Clinical Management Issues Pub Date : 2021-01-01 DOI: 10.22394/2304-3369-2021-4-62-77
A. Mokronosov, E. Zaytseva
{"title":"Ways to improve the balanced scorecard system applied to the evaluation of management effectiveness in small and medium-sized businesses","authors":"A. Mokronosov, E. Zaytseva","doi":"10.22394/2304-3369-2021-4-62-77","DOIUrl":"https://doi.org/10.22394/2304-3369-2021-4-62-77","url":null,"abstract":"","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85797532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of budget constraints in human resources management of organization 预算约束在组织人力资源管理中的作用
IF 0.3
Clinical Management Issues Pub Date : 2021-01-01 DOI: 10.22394/2304-3369-2021-3-135-147
V. Mortikov
{"title":"The role of budget constraints in human resources management of organization","authors":"V. Mortikov","doi":"10.22394/2304-3369-2021-3-135-147","DOIUrl":"https://doi.org/10.22394/2304-3369-2021-3-135-147","url":null,"abstract":"","PeriodicalId":40270,"journal":{"name":"Clinical Management Issues","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86603121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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