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Arhiv za Farmaciju最新文献

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Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems 疫苗配方中已建立和先进的佐剂:矿物吸附剂、纳米颗粒载体和微针递送系统
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/arhfarm1906420k
D. Krajišnik, T. Ilić, I. Nikolić, S. Savić
{"title":"Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems","authors":"D. Krajišnik, T. Ilić, I. Nikolić, S. Savić","doi":"10.5937/arhfarm1906420k","DOIUrl":"https://doi.org/10.5937/arhfarm1906420k","url":null,"abstract":"In the era of modern vaccinology, limited immunogenicity of the most commonly used antigens has enforced the use of various adjuvants in vaccine formulations to achieve desired immune response. Aluminum-containing adjuvants have been, historically, the most widely used mineral immunostimulants, generally regarded as safe to use in human vaccines. The great academic progress in inorganic (nano)materials synthesis, structure control and functionalization design has led to a growing interest in innovative adjuvants such as clays, mesoporous silica nanoparticles, zinc oxide, iron oxide and iron hydroxide nanoparticles, etc. On the other hand, there has been an intention to use specific nanoparticulated antigen delivery systems, such as nanoemulsions, in order to protect antigens from premature proteolytic degradation and/or to improve antigen immunogenicity by facilitating antigen uptake and processing by antigen presenting cells. Simultaneously, numerous research efforts have been focused on the development of innovative technologies for antigen delivery into the skin (such as microneedles), with the aim to improve vaccine efficacy alongside with enhanced patient adherence, particularly in children population (noninvasive or minimally invasive administration). Therefore, this review deals with each of these approaches in more detail, with the special emphasis on examples of their use in vaccine formulations as well as on the factors influencing their efficacy and safety.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes 电晕带电气溶胶检测器用于研究替米沙坦:b -环糊精包合物的潜力
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/arhfarm1901001m
Nevena Maljurić, Jelena Golubović, Biljana Otašević, Jovana Krmar, M. Zečević, A. Protić
{"title":"The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes","authors":"Nevena Maljurić, Jelena Golubović, Biljana Otašević, Jovana Krmar, M. Zečević, A. Protić","doi":"10.5937/arhfarm1901001m","DOIUrl":"https://doi.org/10.5937/arhfarm1901001m","url":null,"abstract":"Cyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation of inclusion complexes with variety of organic compounds. As structures lacking chromophores, CDs could not be detected by Photodiode Array (PDA) detector and Corona Charged Aerosol Detector (CAD) was introduced as the most appropriate detector for the formed complexes. The aim of the study was to investigate the degree of complexation between telmisartan, used as a model substance, and β-CD. Moreover, the effect of different β-CD concentrations (5-15 mM) and pH of the aqueous part of mobile phase (3-7) on the degree of complexation was also assessed. The intensity of the formed complex appeared to be the highest when 15 mM β-CD was used for the complexation. Also, it was noticed that the increase in peak areas with an increasing β-CD concentration was more evident at pH 7 in comparison with the same trend at lower pH values. The reproducibility of the measurement was confirmed by low relative standard deviation (RSD) of peak areas within five measurements. These findings support the use of HPLC-CAD methods for studying the process of inclusion complexes formation.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New vaccines on the horizon 新疫苗即将问世
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/arhfarm1906385a
N. Arsenović-Ranin
{"title":"New vaccines on the horizon","authors":"N. Arsenović-Ranin","doi":"10.5937/arhfarm1906385a","DOIUrl":"https://doi.org/10.5937/arhfarm1906385a","url":null,"abstract":"","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obstructive sleep apnea and cardiometabolic risk 阻塞性睡眠呼吸暂停和心脏代谢风险
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/arhfarm1903153v
J. Vekić, Z. Jelić-Ivanović, A. Zeljković, A. Stefanović, V. Spasojević-Kalimanovska
{"title":"Obstructive sleep apnea and cardiometabolic risk","authors":"J. Vekić, Z. Jelić-Ivanović, A. Zeljković, A. Stefanović, V. Spasojević-Kalimanovska","doi":"10.5937/arhfarm1903153v","DOIUrl":"https://doi.org/10.5937/arhfarm1903153v","url":null,"abstract":"","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of magnesium sulfate in the treatment of acute postoperative pain 硫酸镁在急性术后疼痛治疗中的作用
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/arhfarm1905349v
S. Vučković, K. Savic-Vujovic, D. Srebro, Lepa Jovanović, M. Prostran
{"title":"Role of magnesium sulfate in the treatment of acute postoperative pain","authors":"S. Vučković, K. Savic-Vujovic, D. Srebro, Lepa Jovanović, M. Prostran","doi":"10.5937/arhfarm1905349v","DOIUrl":"https://doi.org/10.5937/arhfarm1905349v","url":null,"abstract":"","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of prophylactic vaccines in the elderly 预防疫苗在老年人中的应用
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/arhfarm1906469b
B. Bufan
{"title":"Application of prophylactic vaccines in the elderly","authors":"B. Bufan","doi":"10.5937/arhfarm1906469b","DOIUrl":"https://doi.org/10.5937/arhfarm1906469b","url":null,"abstract":"Produženje ljudskog veka i povećanje broja starih (stariji od 65 godina) na svetskom nivou nosi sa sobom izazove za javno-zdravstveni sistem jer se radi o populaciji podložnoj infektivnim bolestima. Vakcinacija je jedan od načina prevencije ovih bolesti. U cilju poboljšanja kvaliteta života, smanjenja komplikacija bolesti, hospitalizacija i mortaliteta starih, mnoge evropske države i Sjedinjene Američke Države, kod starih osoba, preporučuju vakcinaciju protiv gripa, pneumokoka, varičela-zoster virusa (VZV), kao i „booster” vakcinacije protiv tetanusa, pertusisa i difterije. Razlog veće podložnosti infektivnim bolestima i manjoj efikasnosti vakcina kod starih su starenjem uslovljene promene koje pogađaju imunski sistem, a koje utiču na njegovu funkciju. Sezonska vakcina protiv gripa se u većini evropskih zemalja preporučuje starijima od 65 godina. Budući da je njena efikasnost niža kod starih nego kod odraslih osoba, razvijaju se strategije koje bi prevazišle ovaj problem (uključivanje adjuvansa u formulaciju, povećanje doze, promena puta unošenja antigena, razvoj vektorskih vakcina). Protiv pneumokoka su dostupne polisaharidna i konjugovana vakcina, a podaci o njihovoj efikasnosti su nekonzistentni. Vakcina protiv VZV je atenuisana, živa vakcina i pokazala se efikasna u smanjenju incidencije herpes zostera i post-herpetične neuralgije. Podizanje svesti o značaju vakcinacije starih osoba i razvoj vakcina prilagođenih ovoj populaciji su od velikog značaja za očuvanje njihovog zdravlja.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Active immunotherapy of cancer: An overview of therapeutic vaccines 癌症的主动免疫治疗:治疗性疫苗综述
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/arhfarm1906490f
B. Filipic, Z. Stojić-Vukanić
{"title":"Active immunotherapy of cancer: An overview of therapeutic vaccines","authors":"B. Filipic, Z. Stojić-Vukanić","doi":"10.5937/arhfarm1906490f","DOIUrl":"https://doi.org/10.5937/arhfarm1906490f","url":null,"abstract":"","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacotherapy of the most frequent headaches in adults 成人最常见头痛的药物治疗
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/ARHFARM1806032Z
J. Zidverc-Trajkovic
{"title":"Pharmacotherapy of the most frequent headaches in adults","authors":"J. Zidverc-Trajkovic","doi":"10.5937/ARHFARM1806032Z","DOIUrl":"https://doi.org/10.5937/ARHFARM1806032Z","url":null,"abstract":"","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A personalized approach to assessing and managing pain in patients with cancer 一种评估和管理癌症患者疼痛的个性化方法
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/ARHFARM1806045D
J. Dimitrijevic
{"title":"A personalized approach to assessing and managing pain in patients with cancer","authors":"J. Dimitrijevic","doi":"10.5937/ARHFARM1806045D","DOIUrl":"https://doi.org/10.5937/ARHFARM1806045D","url":null,"abstract":"","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Herbal medicinal products in the treatment of cough associated with colds 治疗感冒引起的咳嗽的草药产品
Arhiv za Farmaciju Pub Date : 2019-01-01 DOI: 10.5937/arhfarm1904270k
T. Kundaković-Vasović, J. Radović
{"title":"Herbal medicinal products in the treatment of cough associated with colds","authors":"T. Kundaković-Vasović, J. Radović","doi":"10.5937/arhfarm1904270k","DOIUrl":"https://doi.org/10.5937/arhfarm1904270k","url":null,"abstract":"","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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