Precision Medical Sciences最新文献_第9页

Rare and novel GNAS gene mutations in Chinese patients with thyroid cancer 中国癌症甲状腺患者罕见新GNAS基因突变

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Precision Medical Sciences Pub Date : 2021-03-09 DOI: 10.1002/prm2.12039

Zhuo Wang, Changwen Jing, H. Cao, Jianzhong Wu, Rong Ma

引用次数: 0

Utilizing circulating free DNA in diagnosing early gastric cancer in a patient with situs inversus totalis: A case report and literature review 应用循环游离DNA诊断一例全倒位早期癌症的病例报告及文献复习

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Precision Medical Sciences Pub Date : 2021-03-03 DOI: 10.1002/prm2.12037

W. Jian, Chen Huanqiu, Yuelian Chao

{"title":"Utilizing circulating free DNA in diagnosing early gastric cancer in a patient with situs inversus totalis: A case report and literature review","authors":"W. Jian, Chen Huanqiu, Yuelian Chao","doi":"10.1002/prm2.12037","DOIUrl":"https://doi.org/10.1002/prm2.12037","url":null,"abstract":"To offer a pilot view on the application of cfDNA in diagnosing early gastric cancer in patient with situs inversus totalis (SIT), accompanied by a literature review. Within this study, we assessed the feasibility of diagnosing early gastric cancer in a SIT patient by detecting cfDNA concentration and mutations. Meanwhile, a search through PubMed using key words of “situs inversus totalis and gastric cancer” covering English studies from 2008 to 2019 was carried out to provide an associated literature review. Of all the 24 publications we reviewed, 25 patients were diagnosed with SIT and GC. The majority of them (23/25) were from the eastern Asia area. More than 40% (11/25) of the patients were diagnosed at advanced tumor stages. In the case of an early staged GC in our center, when both radiographic and endoscopic exams failed to establish an accurate diagnose, we found that not only the concentration of cfDNA was above normal, the frequent genetic mutations for GC were also detected within preoperative cfDNA. The concomitance of SIT and GC is still a rare incident, only limited cases have been reported and were often diagnosed in late cancer stages. By measuring the concentration and mutations of cfDNA, early GC may be detected in SIT patients.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"90 - 95"},"PeriodicalIF":0.5,"publicationDate":"2021-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46499482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision health in Alzheimer disease: Risk assessment‐based strategies 阿尔茨海默病的精准健康：基于风险评估的策略

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Precision Medical Sciences Pub Date : 2021-03-01 DOI: 10.1002/prm2.12036

J. Azar, M. Salama, Saravanabau Chidambaram, Buthaina Al-Balushi, M. Essa, M. Qoronfleh

{"title":"Precision health in Alzheimer disease: Risk assessment‐based strategies","authors":"J. Azar, M. Salama, Saravanabau Chidambaram, Buthaina Al-Balushi, M. Essa, M. Qoronfleh","doi":"10.1002/prm2.12036","DOIUrl":"https://doi.org/10.1002/prm2.12036","url":null,"abstract":"Alzheimer disease (AD) is a chronic neurodegenerative condition that affects an individual's cognitive function over an extended period. Treatment and prevention for AD have long been sought after; however, no strategy has yet been successful, as individuals with cognitive impairment usually present to the clinic when they have reached an advanced stage of the disease. The disease is progressive and multifactorial in its pathogenesis. Precision medicine (PM) is the new era of medicine comprising a holistic approach in dealing with diseases. With scientific innovations, PM has improved our disease knowledge, altered diagnoses and therapy approaches resulting in a more precise, predictive, preventative and personalized patient care. PM in AD focuses, among other things, on stratifying individuals according to their risk factors of developing the disease and applying preventative strategies and personalized treatment approaches for a better outcome. In this mini‐review, we have focused on a few modifiable and non‐modifiable risk factors and presented recommendations for future consideration to implement.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"54 - 70"},"PeriodicalIF":0.5,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45575907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Guidewire‐guided electrocardiogram for positioning the catheter tip of upper arm port in breast cancer patients 导丝引导心电图在乳腺癌患者上臂端口导管尖端定位中的应用

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Precision Medical Sciences Pub Date : 2021-03-01 DOI: 10.1002/prm2.12029

L. Gu, Liyong Xu, Aifeng Meng, Ruchun Shi, D. Jiang, Chunli Liu, Jing Mao

{"title":"Guidewire‐guided electrocardiogram for positioning the catheter tip of upper arm port in breast cancer patients","authors":"L. Gu, Liyong Xu, Aifeng Meng, Ruchun Shi, D. Jiang, Chunli Liu, Jing Mao","doi":"10.1002/prm2.12029","DOIUrl":"https://doi.org/10.1002/prm2.12029","url":null,"abstract":"Intracavitary electrocardiogram (ECG) is a reliable and safe method for real‐time, confirming the tip of central venous access devices. Saline and guidewire are the most commonly used as an intracavitary electrode for introducing ECGs. However, little information about the ECG technique using for the catheter tip of arm port. We aimed to explore the effects of guidewire‐guided ECG approach for locating the catheter tip of the upper arm port in breast cancer patients. We performed a prospective single‐center study, 36 patients with breast cancer were enrolled. Thirty‐six upper arm ports were implanted using a guidewire guided ECG approach, to evaluate the accuracy of the catheter tip position, the operation time, and the stability of the ECG waveform. The ECG‐based tip location was compared with post‐procedural tip location by chest X‐ray. We found that all the upper arm ports implantation were successful in this study. The tip was located at the lower 1/3 superior vena cava or cava‐atrial junction in 35 cases and the upper right atrium in one case. The average operation time of the ECG was 269.25 ± 52.79 second, (range: 190‐345 seconds). The correct rate of the catheter tip position was 97.22%. All the ECG waveform was stable and easy to read. In conclusion, the guidewire‐guided ECG technique is valid and accurate for locating the upper arm port catheter tip; it is also convenient.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"15 - 20"},"PeriodicalIF":0.5,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42320158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged survival in advanced squamous cell lung carcinoma by rational and standardized treatment: A case report of long‐term survival in a patient with NSCLC 通过合理和规范的治疗延长晚期鳞状细胞肺癌的生存期:一例NSCLC患者的长期生存报告

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Precision Medical Sciences Pub Date : 2021-02-23 DOI: 10.1002/prm2.12035

Min Ji, Yue Shi, Renrui Zou, Yingying Jiang, Li Wang, Rong Ma, Xiuming Zhang, Xiang-zhi Zhu, Cheng Chen, M. Shi, Xiaohua Wang, Jifeng Feng

引用次数: 1

Prognostic factors for mortality in patients with congenital duodenal obstruction at DR. Moewardi Hospital Surakarta 苏拉卡塔Moewardi医院先天性十二指肠梗阻患者死亡率的预后因素

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Precision Medical Sciences Pub Date : 2021-02-23 DOI: 10.1002/prm2.12034

Estiarla, N. Agustriani

引用次数: 0

CT‐guided liver beacon transponder implantation CT引导下肝脏信标应答器植入

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Precision Medical Sciences Pub Date : 2021-02-18 DOI: 10.1002/prm2.12033

Yufeng Zhang, Xia He, Wen-jie Guo, Li Sun, Chang Guo, Yong Feng

引用次数: 0

Role of ATP5B in colorectal cancer ATP5B在结直肠癌中的作用

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Precision Medical Sciences Pub Date : 2021-01-01 DOI: 10.1002/prm2.12030

Yue Zhu, Wei Wei, Yuan-Mao Zhang, Jianzhong Wu, Rong Ma, Jifeng Feng

引用次数: 0

MicroRNA signatures as predictive biomarkers in transarterial chemoembolization‐treated hepatocellular carcinoma MicroRNA标记作为经动脉化疗栓塞治疗肝细胞癌的预测性生物标志物

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Precision Medical Sciences Pub Date : 2021-01-01 DOI: 10.1002/prm2.12031

M. Fawzy, E. Toraih

{"title":"MicroRNA signatures as predictive biomarkers in transarterial chemoembolization‐treated hepatocellular carcinoma","authors":"M. Fawzy, E. Toraih","doi":"10.1002/prm2.12031","DOIUrl":"https://doi.org/10.1002/prm2.12031","url":null,"abstract":"Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide. Unfortunately, many patients are diagnosed at a late stage with a delay in the optimal timing for tumor resection. Transarterial chemoembolization (TACE) is currently considered the standard of care for patients with unresectable HCC Barcelona system class B classification. However, the treatment response of HCC patients to TACE varies widely, and there is no reliable marker for predicting a patient's response to TACE. Thus, the identification of patients who are sensitive or resistant to TACE is important for individualized therapy. Recently, our understanding of cancer cell biology has progressed enormously. Much of this progress has been driven by technological advances enabling previously unachievable studies to be performed and yield a constantly evolving picture of the regulatory role of noncoding RNAs (ncRNAs) in tumor biology. MicroRNAs (miRNAs) are a class of ncRNA molecules that regulate nearly one‐third of all protein‐coding RNAs. The existing literature indicates that the deregulation of miRNAs can contribute to tumorigenesis and metastasis in multiple cancers, including HCC, via the control of cell proliferation, apoptosis, invasion, or metastasis. Analysis and evaluation of this type of regulatory RNA could shed new light on the behavior of many cancers and provide new diagnostic and prognostic biomarkers as well as pharmacological targets for novel treatment strategies. To this end, this review highlights the expression and functional roles of miRNAs in TACE‐treated HCC and explores the potential applications of miRNAs as diagnostic markers and therapeutic targets.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"10 1","pages":"14 - 4"},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51249154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Green approach for fabrication of chitosan‐neem gum polyelectrolyte stabilized penta and hexagonal nanoparticles and in‐vitro cytotoxic potential toward breast cancer (MCF‐7) cells 壳聚糖-楝树胶聚电解质稳定的五边形和六边形纳米颗粒的绿色制备方法及其对乳腺癌(MCF - 7)细胞的体外细胞毒性潜力

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Precision Medical Sciences Pub Date : 2020-11-01 DOI: 10.1002/prm2.12025

R. Malviya

{"title":"Green approach for fabrication of chitosan‐neem gum polyelectrolyte stabilized penta and hexagonal nanoparticles and in‐vitro cytotoxic potential toward breast cancer (MCF‐7) cells","authors":"R. Malviya","doi":"10.1002/prm2.12025","DOIUrl":"https://doi.org/10.1002/prm2.12025","url":null,"abstract":"The present investigation aimed to utilize chitosan‐neem gum polysaccharide (Ch‐NGP) polyelectrolyte complex for the fabrication of hexagonal and pentagonal nanoparticles using antisolvent precipitation method. Fabricated nanoparticles were found in the range of 63.1 to 447.2 nm with the entrapment efficiency of 76.80 ± 1.28 to 89.82 ± 2.32%. A nonlinear correlation between the independent variable and response was observed after the regression coefficient based linearity analysis. Drug release was carried out using the egg membrane and tomato membrane as a biological barrier. All the formulations show peculiar release pattern viz. initial immediate release, followed by sustained release and final burst release of the drug. Similarity factor analysis easily showed a significant difference in drug release patterns when the egg membrane and tomato membrane were utilized as biological barriers (S˂50). Anticancerous effect against breast cancer cells line (MCF‐7) shows better control over cell growth when etoricoxib loaded nanoparticles were used in place of pure etoricoxib. Particle size growth analysis elicits that significantly no “Ostwald ripening” was observed after 45 days. It can be concluded from the findings of the experiments that Ch‐NGP polyelectrolyte functionalized hexagonal and pentagonal nanoparticles can be utilized for passive targeting of tumor cells due to its unique properties.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"9 1","pages":"68 - 82"},"PeriodicalIF":0.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/prm2.12025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44531562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3