Orthopaedics and Surgical Sports Medicine最新文献

{"title":"Zoledronate and ibandronate treatments provide a significant improvement in BMD values in osteoporosis patients","authors":"Jaxon Dawson","doi":"10.31579/2641-0427/013","DOIUrl":"https://doi.org/10.31579/2641-0427/013","url":null,"abstract":"Objective: In this study, we aimed to make a comparative analysis of short term clinical effectivity and side effects of intravenous zoledronate administration as single dose yearly and intravenous ibandronate administration as four doses per year. Methods: The patients whom were included in our study had osteoporosis according to WHO criteria and were treated with either parenteral zoledronate or ibandronate. 43 patients were treated with single dose of 5mg intravenous zolendronat which was applied once in a year; whereas in 39 patients were treated with 3 mg intravenous ibandronate which was applied four times in a year in three months intervals. Biochemical tests were performed in all patients before intravenous drug infusion. Side effects during drug administration and also in the first three months of the treatment were noted for all patients. Clinical effectivity was analyzed according to changes in bone mineral density (BMD) at the end of two year after treatment. Results: Eighty-two patients who were followed-up and evaluated for the effectivity and side effects of the treatment were included in our study. The compliance of patients were 100% in both groups. Mean age was 75.23±6.9 years and mean body mass index (BMI) was 26.94±7.2. In zoledronate group in which there were 23 females and 20 males. Mean age was 73.64±8.7 years and mean BMI was 27.34±4.4. In ibandronate group in which there were 39 females. There were no statistically significant differences between the groups in terms of gender (p=0.000) Mean age, BMI and rate of diagnosed side effects were not statistically significant in between the groups. According to a one-year follow-up in both groups comparison with before application had a statistically significant increase in BMD (p<0.01). However, a one-year follow-up between the two groups in terms of mean values of bone mineral density did not differ significantly (p>0.05). Conclusion: Choice of medical treatment is decided according to bone mineral density and personal risk factors in osteoporosis. Parenteral agents in the treatment of osteoporosis may be the preferred choice for the patients with comorbid diseases, using multiple drug therapies, or having trouble in using oral drug therapy. However, it should always be kept in mind that drug related side effects may be seen more commonly with parenteral agents. Clinicians should be aware of the probable side effects during and after application.","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116250317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of different cell-based therapies at a critical time point during the soft-tissue healing process","authors":"Sumit Jain","doi":"10.31579/2641-0427/010","DOIUrl":"https://doi.org/10.31579/2641-0427/010","url":null,"abstract":"Background: Cell-based therapy for soft tissue injuries remains controversial. Adult mesenchymal stem cells (MSCs) are therapeutic candidates given their capacity for self-renewal, immunoprivilege, and differentiation capacity for chondrocyte and tenocyte lineages. Platelet rich plasma (PRP) has been reported to promote collagen synthesis and cell proliferation, influencing the healing of ligaments and cartilage. We hypothesize that allogeneic MSCs and PRP have additive effects on promoting ligament healing in an in-vivo rat medial collateral ligament (MCL) injury model. Methods: MCLs of 20 females Sprague rats were bilaterally transected and treated with either saline (controls) or 1 of 3 treatment groups; (1) allogeneic MSCs (10 5 cells), (2) PRP and (3) allogeneic MSCs & PRP. In addition, five rats were used for the Sham group (surgery + no ligament injury). Rats were sacrificed two weeks post-surgery and the MCLs harvested for histological analysis by hematoxylin and eosin and alcian blue staining. Statistical analysis was performed using Fischer’s exact test with pair-wise comparisons and Bonferroni multiple comparison correction. Results: Histologically, differences across all injured groups (treatment groups and controls) were observed in cellularity (p < 0.0185), regeneration of collagen fibers (p < 0.0084), vascularity (p = 0.0129), inflammation (p = 0.0121) and glycosaminoglycan content (p = 0.0085). From pair-wise comparisons, only the combination allogeneic MSCs & PRP group differed significantly from controls in increased cellularity (p = 9.04 x 10 -4 ) and regeneration of collagen fibers (p = 6.58x10 -4 ). In addition, the PRP group showed significant increase in glycosaminoglycan (p = 0.006) content when compared to the allogeneic MSCs group. Conclusions: The addition of allogeneic MSCs and PRP to an injured MCL show a significant histological increase in degree of cellularity, vascularity and the regeneration of collagen fibers when compared to controls. These data support a possible additive effect of combining allogeneic MSCs and PRP therapy to increase important repair factors during the proliferation/repair phase of post ligament injury. This preliminary study demonstrates that additional functional and biomechanical studies are warranted to determine the role that inflammatory responses versus tissue regeneration are contributing to this mechanism.","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134109329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodical clinical measurement of knee deformity","authors":"Kumar Ma","doi":"10.31579/2641-0427/008","DOIUrl":"https://doi.org/10.31579/2641-0427/008","url":null,"abstract":"The recognition of the pattern and severity of deformity in knee osteoarthritis has important implications in its management and prognosis. A number of methods can be used to assess and measure the coronal and sagittal knee alignment: clinical deformity measuring device like a goniometer, standard knee radiographs, hip-knee-ankle (HKA) radiographs, computer navigation systems, magnetic resonance scan, computerized tomographic scan or simply a surgeon’s subjective measurement. Each of these methods has advantages and disadvantages. The aim of this study was to compare three methods of measurement: clinical measurement with a goniometer; HKA radiographs and computer navigation. This study included 54 patients with arthritic knees, who underwent total knee replacement with computer navigation. The deformity in both coronal and sagittal planes was measured using the three methods and the results compared using Bland Altman limits of agreement. The clinical measurement differed greatly from radiographic and computer navigation measurements. According to Bland Altman limits of agreement clinical measurements could be up to 10° away from the radiographic or computer navigated measurements in coronal plane. In the sagittal plane the clinical measurements could be up to 12° away compared to computer navigation measurements. A combination of these measurements methods should be taken into account when assessing the deformity of a knee especially in relation to posture and weight bearing status. The methodical clinical measurement of knee deformity as described in this paper gives too wide a margin of error and should not be relied upon in isolation.","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125948185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Can resistance training improve the symptoms of polycystic ovary syndrome?","authors":"P. Pericleous","doi":"10.31579/2641-0427/006","DOIUrl":"https://doi.org/10.31579/2641-0427/006","url":null,"abstract":"PCOS; resistance; weight; training; diet; macronutrient.","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132014713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TCI is a new index representing the relationship between the smaller trochlear and larger capitellar angles of the measured elbow","authors":"H. Karabağ","doi":"10.31579/2641-0427/009","DOIUrl":"https://doi.org/10.31579/2641-0427/009","url":null,"abstract":"Background: In children supracondylar fracture of the humorous is one of the most common fractures in the first decade of life. This study was conducted to establish the efficacy and the accuracy of a new own method for measuring the Trochleocapitellar index (TCI) in the management of supracondylar humeral fracture in children versus Baumann’s angle. Methods: This study made on base AP elbow radiograms and clinical charts of 54 children that were treated due to supracondylar fracture of the elbow. Cases included were of either gender with age range from four to 13 years with a supracondylar fracture presenting within 72 hours of the reduction. Outcome measures: Two measure roentgen logic modalities studied for comparison: Baumann’s angle and TCI were taken into consideration when examining the AP roentgenograms (immediately after the reduction and during 1-3 months thereafter). Results: During 1-3 months after the reduction Baumann’s angle modality gave normal results in 51 (94.4%), valgus result in one (1.9%) and varus result in two (3.7%) patients. While TCI showed normal results in 31 (57.4%), valgus result in one (1.9%) and varus results in 22 (40.7%) patients. Correlation was found between the measurements of the normal Baumann’s angle and normal TCI immediately after fracture reduction (r=0.75, p<0.001) and on the period between one to three months follow-up (r=0.54, p<0.001). TCI was found as more accurate for detection of cubitus varus. Conclusions: Authors recommends post reduction measurement of the TCI in supracondylar fractures to determine the adequacy of reduction.","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134381772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive bone grafting for symptomatic meniscal tearing with concomitant bone marrow edema","authors":"Abdeldayem Ma","doi":"10.31579/2641-0427/007","DOIUrl":"https://doi.org/10.31579/2641-0427/007","url":null,"abstract":"","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117048622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SURGICAL MANAGEMENT OF SYMPTOMATIC ADULT LYTIC SPONDYLOPTOSIS BY MODIFIED/THREE STAGE GAINES PROCEDURE: CASE REPORT","authors":"C. Dhillon, Auctores","doi":"10.31579/2641-0427/003","DOIUrl":"https://doi.org/10.31579/2641-0427/003","url":null,"abstract":"Spondyloptosis or complete anterior dislocation of the L5 vertebrae over S1 is a rare clinical condition. Generally, the surgical management of spondyloptosis includes either posterior long segment in-situ fusion (with total disregard for altered biomechanics) or restoration of lumbosacral kyphosis by reduction of spondyloptosis using multi-staged procedures. Reduction is possible in spondyloptosis only after sacral dome osteotomy or L5 Corpectomy with interbody fusion of L4 over S1 as described by Robert Gaines. We present our case of a manual laborer who was treated successfully by modified/Three stage Gaines procedure.","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125471718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEALTH BENEFITS OF HYDROTHERAPY IN OSTEOPOROSIS","authors":"R. Hajare, Auctores","doi":"10.31579/2641-0427/004","DOIUrl":"https://doi.org/10.31579/2641-0427/004","url":null,"abstract":"","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"375 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120865759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latrogenic Vertebral Artery Injury During Cervical Spine Surgery: A Case Report","authors":"M. Rkhami, Auctores","doi":"10.31579/2641-0427/002","DOIUrl":"https://doi.org/10.31579/2641-0427/002","url":null,"abstract":"","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117350390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DO DIFFERENT WOUND DRESSINGS AFTER TOTAL JOINT ARTHROPLASTY MAKE A DIFFERENCE?Do Different Wound Dressings After Total Joint Arthroplasty Make A Difference?","authors":"R. Schwarzkopf","doi":"10.31579/2641-0427/001","DOIUrl":"https://doi.org/10.31579/2641-0427/001","url":null,"abstract":"Do Different Wound Dressings After Total Joint Arthroplasty Make a Difference? Afshin A. Anoushiravani MD, James E. Feng, MD, Ran Schwarzkopf, MD, MSc Department of Orthopedic SurgeryNYU Langone Health ,New York, NY, 10003 *Corresponding Author: Ran Schwarzkopf, MD, MSc, Department of Orthopedic SurgeryNYU Langone Health 301 E. 17 St., Suite 1402 New York, NY, 10003, e-mail: ran.schwarzkopf@nyumc.org","PeriodicalId":394480,"journal":{"name":"Orthopaedics and Surgical Sports Medicine","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124769909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}