Malaysian Family Physician最新文献_第8页

Glycogenic hepatopathy - An underrecognised cause of transaminitis in primary care settings: A case report. 糖原性肝病-初级保健机构中未被充分认识的转氨炎病因：一个病例报告。

Malaysian Family Physician Pub Date : 2025-08-27 eCollection Date: 2025-01-01 DOI: 10.51866/cr.926

Zainul Abidin Nordiyana, Ying Ying Ng, Zakaria Rosnani, Samsuddin Noor Aellmas

{"title":"Glycogenic hepatopathy - An underrecognised cause of transaminitis in primary care settings: A case report.","authors":"Zainul Abidin Nordiyana, Ying Ying Ng, Zakaria Rosnani, Samsuddin Noor Aellmas","doi":"10.51866/cr.926","DOIUrl":"10.51866/cr.926","url":null,"abstract":"Glycogenic hepatopathy (GH) is a rare but reversible hepatic condition associated with poorly controlled type 1 diabetes mellitus (T1DM). It results from excessive glycogen accumulation in hepatocytes, leading to hepatomegaly and elevated liver enzyme levels. We report the case of a 28-year-old man with T1DM who presented to a primary care clinic with persistent transaminitis despite discontinuation of potential hepatotoxic agents. Extensive investigations were conducted to exclude common liver pathologies, all of which returned negative. His condition improved following the intensification of insulin therapy and improvement of glycaemic control. This case underscores the role of family physicians in recognising GH as a differential diagnosis in patients with diabetes mellitus with unexplained liver enzyme abnormalities. It also highlights the importance of timely interventions to prevent unnecessary invasive investigations. Early recognition and appropriate glycaemic management in primary care can reverse the condition and minimise the need for extensive testing.","PeriodicalId":40017,"journal":{"name":"Malaysian Family Physician","volume":"20 ","pages":"57"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case scenario: Management of sexually transmitted infections in primary care based on the fifth edition of the Malaysian guidelines. 案例情景：基于马来西亚指南第五版的初级保健性传播感染管理。

Malaysian Family Physician Pub Date : 2025-08-23 eCollection Date: 2025-01-01 DOI: 10.51866/cpg.916

Zainal Fitri Zakaria, Rupinder Kaur

引用次数: 0

Prognosis of patients with coronavirus disease with or without anosmia: A systematic review. 冠状病毒病伴或不伴嗅觉丧失患者的预后：一项系统综述

Malaysian Family Physician Pub Date : 2025-08-16 eCollection Date: 2025-01-01 DOI: 10.51866/rv.672

Nabeel Ibraheem Jaafar Albazah, Jie Sin Tiong, Muruganand Yoshana, Azma Aishath, Yu Tzong Yeo, Sherreen Elhariri

{"title":"Prognosis of patients with coronavirus disease with or without anosmia: A systematic review.","authors":"Nabeel Ibraheem Jaafar Albazah, Jie Sin Tiong, Muruganand Yoshana, Azma Aishath, Yu Tzong Yeo, Sherreen Elhariri","doi":"10.51866/rv.672","DOIUrl":"10.51866/rv.672","url":null,"abstract":"Introduction: According to numerous research, anosmia has been reported more frequently as one of coronavirus disease (COVID-19) symptoms. However, whether anosmia is a relevant prognostic factor of COVID-19 outcomes is still unknown. A systematic review and meta-analysis were conducted to evaluate the relationship between anosmia and COVID-19 prognosis.Methods: PubMed, PubMed Central, Google Scholar and the WHO COVID-19 Research Database were scanned for published literature from September 2021 to December 2022 about the prognosis of patients positive for COVID-19 with anosmia. 'COVID-19' and 'prognosis' were among the search terms used. Pooled estimates of odds ratios (ORs) were then calculated by comparing patients with and without anosmia in terms of intensive care unit (ICU) admission and death.Results: A total of 16 full-text articles were included in this systematic review. There were a total of 40 deaths among the patients with olfactory dysfunction and 1681 deaths among those without olfactory dysfunction, with an OR of 0.19 (95% confidence interval: 0.10, 0.34; P<0.0001), indicating that the patients with COVID-19 with olfactory dysfunction had a decreased mortality rate.Conclusion: The good prognosis of patients with COVID-19 with anosmia is demonstrated in our study by the low mortality rate in those with anosmia. However, there is no association between the prognosis and ICU admission among patients with COVID-19 with anosmia.","PeriodicalId":40017,"journal":{"name":"Malaysian Family Physician","volume":"20 ","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recognising atypical presentations of benign acute childhood myositis: Insights from a case series and literature review. 识别良性急性儿童肌炎的非典型表现：来自病例系列和文献回顾的见解。

Malaysian Family Physician Pub Date : 2025-08-09 eCollection Date: 2025-01-01 DOI: 10.51866/cr.805

Syed Ahmed Zaki

引用次数: 0

Beyond graduation: The journey of a young family doctor in Malaysia. 毕业之后：马来西亚一位年轻家庭医生的旅程。

Malaysian Family Physician Pub Date : 2025-08-09 eCollection Date: 2025-01-01 DOI: 10.51866/mol.96y

Marina Antony Nicholson

引用次数: 0

Suspected liraglutide (glucagon-like peptide-1 receptor agonist)-induced hyperthyroidism: A case report. 疑似利拉鲁肽（胰高血糖素样肽-1受体激动剂）诱导的甲亢1例报告。

Malaysian Family Physician Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.51866/cr.886

Siti Nur Syakinah Md Sabudin, Lili Husniati Yaacob, Muhammad Rahmat Che Omar

{"title":"Suspected liraglutide (glucagon-like peptide-1 receptor agonist)-induced hyperthyroidism: A case report.","authors":"Siti Nur Syakinah Md Sabudin, Lili Husniati Yaacob, Muhammad Rahmat Che Omar","doi":"10.51866/cr.886","DOIUrl":"10.51866/cr.886","url":null,"abstract":"Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), is widely used for weight management and glycaemic control. While generally well-tolerated, various adverse effects have been reported. Thyroid dysfunction, particularly hyperthyroidism, is rare. This report describes the case of a 34-year-old woman with new-onset hyperthyroidism following liraglutide use for weight loss. The patient presented with worsening palpitations and insomnia after 3 weeks of liraglutide use. She had no prior thyroid disease or significant family history. Examination revealed sinus tachycardia with no goitre or tremors. Laboratory findings confirmed hyperthyroidism with a suppressed TSH level (0.03 mlU/L) and an elevated free T4 level (20.8 pmol/L). Thyrotropin receptor antibody was negative, ruling out Graves' disease. Liraglutide was discontinued, and the patient was treated with carbimazole and propranolol, resulting in symptom resolution and normalisation of thyroid function within weeks. Liraglutide-induced thyroid dysfunction is poorly understood. Possible mechanisms include GLP-1 receptor activity in thyroid tissue, disruption of the hypothalamic-pituitary-thyroid axis or inflammation of thyroid follicular cells. This case demonstrates a strong temporal association between liraglutide use and hyperthyroidism, which resolved upon drug discontinuation. Although thyroid dysfunction with GLP-1 RAs has been noted in preclinical studies, human data remain limited. This case highlights a rare adverse effect of liraglutide and underscores the need for vigilance when monitoring patients on GLP-1 RAs. Monitoring of thyroid function should be considered in symptomatic patients. Further research is warranted to better understand the underlying mechanisms and prevalence of GLP-1 RA-induced thyroid abnormalities.","PeriodicalId":40017,"journal":{"name":"Malaysian Family Physician","volume":"20 ","pages":"58"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphoedema - Filariasis or soft tissue sarcoma? A case report. 淋巴水肿-丝虫病还是软组织肉瘤？一份病例报告。

Malaysian Family Physician Pub Date : 2025-07-29 eCollection Date: 2025-01-01 DOI: 10.51866/cr.877

Tamring Sarinah, Mat Nawi Zanaridah, Nik Yusof Fuad Nik Farah, Joon Hi Tham, Mohamad Setia Awang Shahrunizam

引用次数: 0

Prevalence and associated factors of female sexual dysfunction among primary care practitioners in Malaysia: A cross-sectional study. 马来西亚初级保健从业者中女性性功能障碍的患病率和相关因素：一项横断面研究。

Malaysian Family Physician Pub Date : 2025-07-29 eCollection Date: 2025-01-01 DOI: 10.51866/oa.883

Rosli Salwa, Abd Halim Haizlene, Md Yasin Mazapuspavina, Leny Suzana Suddin

{"title":"Prevalence and associated factors of female sexual dysfunction among primary care practitioners in Malaysia: A cross-sectional study.","authors":"Rosli Salwa, Abd Halim Haizlene, Md Yasin Mazapuspavina, Leny Suzana Suddin","doi":"10.51866/oa.883","DOIUrl":"10.51866/oa.883","url":null,"abstract":"Introduction: Sexual health is integral to quality of life, and female sexual dysfunction (FSD) is a significant public health concern recognised by the World Health Organization. Its prevalence is rising globally, with limited data among primary care practitioners (PCPs). Multifactorial issues such as high work burden in PCPs, coupled with low help-seeking behaviours, contribute to the likelihood of FSD and poor quality of life. This study aimed to determine the prevalence and associated factors of FSD among PCPs in Malaysia.Methods: This cross-sectional study was conducted using a self-administered online questionnaire for 6 months duration in Malaysia. Sociodemographic, marital and clinical data were collected, and two validated questionnaires namely the Malay Version of the Female Sexual Function Index (MVFSFI) and the Depression, Anxiety and Stress Scale (DASS-21) were utilised. Data analysis included descriptive statistics and logistic regression.Results: The study included 382 participants. The prevalence of FSD was 14.7% (95% confidence interval [CI] : 11.1, 18.2) among the participants, and the most affected domain was desire disorder (25.4%). Significant associations were observed between sexual activity two or fewer times per month (adjusted odds ratio [aOR]: 4.880; 95% CI: 2.522, 9.442; P<0.001), depression (aOR: 3.450; 95% CI: 1.653, 7.204; P<0.001) and degree-level education (aOR: 2.659; 95% CI: 1.338, 5.285; P=0.005) and FSD.Conclusion: This study identifies FSD as a prevalent issue among Malaysian PCPs, emphasising its biopsychosocial complex and the need for a holistic approach. Understanding the cultural determinants of FSD is important to tailor screening and intervention strategies.","PeriodicalId":40017,"journal":{"name":"Malaysian Family Physician","volume":"20 ","pages":"55"},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Practice Guidelines on the Management of Menopause in Malaysia 2022: A review from a primary care perspective. 马来西亚2022年更年期管理临床实践指南：从初级保健角度回顾。

Malaysian Family Physician Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.51866/cpg.910

Wai Khew Lee, Noreen Zhi Min Ooi, Soo Lee Goh

{"title":"Clinical Practice Guidelines on the Management of Menopause in Malaysia 2022: A review from a primary care perspective.","authors":"Wai Khew Lee, Noreen Zhi Min Ooi, Soo Lee Goh","doi":"10.51866/cpg.910","DOIUrl":"10.51866/cpg.910","url":null,"abstract":"Introduction: Clinical practice guidelines (CPGs) are important tools that assist primary care doctors in their daily practice. Menopause is a physiological condition that affects all women, and the latest Malaysian CPG on menopause can provide guidance on the optimal management of women facing this condition. However, not all CPGs are of acceptable quality, and it is important that primary care doctors learn to critically appraise CPGs to ensure their practice is evidence-based and relevant to their patients. This review aimed to critically appraise the Clinical Practice Guidelines on the Management of Menopause in Malaysia 2022 to ensure that it is valid and applicable to primary care in Malaysia.Methods: Three family medicine specialists independently appraised the CPG using the AGREE II Instrument, which consists of six domains assessing the following: (1) scope and purpose, (2) stakeholder involvement, (3) rigour of development, (4) clarity and presentation, (5) applicability and (6) editorial independence. They also provided an overall assessment of quality and recommendation on the use of the CPG following the AGREE II guideline.Results: The CPG scored >70%, which is the threshold of quality in all domains except for applicability. The reviewers deemed the CPG to be of high quality and recommended its adoption without any modifications.Discussion: It is important to ensure that recommendations in a CPG are evidence-based and valid before they are adopted into practice. The AGREE II Instrument can assist primary care doctors in critically appraising CPGs.","PeriodicalId":40017,"journal":{"name":"Malaysian Family Physician","volume":"20 ","pages":"50"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cautionary tale of hyponatraemia in an older person: Could This Have Been Prevented? 一个老年人低钠血症的警示故事：这是可以预防的吗？

Malaysian Family Physician Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.51866/tyk.502

Yi Bin Ho, Rebecca Kai Jan Choong, Kit Mun Tan

引用次数: 0