Precision Medical Sciences最新文献

{"title":"Correlation between serum triglyceride to HDL cholesterol ratio and blood pressure in patients with primary hypertension","authors":"O. Kurtkulagi, G. Aktas, T. Taslamacioglu Duman, S. Bilgin, B. A. Atak Tel, G. Kahveci","doi":"10.1002/prm2.12080","DOIUrl":"https://doi.org/10.1002/prm2.12080","url":null,"abstract":"Hypertension (HT) is associated with significant morbidity and mortality. The efficacy of the treatment in HT patients is mostly depending on the office or home blood pressure monitoring. Triglyceride to high density lipoprotein (HDL) cholesterol ratio (THR) is an inflammatory and metabolic predictor. We aimed to compare THR levels of the HT patients with poorly controlled blood pressure levels to those with well‐controlled hypertensive subjects. In present cross sectional study, we grouped patients with HT either as well or poorly controlled hypertensive subjects according to the blood pressure measurement. THR of the groups compared. The THR of the poorly controlled HT group (3.9 [1.91–88.7]%) was significantly higher than the THR of the well‐controlled HT group (3.07 [0.71–35.8]%), (p < .001). The sensitivity and specificity of THR higher than 3.26% in predicting poor blood pressure control were 72% and 52%, respectively (AUC: 0.64, p <.01, %95 CI: %59–70). High THR levels in HT patients may warrant closer monitorization of blood pressure since it may predict poor blood pressure control in this population.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"100 - 105"},"PeriodicalIF":0.5,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44910117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of magnetic resonance ultrasmall magnetic Fe3O4 nano bimodal contrast agent in rabbit orthotopic liver tumors","authors":"Wang Yuhuang, Ball Chen, Feng Guodong, Zhang Xiuming, Shi Dan, Zhang Yu, Liu Nianlong","doi":"10.1002/prm2.12078","DOIUrl":"https://doi.org/10.1002/prm2.12078","url":null,"abstract":"To investigate the diagnostic value of ultra‐small superparamagnetic Fe3O4 nanoparticles as dual modal contrast agent in rabbit orthotopic liver tumor. Twenty‐four New Zealand rabbits with orthotopic liver tumor were randomly divided into experimental group and control group. The experimental group contained 12 rabbits which intravenously injected with Fe3O4 nanoparticles and the control group contained 12 rabbits which intravenously injected with Gd‐DTPA. After injection, the cross‐sectional T1 and T2‐weighted scan images of experimental group and cross‐sectional T1‐weighted scan images of control group were obtained at the different timepoints (including 0, 5, 15, 20, 30, 45, 60, 75, 90, 120, 180, and 240 min) with a clinical 3.0 T MRI scanner. The SNR value of the tumor site and the normal liver site at different time points were calculated, respectively, and then the signal change value (CNR) of the tumor relative to the normal liver tissue was obtained. The r1 value of Fe3O4 nanoparticles was significantly higher than Gd‐DTPA (6.97 mM−1 s−1 for Fe3O4 nanoparticles and 4.75 mM−1 s−1 for Gd‐DTPA and only Fe3O4 nanoparticles exhibited the r2 relaxation rate which was 22.53 mM−1 s−1). In addition, the r2/r1 ratio of Fe3O4 was 3.23 which also demonstrated the strong MR relaxation characteristics of Fe3O4 nanoparticles. Compare with clinical used MRI contrast agent (Gd‐DTPA), the ultra‐small magnetic Fe3O4 nanoparticles not only showed the better T1 contrast enhancement but also exhibited the T1/T2 dual‐modal enhanced contrast ability, which could improve the accuracy and sensitivity of MRI diagnosis and realize the early diagnosis of diseases in prospect.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"130 - 135"},"PeriodicalIF":0.5,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44717494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mother's iliac bone graft for severe collapsed lumbar tuberculosis: A case report","authors":"Yonggang You, Suli Chen, Zhanqing Li, Yuanwen Zhang, Wen-feng Qiu","doi":"10.1002/prm2.12076","DOIUrl":"https://doi.org/10.1002/prm2.12076","url":null,"abstract":"Early diagnosis of spinal tuberculosis in young children is difficult due to atypical clinical features. We report a case of lumbar tuberculosis with abscess of the psoas major muscle in a 4‐year‐old child. Spinal reconstruction was challenging due to the involvement of multiple vertebral levels. The child complained of lumbar and back pain. Preoperative magnetic resonance imaging (MRI) revealed bone destruction of the L1–L3 vertebral body and abscess formation of the psoas major muscle. The child underwent excision of the vertebral lesions and a fresh iliac bone graft from his mother through an anterior approach and posterior fixation with T12–L1 and L4–L5 pedicle screws. At the 15‐month follow‐up, the patient had good clinico‐radiologic outcomes with evidence of bony fusion. No functional impairment of lumbar movements was found through physical examination during the follow‐up period. The report highlights the diagnostic dilemma of early childhood spinal tuberculosis due to lesions seen both on radiology and during surgery and discusses challenges in management of the disease and the relevant literature. The mother's iliac bone graft we describe can be a viable option in very young children with severe vertebral bone destruction requiring reconstruction by surgical procedure.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"111 - 116"},"PeriodicalIF":0.5,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47941917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence rate, basic characteristics, and survival outcomes of bladder squamous cell carcinoma","authors":"Feng Qi, Wenbo Xu, Xiao Li, Ting Xu, Qing Zou, Zicheng Xu","doi":"10.1002/prm2.12079","DOIUrl":"https://doi.org/10.1002/prm2.12079","url":null,"abstract":"To explore the incidence rate (IR), clinicopathological characteristics, and prognostic factors of bladder squamous cell carcinoma (BSCC) based on surveillance, epidemiology, and end results (SEER) database. We extracted the IRs of BSCC from 1975 to 2016 in the SEER database, and plotted the trending curves. Then, the clinicopathological characteristics of BSCC patients diagnosed from 2010 to 2015 were selected and compared with those of patients with urothelial carcinoma (UC) in the same period. Furthermore, differences in overall survival (OS) and cancer‐specific survival (CSS) of BSCC and UC patients were compared. Finally, COX regression models were constructed to explore the risk factors affecting OS and CSS in BSCC patients. The IR of BSCC showed a downward trend from 1975 to 2000 and stabilized at about 0.3/100 000 after 2000. BSCC patients had a later stage at diagnosis and worse prognosis when compared with those with UC. Older age, higher TNM stage, no surgical treatment, and unmarried status were significantly related to worse prognosis of BSCC patients. This study explored the IR trends, clinicopathological characteristics, and prognostic factors of BSCC. In the future, prospective, large sample, and well‐designed clinical studies are needed to verify our results.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"136 - 142"},"PeriodicalIF":0.5,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46385512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of dermatitis during radiation for vulvar carcinoma","authors":"Xue Teng, Xian Zhang, Xiaoxu Zhi, Yan Chen, D. Xu, Aifeng Meng, Yinghong Zhu","doi":"10.1002/prm2.12077","DOIUrl":"https://doi.org/10.1002/prm2.12077","url":null,"abstract":"Radiodermatitis, inflammatory lesions of skin and mucosa caused by radiation, is a common adverse effect during the radiation therapy of vulvar carcinoma. The incidence of radiodermatitis is affected by various factors, and the purpose of this study was to investigate the risk factors of radiodermatitis in patients with vulvar carcinoma. Patients with vulvar tumors who received radiotherapy from January 2015 to December 2020 were included in this retrospective study. Radiodermatitis was graded according to the grading criteria of the American Center for Radiological Oncology, and then univariate analysis and logistic multivariate regression analysis were used to determine the risk factors of radiodermatitis. A total of 60 eligible patients were enrolled, including 3 (5%), 25 (41.7%), 28 (46.7%), and 4 (6.6%) patients with grade 0, 1, 2, and 3 radiodermatitis, respectively. Univariate analysis showed that the incidence of radiodermatitis was significantly correlated with age, therapeutic strategy, pathological stage and radiotherapy dose (p < .05). Multivariate regression analysis indicated that age, therapeutic strategy and radiotherapy dose were independent risk factors for radiodermatitis (p < .05). In the current study, we identified the independent risk factors for radiodermatitis in patients with vulvar carcinoma were age, therapeutic strategy and radiotherapy dose, which might be conducive to identify high‐risk patients, so as to adjust their treatment plan in time and reduce the risk of radiation‐induced skin toxicity.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"106 - 110"},"PeriodicalIF":0.5,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49357855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of immediate breast reconstruction using latissimus dorsi muscular flap in breast cancer","authors":"Jian Li, Rong Deng, Da-wei Sun, J. Gong, Q. Yu, Qing Hu","doi":"10.1002/prm2.12069","DOIUrl":"https://doi.org/10.1002/prm2.12069","url":null,"abstract":"The aim of this study is to explore the clinical efficacy of immediate breast reconstruction (IBR) using the latissimus dorsi muscular flap in Chinese breast cancer patients. The clinical data of 17 breast cancer patients who underwent IBR using the latissimus dorsi muscular flap between August 2013 and September 2021 at Affiliated Cancer Hospital of Nanjing Medical University were analyzed retrospectively. Harris scoring standard was used to evaluate the cosmetic effect. All the 17 cases were successfully treated. The median age was 43 years old (age range: 32–54 years old). In the clinical staging, the patients were mainly early and mid‐stage patients, with two cases in stage 0, 12 cases in stage II, and three cases in stage III. Postoperative pathology was predominantly invasive breast cancer (15/17), and two cases were carcinoma in situ. The median operation time was 300 min (range: 180–450 min) and only two patients developed complications. After 2–97 months of follow‐up, no patients had recurrence or metastasis. According to the Harris method, 9, 6, 2, and 0 cases were evaluated as “excellent”, “good”, “fair,” and “poor” respectively. The practical application of IBR using the latissimus dorsi muscular flap is a safe and feasible way to improve physical and mental health in breast cancer patients.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"117 - 121"},"PeriodicalIF":0.5,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45170771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of preoperative walking on bowel function recovery for patients undergoing gynecological malignancy laparoscopy","authors":"Xiao P Xia, Guirong Ding, Lingyun Shi, Meixiang Wang, Jing Tian","doi":"10.1002/prm2.12071","DOIUrl":"https://doi.org/10.1002/prm2.12071","url":null,"abstract":"To investigate effects of preoperative walking on bowel function recovery for patients after gynecological malignancy laparoscopy. The 156 patients with gynecoligical cancers after laparoscopy in Jiangsu from June 2020 to September 2021 were selected as research subjects, who were randomized into an experimental group (n = 78) and a control group (n = 78). Both of the groups received routine nursing care during the study. In addition, the experimental group underwent low‐moderate intensity walking exercise 1 week before surgery. The bowel function (including the time of first defecation, the time of first passage of flatus/”gas‐out time” and the recovery time of bowel sound), adverse events (nausea, vomiting abdominal distension and abdominal pain), as well as postoperative complications (ileus symptoms, deep venous thrombosis, infections and etc.), were measured daily. The time of first defecation, the time of first passage of flatus and the recovery time of bowel sound in experimental group were less than the control group after treatment (p < .05). Repeated measures analysis of variance showed that the adverse reactions (nausea, vomiting, abdominal distension, abdominal pain, and ileus symptoms) of the experimental group were weaker than those of the control group at different time points after the intervention (p < .05). Walking before surgery can effectively promote the recovery of bowel function and reduce the adverse reactions, as well as the risk of ileus related to gynecological malignancy laparoscopy.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"122 - 129"},"PeriodicalIF":0.5,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42652393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of full‐field digital mammography versus digital breast","authors":"Mengru Wang, Shan Zhuang, Liuli Sheng, Yu Nian Zhao, W. Shen","doi":"10.1002/prm2.12068","DOIUrl":"https://doi.org/10.1002/prm2.12068","url":null,"abstract":"Studies have shown that the combination of digital breast tomosynthesis (DBT) and digital mammography (DM) can improve the display of malignant tumors, reduce false positive results, and make up for the major deficiencies of traditional DM. In addition, the recall rate of patients with combined DBT was significantly reduced, especially those under 50 years of age and those with dense breast glands. The objective of this study is to compare the difference of DM and DM+ DBT in the diagnosis of benign and malignant tumors in different subgroups. A retrospective analysis was performed on 578 pathologically confirmed breast diseases in Jiangsu Cancer Hospital from January 2019 to December 2021. All were female, aged 23–85, with an average age of 53. Their DM and DBT images will be reviewed in an independent blind manner by an experienced radiologist. The doctor was unable to obtain the results of previous tests. The sensitivity and specificity of population samples and different subgroups were calculated. Overall sensitivity was 65% for DM, 93% for DM+ DBT. The addition of DBT significantly increased the tumor detection rate (odds ratio, 7.05; 95% confidence interval: 4.78, 10.4; p = .00), the difference was statistically significant. For patients <50 years of age, the sensitivity of DM+ DBT (94%) was significantly higher than that of DM (54%), and for patients with breast density of 50% or more, the sensitivity of DM and DM+ DBT were 59% and 92% (p < .001). The sensitivity of DM+ DBT (92%) was significantly higher than that of DM alone (39%) in patients whose primary imaging feature was non‐mass (p < 0.001). Specificity was 77% for DM and 87% for DM+ DBT. The addition of DBT improved the specificity of DM in patients with high‐density breast and the sensitivity of DM to all subgroups. DBT has potential benefits for diagnosing of benign and malignant tumors, especially for young women with dense breasts.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"56 - 61"},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48995868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare presentations of hydatid cyst disease","authors":"G. Aktas","doi":"10.1002/prm2.12072","DOIUrl":"https://doi.org/10.1002/prm2.12072","url":null,"abstract":"To the Editor, I read the latest case report of Wei et al with great interest which published in your journal in June, 2022. Authors reported an interesting hydatid cyst case which mimicked malignant cancer. Interestingly, hydatid cyst really mimics other clinical conditions. I would like to present other unusual and rare presentations of the hydatid cyst disease along with a short expression of general information about the infection. Hydatid cyst disease is caused by Echinococcus granulosus infection and usually present with cysts in internal organs. Most of the cysts appear in liver and lung in hydatid cyst disease. However, cysts can be seen in other organs, such as spleen and heart. After accidentally ingestion of parasite, acidity of upper gastrointestinal tract cause opening of Echinococcus granulosus eggs. Released larvae of the parasite penetrate the bowel wall and pass into portal circulation. When they cross out portal filter, every organ could be potentially reached by the parasite. Parasitic infection may cause hydatid cysts in liver, lungs, spleen, and other rare localizations. Hydatid cyst disease is commonly asymptomatic. It may be diagnosed incidentally on imaging studies. It may present with symptoms caused by an enlarging or superinfected cyst. Otherwise, signs and symptoms of hydatic cyst disease are usually nonspecific and generally based on the localization of the cysts. Signs and symptoms include but not limited to abdominal pain, chest pain, biliary obstruction, cholangitis, portal hypertension, cirrhosis, bronchial obstruction, and abscesses. Uncommon clinical presentations may also be seen in infected patients. For instance, large hepatic cyst which compresses renal artery may cause secondary hypertension. The disease may also present with pulmonary hypertension, infective endocarditis, and abdominal compartment syndrome. Rarely, presentation with anaphylactic shock due to the rupture of the cysts may occur. In another case report authors stated that a hydatid cyst with 12 1.5 cm dimensions was revealed in bladder neck which caused pollakiuria symptom in the patient. In another interesting case, authors reported pancreatic hydatid cyst in a patient presented with abdominal pain and jaundice. Therefore, the disease can mimic a number of clinical conditions. In Wei et al's study, the disease mimicked renal cell carcinoma. Indeed, alike with cancers, hydatid cyst is also associated increased inflammatory burden. In conclusion, hydatid cyst due to Echinococcus granulosus infection may present with a wide range of signs and symptoms. Physicians should have high degree of suspicion in sake of early diagnosis of the disease.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44762368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of adverse drug reactions of Osimertinib in the 2nd‐line treatment of EGFR mutant advanced nonsmall cell lung cancer","authors":"Yingying Jiang, Yue Shi, Zihan Wang, Hang-Yu Li, Zhitong Wang, Kang He, Yuxin Ma, Jingjing Xue, Yumeng Shi, Jianwei Lu, M. Shi, B. Shen, Guoren Zhou, Xiaohua Wang, Cheng Chen, Jifeng Feng","doi":"10.1002/prm2.12075","DOIUrl":"https://doi.org/10.1002/prm2.12075","url":null,"abstract":"The aim was to analyze the clinical characteristics of adverse drug reactions (ADRs) induced by Osimertinib and their effects on the prognosis, so as to further provide reference for clinical medication. This was a retrospective study, and 66 nonsmall cell lung cancer (NSCLC) patients who had ADR in the 2nd‐line treatment with Osimertinib from January 2017 to December 2018 were included. Clinical characteristics and survival in subgroups of Osimertinib‐related ADRs were analyzed. The majority of patients who developed ADRs after the 2nd‐line treatment of Osimertinib were mainly middle‐aged and elderly women. Osimertinib‐related ADRs were mainly found in the skin, respiratory and digestive systems. The most common ADRs were rash (69.70%), diarrhea (66.67%), stomatitis (54.55%), and fatigue (51.52%). The degree of Osimertinib‐related ADRs was tolerable. Only seven patients experienced grade 3 ADRs, all of which involved the skin system. Exactly 92.42% of patients had more than two adverse reactions. The median PFS was influenced by the type, quantity, and severity of Osimertinib‐related ADRs. Osimertinib‐related ADRs are closely related to the prognosis of patients so that more attention should be paid to monitoring the occurrence of ADRs in clinical use of Osimertinib, especially ADRs in the skin, respiratory system and digestive system.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"69 - 81"},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45868204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}