The Laryngoscope最新文献

{"title":"Postoperative Disposition Following Pediatric Sistrunk Procedures: A National Database Query.","authors":"Jennifer A Brooks,&nbsp;Michael J Cunningham,&nbsp;Amy L Hughes,&nbsp;Kosuke Kawai,&nbsp;Natasha D Dombrowski,&nbsp;Eelam Adil","doi":"10.1002/lary.29331","DOIUrl":"https://doi.org/10.1002/lary.29331","url":null,"abstract":"<p><strong>Objective/hypothesis: </strong>Variability exists in the postoperative disposition of children following Sistrunk procedures. Management options include discharge home versus overnight observation, with the latter allowing monitoring for immediate postoperative complications, presumably reducing the need for subsequent readmission. This study investigates the association between overnight observation and ambulatory management of children undergoing Sistrunk procedures and relevant postoperative complication and revisit rates to clarify best practice for these patients.</p><p><strong>Methods: </strong>This was a retrospective database review using the Pediatric Health Information System database from 2007 to 2016.</p><p><strong>Results: </strong>The cited dataset identified 6,434 qualifying patients, categorized into ambulatory versus overnight observation cohorts. The overall 30-day revisit rate was 4.9%; the revisit rate with overnight observation (6.1%) was higher than for ambulatory patients (3.8%, adjusted odds ratio (OR) 1.60; 95% confidence interval (CI): 1.21, 2.12). Revisit rates were significantly higher in patients 2 years of age or younger compared to older patients (6.7% vs. 4.3%). The rates of return to the operating room for the observation versus ambulatory groups were 1.8% and 0.5%, respectively. Cervical fluid collection and neck swelling were among the most common revisit indications in both groups, with a mean time to presentation of 9 days.</p><p><strong>Conclusions: </strong>This study demonstrates that ambulatory management following a Sistrunk procedure is not associated with increased rates of common postoperative complications, readmission, or need for secondary surgical intervention. A Sistrunk procedure may be safely performed on an ambulatory basis in select cases.</p><p><strong>Level of evidence: </strong>IV Laryngoscope, 131:E2352-E2355, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"E2352-E2355"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38807512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis.","authors":"Hsiu-Wen Tsai,&nbsp;Ioan Lina,&nbsp;Kevin M Motz,&nbsp;Liam Chung,&nbsp;Dacheng Ding,&nbsp;Michael K Murphy,&nbsp;Michael Feeley,&nbsp;Jennifer H Elisseeff,&nbsp;Alexander T Hillel","doi":"10.1002/lary.29385","DOIUrl":"https://doi.org/10.1002/lary.29385","url":null,"abstract":"<p><strong>Objective/hypothesis: </strong>Glutamine inhibition has been demonstrated an antifibrotic effect in iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts in vitro. We hypothesize that broadly active glutamine antagonist, DON will reduce collagen formation and fibrosis-associated gene expression in iLTS mice.</p><p><strong>Study design: </strong>Prospective controlled animal study.</p><p><strong>Methods: </strong>iLTS in mice were induced by chemomechanical injury of the trachea using a bleomycin-coated wire brush. PBS or DON (1.3 mg/kg) were administered by intraperitoneal injection (i.p.) every other day. Laryngotracheal complexes were harvested at days 7 and 14 after the initiation of DON treatment for the measurement of lamina propria thickness, trichrome stain, immunofluorescence staining of collagen 1, and fibrosis-associated gene expression.</p><p><strong>Results: </strong>The study demonstrated that DON treatment reduced lamina propria thickness (P = .025) and collagen formation in trichrome stain and immunofluorescence staining of collagen 1. In addition, DON decreased fibrosis-associated gene expression in iLTS mice. At day 7, DON inhibited Col1a1 (P < .0001), Col3a1 (P = .0046), Col5a1 (P < .0001), and Tgfβ (P = .023) expression. At day 14, DON reduced Co1a1 (P = .0076) and Tgfβ (P = .023) expression.</p><p><strong>Conclusions: </strong>Broadly active glutamine antagonist, DON, significantly reduces fibrosis in iLTS mice. These results suggest that the concept of glutamine inhibition may be a therapeutic option to reduce fibrosis in the laryngotracheal stenosis.</p><p><strong>Level of evidence: </strong>N/A Laryngoscope, 131:E2125-E2130, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"E2125-E2130"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38812223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Insurance Status and Demographic Factors on Outcomes Following Tracheostomy.","authors":"Rohini Bahethi,&nbsp;Christopher Park,&nbsp;Anthony Yang,&nbsp;Mingyang Gray,&nbsp;Kevin Wong,&nbsp;Alfred Iloreta,&nbsp;Mark Courey","doi":"10.1002/lary.28967","DOIUrl":"https://doi.org/10.1002/lary.28967","url":null,"abstract":"<p><strong>Objectives/hypothesis: </strong>Little data exists regarding the relationship between socioeconomic and demographic factors and tracheostomy outcomes. The goal of this study was to determine associations between socioeconomic status (SES), demographic factors, and insurance status with hospital length of stay (LOS), intensive care unit (ICU) LOS, and mortality following tracheostomy.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>A retrospective analysis of all patients who underwent tracheostomy at an urban tertiary-care academic hospital from 2016 to 2017 was performed. Patients were aggregated into low-, middle-, and high-income brackets. Other variables included age, sex, race, ethnicity, body mass index, and Charlson Comorbidity Index (CCI). Outcomes included hospital and ICU LOS, in-hospital mortality, and 30-day mortality following tracheostomy. Outcomes were compared using Kruskal-Wallis tests for continuous variables and χ² or Fisher exact tests for categorical variables. The α level was set to .05.</p><p><strong>Results: </strong>In total, 523 patients were included in the study. Patients from high-income areas were more likely to be male (P < .01), white (P < .01), and had lower body mass index (P = .04). On multiple regression analysis, Hispanic or Latino ethnicity was associated with an increased odds of 30-day mortality (odds ratio [OR]: 4.43, P = .020). CCI was also associated with increased odds of 30-day mortality (OR: 1.12, P = .039).</p><p><strong>Conclusions: </strong>Lower SES was not associated with increased morbidity or mortality after tracheostomy. Although Hispanic patients tended to have a lower CCI score, they had increased 30-day mortality, suggesting there are factors specific to this population that may influence outcomes, and future targeted studies are warranted to study these relationships.</p><p><strong>Level of evidence: </strong>4 Laryngoscope, 131:1463-1467, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"1463-1467"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.28967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38242689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contralateral Rerouting of Hypoglossal Nerve Implant Pulse Generator and Stimulation Lead.","authors":"Robert J Macielak,&nbsp;Eric J Olson,&nbsp;Mithri R Junna,&nbsp;Michael D Olson","doi":"10.1002/lary.29463","DOIUrl":"https://doi.org/10.1002/lary.29463","url":null,"abstract":"<p><p>As use of hypoglossal nerve stimulators has become more widespread in the treatment of obstructive sleep apnea, certain scenarios have dictated alterations to the previously described surgical technique. This report describes a situation in which revision of a hypoglossal nerve stimulator implant was required given the need for breast cancer surgery. It serves as the first description of the contralateral rerouting of a stimulation lead to a left-sided impulse generator and the first description of respiratory sensing lead placement within the left second intercostal space for such a device. Laryngoscope, 131:E2409-E2412, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"E2409-E2412"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25468987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Excellence in Otolaryngology-Head and Neck Surgery: Examples from the Published Literature.","authors":"Grace E Snow,&nbsp;Patrick Byrne,&nbsp;C Matthew Stewart,&nbsp;David W Eisele,&nbsp;Scott M Wright,&nbsp;Lee M Akst","doi":"10.1002/lary.29511","DOIUrl":"https://doi.org/10.1002/lary.29511","url":null,"abstract":"<p><strong>Objective/hypothesis: </strong>To apply the domains of clinical excellence, as published by the Miller-Coulson Academy of Clinical Excellence, to the field of otolaryngology-head and neck surgery (OHNS) as a framework for evaluating and improving clinical excellence.</p><p><strong>Methods: </strong>A search of PubMed, Scopus, the Cochrane Library, and the National Institute for Health and Care Excellence (NICE) databases was performed and 229 publications were reviewed.</p><p><strong>Results: </strong>Case reports and other articles were selected that exemplify each of the distinct domains of clinical excellence within our specialty.</p><p><strong>Conclusions: </strong>The Miller-Coulson Academy's domains of clinical excellence are relevant to OHNS and can provide a framework for fostering clinical excellence in otolaryngologists. The many examples of excellent care by otolaryngologists found in the published literature can inspire otolaryngologists to provide outstanding care to all patients consistently and to advance our specialty.</p><p><strong>Level of evidence: </strong>N/A Laryngoscope, 131:E2153-E2158, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"E2153-E2158"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29511","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25504564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Patient Demographics and Tracheostomy Timing and Technique on Patient Survival.","authors":"Christopher Park,&nbsp;Rohini Bahethi,&nbsp;Anthony Yang,&nbsp;Mingyang Gray,&nbsp;Kevin Wong,&nbsp;Mark Courey","doi":"10.1002/lary.29000","DOIUrl":"https://doi.org/10.1002/lary.29000","url":null,"abstract":"<p><strong>Objectives: </strong>The ideal timing and technique of tracheostomy vary among patients and may impact outcomes. We aim to examine the association between tracheostomy timing, placement technique, and patient demographics on survival.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>A retrospective review was performed for all patients who underwent tracheostomy in 2016 and 2017 at one urban academic tertiary-care hospital. Kaplan-Meier curves were created based on combinations of tracheostomy timing and technique (early percutaneous, early non-percutaneous, late percutaneous, and late non-percutaneous). Cox proportional hazard models were used to determine multivariable effects of timing, technique, and other demographic factors. Primary outcome measures were tracheostomy-related mortality and overall survival. Secondary outcomes were in-hospital, 30-day, and 90-day mortality.</p><p><strong>Results: </strong>Our study included 523 patients. There were six tracheostomy-related deaths, with hemorrhage and tracheoesophageal fistula being the most common causes. Tracheostomy timing and technique combinations were not associated with differences in all-cause mortality or survival following discharge. Cox proportional hazard models showed that Charlson Comorbidity Index (CCI) and unknown partner status were associated with a decrease in survival (P < .01 and P = .05, respectively). Additionally, patient age, gender, race, CCI, and body mass index were not independently associated with changes in survival.</p><p><strong>Conclusion: </strong>Late and non-percutaneous tracheostomies were associated with more tracheostomy-related deaths, but timing and technique were not associated with differences in patient survival. Multiple regression analysis showed that increased patient comorbidities, measured via CCI, and unknown partner status were independently associated with decreased survival. Proceduralists should discuss timing, technique, and patient social factors together with the medical care team when constructing plans for postdischarge management.</p><p><strong>Level of evidence: </strong>4 Laryngoscope, 131:1468-1473, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"1468-1473"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38437103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon Eustachian Tuboplasty in Pediatric Patients: Is it Safe?","authors":"Anthony Howard,&nbsp;Seilesh Babu,&nbsp;Michael Haupert,&nbsp;Prasad John Thottam","doi":"10.1002/lary.29241","DOIUrl":"https://doi.org/10.1002/lary.29241","url":null,"abstract":"<p><strong>Objectives/hypothesis: </strong>The objective of this study is to demonstrate that balloon eustachian tuboplasty (BET) is safe and had limited complications in the pediatric patient population.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Methods: </strong>This study analyzed the medical records of 43 consecutive encounters of patients under the age of 18 years old who underwent attempted BET. Charts of patients' postoperative appointments and appointments 30 days following the procedure were reviewed. Any complications that were reported by the surgeons' operative report or documented postoperatively were stratified by the Classification of Surgical Complications as outlined by the American College of Surgeons. Additional data points that were analyzed included concomitant surgical procedures, estimated blood loss, and demographic information.</p><p><strong>Results: </strong>A cohort of 43 pediatric patient encounters were investigated. There was a total of two complications from BET (4.7%) and one aborted case. The complications included epistaxis controlled with oxymetazoline and pressure, and vertigo that was later attributed to vestibular migraines. One case was aborted due to inadequate exposure. The average age of patients evaluated was 12.4 ± 3.2 years old with a range of 6.6 to 17.7 years old.</p><p><strong>Conclusions: </strong>In this retrospective cohort, BET was demonstrated to be a relatively safe intervention with an overall complication rate of 4.7% in patients as young as 6.6 years old with recurrent or chronic eustachian tube dysfunction and/or related issues.</p><p><strong>Level of evidence: </strong>4 Laryngoscope, 131:1657-1662, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"1657-1662"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38569417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Involution of Juvenile Nasopharyngeal Angiofibromas: Report of a Case.","authors":"Janice T Chua,&nbsp;Joseph A Choy,&nbsp;Ronald Sahyouni,&nbsp;Jack L Birkenbeuel,&nbsp;Dillon C Cheung,&nbsp;Edward C Kuan,&nbsp;Naveen D Bhandarkar","doi":"10.1002/lary.29246","DOIUrl":"https://doi.org/10.1002/lary.29246","url":null,"abstract":"<p><p>Juvenile nasopharyngeal angiofibroma (JNA) is a locally aggressive tumor that predominantly affects adolescent males. Surgical resection is generally considered the standard treatment for both primary and recurrent tumors, regardless of staging. The natural history of these tumors, particularly when untreated or in the setting of residual tumor, is not well characterized. In this article, we report a case of true spontaneous JNA involution. Although the involution of residual tumor after surgical resection has previously been reported, to our knowledge, this is the first documented case of spontaneous JNA involution following a period of tumor growth post-treatment. Laryngoscope, 131:1455-1457, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"1455-1457"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38587268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pre-operative Multidisciplinary Evaluation on Laryngotracheal Reconstruction Outcomes.","authors":"Aileen Wertz,&nbsp;Matthew Ryan,&nbsp;Ian Jacobs,&nbsp;Joseph Piccione","doi":"10.1002/lary.29338","DOIUrl":"https://doi.org/10.1002/lary.29338","url":null,"abstract":"<p><strong>Objective/hypothesis: </strong>Determine if diagnostic findings from pre-operative multidisciplinary evaluations are associated with single surgery or overall success rates in pediatric laryngotracheal reconstruction (LTR).</p><p><strong>Study design: </strong>Retrospective cohort.</p><p><strong>Methods: </strong>Retrospective cohort study of patients undergoing LTR at a tertiary care children's hospital between January 01, 2008 and December 31, 2017. Success is defined as decannulation rate if tracheostomy present, and resolution of symptoms if tracheostomy not present. Cohorts compared were those who did and did not receive pulmonary and gastrointestinal preoperative testing. Multivariate, logistic regression, and Kaplan Meier analyses performed.</p><p><strong>Results: </strong>About 165 children were included in the study. Median age was 3 years at the time of surgery; 73% of LTRs were double-stage procedures. Single surgery and overall success rates were 75% and 87%, respectively. After adjusting for severity of stenosis and surgical approach, performing esophagogastroduodenoscopy (EGD) and normal gross appearance on EGD were associated with increased single surgery (P = .01, .005) and overall success (P = .005, .0003). Performing pH probe and normal EGD biopsy results was associated with increased overall success (P = .03, .007). Asthma and musculoskeletal comorbidities, postoperative complications, and need for postoperative balloon dilation were associated with decreased success. No other comorbidities evaluated impacted success.</p><p><strong>Conclusions: </strong>Aerodigestive comorbidities are common in children undergoing LTR, and preoperative multidisciplinary workup often results in changes in management. After adjusting for grade and level of stenosis and staged approach, performing EGD and pH/impedance probe as well as normal gross and microscopic EGD findings was independently associated with increased LTR surgical success.</p><p><strong>Level of evidence: </strong>4 (retrospective cohort study) Laryngoscope, 131:E2356-E2362, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"E2356-E2362"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38755591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Outcomes of Juvenile Onset Recurrent Respiratory Papillomatosis with Pulmonary Involvement.","authors":"Qingwen Yang,&nbsp;Yanru Li,&nbsp;Lijing Ma,&nbsp;Yang Xiao,&nbsp;Huijun Wang,&nbsp;Yiming Ding,&nbsp;Rong Hu,&nbsp;Xiaoyi Wang,&nbsp;Lingzhen Meng,&nbsp;Jun Wang,&nbsp;Wen Xu","doi":"10.1002/lary.29376","DOIUrl":"https://doi.org/10.1002/lary.29376","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical characteristics and long-term outcomes of juvenile onset recurrent respiratory papillomatosis (JORRP) with or without pulmonary involvement.</p><p><strong>Methods: </strong>A group of patients with JORRP who had clinical course over an extended period of time (at least 5 years) in the Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital were included in this retrospective study. Lung/bronchus involvement was revealed by lung imaging. Data on mortality rate, frequency of surgical interventions, and age of disease onset were collected and analyzed.</p><p><strong>Results: </strong>The 192 patients (107 male and 85 female) included had a median [quartiles] age of JORRP onset of 2 [1, 4] years, and median follow-up duration of 10 [7, 13] years; 17 patients (8.9%) had papilloma with bronchial and pulmonary involvement 7.0 [4.0, 12.5] years after the onset of the disease. Compared to patients without lung involvement, patients with lung involvement had a younger age of disease onset (P = .001), higher frequency of surgical interventions (P < .001), higher mortality rate (OR = 94.909), and an increased risk of tracheotomy that could not be decannulated (P < .001). They also had a younger age of disease onset, and a higher frequency of surgical interventions and mortality compared to patients with tracheotomy but free from lung involvement (P < .001).</p><p><strong>Conclusions: </strong>Children with JORRP and with pulmonary involvement have a higher average number of operations per year than those without pulmonary involvement, and pulmonary involvement indicates a higher incidence of tracheotomy that cannot be decannulated.</p><p><strong>Level of evidence: </strong>4 Laryngoscope, 131:E2277-E2283, 2021.</p>","PeriodicalId":400976,"journal":{"name":"The Laryngoscope","volume":" ","pages":"EE2277-E2283"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lary.29376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38793612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}