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Metformin Improves Glycemic Control and Postprandial Metabolism and Enhances Postprandial Glucagon-Like Peptide 1 Secretion in Patients With Type 2 Diabetes and Heart Failure: A Randomized, Double-Blind, Placebo-Controlled Trial. 二甲双胍改善2型糖尿病和心力衰竭患者的血糖控制、餐后代谢和餐后胰高血糖素样肽1分泌：一项随机、双盲、安慰剂对照试验
Clinical Diabetes Pub Date : 2024-09-09 eCollection Date: 2025-01-01 DOI: 10.2337/cd24-0003
Vojtěch Melenovský, Eva Hošková, Kateřina Velebová, Jiří Veleba, Barry A Borlaug, Jan Benes, Ondřej Kuda, Tomáš Čajka, Markéta Segeťová, Lenka Thieme, Jan Kopecký, Jan Kopecký, Terezie Pelikánová, Martin Haluzík, Martin Hill, Hana Kahleová
{"title":"Metformin Improves Glycemic Control and Postprandial Metabolism and Enhances Postprandial Glucagon-Like Peptide 1 Secretion in Patients With Type 2 Diabetes and Heart Failure: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Vojtěch Melenovský, Eva Hošková, Kateřina Velebová, Jiří Veleba, Barry A Borlaug, Jan Benes, Ondřej Kuda, Tomáš Čajka, Markéta Segeťová, Lenka Thieme, Jan Kopecký, Jan Kopecký, Terezie Pelikánová, Martin Haluzík, Martin Hill, Hana Kahleová","doi":"10.2337/cd24-0003","DOIUrl":"https://doi.org/10.2337/cd24-0003","url":null,"abstract":"<p><p>This randomized trial tested the effect of metformin on glycemic control and cardiac function in patients with heart failure (HF) and type 2 diabetes while evaluating intestinal effects on selected gut microbiome products reflected by trimethylamine-N-oxide (TMAO) and gut-derived incretins. Metformin treatment improved glycemic control and postprandial metabolism and enhanced postprandial glucagon-like peptide 1 (GLP-1) secretion but did not influence cardiac function or the TMAO levels. Metabolic effects of metformin in HF may be mediated by an improvement in intestinal endocrine function and enhanced secretion of the gut-derived incretin GLP-1.</p>","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"43 1","pages":"23-32"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing Requirements for Insulin Pump Referral Improves Pump Initiation for Publicly Insured Children and Youth With Type 1 Diabetes. 减少对胰岛素泵转诊的要求可改善公共保险儿童和青少年1型糖尿病患者的胰岛素泵启动。
Clinical Diabetes Pub Date : 2024-09-06 eCollection Date: 2025-01-01 DOI: 10.2337/cd24-0037
Brian Miyazaki, Jennifer Baldwin, James Connard, Jose Aceves, Jessica Llovido Alula, Casey Berman, Jessica Ferris, Debra Miller, Ori Odugbesan, Rebecca Ortiz La Banca Barber, Lily C Chao
{"title":"Reducing Requirements for Insulin Pump Referral Improves Pump Initiation for Publicly Insured Children and Youth With Type 1 Diabetes.","authors":"Brian Miyazaki, Jennifer Baldwin, James Connard, Jose Aceves, Jessica Llovido Alula, Casey Berman, Jessica Ferris, Debra Miller, Ori Odugbesan, Rebecca Ortiz La Banca Barber, Lily C Chao","doi":"10.2337/cd24-0037","DOIUrl":"https://doi.org/10.2337/cd24-0037","url":null,"abstract":"<p><p>Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of <i>Clinical Diabetes</i>. The following article describes a quality improvement initiative to reduce barriers to insulin pump initiation for people with type 1 diabetes.</p>","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"43 1","pages":"156-160"},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A National Physician Survey Examining Switching From Sulfonylureas or Insulin to Newer Diabetes Medications. 一项关于从磺脲类药物或胰岛素转向新型糖尿病药物的全国医师调查。
Clinical Diabetes Pub Date : 2024-09-05 eCollection Date: 2025-01-01 DOI: 10.2337/cd24-0043
Scott J Pilla, Isabelle J Wang, Olive Tang, Nancy L Schoenborn, Cynthia M Boyd, Michael P Bancks, Nestoras N Mathioudakis, Nisa M Maruthur
{"title":"A National Physician Survey Examining Switching From Sulfonylureas or Insulin to Newer Diabetes Medications.","authors":"Scott J Pilla, Isabelle J Wang, Olive Tang, Nancy L Schoenborn, Cynthia M Boyd, Michael P Bancks, Nestoras N Mathioudakis, Nisa M Maruthur","doi":"10.2337/cd24-0043","DOIUrl":"10.2337/cd24-0043","url":null,"abstract":"<p><p>This study was a national survey of U.S. physicians in general medicine, geriatrics, or endocrinology who were asked what medication change they would make for adults with type 2 diabetes taking sulfonylureas or insulin with an A1C below their individualized goal. Responding physicians switched the hypoglycemia-causing medication a median of 4 times (interquartile range 1-9) among 27 opportunities and selected dipeptidyl peptidase 4 inhibitors most often when switching. Sodium-glucose cotransporter 2 inhibitors were selected less frequently, including when indicated for cardiovascular and renal comorbidities, but significantly more often among physicians caring for a greater proportion of patients with private health insurance. Overcoming barriers to switching hypoglycemia-causing medications may help to reduce rates of hypoglycemia while targeting cardiovascular and renal comorbidities.</p>","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"43 1","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Double Diabetes: A Clinical Challenge. 双重糖尿病：临床挑战。
Clinical Diabetes Pub Date : 2024-08-27 eCollection Date: 2025-01-01 DOI: 10.2337/cd24-0025
Amber M Healy, Jay H Shubrook
{"title":"Double Diabetes: A Clinical Challenge.","authors":"Amber M Healy, Jay H Shubrook","doi":"10.2337/cd24-0025","DOIUrl":"https://doi.org/10.2337/cd24-0025","url":null,"abstract":"","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"43 1","pages":"128-130"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Degludec in Youth With Type 1 Diabetes and Recurrent Diabetic Ketoacidosis. Degludec在青少年1型糖尿病及复发性糖尿病酮症酸中毒中的应用。
Clinical Diabetes Pub Date : 2024-08-27 eCollection Date: 2025-01-01 DOI: 10.2337/cd24-0001
Mili Vakharia, Xiaofan Huang, Charles Minard, Tracy Patel, Sarah K Lyons, Siripoom McKay
{"title":"Use of Degludec in Youth With Type 1 Diabetes and Recurrent Diabetic Ketoacidosis.","authors":"Mili Vakharia, Xiaofan Huang, Charles Minard, Tracy Patel, Sarah K Lyons, Siripoom McKay","doi":"10.2337/cd24-0001","DOIUrl":"https://doi.org/10.2337/cd24-0001","url":null,"abstract":"<p><p>This article describes a pediatric diabetes center quality improvement initiative to switch youth with type 1 diabetes and diabetic ketoacidosis (DKA) from insulin glargine to longer-duration insulin degludec to determine whether this change would reduce DKA recurrence. Overall, the change in DKA recurrence with degludec was not statistically significant. However, subgroup analysis showed that race/ethnicity and insurance status were significantly associated with change in DKA rates. The association of degludec and decreased rates of repeat DKA in Hispanics and privately insured individuals requires further exploration.</p>","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"43 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing Access to Connected Insulin Pens by Promoting Shared Decision-Making Through Collaborative Quality Improvement. 通过合作质量改进促进共同决策，从而增加连接胰岛素笔的使用。
Clinical Diabetes Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI: 10.2337/cd24-0057
Jared G Friedman, Ori Odugbesan, Osagie Ebekozien, Grazia Aleppo
{"title":"Increasing Access to Connected Insulin Pens by Promoting Shared Decision-Making Through Collaborative Quality Improvement.","authors":"Jared G Friedman, Ori Odugbesan, Osagie Ebekozien, Grazia Aleppo","doi":"10.2337/cd24-0057","DOIUrl":"10.2337/cd24-0057","url":null,"abstract":"","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"42 4","pages":"470-473"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing Awareness and Uptake of Connected Insulin Pens for Eligible Patients With Diabetes: A Quality Improvement Success Story. 提高符合条件的糖尿病患者对联网胰岛素笔的认识和使用率：质量改进的成功案例。
Clinical Diabetes Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI: 10.2337/cd24-0055
Victoria Lee He, Nancy Shin, Henna Shaghasi, Sandra A Tsai
{"title":"Increasing Awareness and Uptake of Connected Insulin Pens for Eligible Patients With Diabetes: A Quality Improvement Success Story.","authors":"Victoria Lee He, Nancy Shin, Henna Shaghasi, Sandra A Tsai","doi":"10.2337/cd24-0055","DOIUrl":"10.2337/cd24-0055","url":null,"abstract":"<p><p>Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of <i>Clinical Diabetes</i>. The following article is part of a special article collection from the T1D Exchange Quality Improvement Collaborative. It describes an initiative to increase the use of connected insulin pens in two primary care clinics and one endocrinology clinic serving diverse populations within the Stanford Health Care system in the San Francisco Bay area of California.</p>","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"42 4","pages":"479-483"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partnering With Families Through Shared Decision-Making to Increase Connected Pen Use: A Quality Improvement Success Story. 通过共同决策与家庭合作，提高连接笔的使用率：质量改进的成功案例。
Clinical Diabetes Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI: 10.2337/cd24-0054
Blake V Adams, Anna T Heston, Diveena Davis, Grace B Nelson
{"title":"Partnering With Families Through Shared Decision-Making to Increase Connected Pen Use: A Quality Improvement Success Story.","authors":"Blake V Adams, Anna T Heston, Diveena Davis, Grace B Nelson","doi":"10.2337/cd24-0054","DOIUrl":"10.2337/cd24-0054","url":null,"abstract":"<p><p>Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of <i>Clinical Diabetes</i>. The following article is part of a special article collection from the T1D Exchange Quality Improvement Collaborative. It describes efforts at an academic pediatric diabetes clinic in Memphis, TN, to increase both the use of connected insulin pens (CIPs) and shared decision-making around diabetes technology aided by patient information and self-reflection handouts.</p>","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"42 4","pages":"484-487"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to Increase the Use of Connected Insulin Pens Through Shared Decision-Making: A Quality Improvement Success Story. 通过共同决策提高连接胰岛素笔使用率的策略：质量改进的成功案例。
Clinical Diabetes Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI: 10.2337/cd24-0056
Jared G Friedman, Philip Silberman, Stefanie Herrmann, Grazia Aleppo
{"title":"Strategies to Increase the Use of Connected Insulin Pens Through Shared Decision-Making: A Quality Improvement Success Story.","authors":"Jared G Friedman, Philip Silberman, Stefanie Herrmann, Grazia Aleppo","doi":"10.2337/cd24-0056","DOIUrl":"10.2337/cd24-0056","url":null,"abstract":"<p><p>Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of <i>Clinical Diabetes</i>. The following article is part of a special article collection from the T1D Exchange Quality Improvement Collaborative. It describes an initiative to reduce inequities in diabetes technology access and use and increase the use of connected insulin pens at an academic endocrinology practice in Chicago, IL.</p>","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"42 4","pages":"474-478"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out of Sight, Out of Mind: A Call to Action for the Treatment of Hypoglycemia. 看不见，摸不着：治疗低血糖的行动呼吁》。
Clinical Diabetes Pub Date : 2024-08-14 eCollection Date: 2024-01-01 DOI: 10.2337/cd24-0014
Jennifer D Goldman, Diana Isaacs
{"title":"Out of Sight, Out of Mind: A Call to Action for the Treatment of Hypoglycemia.","authors":"Jennifer D Goldman, Diana Isaacs","doi":"10.2337/cd24-0014","DOIUrl":"10.2337/cd24-0014","url":null,"abstract":"<p><p>Hypoglycemia will inevitably occur. Being prepared and implementing a treatment plan should help to restore euglycemia and resolve hypoglycemia symptoms. The plan comprises fast-acting carbohydrates and, importantly, ready-to-use glucagon for self-administration when carbohydrates are not working or for third-party administration when the affected person is unwilling or unable to swallow (e.g., unconscious or in a coma).</p>","PeriodicalId":39894,"journal":{"name":"Clinical Diabetes","volume":"42 4","pages":"515-531"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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