Abstract B52: The T-cell architecture of pancreatic ductal adenocarcinoma

Abstract

Pancreatic cancer has the worst prognosis of any human malignancy. Our recent work has shown that immune infiltrate by transcriptomics and histopathology can predict prognosis after a Whipple’s operation, with lymphocyte infiltration being the most important prognostic marker. We have profiled T cells within primary pancreatic cancer to understand the T-cell architecture within the tumor. We have used a 37-marker T cell-focused panel to study the immune infiltrate. We see a diverse immunosuppressive immune microenvironment within the primary tumor. There is a complex architecture of macrophages, neutrophils, and T cells. The commonest CD4 T cells in the microenvironment are Tregs. There are potential novel therapeutic strategies for Tregs using unique checkpoint inhibitors. The CD8 T cells have PD-1 activity but are not activated or proliferating. The poor prognosis of pancreatic cancer could be explained by the immunosuppressive microenvironment, but there are opportunities to drug Tregs in this disease. Citation Format: Shivan Sivakumar, Enas Abu Shah, David Ahern, Nagina Mangal, Srikanth Reddy, Aniko Rendek, Zahir Soonawalla, Michael Silva, Mark Middleton, Michael Dustin. The T-cell architecture of pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2019 Sept 6-9; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2019;79(24 Suppl):Abstract nr B52.