Model Systems最新文献

筛选
英文 中文
Abstract B52: The T-cell architecture of pancreatic ductal adenocarcinoma 摘要:胰腺导管腺癌的t细胞结构
Model Systems Pub Date : 2019-12-15 DOI: 10.1158/1538-7445.PANCA19-B52
S. Sivakumar, E. A. Shah, D. Ahern, N. Mangal, S. Reddy, A. Rendek, Z. Soonawalla, Michael Silva, M. Middleton, Michael Loran Dustin
{"title":"Abstract B52: The T-cell architecture of pancreatic ductal adenocarcinoma","authors":"S. Sivakumar, E. A. Shah, D. Ahern, N. Mangal, S. Reddy, A. Rendek, Z. Soonawalla, Michael Silva, M. Middleton, Michael Loran Dustin","doi":"10.1158/1538-7445.PANCA19-B52","DOIUrl":"https://doi.org/10.1158/1538-7445.PANCA19-B52","url":null,"abstract":"Pancreatic cancer has the worst prognosis of any human malignancy. Our recent work has shown that immune infiltrate by transcriptomics and histopathology can predict prognosis after a Whipple’s operation, with lymphocyte infiltration being the most important prognostic marker. We have profiled T cells within primary pancreatic cancer to understand the T-cell architecture within the tumor. We have used a 37-marker T cell-focused panel to study the immune infiltrate. We see a diverse immunosuppressive immune microenvironment within the primary tumor. There is a complex architecture of macrophages, neutrophils, and T cells. The commonest CD4 T cells in the microenvironment are Tregs. There are potential novel therapeutic strategies for Tregs using unique checkpoint inhibitors. The CD8 T cells have PD-1 activity but are not activated or proliferating. The poor prognosis of pancreatic cancer could be explained by the immunosuppressive microenvironment, but there are opportunities to drug Tregs in this disease. Citation Format: Shivan Sivakumar, Enas Abu Shah, David Ahern, Nagina Mangal, Srikanth Reddy, Aniko Rendek, Zahir Soonawalla, Michael Silva, Mark Middleton, Michael Dustin. The T-cell architecture of pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2019 Sept 6-9; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2019;79(24 Suppl):Abstract nr B52.","PeriodicalId":399774,"journal":{"name":"Model Systems","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133831759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信