Regular and Young Investigator Award Abstracts最新文献_第6页

113 Uncovering the dark immunopeptidome of head and neck squamous cell carcinoma (HNSCC): relevance for universal cancer vaccines, immunological monitoring and TIL therapy 113揭示头颈部鳞状细胞癌(HNSCC)的暗免疫肽:与通用癌症疫苗、免疫监测和TIL治疗的相关性

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0113

N. Iwamoto, T. Shimada, T. Moudgil, Ryan Meng, Tanisha Christie, Alexander C. Dowell, R. Leidner, B. Bell, William L. Redmond, E. Tran, Hong-Ming Hu, T. Hilton, B. Piening, Y. Koguchi, B. Fox

{"title":"113 Uncovering the dark immunopeptidome of head and neck squamous cell carcinoma (HNSCC): relevance for universal cancer vaccines, immunological monitoring and TIL therapy","authors":"N. Iwamoto, T. Shimada, T. Moudgil, Ryan Meng, Tanisha Christie, Alexander C. Dowell, R. Leidner, B. Bell, William L. Redmond, E. Tran, Hong-Ming Hu, T. Hilton, B. Piening, Y. Koguchi, B. Fox","doi":"10.1136/jitc-2022-sitc2022.0113","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0113","url":null,"abstract":"Background Discoveries of the last two years have initiated a renaissance in our understanding of the targets T cells recog-nize on cancer cells. Identification of HLA-presented non-can-onical or cryptic peptides that are non-mutated and have high interpatient sharing in AML [PMID: 33740418], coupled with their absence from the thymus, led them to be designated as alternative neoantigens with potential for being universal cancer vaccines [PMID: 33852826]. These cryptic genes, in some cases, appear to play a role in promoting malignancy, further strengthening the rationale for their identification and use as targets for immunotherapy. Our group seeks to identify the Dark Immunopeptidome of HNSCC. Over the last several months we have swithed from exome-capture RNA-Seq, which fails to detect non-canonical gene sequences, to ribo-Seq, which can capture these cryptic transcripts.","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116605415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

799 Real-world use of pembrolizumab combination regimens in first-line recurrent/metastatic head and neck squamous cell carcinoma 799派姆单抗联合方案在一线复发/转移性头颈部鳞状细胞癌中的实际应用

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0799

C. Black, Liya Wang, K. Ramakrishnan, D. Goto

引用次数: 0

1309 Differential microbial enrichment is associated with oral cancer and perineural invasion 1309 .不同的微生物富集与口腔癌和神经周围浸润有关

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.1309

August Culbert, A. Chow, Raad Gharaibah, Naseer Sangwan, M. Dwidar, Rachel C. Newsome, Jin Dai, Siming Ma, Kristianna M Fredenburg, E. Yilmaz, S. Koyfman, Daniel McGrail, J. Ku, C. Jobin, N. Silver

{"title":"1309 Differential microbial enrichment is associated with oral cancer and perineural invasion","authors":"August Culbert, A. Chow, Raad Gharaibah, Naseer Sangwan, M. Dwidar, Rachel C. Newsome, Jin Dai, Siming Ma, Kristianna M Fredenburg, E. Yilmaz, S. Koyfman, Daniel McGrail, J. Ku, C. Jobin, N. Silver","doi":"10.1136/jitc-2022-sitc2022.1309","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1309","url":null,"abstract":"Background Advanced oral cavity squamous cell carcinoma (OSCC) is an aggressive disease, with 5-year overall survival rates below 50%. 1 While smoking and alcohol are the most established risk factors, there is growing evidence implicating the role of the oral microbiome in promoting immunosuppres-sive states in OSCC. 2-6 The objective of this study was to evaluate the taxonomic profile of oral bacteria in advanced OSCC patients and correlate with clinicopathologic features. approved this study of patients diagnosed with treated from Samples were taken from tumor and paired adjacent normal tissues at the time of surgery and snap frozen. Demographics, clinical and pathologic information was collected. DNA from 51 samples was isolated and 16s rRNA gene sequencing was performed after PCR amplification of the V1-V3 regions of the 16s rRNA gene for paired samples. 16S rRNA sequences were processed using DADA2, implemented in QIIME2 package, and taxonomic assignments were made using RDA classifier using the Human Oral Microbiome Data-base V15.22 as the reference database. Sequencing reads proc-essing, denoising, dereplicating, chimeras filtering, and amplicon sequence variants (ASVs) generation was done using DADA2. The association between clinicopathological factors and bacterial profiles was evaluated using R Software.","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117019902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

81 T cell stimulation assay and immunoassays comparison for soluble cytokines profiling in drug discovery T细胞刺激试验和免疫试验在药物发现中可溶性细胞因子分析的比较

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0081

C. Lefranc, Nicole Meritet, K. Berthelot, O. Flamand, J. Baudhuin, Jack Pollard, L. Canard, A. Biancotto

引用次数: 0

20 Development of VISTA-centric tumor immunophenotyping as a novel approach for identification of potential biomarkers for anti-VISTA therapy 以vista为中心的肿瘤免疫分型作为一种鉴定抗vista治疗潜在生物标志物的新方法的发展

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0020

A. Ugolkov, R. Roemeling, Alexander Martin, R. Martell

引用次数: 1

702 Tertiary lymphoid structures (TLS) observed in non-small cell lung cancer (NSCLC) tumors treated with pulsed electric fields 脉冲电场治疗非小细胞肺癌(NSCLC)肿瘤观察到三级淋巴样结构(TLS)

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0702

J. Iding, Paul VanderLaan, Marcelo Jimenez, J. F. García-Hierro, J. F. Aldeyturriaga, Erik H. F. M. Heijden, C. Ng, R. Lau, Maria Ludeña, Rafael Carías, O. Cedeño, Alicia Moreno-Gonzalez, B. Hatton, W. Krimsky

引用次数: 1

903 APR-246 induces an increase in tumor immunogenicity in a p53 independent manner 903 APR-246以p53独立的方式诱导肿瘤免疫原性的增加

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0903

D. Venkatesh, J. Michels, Cailin Lu, S. Budhu, Mariam M. George, O. Ouerfelli, L. Abrahmsén, R. Zappasodi, J. Wolchok, T. Merghoub

引用次数: 0

1015 Natural killer cells in immunotherapy-induced MHC-I tumor escape 1015免疫治疗诱导的MHC-I肿瘤逃逸中的自然杀伤细胞

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.1015

E. Miao, Jennifer Poursine‐Laurent, K. Sheehan, R. Schreiber, W. Yokoyama, S. Piersma

引用次数: 0

999 Investigating the immunomodulatory role of innate lymphoid cells in epithelial ovarian carcinoma 研究先天淋巴样细胞在上皮性卵巢癌中的免疫调节作用

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0999

D. Chung, K. Warner, Jehan Vakharia, SeongJun Han, M. Ghaedi, Carlos R. Garcia-Batres, N. Jacquelot, Azin Sayad, Sarah Ferguson, P. Ohashi

引用次数: 0

977 Highly cytotoxic resilient CD8+T cells avoid exhaustion by lowering ROS through ME1 upregulation 977高细胞毒性韧性CD8+T细胞通过上调ME1降低ROS来避免衰竭

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0977

Joanina K. Gicobi, Haidong Dong, Cindy Liu

引用次数: 0