Hematology/ Oncology and Stem Cell Therapy最新文献_第6页

Changes in Heme Levels During Acute Vaso-occlusive Crisis in Sickle Cell Anemia. 镰状细胞性贫血急性血管闭塞危象期间血红素水平的变化。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2023-01-17 DOI: 10.1016/j.hemonc.2021.08.002

Evilazio Cunha Cardoso, Pedro Vieira Silva-Neto, Bidossessi Wilfried Hounkpe, Francine Chenou, Cintia Cristina Mateus Xerez Albuquerque, Nadja Pinto Garcia, Alexander Leonardo Silva-Junior, Adriana Malheiro, Purim Cesar, Franciele de Lima, Erich V De Paula, Nelson Abrahim Fraiji

{"title":"Changes in Heme Levels During Acute Vaso-occlusive Crisis in Sickle Cell Anemia.","authors":"Evilazio Cunha Cardoso, Pedro Vieira Silva-Neto, Bidossessi Wilfried Hounkpe, Francine Chenou, Cintia Cristina Mateus Xerez Albuquerque, Nadja Pinto Garcia, Alexander Leonardo Silva-Junior, Adriana Malheiro, Purim Cesar, Franciele de Lima, Erich V De Paula, Nelson Abrahim Fraiji","doi":"10.1016/j.hemonc.2021.08.002","DOIUrl":"https://doi.org/10.1016/j.hemonc.2021.08.002","url":null,"abstract":"Objective/background: Sickle cell anemia (SCA) is associated with increased levels of extracellular heme, which is a key mediator of inflammation in this condition. Despite abundant evidence supporting this concept in cell and animal models, few studies addressed the association between heme levels and the development and severity of acute vasoocclusive crises (VOC) in humans.Methods: A cross-sectional study was conducted in patients with acute VOC. Total extracellular heme levels were measured in both plasma and serum at admission and after convalescence, and correlated with other clinical and laboratory markers of SCA severity.Results: A total of 28 episodes of VOC in 25 patients were included. Heme levels were similar between admission and convalescence, and correlated with the difference between pre and post hemoglobin, and SCA severity estimated by a composite score of clinical and laboratory markers. Heme levels were neither associated with VOC severity nor with markers of hemostasis activation, and were similar to those reported in an independent population of SCA patients at steady state.Discussion: Acute VOC are not characterized by significant increases in total extracellular heme levels. Studies measuring the fraction of free extracellular heme unbound to proteins are warranted to further refine our understanding of the role of heme in acute VOC.","PeriodicalId":39226,"journal":{"name":"Hematology/ Oncology and Stem Cell Therapy","volume":"16 2","pages":"124-132"},"PeriodicalIF":0.0,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hemonc.2021.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10636552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Predicting if Lung Cancer Will Relapse-The Role of Neutrophil/Lymphocyte Ratio. 预测肺癌是否复发——中性粒细胞/淋巴细胞比值的作用。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2023-01-17 DOI: 10.1016/j.hemonc.2021.08.003

Abigail Chan, Søren Bentzen, Amit Rout, Kenneth Miller

{"title":"Predicting if Lung Cancer Will Relapse-The Role of Neutrophil/Lymphocyte Ratio.","authors":"Abigail Chan, Søren Bentzen, Amit Rout, Kenneth Miller","doi":"10.1016/j.hemonc.2021.08.003","DOIUrl":"https://doi.org/10.1016/j.hemonc.2021.08.003","url":null,"abstract":"Objective/background: Baseline neutrophil/lymphocyte ratio (NLR), a surrogate marker for systemic inflammation and immunosuppression, is a well-studied prognostic marker in non-small cell lung cancer (NSCLC). This study tests if interim NLR is prognostic in NSCLC patients in remission.Methods: This single-center, retrospective cohort study analyzed 131 NSCLC patients treated from 2010 to 2015 who achieved complete remission. NLR was calculated at baseline and from the first available blood sample during remission. Kaplan-Meier estimates of overall survival (OS) and time to recurrence were compared using the log-rank test for trend. Multivariable analysis was conducted using the Cox proportional hazards model.Results: Of the 131 cases, 63 had subsequently recurred at the last follow-up. The mean age was 64 ± 10 years. Patients with stage I (35%), II (24%), and III (41%) were included. Histology were adenocarcinoma (60%), squamous cell (33%), and unspecified (7%). The majority of patients were smokers. For the univariate analysis interim NLR was binned into tertiles, NLR < 2, 2-4.08, and > 4.08. Of those with an interim NLR > 4.08, prognosis and recurrence risk were higher. In the multivariable analysis, remission NLR was strongly prognostic for OS ( p < .001) as did patient's age ( p = .002), but not stage, race, sex, and baseline NLR.Conclusions: Our study found that interim NLR, obtained in remission, was strongly prognostic for OS and recurrence.","PeriodicalId":39226,"journal":{"name":"Hematology/ Oncology and Stem Cell Therapy","volume":"16 2","pages":"158-161"},"PeriodicalIF":0.0,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10632106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prophylactic Pretransplant Ganciclovir to Reduce Cytomegalovirus Infection After Hematopoietic Stem Cell Transplantation. 移植前预防性使用更昔洛韦减少造血干细胞移植后巨细胞病毒感染。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2023-01-12 DOI: 10.1016/j.hemonc.2021.05.001

Daniel R Reed, Gina R Petroni, Melissa West, Caroline Jones, Abeer Alfaraj, Paige G Williams, Kathlene DeGregory, Kyle Grose, Sandra Monson, Indumathy Varadarajan, Leonid Volodin, Gerald R Donowitz, Tamila L Kindwall-Keller, Karen K Ballen

{"title":"Prophylactic Pretransplant Ganciclovir to Reduce Cytomegalovirus Infection After Hematopoietic Stem Cell Transplantation.","authors":"Daniel R Reed, Gina R Petroni, Melissa West, Caroline Jones, Abeer Alfaraj, Paige G Williams, Kathlene DeGregory, Kyle Grose, Sandra Monson, Indumathy Varadarajan, Leonid Volodin, Gerald R Donowitz, Tamila L Kindwall-Keller, Karen K Ballen","doi":"10.1016/j.hemonc.2021.05.001","DOIUrl":"https://doi.org/10.1016/j.hemonc.2021.05.001","url":null,"abstract":"Objective/background: Cytomegalovirus (CMV) reactivation remains a serious complication after allogeneic hematopoietic cell transplantation (HCT) occurring in approximately 60-70% of CMV-seropositive HCT recipients. CMV reactivation leads to adverse outcomes including end-organ damage, graft-versus-host disease, and graft failure.Methods: Ganciclovir was administered pretransplant at 5 mg/kg twice daily intravenously from the start of conditioning to Day T-2 to CMV-seropositive patients receiving their first allogeneic HCT. CMV DNA was monitored weekly until at least Day 100 posttransplant.Results: A total of 109 consecutive patients were treated, median age 57 (range 20-73) years. Of these, 36 (33%) patients had a CMV reactivation within the first 105 days posttransplant with a median time of reactivation of 52.5 (range 36-104) days posttransplant. The cumulative incidence of CMV reactivation at Day 105 posttransplant was 33.1% (95% confidence interval: 24.4-42.0). One patient developed CMV disease.Conclusion: The use of pretransplant ganciclovir was associated with low incidence of CMV reactivation and disease. These data suggest that pretransplant ganciclovir with preemptive therapy for viral reactivation may be a useful strategy to reduce CMV reactivation. Future prospective trials are needed to compare strategies for CMV prophylaxis.","PeriodicalId":39226,"journal":{"name":"Hematology/ Oncology and Stem Cell Therapy","volume":"16 1","pages":"61-69"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hemonc.2021.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9434797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Outcome of Myeloma Patients with COVID-19 on Active Lenalidomide-Based Therapy: Does Lenalidomide Protect From Severe COVID-19? 来那度胺治疗骨髓瘤COVID-19患者的疗效:来那度胺是否能预防严重的COVID-19?

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2023-01-12 DOI: 10.1016/j.hemonc.2020.08.002

Imran K Tailor, Nawal F Alshehry, Syed Z Zaidi, Mohammed A Marei, Ibraheem H Motabi, Mansour Alfayez, Syed Y Altaf

引用次数: 2

Clinical Utility of Neutrophil to Lymphocyte Ratio in Sickle Cell Disease With Vaso-Occlusive Crisis. 中性粒细胞与淋巴细胞比值在镰状细胞病伴血管闭塞危象中的临床应用。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2023-01-12 DOI: 10.56875/2589-0646.1046

Satish Maharaj, Simone Chang

{"title":"Clinical Utility of Neutrophil to Lymphocyte Ratio in Sickle Cell Disease With Vaso-Occlusive Crisis.","authors":"Satish Maharaj, Simone Chang","doi":"10.56875/2589-0646.1046","DOIUrl":"https://doi.org/10.56875/2589-0646.1046","url":null,"abstract":"Background and objectives: The neutrophil-to-lymphocyte ratio represents a universally accessible value that correlates with inflammation and prognosis in several disease states; however, the role of this biomarker in sickle cell disease remains poorly explored. Hence, the objective of the present study was to determine its potential clinical utility in patients with sickle cell disease.Patients: Herein, we retrospectively reviewed 143 patients with sickle cell disease who presented to the emergency department with fever and painful vaso-occlusive crisis.Results: The examined cohort had a prevalence of 11% confirmed bacterial infection, with approximately two-thirds reporting the use of hydroxyurea. The neutrophil-to-lymphocyte ratio was lowest in the vaso-occlusive crisis-only group when compared with all other groups; this ratio was the highest in those with a confirmed bacterial infection. Patients with confirmed bacterial infection experienced the longest mean length of in-hospital stay, approximately 2 weeks, whereas patients with viral infections and vaso-occlusive crisis had the shortest stay (4-5 days). An elevated neutrophil-to-lymphocyte ratio on presentation correlated with confirmed bacterial infection (area under the curve 0.76); maximum specificity (76%) and sensitivity (69%) for confirmed bacterial infection were achieved using a neutrophil-to-lymphocyte ratio threshold ≥4.6. However, the neutrophil-to-lymphocyte ratio did not predict acute chest syndrome in this patient cohort.Conclusion: The neutrophil-to-lymphocyte ratio is a promising biomarker in sickle cell disease with diagnostic and prognostic utility.","PeriodicalId":39226,"journal":{"name":"Hematology/ Oncology and Stem Cell Therapy","volume":"16 1","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9079685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Priapism in Lymphoproliferative Disorders: A Systematic Review. 淋巴增生性疾病中的阴茎勃起:系统综述。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2022-12-23 DOI: 10.1016/j.hemonc.2021.05.003

Elrazi A Ali, Sundus Sardar, Mohamed A Yassin

引用次数: 3

Cold Agglutinin Disease and Autoimmune Hemolytic Anemia with Pulmonary Embolism as a Presentation of COVID-19 Infection. 冷凝素病和自身免疫性溶血性贫血合并肺栓塞是COVID-19感染的表现。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2022-12-23 DOI: 10.1016/j.hemonc.2020.06.005

Neha R Patil, Erica S Herc, Marian Girgis

{"title":"Cold Agglutinin Disease and Autoimmune Hemolytic Anemia with Pulmonary Embolism as a Presentation of COVID-19 Infection.","authors":"Neha R Patil, Erica S Herc, Marian Girgis","doi":"10.1016/j.hemonc.2020.06.005","DOIUrl":"https://doi.org/10.1016/j.hemonc.2020.06.005","url":null,"abstract":"Background: Lymphopenia, thrombocytopenia, and elevated D-dimer and ferritin levels are frequently reported in patients with severe coronavirus disease 2019 (COVID-19). Here we report a case of cold agglutinin disease (CAD), autoimmune hemolytic anemia (AIHA), and pulmonary embolism as a presentation of COVID-19 infection.Case report: A 51-year-old African-American woman presented to the emergency room with fever and shortness of breath. She was tachycardic, febrile, and had an oxygen saturation of 88% on room air. Laboratory studies showed hemoglobin (Hb) 5.1 g/dL, D-dimer 4.55 μg/mL, and C-reactive protein 12.3 mg/dL. Computed tomography scan of the chest showed acute pulmonary embolism involving the bilateral lower lobe segmental branches. Her influenza test was negative, but her SARS-CoV-2 test returned positive. Due to severe anemia, she was not started on any anticoagulation. Haptoglobin was low. Direct antiglobulin test returned positive for anticomplement and negative for anti-immunoglobulin G. Cold agglutinin titer was 80. Mycoplasma, Epstein-Barr virus, parvovirus, human immunodeficiency viruses, and acute hepatitis screen were negative. Abdominal and pelvic computed tomography showed a normal liver and spleen without lymphadenopathy. Peripheral blood smear showed red blood cell agglutination. On Day 2, she became hypoxic requiring 6 L oxygen. Since her Hb remained stable, she was started on low-intensity unfractionated heparin. Inflammatory markers subsequently improved and she was weaned off oxygen. Her Hb remained stable at 9 g/dL and she was discharged home. After 2 weeks, her Hb increased to 11 g/dL.Conclusion: As exemplified in this case report, COVID-19 infection can lead to thromboembolism, CAD, and AIHA and it should be recognized as a potential etiology to such rare diseases.","PeriodicalId":39226,"journal":{"name":"Hematology/ Oncology and Stem Cell Therapy","volume":"15 4","pages":"213-216"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hemonc.2020.06.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10521521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Cytogenetic Influence on Prognosis in Acute Promyelocytic Leukaemia: A Cohort Study in Vietnam. 细胞遗传学对急性早幼粒细胞白血病预后的影响:越南一项队列研究。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2022-12-23 DOI: 10.1016/j.hemonc.2021.06.003

Minh Phuong Vu, Cuc Nhung Nguyen, Hoang Vu

{"title":"Cytogenetic Influence on Prognosis in Acute Promyelocytic Leukaemia: A Cohort Study in Vietnam.","authors":"Minh Phuong Vu, Cuc Nhung Nguyen, Hoang Vu","doi":"10.1016/j.hemonc.2021.06.003","DOIUrl":"https://doi.org/10.1016/j.hemonc.2021.06.003","url":null,"abstract":"Objective/background: To analyse the influence of chromosomal aberrations in addition to t(15;17)(q22;q21) in acute promyelocytic leukaemia (APL) on clinical characteristics and treatment outcomes.Methods: Fifty-seven patients with new APL diagnoses underwent conventional cytogenetic analysis; fluorescence in situ hybridization for t(15;17)(q22;q21) and reverse transcriptase-polymerase chain reaction detected PML/RARα in two forms: L (length) and S (short) and accepted treatment with all-trans retinoic acid and chemotherapy. Patients with additional chromosome aberrations were designated as the complex karyotype group and were compared with patients with only t(15;17), who were designated as the simple karyotype group.Results: Additional chromosome aberrations was observed in 18/57 patients (31.6%) at initial diagnosis. Outcome was significantly different between the simple karyotype group and the complex karyotype group for complete remission (92.3% vs. 66.7% respectively, p = .025), overall survival at 3 years (92.3% vs. 65.0%, respectively, p = .017), and progression-free survival at 3 years (81.4% vs. 44.4%, respectively, p = .024).Conclusions: Additional chromosome aberrations had adverse effects on the prognosis in APL.","PeriodicalId":39226,"journal":{"name":"Hematology/ Oncology and Stem Cell Therapy","volume":"15 4","pages":"151-153"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hemonc.2021.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10795091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effect of Ibrutinib on Hmphocytic Leukemia: a Single-Center Experience. 伊鲁替尼对淋巴细胞白血病的影响:单中心经验。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2022-12-23 DOI: 10.1016/j.hemonc.2021.07.004

Hamza Hassan, Mohammad Ammad Ud Din, Saad Jamshed, Jonathan Bress, S Shahzad Mustafa

{"title":"Effect of Ibrutinib on Hmphocytic Leukemia: a Single-Center Experience.","authors":"Hamza Hassan, Mohammad Ammad Ud Din, Saad Jamshed, Jonathan Bress, S Shahzad Mustafa","doi":"10.1016/j.hemonc.2021.07.004","DOIUrl":"https://doi.org/10.1016/j.hemonc.2021.07.004","url":null,"abstract":"Objective/background: In the era of novel agents, Bruton tyrosine kinase (BTK) inhibitors have changed the dynamics of treating chronic lymphocytic leukemia. However, small studies have shown conflicting results regarding the additive humoral dysfunction with their use.Methods: We prospectively compared vaccine responses in patients on ibrutinib (n = 10) with matched controls (n = 16) and analyzed whether a protein-based (tetanus-diphtheria toxoid) or a carbohydrate (Pneumovax) moiety will result in an improved immunological response.Results: An appropriate serological response in IgG titers for diphtheria was seen in 40% of patients on ibrutinib and 31% of patients in the control group. About 30% of patients on ibrutinib and 44% of patients in the control group had an adequate response to tetanus toxoid. None of the patients on ibrutinib mounted an adequate response to Pneumovax, while 31% of patients in the control arm responded appropriately. These differences in the results were considered insignificant as all p values were greater than the cut-off of 0.05.Conclusion: Our study did not show significant detrimental vaccine responses with ibrutinib and calls for larger multicenter studies to elucidate long-term effects, especially in patients with prior exposure to anti-CD20 monoclonal antibodies.","PeriodicalId":39226,"journal":{"name":"Hematology/ Oncology and Stem Cell Therapy","volume":"15 4","pages":"208-212"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hemonc.2021.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10521535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Primary Mediastinal Large B-cell Lymphoma : Impact of Chemotherapy Choice. 原发性纵隔大b细胞淋巴瘤:化疗选择的影响。

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2022-12-23 DOI: 10.1016/j.hemonc.2021.05.002

Rehab Elhagracy, Abdulaziz Hamadah, Karen Pinto, Amany Hussain, Mohammad Osmani, Salem Alshemmari

{"title":"Primary Mediastinal Large B-cell Lymphoma : Impact of Chemotherapy Choice.","authors":"Rehab Elhagracy, Abdulaziz Hamadah, Karen Pinto, Amany Hussain, Mohammad Osmani, Salem Alshemmari","doi":"10.1016/j.hemonc.2021.05.002","DOIUrl":"https://doi.org/10.1016/j.hemonc.2021.05.002","url":null,"abstract":"Objective/background: Data generated from retrospective studies on primary mediastinal B-cell lymphoma (PMBCL) outcome are valuable as no prospective phase 3 trials have been conducted in this rare type of lymphoma.Methods: Our goal was to assess the long-term outcome of 41 patients with PMBCL who were treated at the Kuwait Cancer Center. We evaluated two types of multidrug treatment, R-CHOP (rituximab, vincristine, doxorubicin, cyclophosphamide, and prednisone) and DA-EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab), and determined overall survival and complete response (CR) as primary endpoints.Results: In our cohort, 27 (66%) cases were treated with R-CHOP and 14 (34%) cases were treated with DA-EPOCH-R. The overall median follow-up time was 34 months. Among the patients treated with R-CHOP, 23 out of 27 (92.6%) patients achieved CR; similarly, 10 out of 14 patients (85.7%) in the DA-EPOCH-R group achieved CR after initial treatment. There were no differences in OS between patients treated with R-CHOP versus DA-EPOCH-R.Conclusion: The findings of this study indicate that combined chemotherapy and immunotherapy results in excellent long-term outcome of patients with PMBCL. At our center, we prefer R-CHOP to DA-EPOCH-R for low-risk patients with nonbulky disease.","PeriodicalId":39226,"journal":{"name":"Hematology/ Oncology and Stem Cell Therapy","volume":"15 4","pages":"196-200"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hemonc.2021.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1