Medica Jadertina最新文献

{"title":"Arnold-Chiari malformation","authors":"Dobrila Karlica Utrobičić, Žana Ljubić","doi":"10.57140/mj.52.2.9","DOIUrl":"https://doi.org/10.57140/mj.52.2.9","url":null,"abstract":"A case of a 14-year-old girl suffering from intense headaches is presented. At the first pediatrician's examination, the patient had regular findings. Prolonged P100 wave latencies were found by testing the visual evoked potentials. After further examination following repeated headaches, Arnold Chiari type I malformation was diagnosed. Arnold Chiari malformation is classified as downward displacement of one or both cerebellar tonsils through foramen magnum. The most common symptom is occipital or suboccipital headaches that usually happens after hard physical effort. Changes in visual evoked potential latencies can be present before other clinical symptoms and can be a useful tool in the diagnostics of headaches in children and adolescents.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46725455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiologija u dječjoj i adolescentnoj psihijatriji","authors":"Iva Radoš, Z. Kušević","doi":"10.57140/mj.52.2.5","DOIUrl":"https://doi.org/10.57140/mj.52.2.5","url":null,"abstract":"Epidemiologija psihičkih poremećaja djece i adolescenata predstavlja važno područje u praćenju morbiditeta i planiranju zdravstvene zaštite ove populacije, kao i kapaciteta multimodalnog pristupa. Puno je manje istraživanja u tom području, nego u istom području kod odraslih. Malobrojna istraživanja upućuju na trend povećanja morbiditeta, a aktualna situacija pandemije COVID-19 predstavlja dodatni rizik.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43680499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible immunological mechanisms in COVID-19 patients with immune thrombocytopenic purpura","authors":"M. Bahadoram, A. Saeedi-Boroujeni, M. Mahmoudian-sani","doi":"10.57140/mj.52.2.6","DOIUrl":"https://doi.org/10.57140/mj.52.2.6","url":null,"abstract":"Millions of people around the world were, or are still involved with COVID-19 due to infection with SARS-CoV-2. In addition to hallmark symptoms, thrombotic problems, lymphopenia, and thrombocytopenia have also been reported in COVID-19 patients, of which ITP is the most common and occurs in more than one-third of COVID-19 patients. Hyperinflammation, cytokine storms, and generally immune dysregulation in a percentage of patients develop the main consequences of diseases such as ALI, ARDS and multiple organ failure. Some of the important events in the immunopathogenesis of this disease are disruption of T-cell effector differentiation and the destructive role of Th17 lymphocytes, neutrophil function and inflammatory macrophages. NLRP3-inflammasome hyperactivity causes serious dysfunction of innate immune cells and, consequently, T lymphocytes in many inflammatory disorders, most notably in the COVID-19. A closer look at the immunopathogenesis of ITP and COVID-19 brings us to common ground. The purpose of this study was to review and summarize the findings of various studies on the immunopathogenesis of ITP and its possible causes in COVID-19. Finally, enhanced differentiation of Th17 and Th1, the cell death called as pyroptosis, hyperinflammation and dysfunction of inflammatory neutrophils and macrophages, and NLRP3- inflammasome hyperactivity are important factors in the development of thrombocytopenia in patients with COVID-19. Further studies are needed to better understand immunopathogenesis and effective treatments for ITP, especially in inflammatory disorders","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41620241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transteorijski model u ispitivanju procesa promjene kod anoreksije nervoze","authors":"Maša Atlaga, Nataša Šimić","doi":"10.57140/mj.52.2.4","DOIUrl":"https://doi.org/10.57140/mj.52.2.4","url":null,"abstract":"Bolesnici koji pate od anoreksije nervoze relativno često manifestiraju ambivalenciju glede promjene vlastitog stanja, a manjak motivacije za promjenom predstavlja ključnu barijeru u intervenciji i liječenju ovoga poremećaja. Dosadašnja istraživanja pokazala su da je slaba motivacija za promjenom značajan prediktor nepovoljnih ishoda u tretmanu, jednako kao i visoke stope odustajanja od istog. Transteorijski model je integrativni model namjerne promjene ponašanja koji opisuje i predviđa kada i kako će osoba promijeniti svoje ponašanje. Model postulira da pojedinci prolaze kroz šest stadija u procesu promjene (predkontemplacija, kontemplacija, priprema, akcija, održavanje i završetak). Prema dosadašnjim istraživanjima, područja evaluacije modela su uključivala različite ovisnosti poput ovisnosti o alkoholu, pušenju, psihoaktivnim tvarima, kockanju, ali i poremećaje hranjenja i jedenja, kao što su anoreksija i bulimija nervoza. Transteorijski model pretpostavlja da važnu ulogu na putu prema promjeni ponašanja imaju procesi promjene, percipirana samoefikasnost, te uravnoteženost prednosti i nedostataka vlastitoga stanja u procesu donošenja odluke. Budući da su istraživanja koja se temelje na evaluaciji i primjeni ovoga modela još uvijek malobrojna, cilj ovog rada je pružiti prikaz istraživanja usmjerenih na evaluaciju i primjenu transteorijskog modela kod anoreksije nervoze s naglaskom na operacionalizaciju i mjerenje njegovih glavnih varijabli. Dosadašnja su istraživanja potvrdila osnovne postavke modela na oboljelima od anoreksije, a u ovom se radu predstavljaju smjernice za daljnja istraživanja.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44687100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Azatioprin u liječenju bolesnika s ulceroznim kolitisom","authors":"Franjo Barun, Dražen Zekanović, Neven Ljubičić","doi":"10.57140/mj.52.2.8","DOIUrl":"https://doi.org/10.57140/mj.52.2.8","url":null,"abstract":"Ulcerozni kolitis kronična je upalna bolest za koju su karakteristične ulceracije sluznice debeloga crijeva i klinički tijek obilježen razdobljima remisije i relapsa bolesti. Klinički se ulcerozni kolitis najčešće očituje učestalim sluzavo-krvavim proljevima. Azatioprin je tiopurin koji imunosupresiju postiže putem svojih aktivnih metabolita. Oni potiču apoptozu T-limfocita, te, inkorporirajući se u replicirajući lanac DNA i blokirajući de novo sintezu purina, smanjuju njihovu proliferaciju. Mjerenjem aktivnosti tiopurin Smetiltransferaze i praćenjem metabolita tiopurina, uspješno se postiže optimizacija terapije. Time se poboljšava klinička djelotvornost liječenja, te sprječava neuspjeh liječenja uzrokovan štetnim nuspojavama azatioprina. Unatoč pretpostavkama da će u budućnosti, zbog razvoja učinkovitijih i sigurnijih lijekova, uloga tiopurina u liječenju bolesnika s ulceroznim kolitisom biti ograničenija, azatioprin i dalje ostaje neizostavan lijek u liječenju bolesnika s ulceroznim kolitisom.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43984933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osobine bolesnika liječenih zbog infekcijskog endokarditisa u tercijarnom referentnom centru od 2012. do 2020. godine","authors":"A. Vrdoljak, V. Čapkun, Damir Fabijanić, Zorislav Šušak, Dražen Zekanović, Vedran Carević, Tina Bečić, Robert Glavinić, Duško Kardum","doi":"10.57140/mj.52.2.2","DOIUrl":"https://doi.org/10.57140/mj.52.2.2","url":null,"abstract":"Cilj: Utvrditi osobine i ishode liječenja bolesnika liječenih zbog infekcijskog endokarditisa (IE) u tercijarnom referentnom centru. Ispitanici i metode: U retrospektivno presječno istraživanje od siječnja 2012. do prosinca 2020. uključen je 101 bolesnik s dijagnozom IE. Analizirani su klinički i demografski podaci, ranije bolesti, primjena lijekova s imunosupresivnim učinkom, intravenska primjena droga, simptomi prilikom prijama, vrijednosti hematoloških i biokemijskih pokazatelja, nalazi mikrobiološke obrade, trajanje i ishodi liječenja (otpust, premještaj na kardiokirurgiju, smrt). Rezultati: Najčešći čimbenici srčano-žilnog rizika bili su arterijska hipertenzija (35,6%), pušenje (22,8%) i kronično zatajivanje bubrega (13,1%), dok je kod 7,9% bolesnika zabilježena intravenska primjena droga. Najčešći simptomi zabilježeni prilikom prijama bolesnika bili su povišena tjelesna temperatura (92%) i novonastali ili pojačan intenzitet od ranije poznatog srčanog šuma (77%). Najčešće zahvaćeni prirodni zalistak bio je mitralni (32,67%), a umjetni aortni (18,82%). Najčešći uzročnici IE bili su Streptococcus viridans (23,8%), meticilin osjetljivi Staphylococcus aureus (22,8%) i enterokok (16,8%), a negativan nalaz hemokultura zabilježen je u 15,8 % bolesnika. U liječenju su najčešće korišteni beta-laktamski antibiotici (92,22%), gentamicin (33,7%) i vankomicin (17,8%). Na kućno liječenje otpušteno je 62,4% bolesnika, 22,7% ih je podvrgnuto kardiokirurškom zahvatu, dok je u 14,9% bolesnika zabilježen smrtni ishod. Jedini predskazatelj smrti bila je dob bolesnika (> 65 godina). Zaključci: Osobine naših bolesnika su podudarne, a ishodi bolesti povoljniji u odnosu na rezultate zabilježene u ustanovama iste razine u zemljama zapadnoga svijeta. Jedini nezavisni predskazatelj smrti u naših bolesnika s IE bila je dob veća od 65 godina.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41374807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obligatory exercise in young adults","authors":"I. Duvnjak, Josip Cvenić, I. Šklempe Kokić","doi":"10.57140/mj.52.2.3","DOIUrl":"https://doi.org/10.57140/mj.52.2.3","url":null,"abstract":"Introduction: Physical activity and exercise have numerous physical and psychological benefits. However, some individuals persevere in exercise despite the various problems it causes – physical, emotional, social and psychological. Aim: The present study aimed to explore the effects of gender, group of exercisers and supplements on the occurrence of obligatory exercise in young adults. Another aim was to explore and present psychometric characteristics and factor structure of the Croatian version of The Obligatory Exercise Questionnaire (OEQ). Methods: The study included 124 kinesiology students and 109 recreational exercisers (107 males and 126 females) in early adulthood engaged in some kind of physical activity. The participants provided information about sociodemographic characteristics and completed The Obligatory Exercise Questionnaire. Results: Analysis of the factor structure of the Obligatory Exercise Questionnaire revealed three factors: exercise frequency and commitment, exercise preoccupation and intensity, and exercise emotionality. Obtained findings correspond to the previous modified and reduced versions of the instrument. The results of the research indicate that male participants and kinesiology students exercise more often and are more committed than females and recreational exercisers. Participants using vitamin and nutritional supplements exercise more often, are more committed and more preoccupied and exercise more intensely than those who are not using any supplements. Likewise, male students using vitamin and nutritional supplements show the highest levels of exercise emotionality. Conclusion: The results suggest that the male gender, kinesiology students, and those who use the supplements may be riskier for obligatory exercise development.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42877911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Važnost primjene fizikalne terapije u skrbi za trudnice","authors":"Filip Petković, Sonja Iža, Ines Ivanković","doi":"10.57140/mj.52.2.7","DOIUrl":"https://doi.org/10.57140/mj.52.2.7","url":null,"abstract":"Uvod: Trudnoća donosi mnogobrojne promjene na organizam žene, te se intenzitet promjena mijenja ovisno o razdoblju trudnoće u kojem se žena nalazi. Upravo fizioterapeut svojim intervencijama utječe na poboljšanje funkcije i olakšavanje tih promjena. Postupci: Prikupljeni su podaci iz medicinske literature, odnosno knjiga u tiskanom i elektronskom izdanju, te iz znanstveno-medicinskih baza podataka Scopus, PubMed/Medline na engleskom jeziku, te CROSBI i Hrčak za časopise na hrvatskom jeziku. Prikaz teme: Trudnoća utječe na promjenu respiratornog, kardiovaskularnog i mišićno-koštanog sustava, što može dovesti do pojave boli, pogoršanja funkcije, anksioznosti i depresije trudnice. Fizioterapeut pravilnom procjenom i fizioterapijskom intervencijom utječe na poboljšani ishod i tijek poroda primjenom individualizirane tjelovježbe, čime se utječe na tjelesnu težinu majke i postiže pozitivan učinak na kliničku sliku djeteta pri rođenju, te se sprječavaju neke moguće komplikacije u zdravlju djeteta. Zaključak: Za zdravlje majke i djeteta u trudnoći i pri porodu bitno je pravilnim fizioterapijskim intervencijama koje uključuju tjelesno vježbanje, procjenu muskulature i dijastaze, pravilnu prehranu i edukaciju, utjecati na kompletno psihofizičko zdravlje trudnice.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41545959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of symptoms and clinical signs of laryngopharyngeal reflux depending on pepsia in saliva","authors":"J. Maleš, M. Rezo, I. Abičić, Tihana Mendeš, Andrijana Včeva, Tin Prpić","doi":"10.57140/mj.52.2.1","DOIUrl":"https://doi.org/10.57140/mj.52.2.1","url":null,"abstract":"In the last fifty years, an epidemic of reflux disease has occurred as a result of poor eating habits, stress, and activities of the food industry. Part of this disease is laryngopharyngeal reflux, a disease characterized by the return of gastric contents to the throat and surrounding organs, leading to hoarseness, coughing, difficulty in swallowing and breathing, and ultimately the development of benign and malignant changes in the larynx. This study is aimed to examine the symptoms and signs of laryngopharyngeal reflux in the study group before and after therapy and to compare the concentration of pepsin in saliva with the above. The prospective longitudinal cohort study included 50 subjects, divided into two groups. The first group consisted of 25 subjects with laryngopharyngeal reflux. The second group consisted of 25 healthy subjects without symptoms and signs of laryngopharyngeal reflux. Symptoms and signs before and after therapy were collected using RSI and RFS questionnaires. Pepsin in saliva was measured with Peptest before and after therapy. The most pronounced symptoms are hoarseness, postnasal drip, and a feeling of \"a lump in the throat\". The median RSI score after three months of therapy was reduced from 20 to 8. From the first group, 7 subjects had measurable levels of pepsin in saliva, and none after therapy. In the control group, no subjects were found to have pepsin in their saliva. Significant improvement was observed in clinical findings (subglottic edema, posterior commissure hypertrophy, vocal cord edema, dense endolaryngeal secretion) after three months of therapy in subjects with LPR. No association of pepsin with LPR symptoms was observed but there is a significant positive association between pepsin and the clinical finding of erythema/hyperemia. In most cases, we start therapy with medication. It is, therefore, important to emphasize that laryngopharyngeal reflux treatment must always begin with a change in diet, lifestyle, and stress regulation. Treatment must be individual and should include a multidisciplinary team with a nutritionist, psychologist, and psychiatrist.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47128823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of inflammatory scoring systems in critically ill patients with COVID-19 infection","authors":"Damir Mihić, L. Maričić, Ivana Tolj, Domagoj Loinjak, Livija Sušić, I. Begić","doi":"10.57140/mj.52.1.1","DOIUrl":"https://doi.org/10.57140/mj.52.1.1","url":null,"abstract":"Aim: The outbreak of novel coronavirus pneumonia that was first detected in Wuhan in December 2019 resulted in a worldwide pandemic. Approximately 25% of confirmed cases developed a severe disease and the need for intensive care unit admission. The aim of this study was to determine the role of three inflammatory scoring systems, C-reactive protein/albumin ratio, fibrinogen/albumin ratio, C-reactive protein/lymphocyte ratio and their association with survival, comorbidities, and the occurrence of additional complications in the intensive care of these patients. Materials and methods: This retrospective study was conducted based on data collected by the Department of Respiratory Center. Ethical approval for the study was obtained from the Ethics Committee of Osijek University Hospital. This study analysed data retrospectively between October and December 2020, and included 137 critically ill patients with a diagnosis of COVID-19. Results: Data analysis of three examined inflammatory points of the system, below and above the median found a significant association in the group below the median C-reactive protein/albumin ratio with the presence of complications (p= 0,039) in the group above the median in the study of fibrinogen/albumin ratio found a significant association with sepsis (p=0,043). In the group of participants who were above its median in terms of C-reactive protein/lymphocyte ratio, there were more of those with the development of acute kidney injury (p=0,014), and sepsis (p=0,009). Conclusion: Inflammatory scoring systems, C-reactive protein/albumin ratio, fibrinogen/albumin ratio and C‐reactive protein/lymphocyte ratio represent an independent prognostic indicator of the clinical course in critically ill patients with COVID-19 infection.","PeriodicalId":39401,"journal":{"name":"Medica Jadertina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41408187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}