发布求助
文献互助 智能选刊 最新文献

Regular and Young Investigator Award Abstracts最新文献

筛选
英文 中文
161 Single-cell spatial in situ transcriptomics unravels vulvar HSIL composition associated with complete response to therapeutic vaccination 161单细胞空间原位转录组学揭示了外阴HSIL组成与治疗性疫苗完全应答相关
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0161
Z. Abdulrahman, M. V. Poelgeest, M. Welters, S. H. Burg
{"title":"161 Single-cell spatial in situ transcriptomics unravels vulvar HSIL composition associated with complete response to therapeutic vaccination","authors":"Z. Abdulrahman, M. V. Poelgeest, M. Welters, S. H. Burg","doi":"10.1136/jitc-2022-sitc2022.0161","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0161","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121228490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1016 IL-2 expanded tumor infiltrated Natural Killer (TINK) cells from canine sarcomas possess potent anti-tumor cytotoxicity 犬肉瘤的IL-2扩增肿瘤浸润自然杀伤细胞具有很强的抗肿瘤细胞毒性
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.1016
Weiqing Jing, Himaly Shinglot, Juliana Chi Kei Ng, A. Zhang, B. Séguin, Jeffrey C. Bryan, T. Fan, Jennifer Wu, S. Pollack
{"title":"1016 IL-2 expanded tumor infiltrated Natural Killer (TINK) cells from canine sarcomas possess potent anti-tumor cytotoxicity","authors":"Weiqing Jing, Himaly Shinglot, Juliana Chi Kei Ng, A. Zhang, B. Séguin, Jeffrey C. Bryan, T. Fan, Jennifer Wu, S. Pollack","doi":"10.1136/jitc-2022-sitc2022.1016","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1016","url":null,"abstract":"Background Tumor infiltrating NK (TINK) cells are present and linked to prognosis in many solid tumors. 1 While these cells may have potent antitumor effector function, they are thought to be dysfunctional in the tumor microenvironment (TME). 2 Because it is difficult to culture potent TINKs from human tumors, relatively little is known about their interac-tions with various TME components or their potential for therapeutic applications. Here we report reproducible culture of highly potent TINKs from naturally occurring canine sarcomas for use in modeling the human TME.","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121235335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
832 Antigen spread mediated by oncolytic adenovirus Delta-24-RGDOX during intratumoral adoptive T cell therapy in immunocompetent mice with disseminated tumors 832溶瘤腺病毒δ -24- rgdox介导的肿瘤内过继T细胞治疗中弥散性肿瘤免疫活性小鼠的抗原扩散
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0832
Hong Jiang
{"title":"832 Antigen spread mediated by oncolytic adenovirus Delta-24-RGDOX during intratumoral adoptive T cell therapy in immunocompetent mice with disseminated tumors","authors":"Hong Jiang","doi":"10.1136/jitc-2022-sitc2022.0832","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0832","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121310320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
781 DELTA-2: A phase 1, open-label, multicenter study of ITIL-168, an autologous tumor-infiltrating lymphocyte (TIL) cell therapy, with pembrolizumab in patients with advanced solid tumors 781 DELTA-2:一项i期、开放标签、多中心研究，itl -168是一种自体肿瘤浸润性淋巴细胞(TIL)细胞疗法，联合派姆单抗治疗晚期实体瘤患者
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0781
O. Yeku, D. Olson, J. Ward, S. Patel, J. Aycock, Amber C. Donahue, Yi-zhou Jiang, J. Gall, Z. Roberts, Rubén Álvarez-Rodríguez, Judy Seng, Tong Shen, N. Kothari
{"title":"781 DELTA-2: A phase 1, open-label, multicenter study of ITIL-168, an autologous tumor-infiltrating lymphocyte (TIL) cell therapy, with pembrolizumab in patients with advanced solid tumors","authors":"O. Yeku, D. Olson, J. Ward, S. Patel, J. Aycock, Amber C. Donahue, Yi-zhou Jiang, J. Gall, Z. Roberts, Rubén Álvarez-Rodríguez, Judy Seng, Tong Shen, N. Kothari","doi":"10.1136/jitc-2022-sitc2022.0781","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0781","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127056542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
228 Multi-arming and regulator dial gene circuits tackle key challenges in solid tumors 多武装和调节拨号基因电路解决实体肿瘤的关键挑战
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0228
Marcela Guzman Ayala, Michelle Hung, Deepika Kaveri, Rebecca Cottman, Elizabeth G. Leitner, Priscilla Wong, Ronni Ponek, Enping Hong, Manan Shah, Andrew Banicki, Lawrence Naitmazi, Kelly Lee, W. Gorman, Russell M. Gordley, Philip Lee, Timothy Lu
{"title":"228 Multi-arming and regulator dial gene circuits tackle key challenges in solid tumors","authors":"Marcela Guzman Ayala, Michelle Hung, Deepika Kaveri, Rebecca Cottman, Elizabeth G. Leitner, Priscilla Wong, Ronni Ponek, Enping Hong, Manan Shah, Andrew Banicki, Lawrence Naitmazi, Kelly Lee, W. Gorman, Russell M. Gordley, Philip Lee, Timothy Lu","doi":"10.1136/jitc-2022-sitc2022.0228","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0228","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127256173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1208 DuoBody®-PD-L1x4–1BB (GEN1046) reverses T-cell exhaustionin vitro 1208 DuoBody®-PD-L1x4-1BB (GEN1046)在体外逆转t细胞衰竭
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.1208
Jordan M. Blum, V. Spires, G. Masters, Christina Yu, S. Burm, Matt Hancock, O. Jabado, Brandon Higgs, A. Muik, K. Nuermberger, Friederike Gieseke, T. Ahmadi, K. Sasser, Ozlem Tureci, M. Jure-Kunkel, U. Şahin, M. Fereshteh, N. Pencheva
{"title":"1208 DuoBody®-PD-L1x4–1BB (GEN1046) reverses T-cell exhaustionin vitro","authors":"Jordan M. Blum, V. Spires, G. Masters, Christina Yu, S. Burm, Matt Hancock, O. Jabado, Brandon Higgs, A. Muik, K. Nuermberger, Friederike Gieseke, T. Ahmadi, K. Sasser, Ozlem Tureci, M. Jure-Kunkel, U. Şahin, M. Fereshteh, N. Pencheva","doi":"10.1136/jitc-2022-sitc2022.1208","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1208","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124832897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
692 Circulating tumor DNA analysis of advanced hepatocellular cancer (HCC) patients treated with neoantigen targeted personalized cancer DNA vaccine (GNOS-PV02) in combination with plasmid IL-12 (pIL12) and anti-PD1 (pembrolizumab) 新抗原靶向个体化癌症DNA疫苗(GNOS-PV02)联合质粒IL-12 (pIL12)和抗pd1(派姆单抗)治疗晚期肝癌(HCC)患者的692例循环肿瘤DNA分析
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0692
Renzo Perales, A. Perales-Puchalt, G. Bartha, Josette M. Northcott, Richard O. Chen, J. Lyle, D. Norton, Neil Cooch, E. Gane, M. Yarchoan, T. Marron, Sarah Rochestie, J. Peters, I. Csiki, Jian Yan, N. Sardesai
{"title":"692 Circulating tumor DNA analysis of advanced hepatocellular cancer (HCC) patients treated with neoantigen targeted personalized cancer DNA vaccine (GNOS-PV02) in combination with plasmid IL-12 (pIL12) and anti-PD1 (pembrolizumab)","authors":"Renzo Perales, A. Perales-Puchalt, G. Bartha, Josette M. Northcott, Richard O. Chen, J. Lyle, D. Norton, Neil Cooch, E. Gane, M. Yarchoan, T. Marron, Sarah Rochestie, J. Peters, I. Csiki, Jian Yan, N. Sardesai","doi":"10.1136/jitc-2022-sitc2022.0692","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0692","url":null,"abstract":"Renzo Perales, Alfredo Perales-Puchalt, Gabor Bartha, Josette Northcott, Richard Chen, John Lyle, Dan Norton, Neil Cooch, Edward Gane, Mark Yarchoan, Thomas Marron, Sarah Rochestie, Joann Peters, Ildiko Csiki, Jian Yan*, Niranjan Sardesai. Geneos Therapeutics, Plymouth Meeting, PA, USA; Personalis, Inc, Menlo Park, CA, USA; The University of Auckland, Auckland, New Zealand; The Johns Hopkins Hospital, Baltimore, MD, USA; The Tisch Cancer Institute, New York, NY, USA","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125000349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
312 Identification of novel NSC lung cancer Dark Antigens™ with expression in multiple tumor types, as promising targets for immunotherapies 312 .在多种肿瘤类型中表达的新型NSC肺癌Dark抗原™的鉴定，作为免疫治疗的有希望的靶点
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0312
Rachel Abbott, Okba Alassadi, M. Davies, Magdaléna von Essen, Verónica Freire-Benéitez, Vicki Jefferson, S. Kundu, P. Kurupati, Ralf Leonhardt, Samuel L. Lukowski, Fabio Marino, G. Masi, R. Queiroz, Hayden J. Selvadurai, J. Senra, E. Tye, J. Dukes
{"title":"312 Identification of novel NSC lung cancer Dark Antigens™ with expression in multiple tumor types, as promising targets for immunotherapies","authors":"Rachel Abbott, Okba Alassadi, M. Davies, Magdaléna von Essen, Verónica Freire-Benéitez, Vicki Jefferson, S. Kundu, P. Kurupati, Ralf Leonhardt, Samuel L. Lukowski, Fabio Marino, G. Masi, R. Queiroz, Hayden J. Selvadurai, J. Senra, E. Tye, J. Dukes","doi":"10.1136/jitc-2022-sitc2022.0312","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0312","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125065776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
6 Use of real-world (RW) data to assess the ability of circulating cell-free tumor DNA (ctDNA) molecular response to assess therapeutic outcomes in patients with non-small cell lung cancer (NSCLC) 使用真实世界(RW)数据评估循环无细胞肿瘤DNA (ctDNA)分子反应的能力，以评估非小细胞肺癌(NSCLC)患者的治疗结果
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0006
C. Weipert, L. Drusbosky, L. Bucheit, K. Chang, Shaun P. Forbes, S. Gordon
{"title":"6 Use of real-world (RW) data to assess the ability of circulating cell-free tumor DNA (ctDNA) molecular response to assess therapeutic outcomes in patients with non-small cell lung cancer (NSCLC)","authors":"C. Weipert, L. Drusbosky, L. Bucheit, K. Chang, Shaun P. Forbes, S. Gordon","doi":"10.1136/jitc-2022-sitc2022.0006","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0006","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125087469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
454 Real-world treatment patterns among patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC) in a community oncology setting 在社区肿瘤学环境中，454例局部晚期头颈部鳞状细胞癌(LA HNSCC)患者的实际治疗模式
Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI: 10.1136/jitc-2022-sitc2022.0454
E. Nadler, C. Black, K. Ramakrishnan, Wan-Yu Tseng, Charles Wentworth, John Murphy, N. Fulcher, Liya Wang, M. Alexander, G. Patton
{"title":"454 Real-world treatment patterns among patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC) in a community oncology setting","authors":"E. Nadler, C. Black, K. Ramakrishnan, Wan-Yu Tseng, Charles Wentworth, John Murphy, N. Fulcher, Liya Wang, M. Alexander, G. Patton","doi":"10.1136/jitc-2022-sitc2022.0454","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0454","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126030379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信