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International Journal of Computational Biology and Drug Design最新文献

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EyeRIS: Image-Based Identification of Goats using Iris eyeis:利用虹膜进行山羊图像识别
International Journal of Computational Biology and Drug Design Pub Date : 2023-01-01 DOI: 10.1504/ijcbdd.2023.10058565
D. Hajra, Pritam Ghosh, Sanket Dan, Subhranil Mustafi, S. Mandal, Santanu Banik, Shyamal Naskar
{"title":"EyeRIS: Image-Based Identification of Goats using Iris","authors":"D. Hajra, Pritam Ghosh, Sanket Dan, Subhranil Mustafi, S. Mandal, Santanu Banik, Shyamal Naskar","doi":"10.1504/ijcbdd.2023.10058565","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.10058565","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66715470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual screening of plant phytochemicals to discover potent Janus kinase-1 inhibitors against severe COVID-19 and sepsis 虚拟筛选植物化学物质以发现有效的Janus激酶-1抑制剂对抗严重的COVID-19和败血症
International Journal of Computational Biology and Drug Design Pub Date : 2023-01-01 DOI: 10.1504/ijcbdd.2023.10058028
V. Nunia, Mansoor Ali Syed, S. Qureshi, Rakesh Sharma, Shubham Verma, Shradheya R. R. Gupta, Kavita Joshi
{"title":"Virtual screening of plant phytochemicals to discover potent Janus kinase-1 inhibitors against severe COVID-19 and sepsis","authors":"V. Nunia, Mansoor Ali Syed, S. Qureshi, Rakesh Sharma, Shubham Verma, Shradheya R. R. Gupta, Kavita Joshi","doi":"10.1504/ijcbdd.2023.10058028","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.10058028","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"1 1","pages":"391-411"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66715907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SMLBT: secure machine learning and blockchain-based telemedicine model for the remote areas of developing countries SMLBT:面向发展中国家偏远地区的安全机器学习和基于区块链的远程医疗模型
International Journal of Computational Biology and Drug Design Pub Date : 2023-01-01 DOI: 10.1504/ijcbdd.2023.134617
Milon Biswas, Atanu Shome, Prodipta Promit Mukherjee, Loveleen Gaur, Zhongming Zhao
{"title":"SMLBT: secure machine learning and blockchain-based telemedicine model for the remote areas of developing countries","authors":"Milon Biswas, Atanu Shome, Prodipta Promit Mukherjee, Loveleen Gaur, Zhongming Zhao","doi":"10.1504/ijcbdd.2023.134617","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.134617","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135318453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment and Validation of Emulgel Based Salicylic acid Formulation Development to Drug release and Optimization by Statistical Design 乳状水杨酸处方开发对药物释放的评价与验证及统计设计优化
International Journal of Computational Biology and Drug Design Pub Date : 2023-01-01 DOI: 10.1504/ijcbdd.2023.10058216
Pavani Cheekati, Kundansai Balaga, Manasa Banala, Ishwarya Bammidi, Tarakaramarao C H, Yamani Busa
{"title":"Assessment and Validation of Emulgel Based Salicylic acid Formulation Development to Drug release and Optimization by Statistical Design","authors":"Pavani Cheekati, Kundansai Balaga, Manasa Banala, Ishwarya Bammidi, Tarakaramarao C H, Yamani Busa","doi":"10.1504/ijcbdd.2023.10058216","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.10058216","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66715460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EyeRIS: image-based identification of goats using Iris eyeis:利用虹膜对山羊进行图像识别
International Journal of Computational Biology and Drug Design Pub Date : 2023-01-01 DOI: 10.1504/ijcbdd.2023.134616
Satyendra Nath Mandal, Subhranil Mustafi, Sanket Dan, Pritam Ghosh, Dilip Kumar Hajra, Santanu Banik, Shyamal Naskar
{"title":"EyeRIS: image-based identification of goats using Iris","authors":"Satyendra Nath Mandal, Subhranil Mustafi, Sanket Dan, Pritam Ghosh, Dilip Kumar Hajra, Santanu Banik, Shyamal Naskar","doi":"10.1504/ijcbdd.2023.134616","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.134616","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135318466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual screening of plant phytochemicals to discover potent Janus kinase-1 inhibitors against severe COVID-19 and sepsis 虚拟筛选植物化学物质以发现有效的Janus激酶-1抑制剂对抗严重的COVID-19和败血症
International Journal of Computational Biology and Drug Design Pub Date : 2023-01-01 DOI: 10.1504/ijcbdd.2023.133834
Kavita Joshi, Shradheya R.R. Gupta, Shubham Verma, Rakesh Sharma, Sameer Qureshi, Mansoor Ali Syed, Vandana Nunia
{"title":"Virtual screening of plant phytochemicals to discover potent Janus kinase-1 inhibitors against severe COVID-19 and sepsis","authors":"Kavita Joshi, Shradheya R.R. Gupta, Shubham Verma, Rakesh Sharma, Sameer Qureshi, Mansoor Ali Syed, Vandana Nunia","doi":"10.1504/ijcbdd.2023.133834","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.133834","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136004087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulate the agarose gel of the receptor binding domain in Omicron's spike protein inserted into the pGEM®-T Easy vector using SpeI and SacI restriction enzymes 使用SpeI和SacI限制性内切酶模拟插入pGEM®-T Easy载体的Omicron刺突蛋白受体结合域琼脂糖凝胶
International Journal of Computational Biology and Drug Design Pub Date : 2023-01-01 DOI: 10.1504/ijcbdd.2023.134614
Ali Adel Dawood
{"title":"Simulate the agarose gel of the receptor binding domain in Omicron's spike protein inserted into the pGEM®-T Easy vector using SpeI and SacI restriction enzymes","authors":"Ali Adel Dawood","doi":"10.1504/ijcbdd.2023.134614","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.134614","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135318472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Residue interaction network analysis and molecular dynamics simulation of 6K viroporin: Chikungunya virus channel proteins 基孔肯雅病毒通道蛋白6K病毒孔蛋白残基相互作用网络分析及分子动力学模拟
International Journal of Computational Biology and Drug Design Pub Date : 2023-01-01 DOI: 10.1504/ijcbdd.2023.133857
Chaitra Mallasandra Krishnappa, Pratishtha Rai, Ayesha Zeba, Anjali Ganjiwale
{"title":"Residue interaction network analysis and molecular dynamics simulation of 6K viroporin: Chikungunya virus channel proteins","authors":"Chaitra Mallasandra Krishnappa, Pratishtha Rai, Ayesha Zeba, Anjali Ganjiwale","doi":"10.1504/ijcbdd.2023.133857","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.133857","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136002797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Silico Analysis of Multiple Targets (HER2 receptor and DNA) Inhibition by Natural Isoquinoline Derivatives for Breast Cancer Treatment 天然异喹啉衍生物对乳腺癌治疗的多靶点(HER2受体和DNA)抑制作用的计算机分析
International Journal of Computational Biology and Drug Design Pub Date : 2022-01-01 DOI: 10.1504/ijcbdd.2022.10051680
Lokesh Kumar Agarwal N.A.
{"title":"In Silico Analysis of Multiple Targets (HER2 receptor and DNA) Inhibition by Natural Isoquinoline Derivatives for Breast Cancer Treatment","authors":"Lokesh Kumar Agarwal N.A.","doi":"10.1504/ijcbdd.2022.10051680","DOIUrl":"https://doi.org/10.1504/ijcbdd.2022.10051680","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66715722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions of Leptospiral PI-PLC with the membrane phosphoinositides: an insight of the proteinphospholipid association in the pathogenesis 钩端螺旋体PI-PLC与膜磷脂酰肌醇的相互作用：对蛋白-磷脂关联在发病机制中的见解
International Journal of Computational Biology and Drug Design Pub Date : 2020-05-13 DOI: 10.1504/ijcbdd.2020.10029440
T. Samaha
{"title":"Interactions of Leptospiral PI-PLC with the membrane phosphoinositides: an insight of the proteinphospholipid association in the pathogenesis","authors":"T. Samaha","doi":"10.1504/ijcbdd.2020.10029440","DOIUrl":"https://doi.org/10.1504/ijcbdd.2020.10029440","url":null,"abstract":"Protein-phospholipid interactions encompass the basis of many biological processes, including host-pathogen interaction and disease progression. This study reports the interactions of Leptospiral PI-PLC (LA_1375) with PIP2 and PIP3. Molecular docking analysis was carried out to unveil the interactions of the protein with the plasma membrane phosphoinositides. The binding affinities of the interactions, most favourable protein-phospholipid binding poses, and the binding site residues were revealed. The binding energies were found to be -14.04 and -11.64 kcal/mol respectively for PIP2 and PIP3 interaction. Also, the analysis explored the high-affinity binding of the protein with the substrate PIP2. PIP2 is the precursor of intracellular second messengers DAG and IP3; responsible for the activation of pro-inflammatory mediators and other signalling events. Moreover, both PIP2 and PIP3 have been implicated in various cellular processes through the activation of lipid signalling cascades. Hence, further in-vitro confirmation of the annotated interactions may open up new dimensions in the pathogenesis of Leptospirosis.","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"13 1","pages":"200-208"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47553615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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