Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu最新文献

Inteligencia artificial en la educación de Panamá: hacia una transformación digital con equidad y aprendizaje 人工智能在巴拿马教育中的作用：实现数字转型，实现公平和学习

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2025-12-15 DOI: 10.38202/transforma01

Rodolfo Sanjur Maylín

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引用次数: 0

Analysis of the therapeutic strategies used to treat Amyotrophic Lateral Sclerosis caused by TDP-43 aggregation and/or mislocalization TDP-43聚集和/或定位错误引起的肌萎缩侧索硬化症的治疗策略分析

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2024-08-03 DOI: 10.64336/001c.122193

Sonya Sar

{"title":"Analysis of the therapeutic strategies used to treat Amyotrophic Lateral Sclerosis caused by TDP-43 aggregation and/or mislocalization","authors":"Sonya Sar","doi":"10.64336/001c.122193","DOIUrl":"https://doi.org/10.64336/001c.122193","url":null,"abstract":"Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disorder that impairs motor functions, affects 1 in 50,000 people in the world, and has an insignificant hereditary component, with 90% of patients sans any family history of the disease. ALS is a debilitating disease due to the limited effectiveness of treatments. TARDBP, the gene of interest, encodes The TransActive Response DNA-binding protein 43 (TDP-43 (kDa)). Mutations in this gene result in TDP-43 that may undergo deregulated expression (gain or loss of function), be misfolded, cleaved, aggregated, and/or mislocalized. More specifically, TDP-43 may also be aberrantly ubiquitinated, phosphorylated, cleaved, or nuclear depleted. The resultant proteinopathy is associated in the causal chain of many neurodegenerative disorders, including in > 95% of patients with sporadic ALS. TDP-43 consists of mitochondrial and nuclear localization sequences; RNA recognition motifs; intrinsically disordered regions and is involved in the appropriate splicing and transcription of a host of protein-coding-genes. Preventing and/or correcting dysregulated TDP-43 homeostasis and proteinopathy is near-universally effective in vitro and in animal models. This study focuses on analyzing the benefits and limitations of the therapeutic strategies used to treat ALS caused by dysregulated TDP-43 homeostasis and identifying promising methods to target this proteinopathy.","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jhss.scholasticahq.com/article/122193.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147882951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Foreword 前言

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2022-10-01 DOI: 10.4131/jshpreview.31.129

Kazutaka Yamamoto

引用次数: 0

ダイヤモンドアンビルセル中の物質の高温高圧その場熱物性測定金刚石安比尔小区中物质的高温高压当场热物性测定

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2022-09-01 DOI: 10.4131/jshpreview.32.114

Kenji Ohta

引用次数: 0

超伝導量子干渉素子を用いた高圧力下磁気測定使用超导量子干涉元件的高压力下磁力测量

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2022-09-01 DOI: 10.4131/jshpreview.32.138

Masaki Mito

引用次数: 0

High-Pressure Synthesis and In-Situ Physical Property Measurement Using Boron-Doped Diamond 硼掺杂金刚石的高压合成及物理性能原位测试

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2022-09-01 DOI: 10.4131/jshpreview.32.129

R. Matsumoto, Sayaka Yamamoto, Y. Takano

引用次数: 0

Magnetization and NMR Measurements Using Opposed-Type Anvil Cells on Quantum Magnetism and Superconductivity 用对向型砧细胞对量子磁性和超导性进行磁化和核磁共振测量

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2022-09-01 DOI: 10.4131/jshpreview.32.120

K. Kitagawa, Naoka Hiraoka, Y. Arai, H. Takagi

引用次数: 0

第10回アジア高圧会議(10th Asian Conference on High Pressure Research) 報告第10回アジア高圧会议（10th Asian Conference on High Pressure Research）报告

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2022-09-01 DOI: 10.4131/jshpreview.32.159

T. Hattori

引用次数: 0

琉球大学　理学部物質地球科学科物理系　多重自由度相関研究室（物性物理学）琉球大学　理学部物質地球科学科物理系　多重自由度相関研究室（物性物理学）

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2022-09-01 DOI: 10.4131/jshpreview.32.157

Riki Kobayashi

引用次数: 0

高圧バイオサイエンスという異分野交流高压生物科学的跨领域交流

Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu Pub Date : 2022-09-01 DOI: 10.4131/jshpreview.32.111

Fumiyoshi Abe

引用次数: 0