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Medico e Bambino最新文献

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Cosa deve sapere oggi il pediatra del trattamento dell’epatite C nell’era dei nuovi farmaci antivirali? 在新的抗病毒药物时代，儿科医生对丙型肝炎的治疗应该有哪些了解？
Medico e Bambino Pub Date : 2024-05-24 DOI: 10.53126/meb43303
Silvio Veraldi, G. Maggiore
{"title":"Cosa deve sapere oggi il pediatra del trattamento dell’epatite C nell’era dei nuovi farmaci antivirali?","authors":"Silvio Veraldi, G. Maggiore","doi":"10.53126/meb43303","DOIUrl":"https://doi.org/10.53126/meb43303","url":null,"abstract":"The treatment of hepatitis C virus (HCV) infection with the new directacting antivirals (DAAs) has dramatically modified the natural history of the HCV-related disease, eradicating the virus in over 90% of treated patients, with negligible collateral effects. The high costs of treatment, however, represent a factor that limits patients’ access to therapy and burdens the countries’ healthcare systems. In Italy the estimated cost of treatment for a naïve patient (8/12 weeks) amounts to approximately €5,500 (VAT excluded). HCV liver disease especially affects adults, in Italy the average prevalence of hepatitis C ranges between 2.4% and 3.3% in the general population. The prevalence of hepatitis C in children is significantly lower (0.15%) and the liver disease is rarely progressive in the paediatric age; however, there are not tools capable of interrupting the main route of infection, namely the vertical transmission from the infected mother. The effectiveness and great manageability of these new direct antivirals have also allowed their use in paediatrics starting from three years of age.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Le vite salvate dai vaccini negli ultimi 50 anni 过去 50 年中疫苗挽救的生命
Medico e Bambino Pub Date : 2024-05-24 DOI: 10.53126/meb43286
Federico Marchetti
{"title":"Le vite salvate dai vaccini negli ultimi 50 anni","authors":"Federico Marchetti","doi":"10.53126/meb43286","DOIUrl":"https://doi.org/10.53126/meb43286","url":null,"abstract":"Sono 154 milioni di cui 101 milioni di bambini! Progressi straordinari e emozionanti che richiedono uno sforzo congiunto, umanamente possibile, un bene per tutti, per oggi, ma ancora di più per il domani","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I primi anni contano 最初的岁月
Medico e Bambino Pub Date : 2024-04-24 DOI: 10.53126/meb43254
G. Tamburlini
{"title":"I primi anni contano","authors":"G. Tamburlini","doi":"10.53126/meb43254","DOIUrl":"https://doi.org/10.53126/meb43254","url":null,"abstract":"Mettere la prima infanzia al centro di un'Europa sociale","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"19 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difetti congeniti dell’immunità: non solo le vecchie immunodeficienze 先天性免疫缺陷：不仅是古老的免疫缺陷症
Medico e Bambino Pub Date : 2024-04-24 DOI: 10.53126/meb43219
A. Tommasini, Erica Valencic, S. Naviglio
{"title":"Difetti congeniti dell’immunità: non solo le vecchie immunodeficienze","authors":"A. Tommasini, Erica Valencic, S. Naviglio","doi":"10.53126/meb43219","DOIUrl":"https://doi.org/10.53126/meb43219","url":null,"abstract":"Inborn errors of immunity are a rapidly-developing area of clinical study. Based on the description of a small set of disorders with a significant risk of infection that may be identified with a small number of lab tests, the definition has been expanded to include a broader range of diseases that may necessitate a more intricate diagnostic process involving immunological and genetic studies. In this context, the paper presents a compilation of the most prevalent and severe illnesses that should not be overlooked. Additionally, it provides valuable guidance for classifying recently identified conditions, which may manifest as more nuanced and gradual clinical presentations. Prompt identification is es- sential for timely implementation of elective treatments such as bone marrow transplantation or gene therapy in severe instances or for commencing targeted medications that can mitigate present and future hazards in other cases.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"23 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lettere 信件
Medico e Bambino Pub Date : 2024-04-24 DOI: 10.53126/meb43216
A. Selicorni, Marina Macchiaiolo, E. Mazzoni, Luigi Memo, Roberta Onesimo, Fabrizio Faravelli, Silvia Di Michele, Giuseppe Zampino
{"title":"Lettere","authors":"A. Selicorni, Marina Macchiaiolo, E. Mazzoni, Luigi Memo, Roberta Onesimo, Fabrizio Faravelli, Silvia Di Michele, Giuseppe Zampino","doi":"10.53126/meb43216","DOIUrl":"https://doi.org/10.53126/meb43216","url":null,"abstract":"Una sorta di manifesto sulla gestione del bambino ad alta complessità assistenziale: unità di intenti tra i professionisti per evitare sovrapposizioni, fraintendimenti e duplicazione degli interventi.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"27 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140661366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quando l'atassia cerebellare acuta è post-infettiva 当急性小脑共济失调是感染后遗症时
Medico e Bambino Pub Date : 2024-04-24 DOI: 10.53126/meb43259
Arianna Bedeschi
{"title":"Quando l'atassia cerebellare acuta è post-infettiva","authors":"Arianna Bedeschi","doi":"10.53126/meb43259","DOIUrl":"https://doi.org/10.53126/meb43259","url":null,"abstract":"The Authors describe the case of a 2-year-old child presenting to the emergency room with vomiting and diarrhoea.The diagnosis of post-infectious cerebellar ataxia was subsequently made due to the onset of postural instability, inability to walk, and pendular oscillations while seated.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Il nirsevimab nella prevenzione della bronchiolite da virus respiratorio sinciziale 尼舍单抗在预防呼吸道合胞病毒支气管炎中的应用
Medico e Bambino Pub Date : 2024-04-24 DOI: 10.53126/meb43239
Alessandra Consolati, Maria Paola Farinelli, Paolo Serravalle, Christine Rollandin, L. Apprato, Salvatore Bongiorno
{"title":"Il nirsevimab nella prevenzione della bronchiolite da virus respiratorio sinciziale","authors":"Alessandra Consolati, Maria Paola Farinelli, Paolo Serravalle, Christine Rollandin, L. Apprato, Salvatore Bongiorno","doi":"10.53126/meb43239","DOIUrl":"https://doi.org/10.53126/meb43239","url":null,"abstract":"Background RSV is the leading cause of hospitalization for respiratory infections in infants, such as bronchiolitis. In the epidemic season 2023-2024, in Valle D’Aosta Region of Italy (VdA) a universal prevention program against RSV was implemented to protect all infants aged less than 6 months with Nirsevimab. Here we present preliminary data as of 15Feb/2023 regarding coverage rate and effectiveness of nirsevimab. Methods Written consent to the administration of Nirsevimab and the processing of health data was obtained from parents. Nirsevimab administration data were extrapolated from electronic health records managed by Health Authority of VdA, while hospitalizations data for RSV bronchiolitis were extrapolated from hospital discharge records of the same VdA. Results Nirsevimab was available for all infants from 20/Dec/2023. Coverage rates were 65% (292/448) for infants born from 1/May/2023 to 18/Dec/2023, and 86% (77/89) for infants born from 20/Dec/2023 to 15/Feb/2024. There have been 29 hospitalizations for RSV bronchiolitis, 18 in infants born after 1/May/2023. In the past epidemic season 2022/2023, on the same date, the number of hospitalizations was 61, of which 47 in children born after 1/May/2022. The prevalence of RSV bronchiolitis hospitalization in infants who did not receive Nirsevimab was 8.3% (14/168), while there were no hospitalizations due to RSV bronchiolitis in infants who received Nirsevimab (0/369), p<0.001 (Fisher’s exact test). Conclusions The high coverage rate and the solid effectiveness results of Nirsevimab in VdA, as already demonstrated in other countries such as US, Spain, France, Luxemburg, may support Italian policy makers in the implementation of RSV prevention program among the entire country in the next year. Further data on safety and effectiveness on full epidemic season will better explain the potential of this prevention programme.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"92 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening e comunicazione 筛查和交流
Medico e Bambino Pub Date : 2024-04-24 DOI: 10.53126/meb43249
D. Baronciani
{"title":"Screening e comunicazione","authors":"D. Baronciani","doi":"10.53126/meb43249","DOIUrl":"https://doi.org/10.53126/meb43249","url":null,"abstract":"Confrontarsi con l’incertezza a partire dagli originali criteri per adottare uno screening che sono quelli del 1968 di Wilson e Jungner.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening per diabete mellito tipo 1 e celiachia: intenzioni, pregi e difetti 1 型糖尿病和乳糜泻筛查：意图、优点和缺点
Medico e Bambino Pub Date : 2024-04-24 DOI: 10.53126/meb43243
G. Tornese, L. Greco
{"title":"Screening per diabete mellito tipo 1 e celiachia: intenzioni, pregi e difetti","authors":"G. Tornese, L. Greco","doi":"10.53126/meb43243","DOIUrl":"https://doi.org/10.53126/meb43243","url":null,"abstract":"Italy is the first country in the world to have introduced screening on the entire pediatric population for type 1 diabetes mellitus and celiac disease which will be preceded by a preparatory pilot study in 4 regions and on approximately 5000 children aged 2, 6 and 10 years of age. In this article we will give some practical information on screening and we will try to give the reasons for screening and any doubts, keeping in mind the Wilson and Jungner screening criteria.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"61 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infezione da West Nile Virus 西尼罗河病毒感染
Medico e Bambino Pub Date : 2024-04-24 DOI: 10.53126/meb43233
F. Orsi, Giulia Bini, G. Baroncelli, A. Bonuccelli, D. Peroni
{"title":"Infezione da West Nile Virus","authors":"F. Orsi, Giulia Bini, G. Baroncelli, A. Bonuccelli, D. Peroni","doi":"10.53126/meb43233","DOIUrl":"https://doi.org/10.53126/meb43233","url":null,"abstract":"West Nile Virus infection in children may usually occur as a self-limiting febrile illness or rarely as a neuroinvasive disease with possible late neurological sequelae. Therefore, the paediatrician should take into consideration this condition in febrile children who also showed neurological signs or symptoms. Early recognition of the disease and appropriate management may result in a favorable prognosis.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"62 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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