Pediatriya - Zhurnal im G.N. Speranskogo最新文献

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ADOLESCENT PATIENT WITH CHRONIC KIDNEY DISEASE: READINESS FOR TRANSFER FROM PEDIATRIC INTO ADULT NEPHROLOGY HEALTHCARE SYSTEM, CHALLENGES OF THE TRANSITION. BIBLIOGRAPHICAL REVIEW AND AUTHORS’ OWN OBSERVATIONS 青少年慢性肾病患者:准备从儿科转移到成人肾病保健系统,过渡的挑战。参考文献综述和作者自己的观察
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-16-27
G. Makovetskaya, G. Poretskova, L. Mazur, O. A. Sedashkina, V. N. Barinov, S. N. Reshetova
{"title":"ADOLESCENT PATIENT WITH CHRONIC KIDNEY DISEASE: READINESS FOR TRANSFER FROM PEDIATRIC INTO ADULT NEPHROLOGY HEALTHCARE SYSTEM, CHALLENGES OF THE TRANSITION. BIBLIOGRAPHICAL REVIEW AND AUTHORS’ OWN OBSERVATIONS","authors":"G. Makovetskaya, G. Poretskova, L. Mazur, O. A. Sedashkina, V. N. Barinov, S. N. Reshetova","doi":"10.24110/0031-403x-2023-102-4-16-27","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-16-27","url":null,"abstract":"Transition of an adolescent patient with chronic kidney disease (CKD) from pediatric to adult healthcare system is an urgent problem Worldwide. The purpose of this research was to generalize the idea of readiness of adolescents with CKD to transfer into adult nephrology healthcare system, to describe the challenges of such transition period and to determine the roles of participants in the process and their mutual interactions in order to develop and implement the working regional model for organizing the transition of adolescents with CKD within a clustered system of provision of specialized healthcare services. Materials and methods used: a single-center cross-sectional questionnaire surveying of adolescents and young adults with CKD regarding their readiness to transition in two observation groups was carried out on the basis of both adult and pediatric sections of the Samara Oblast Regional Clinical Hospital named after V.D. Seredavin (Samara, Russia) in Jan. 2021-March 2023. Group 1 consisted of young adults aged 18 to 22 y/o with CKD stages 2 to 3; and Group 2 included adolescents aged 13 to 18 y/o with CKD stages 2 to 5. The results were then evaluated with the TRxANSITION Index (formerly TRxANSITION Scale), PedsQL and the SF-36 questionnaire. Adolescents’ parents/caretakers took a survey on the independence of their children as well. Results: the data on the insufficient independence of adolescents were obtained, as follows: 66.7% [34.9-90.1%] (n=8) “never” took medication on their own, 50.0% [21.1-78.9%] (n=6) have never asked their physicians questions (p<0.001), 50.0% [21.1-78.9%] (n=6) “never” and 33.3% [9.9-65.1%] (n=4) “almost never” did they agree to meet with the physician (p=0.005). Adolescents experienced difficulties in both communicating and working together with a physician: 33.3% [9.9-65.1%] (n=4) and 25.0% [5.5-57.2%] (n=3) “difficult,” respectively; 50.0% [21.1-78.9%] (n=6) and 58.3% [27.7-84.8%] (n= 7) “almost difficult,” respectively (p<0.001). On the other hand, “almost everything” and “everything” do they know about their health status 47.1% [23.0-72.2%] (n=8) and 35.4% [14.2-61.7%] (n=6), respectively, of young adults with CKD vs. adolescents (p<0.001). Conclusion: structurization of the participants’ roles in the communication system “patient and his family members - medicine professionals - psychologists - social workers” contributes to the stabilization of an adolescent with CKD during the transition period.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75373835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATION OF THE MEDICAL CARE MODEL FOR CHILDREN WITH TYPE 1 DIABETES MELLITUS CARRIED OUT USING MOBILE APP AND REMOTE CONSULTATIONS. TARGETED ASSISTANCE TO DISABLED PEDIATRIC PATIENTS WITH DIABETES MELLITUS AND THEIR FAMILIES UNDER THE «ALFA-ENDO» CHARITY PROGRAM FOR CHILDREN WITH ENDOCRINE DISEASES 应用移动app和远程会诊对1型糖尿病儿童医疗服务模式的评价根据针对内分泌疾病儿童的" alfa-endo "慈善方案,有针对性地援助患有糖尿病的残疾儿童患者及其家人
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-159-165
D.N. Laptev, A.O. Emelyanov, O.B. Bezlepkina, A.V. Karpushkina, E.S. Demina, E.E. Petryaikina, Yа.V. Girsh, I.V. Gunbina, E.V. Kolbasina, D.Yu. Sorokin, V.A. Peterkova
{"title":"EVALUATION OF THE MEDICAL CARE MODEL FOR CHILDREN WITH TYPE 1 DIABETES MELLITUS CARRIED OUT USING MOBILE APP AND REMOTE CONSULTATIONS. TARGETED ASSISTANCE TO DISABLED PEDIATRIC PATIENTS WITH DIABETES MELLITUS AND THEIR FAMILIES UNDER THE «ALFA-ENDO» CHARITY PROGRAM FOR CHILDREN WITH ENDOCRINE DISEASES","authors":"D.N. Laptev, A.O. Emelyanov, O.B. Bezlepkina, A.V. Karpushkina, E.S. Demina, E.E. Petryaikina, Yа.V. Girsh, I.V. Gunbina, E.V. Kolbasina, D.Yu. Sorokin, V.A. Peterkova","doi":"10.24110/0031-403x-2023-102-4-159-165","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-159-165","url":null,"abstract":"Telemedicine technologies in pediatric patients with type 1 diabetes mellitus (T1D) is an effective approach that have begun to be used recently. The purpose of this research was to evaluate the possibility and effectiveness of remote observation and training of children with newly diagnosed T1D in selected Russia regions. Materials and methods used: a multicenter prospective open uncontrolled experimental clinical study involved 92 children aged 1 to 18 y/o with T1D receiving intensified insulin therapy who were divided into two groups: G1 of 60 patients with T1D manifestation of less than 12 weeks prior to the inclusion in the study, and G2 of 32 children with T1D manifestation lasting over 12 weeks prior to the inclusion with poor disease control (glycated hemoglobin at 8% and above) from troubled families. The main indicator for evaluating the effectiveness was the glycated hemoglobin (HbA1c) level. Results: median age was 9.2 (6.2-11.2) y/o, 47 boys/45 girls. A total of 401 remote consultations had been carried out in various forms. The HbA1c level decreased statistically significantly by the end of the study by 3.5% and 0.6% (p<0.001) in G1 and G2, respectively. Statistically significant (p<0.001) increase in the number of patients with HbA1c at the level of less than 7% was reached, with most of them (52%) reaching the target glycemic control parameters. Telemedicine technologies therefore represent the effective (in terms of glycemic control) addition to the traditional dispensary observation, which in its turn increases the availability of medical care for children with endocrine diseases.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135492800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MORBIDITY STRUCTURE IN 14-YEARS-OLD RESIDENTS OF THE MOSCOW CITY (RUSSIA): CHECKUPS’ STUDY 俄罗斯莫斯科市14岁居民发病率结构:检查研究
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-217-218
A.R. Polishchuk, A. S. Romanova, M.Sh. Khaider, S. Balashov, V. Sevostyanov
{"title":"MORBIDITY STRUCTURE IN 14-YEARS-OLD RESIDENTS OF THE MOSCOW CITY (RUSSIA): CHECKUPS’ STUDY","authors":"A.R. Polishchuk, A. S. Romanova, M.Sh. Khaider, S. Balashov, V. Sevostyanov","doi":"10.24110/0031-403x-2023-102-4-217-218","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-217-218","url":null,"abstract":"For citation: A.R. Polishchuk, A.S. Romanova, M.Sh. Khaider, S.L. Balashov, V.K. Sevostyanov. Morbidity structure in 14-years-old residents of the Moscow City (Russia): checkups’ study. Pediatria n.a. G.N. Speransky. 2023; 102 (4): 217-218. DOI: 10.24110/0031-403X-2023-102-4-217-218.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88582330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SANATORIUM AND RESORT RECREATION SERVICES FOR CHILD POPULATION IN USSR IN POST-WWII PERIOD (1946 TO 1950) 二战后苏联儿童疗养院和度假娱乐服务(1946年至1950年)
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-219-225
S. A. Sher, V. Albitskiy, N. V. Ustinova
{"title":"SANATORIUM AND RESORT RECREATION SERVICES FOR CHILD POPULATION IN USSR IN POST-WWII PERIOD (1946 TO 1950)","authors":"S. A. Sher, V. Albitskiy, N. V. Ustinova","doi":"10.24110/0031-403x-2023-102-4-219-225","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-219-225","url":null,"abstract":"Article represents the results of historical and medical bibliographical research reflecting the issues of restoration and continuous improvement of pediatric sanatorium and resort healthcare system in USSR during the post-WWII period. The purpose of the research was to evaluate the state of sanatorium and resort recreational services for child population whose health indicators highly deteriorated during WWII. The healthcare authorities in USSR faced the task of developing effective measures for the speedy restoration of children's health. In solving this problem, the highest importance was given to the development of children's sanatorium and resort healthcare system. Based on the thorough research of both published and unpublished documents in the State Archive of the Russian Federation (GARF), articles published in journals, scientific digests, chapters from monograph works, etc., it was found that almost all pediatric sanatoriums, the “Pioneer Camps” and other healthcare institutions, especially those located in the Soviet southern resorts, were occupied by the Nazis during the WWII and were fully or partially destroyed due to hostilities, plus the survived ones have then been reorganized into evacuation facilities and temporary hospitals. That is the reason why the restoration of sanatorium and resort recreational facilities became one of the priority tasks in the post-WWII period. Despite huge growth in the number of pediatric sanatoriums and other children’s health-improving institutions in 1947 compared to 1946, a decrease in child morbidity rate, an increase in the medical staff count serving pediatric patients, the recreational system had showed certain defects. Negative trends were caused by the lack in financing, laborers and qualified staff as well as re-profiling of children's healthcare facilities into those for adults. Thanks to the timely and adequate governmental measures intent to the restoration of pediatric sanatorium and resort recreation services, the bed capacity reached the pre-WWII level by 1950; a network of specialized sanatoriums started to develop and therefore increase in the health-improving measures efficiency was noted then.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75875075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF EOSINOPHILIC ESOPHAGITIS IN CHILDREN: A COHORT STUDY 儿童嗜酸性粒细胞性食管炎的临床和形态学特征:一项队列研究
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-63-72
T. N. Budkina, S. Vyazankina, M. Lokhmatov, S. Makarova, N. Murashkin, A. Fisenko, D. S. Yasakov, V. Oldakovsky, A. Tupylenko, G. A. Korolev, A. Potapov, K. Kulikov, O. Ereshko, A. Galimova, I. Gordeeva
{"title":"CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF EOSINOPHILIC ESOPHAGITIS IN CHILDREN: A COHORT STUDY","authors":"T. N. Budkina, S. Vyazankina, M. Lokhmatov, S. Makarova, N. Murashkin, A. Fisenko, D. S. Yasakov, V. Oldakovsky, A. Tupylenko, G. A. Korolev, A. Potapov, K. Kulikov, O. Ereshko, A. Galimova, I. Gordeeva","doi":"10.24110/0031-403x-2023-102-4-63-72","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-63-72","url":null,"abstract":"Number of children with eosinophilic esophagitis (EoE) observed has recently increased, therefore significant experience has been gained in the diagnosis and treatment of this disease. However, the systemic data from Russian pediatric centers’ registers that would summarize the signs of the disease in childhood has not been published as yet. The purpose of this research was to study the demographic, clinical, endoscopic and morphological features of EoE in children and to form the unified register of patients on the basis of a single yet multidisciplinary pediatric hospital. Materials and methods used: a single-center retrospective cohort study included 50 pediatric (under the age of 18 y/o) patients’ (13 (26%) girls/37 (74%) boys) records of those who were included in the National Medical Research Center for Children’s Health (Moscow, Russia) Register of EoE patients in July 2020-May 2023. Demographic indicators were assessed as well as the clinical manifestations, endoscopic and morphological changes and concomitant diseases. Results: the median age of children at the time of the diagnosis onset was 12 (8; 15) y/o. The age and the gender characteristics of patients were typical for the disease: boys aged 11 to 17 y/o had prevailed. The frequency of the EoE detection among children who had underwent esophagogastroduodenoscopy (EGD test) for various reasons was a single case per 253 EGD tests (0.4%). Among the clinical manifestations, dysphagia (44%) and abdominal pain (70%) were noted more often; GERD-like symptoms and poor weight gain were less common. The vast majority of children (84%) had concomitant allergic pathologies. EoE had proceeded comorbidly with other diseases in 60% of cases. Endoscopic manifestations of EoE were described and analyzed in detail. Thus, swelling of the mucous membrane, longitudinal striation and exudate had prevailed. Complicated course of EoE with the formation of esophageal stenosis was noted in 14%. There were no statistically significant differences between the age groups of children aged 1 to 10 y/o and 11 to 17 y/o in relation to clinical manifestations, endoscopic and morphological characteristics of EoE. Conclusion: thorough registration of pediatric patients with EoE does allow studying and summarizing of the features of this disease, in detail, with further provision of the useful information for clinical practice.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77228776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ETIOLOGICAL FACTORS AND CLINICAL MANIFESTATIONS OF NEPHROCALCINOSIS IN CHILDREN 儿童肾钙质沉着症的病因及临床表现
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-46-51
R. Nikolaeva, P. Ananin, T. Vashurina, O. Zrobok, A. Pushkov, K. Savostyanov, A. Fisenko, A. Tsygin
{"title":"ETIOLOGICAL FACTORS AND CLINICAL MANIFESTATIONS OF NEPHROCALCINOSIS IN CHILDREN","authors":"R. Nikolaeva, P. Ananin, T. Vashurina, O. Zrobok, A. Pushkov, K. Savostyanov, A. Fisenko, A. Tsygin","doi":"10.24110/0031-403x-2023-102-4-46-51","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-46-51","url":null,"abstract":"Nephrocalcinosis can result from some of acquired causes as well as being a part of the symptomatic complex of hereditary diseases. Despite monogenic causes of nephrocalcinosis being rare they nevertheless represent a significant disease burden with early onset of symptoms and a risk for the chronic kidney disease development. The purpose of this research was to describe the etiological characteristics and clinical picture of children with nephrocalcinosis as well as to assess its progression and impact on further decline in renal function. Methods used: a retrospective-prospective cohort study of 85 children with nephrocalcinosis was conducted on the basis of the National Medical Research Center for Children’s Health (Moscow, Russia) in 2012-2023. Results: the median age of the nephrocalcinosis detection was 1.5 [0.3; 4.4] y/o. Median observation duration was 2.5 [1.0; 5.0] years. For 37 (63%) there was a causative mutation responsible for the development of the disease associated with nephrocalcinosis diagnosed. Mutations in the CYP24A1, CLCN5, AGXT and HPRT1 genes had predominated. Further nephrocalcinosis progression had no significant effect on kidney function within a 2-year follow-up. Conclusion: nephrocalcinosis may be a part of the diseases with a high risk for progression and poor renal prognosis. Early diagnosis of the nephrocalcinosis cause is important for obtaining accurate prognostic information and timely therapy initiation.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74532247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ON JULY 18, 2023 PEDIATRIC PRACTITIONERS AND SCIENTISTS IN RUSSIA AND WORLDWIDE HAVE CELEBRATED THE ANNIVERSARY OF THE EDITORIAL BOARD MEMBER WITH THE JOURNAL «PEDIATRIA» NAMED AFTER G.N. SPERANSKY, AN OUTSTANDING PEDIATRICIAN OF OUR TIME, HONORED SCIENTIST OF THE RUSSIAN FEDERATION, LAUREATE OF THE RUSSIAN FEDERATION GOVERNMENT PRIZE IN SCIENCE AND TECHNOLOGY, PRESIDENT OF THE UNION OF PEDIATRICIANS OF RUSSIA, ACADEMICIAN OF THE RUSSIAN ACADEMY OF SCIENCES, PROFESSOR LEYLA SEYMUROVNA NAMAZOVA-… 2023年7月18日,俄罗斯和世界各地的儿科医生和科学家共同庆祝了以当代杰出儿科医生、俄罗斯联邦荣誉科学家、俄罗斯联邦政府科学技术奖获得者、俄罗斯儿科医生联盟主席、俄罗斯科学院院士、莱拉·塞穆罗夫娜·纳马索娃教授命名的《儿科》杂志编委会成员周年纪念日。
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-8-9
A.A. Baranov, L.S. Namazova-Baranova
{"title":"ON JULY 18, 2023 PEDIATRIC PRACTITIONERS AND SCIENTISTS IN RUSSIA AND WORLDWIDE HAVE CELEBRATED THE ANNIVERSARY OF THE EDITORIAL BOARD MEMBER WITH THE JOURNAL «PEDIATRIA» NAMED AFTER G.N. SPERANSKY, AN OUTSTANDING PEDIATRICIAN OF OUR TIME, HONORED SCIENTIST OF THE RUSSIAN FEDERATION, LAUREATE OF THE RUSSIAN FEDERATION GOVERNMENT PRIZE IN SCIENCE AND TECHNOLOGY, PRESIDENT OF THE UNION OF PEDIATRICIANS OF RUSSIA, ACADEMICIAN OF THE RUSSIAN ACADEMY OF SCIENCES, PROFESSOR LEYLA SEYMUROVNA NAMAZOVA-…","authors":"A.A. Baranov, L.S. Namazova-Baranova","doi":"10.24110/0031-403x-2023-102-4-8-9","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-8-9","url":null,"abstract":"ON JULY 18, 2023 PEDIATRIC PRACTITIONERS AND SCIENTISTS IN RUSSIA AND WORLDWIDE HAVE CELEBRATED THE ANNIVERSARY OF THE EDITORIAL BOARD MEMBER WITH THE JOURNAL «PEDIATRIA» NAMED AFTER G.N. SPERANSKY, AN OUTSTANDING PEDIATRICIAN OF OUR TIME, HONORED SCIENTIST OF THE RUSSIAN FEDERATION, LAUREATE OF THE RUSSIAN FEDERATION GOVERNMENT PRIZE IN SCIENCE AND TECHNOLOGY, PRESIDENT OF THE UNION OF PEDIATRICIANS OF RUSSIA, ACADEMICIAN OF THE RUSSIAN ACADEMY OF SCIENCES, PROFESSOR LEYLA SEYMUROVNA NAMAZOVA-BARANOVA","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135492799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS IN PREVENTING PROTEINURIA IN BOYS WITH X-LINKED ALPORT SYNDROME: A SINGLE-CENTER COHORT NON-RANDOMIZED STUDY 血管紧张素转换酶抑制剂预防x连锁阿尔波特综合征男孩蛋白尿:一项单中心队列非随机研究
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-58-63
M. Aksenova, N. Konkova, O. Piruzeeva, N. Zaikova, T. Lepaeva, T. Nikishina, V. Obukhova, V. Dlin
{"title":"ANGIOTENSIN-CONVERTING ENZYME INHIBITORS IN PREVENTING PROTEINURIA IN BOYS WITH X-LINKED ALPORT SYNDROME: A SINGLE-CENTER COHORT NON-RANDOMIZED STUDY","authors":"M. Aksenova, N. Konkova, O. Piruzeeva, N. Zaikova, T. Lepaeva, T. Nikishina, V. Obukhova, V. Dlin","doi":"10.24110/0031-403x-2023-102-4-58-63","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-58-63","url":null,"abstract":"Patients with a hemizygous mutation in the COL4A5 gene have a high risk of developing renal failure at a young age. Proteinuria reflects the progression of glomerulopathy in Alport syndrome (AS). In order to improve renal survival in AS patients with proteinuria are prescribed with angiotensin system inhibitors. There is a limited, insufficient number of studies demonstrating the effectiveness of angiotensin-converting enzyme inhibitors (ACEI) in children with AS; the therapeutic effect initiated prior to the development of proteinuria has not been studied as yet. The purpose of the research was to determine the effectiveness of ACEI therapy in the form of enalapril in the prevention of proteinuria in boys with X-linked AS (XLAS). Materials and methods used: boys aged 2 to 15 y/o with genetically confirmed XLAS were included in a single-center prospective cohort study. Enalapril was prescribed at doses of 1 to 3 mg/m2/day. Urinary protein excretion (Pr) and estimated glomerular filtration rate (eGFR) were studied at the time of inclusion and with a frequency of one time per six months for the three-year period or longer. The primary endpoint was the time of onset of proteinuria. Results: 72 boys in total, incl. 29 without proteinuria, who received enalapril therapy (Group 1, age 6.2±1.9 y/o, Pr 67±20 mg/m2/day, eGFR 118±15.2 ml /min/1.73 m2) and 43 children without therapy (Group 2, age 6.8±1.9 y/o, Pr 87±23 mg/m2/day, eGFR 119±17.3 ml/min/1.73 m2). The incidence of proteinuria (0.45 in G1 vs. 0.98 in G2, p<0.001), incl. up to the age of 10 y/o (0.42 vs 0.91, respectively, p<0.001) was statistically significantly lower in G1. Proteinuria developed later in the treatment group (10.2±2.9 vs. 4.9±1.4 years, p=0.300). Non-missense mutations in the COL4A5 gene, episodes of macrohematuria in records and lack of therapy were the risk factors for proteinuria; the lack of enalapril therapy was a predictor for proteinuria. The risk of proteinuria during therapy was reduced by 50% (RR=0.46 (95% CI 0.31; 0.68); ARR=0.53; NNT=1.9). Conclusion: initiation of enalapril therapy at the pre-proteinuria stage of nephropathy in boys with XLAS reduces the risk of proteinuria preventing its occurrence in every 50$ of cases when receiving treatment. Early initiation of therapy may be effective in preventing the progression of kidney disease in boys with XLAS.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75963721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THROMBOLYTIC THERAPY IN PEDIATRIC PRACTICE: A BIBLIOGRAPHICAL REVIEW (PART 2) 儿科溶栓治疗:文献回顾(第二部分)
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-133-140
P. Svirin, L. Larina, I.N. Lavrentyevа
{"title":"THROMBOLYTIC THERAPY IN PEDIATRIC PRACTICE: A BIBLIOGRAPHICAL REVIEW (PART 2)","authors":"P. Svirin, L. Larina, I.N. Lavrentyevа","doi":"10.24110/0031-403x-2023-102-4-133-140","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-133-140","url":null,"abstract":"Part 2 of the Article represents published data dedicated to the thrombolytic therapy (TT) for thrombosis of various localizations in children. Options for dosing and methods of thrombolytic therapy are considered. Indications and contraindications for this method of treatment are described. information on thrombolytic therapy in newborns is provided as well. Part 1 of the Article is available at https://doi.org/10.24110/0031-403X-2023-102-3-145-150: P.V. Svirin, L.E. Larina, I.N. Lavrentyeva. Thrombolytic therapy in pediatric practice (Part 1). Pediatria n.a. G.N. Speransky. 2023; 102 (3): 145-150. DOI: 10.24110/0031-403X-2023-102-3-145-150.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82256339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STANDARDS FOR CONDUCTING AND INTERPRETING THE RESULTS OF URODYNAMIC STUDIES IN CHILDREN 实施和解释儿童尿动力学研究结果的标准
Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-08-10 DOI: 10.24110/0031-403x-2023-102-4-80-92
S. S. Nikitin, N. B. Guseva, R. Ignatiev
{"title":"STANDARDS FOR CONDUCTING AND INTERPRETING THE RESULTS OF URODYNAMIC STUDIES IN CHILDREN","authors":"S. S. Nikitin, N. B. Guseva, R. Ignatiev","doi":"10.24110/0031-403x-2023-102-4-80-92","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-4-80-92","url":null,"abstract":"Article represents a bibliographical review on the problem of standards for conducting urodynamic research methods. The need for urodynamic studies is quite high and is due to the high prevalence of urination disorders in children. At the same time, the Russia urodynamic laboratories count is low and they aren’t available in all Russia regions. Plus, the number of scientific publications on urodynamics and the pediatric neurology in general is clearly insufficient. Performance of urodynamic studies in adult patients is standardized by the ICS guidelines. At the same time not all of the guidelines are acceptable in children, it is therefore necessary to approach each clinical situation individually when choosing methods for urodynamic research. This review discusses methods of urodynamic studies, such as: uroflowmetry, uroflowmetry with simultaneous recording of pelvic floor electromyography, cystometry, pressure-flow study and urethral profilometry. A brief historical background is presented as well as the indications for the methods of urodynamic research, the research techniques and the peculiarities of the results interpretation. In addition, an example of a conclusion is shown when conducting a comprehensive urodynamic study in a pediatric patient. The article is aimed at standardizing the conduct, the interpretation of the results and the formulation of conclusions when conducting urodynamic studies in children.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84404454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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