Open Biomedical Engineering Journal最新文献_第8页

Bioactive titanate layers formed on titanium and its alloys by simple chemical and heat treatments. 通过简单的化学和热处理，在钛及其合金表面形成具有生物活性的钛酸盐层。

Open Biomedical Engineering Journal Pub Date : 2015-02-27 eCollection Date: 2015-01-01 DOI: 10.2174/1874120701509010029

Tadashi Kokubo, Seiji Yamaguchi

{"title":"Bioactive titanate layers formed on titanium and its alloys by simple chemical and heat treatments.","authors":"Tadashi Kokubo, Seiji Yamaguchi","doi":"10.2174/1874120701509010029","DOIUrl":"https://doi.org/10.2174/1874120701509010029","url":null,"abstract":"To reveal general principles for obtaining bone-bonding bioactive metallic titanium, Ti metal was heat-treated after exposure to a solution with different pH. The material formed an apatite layer at its surface in simulated body fluid when heat-treated after exposure to a strong acid or alkali solution, because it formed a positively charged titanium oxide and negatively charged sodium titanate film on its surface, respectively. Such treated these Ti metals tightly bonded to living bone. Porous Ti metal heat-treated after exposure to an acidic solution exhibited not only osteoconductive, but also osteoinductive behavior. Porous Ti metal exposed to an alkaline solution also exhibits osteoconductivity as well as osteoinductivity, if it was subsequently subjected to acid and heat treatments. These acid and heat treatments were not effective for most Ti-based alloys. However, even those alloys exhibited apatite formation when they were subjected to acid and heat treatment after a NaOH treatment, since the alloying elements were removed from the surface by the latter. The NaOH and heat treatments were also not effective for Ti-Zr-Nb-Ta alloys. These alloys displayed apatite formation when subjected to CaCl2 treatment after NaOH treatment, forming Ca-deficient calcium titanate at their surfaces after subsequent heat and hot water treatments. The bioactive Ti metal subjected to NaOH and heat treatments has been clinically used as an artificial hip joint material in Japan since 2007. A porous Ti metal subjected to NaOH, HCl and heat treatments has successfully undergone clinical trials as a spinal fusion device. ","PeriodicalId":39121,"journal":{"name":"Open Biomedical Engineering Journal","volume":"9 ","pages":"29-41"},"PeriodicalIF":0.0,"publicationDate":"2015-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/d9/TOBEJ-9-29.PMC4391211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33234484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

A review paper on biomimetic calcium phosphate coatings. 仿生磷酸钙涂层的研究进展。

Open Biomedical Engineering Journal Pub Date : 2015-02-27 eCollection Date: 2015-01-01 DOI: 10.2174/1874120701509010056

X Lin, K de Groot, D Wang, Q Hu, D Wismeijer, Y Liu

{"title":"A review paper on biomimetic calcium phosphate coatings.","authors":"X Lin, K de Groot, D Wang, Q Hu, D Wismeijer, Y Liu","doi":"10.2174/1874120701509010056","DOIUrl":"https://doi.org/10.2174/1874120701509010056","url":null,"abstract":"Biomimetic calcium phosphate coatings have been developed for bone regeneration and repair because of their biocompatibility, osteoconductivity, and easy preparation. They can be rendered osteoinductive by incorporating an osteogenic agent, such as bone morphogenetic protein 2 (BMP-2), into the crystalline lattice work in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation. Therefore, biomimetic calcium phosphate coatings are considered to be a promising delivery vehicle for osteogenic agents. In this review, we present an overview of biomimetic calcium phosphate coatings including their preparation techniques, physico-chemical properties, potential as drug carrier, and their pre-clinical application both in ectopic and orthotopic animal models. We briefly review some features of hydroxyapatite coatings and their clinical applications to gain insight into the clinical applications of biomimetic calcium phosphate coatings in the near future. ","PeriodicalId":39121,"journal":{"name":"Open Biomedical Engineering Journal","volume":"9 ","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2015-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874120701509010056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33234487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Numerical Simulation and Clinical Verification of the Minimally Invasive Repair of Pectus Excavatum. 漏斗胸微创修复的数值模拟与临床验证。

Open Biomedical Engineering Journal Pub Date : 2014-12-31 eCollection Date: 2014-01-01 DOI: 10.2174/1874120701408010147

WeiHong Zhong, JinDuo Ye, JiFu Liu, ChunQiu Zhang, MeiJiao Zhao

{"title":"Numerical Simulation and Clinical Verification of the Minimally Invasive Repair of Pectus Excavatum.","authors":"WeiHong Zhong, JinDuo Ye, JiFu Liu, ChunQiu Zhang, MeiJiao Zhao","doi":"10.2174/1874120701408010147","DOIUrl":"https://doi.org/10.2174/1874120701408010147","url":null,"abstract":"Objective: In this article we proposed a modeling method by building an assembled model to simulate the orthopedic process of minimally invasive surgery for pectus excavatum and got the clinical verification, which aims to provide some references for clinic diagnoses, treatment, and surgery planning.Methods: The anterior chest model of a 15-year-old patient was built based on his CT images; and his finite element model and the Nuss bar were created. Coupling of nodal displacement was used to connect bones with cartilages of the anterior chest. Turning the Nuss bar over is completed by rotating displacement of it. By comparing the numerical simulation outcomes with clinical surgery results, the numerical simulation results were verified.Results: The orthopedic process of minimally invasive surgery of pectus excavatum was simulated by model construction and numerical analysis. The stress, displacement fields and distribution of the contact pressure between the Nuss bar and costal cartilages were analyzed. The relationship between correcting force and displacement was obtained. Compared with the of clinical results, the numerical simulation results were close to that of the actual clinical surgery in displacement field, and the final contact position of the Nuss bar and the costal cartilages.Conclusion: Compared with the rigid model, the assembled simulation model is in more conformity with the actual clinical practice. The larger curvature results in the maximum equivalent stress, which is the main reason for clinical pain. Soft tissues and muscles should be taken into account in the numerical simulation process.","PeriodicalId":39121,"journal":{"name":"Open Biomedical Engineering Journal","volume":"8 ","pages":"147-52"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874120701408010147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34124967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

3D DWT-DCT and Logistic MAP Based Robust Watermarking for Medical Volume Data. 基于三维DWT-DCT和Logistic MAP的医学体数据鲁棒水印。

Open Biomedical Engineering Journal Pub Date : 2014-12-31 eCollection Date: 2014-01-01 DOI: 10.2174/1874120701408010131

Jingbing Li, Yaoli Liu, Jiling Zhong

引用次数: 3

Optimization of Extraction Process for Polysaccharide in Salvia Miltiorrhiza Bunge Using Response Surface Methodology. 响应面法优化丹参多糖的提取工艺。

Open Biomedical Engineering Journal Pub Date : 2014-12-31 eCollection Date: 2014-01-01 DOI: 10.2174/1874120701408010153

Wang Yanhua, Wu Fuhua, Guo Zhaohan, Peng Mingxing, Zhang Yanan, Pang Zhen Ling, Du Minhua, Zhang Caiying, Liang Zian

{"title":"Optimization of Extraction Process for Polysaccharide in Salvia Miltiorrhiza Bunge Using Response Surface Methodology.","authors":"Wang Yanhua, Wu Fuhua, Guo Zhaohan, Peng Mingxing, Zhang Yanan, Pang Zhen Ling, Du Minhua, Zhang Caiying, Liang Zian","doi":"10.2174/1874120701408010153","DOIUrl":"10.2174/1874120701408010153","url":null,"abstract":"This study was aimed to optimize the extraction process for Salvia miltiorrhiza Bunge polysaccharide using response surface methodology The results showed that four operating parameters including microwave power, microwave time and the particle size had notable effects on the polysaccharide extraction of Salvia miltiorrhiza Bunge. The effects could be ranked in decreasing order of importance as follows:. Microwave power > microwave time > the comminution degree. The optimal extraction parameters were determined as 573.83W of Microwave power and 8.4min of microwave time and 67.51mesh of the comminution degree, resulting in the yield of Salvia miltiorrhiza Bunge polysaccharide of 101.161mg / g. The established regression model describing polysaccharide extraction from as a function of the three extraction parameters was highly significant (R 2 = 0.9953). The predicted and experimental results were found to be in good agreement. Thus, the model can be applicable for the prediction of polysaccharide extraction from Salvia miltiorrhiza Bunge. ","PeriodicalId":39121,"journal":{"name":"Open Biomedical Engineering Journal","volume":"8 ","pages":"153-9"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874120701408010153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34124968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Study on bayes discriminant analysis of EEG data. 脑电数据的贝叶斯判别分析研究。

Open Biomedical Engineering Journal Pub Date : 2014-12-31 eCollection Date: 2014-01-01 DOI: 10.2174/1874120701408010142

Yuan Shi, DanDan He, Fang Qin

引用次数: 1

Research on the Diffusion Law of Oncomelania Along with the Flow Through a Side-weir. 沿侧堰流动的钉螺扩散规律研究。

Open Biomedical Engineering Journal Pub Date : 2014-12-31 eCollection Date: 2014-01-01 DOI: 10.2174/1874120701408010160

A M Liu

{"title":"Research on the Diffusion Law of Oncomelania Along with the Flow Through a Side-weir.","authors":"A M Liu","doi":"10.2174/1874120701408010160","DOIUrl":"https://doi.org/10.2174/1874120701408010160","url":null,"abstract":"Schistosomiasis is a parasitic disease mostly found in areas along the Changjiang River, Oncomelanias is the only intermediate host of schistosomiasis. Oncomelania entering into farmland or the residential zones through the flood discharge or irrigation system is the main reason of spreading schistosomiasis. Therefore it is most essential and effective way to control diffusion of oncomelanias along with flow for preventing epidemic of schistosomiasis disease. In order to simulate the flood discharge when the river dike break or the flow from main to branch channel, a side-weir flow system is set up in this paper, And furtherly the flow characteristic is studied by experiment and mathematical modeling, Finally the research on the diffusion law of oncomelania along with side-weir flow is carried out using the experimental test. The results show that oncomelanias do not equally distribute at floodplain areas, but place where flow velocity is small, i.e. in the vortex areas during oncomelanias moving along with side-weir flow. The settling positions of oncomelanias are obtained, Which lay a good foundation for eliminating oncomelanias. ","PeriodicalId":39121,"journal":{"name":"Open Biomedical Engineering Journal","volume":"8 ","pages":"160-5"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/a3/TOBEJ-8-160.PMC4541301.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33954363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Nucleosome Positioning with Set of Key Positions and Nucleosome Affinity. 核小体的一组关键位置和亲和力定位。

Open Biomedical Engineering Journal Pub Date : 2014-12-31 eCollection Date: 2014-01-01 DOI: 10.2174/1874120701408010166

Jia Wang, Shuai Liu, Weina Fu

{"title":"Nucleosome Positioning with Set of Key Positions and Nucleosome Affinity.","authors":"Jia Wang, Shuai Liu, Weina Fu","doi":"10.2174/1874120701408010166","DOIUrl":"https://doi.org/10.2174/1874120701408010166","url":null,"abstract":"The formation and precise positioning of nucleosome in chromatin occupies a very important role of study in life process. Today, many researchers discover that the positioning where the location of a DNA sequence fragment wraps around a histone in genome is not random but regular. However, the positioning is closely relevant to the concrete sequence of core DNA. So in this paper, we analyzed the relation between the affinity and sequence structure of core DNA sequence, and extracted the set of key positions. In these positions, the nucleotide sequences probably occupied mainly action in the binding. First, we simplified and formatted the experimental data by the affinity. Then, to find the key positions in the wrapping, we used neural network to analyze the positive and negative effect of nucleosome generation for every position in core DNA sequences. However, we reached a class of weights with every position to describe this effect. Finally, based on the positions with high weights, we analyzed the reason why the chosen positions are key positions, and used these positions to construct a model of nucleosome positioning predict. Experimental results show the effectiveness of our method. ","PeriodicalId":39121,"journal":{"name":"Open Biomedical Engineering Journal","volume":"8 ","pages":"166-70"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33964803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development of a bio-inspired mechatronic chest wall simulator for evaluating the performances of opto-electronic plethysmography. 仿生机电胸壁模拟器的研制，用于评估光电胸壁容积描记仪的性能。

Open Biomedical Engineering Journal Pub Date : 2014-12-19 eCollection Date: 2014-01-01 DOI: 10.2174/1874120701408010120

Massaroni C, Schena E, Bastianini F, Scorza A, Saccomandi P, Lupi G, Botta F, Sciuto S A, Silvestri S

{"title":"Development of a bio-inspired mechatronic chest wall simulator for evaluating the performances of opto-electronic plethysmography.","authors":"Massaroni C, Schena E, Bastianini F, Scorza A, Saccomandi P, Lupi G, Botta F, Sciuto S A, Silvestri S","doi":"10.2174/1874120701408010120","DOIUrl":"https://doi.org/10.2174/1874120701408010120","url":null,"abstract":"Instrumented gait analysis based on optoelectronic systems is an expensive technique used to objectively measure the human movement features and it is generally considered as the gold standard. Opto-electronic plethysmography (OEP) is a particular motion analysis system able to: (i) determine chest wall kinematic via the evaluation of marker displacements placed on the thorax and (ii) compute respiratory volumes during breathing. The aim of this work is to describe the performances of a custom made, bio-inspired, mechatronic chest wall simulator (CWS), specifically designed to assess the metrological performances of the OEP system. The design of the simulator is based on the chest wall kinematic analysis of three healthy subjects previously determined. Two sets of experiments were carried out: (i) to investigate the CWS dynamic response using different target displacements (1 - 12 mm), and (ii) to assess the CWS accuracy and precision in simulating quite breathing, covering the physiological range of respiratory frequency and tidal volume. Results show that the CWS allows simulating respiratory frequency up to ~ 60 bpm. The difference between the actual displacement and the set one is always < 9 μm. The precision error, expressed as the ratio between measurement uncertainty and the actual displacement, is lower than 0.32 %. The observed good performances permit to consider the CWS prototype feasible to be employed for assessing the performances of OEP system in periodical validation routines. ","PeriodicalId":39121,"journal":{"name":"Open Biomedical Engineering Journal","volume":"8 ","pages":"120-30"},"PeriodicalIF":0.0,"publicationDate":"2014-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/14/TOBEJ-8-120.PMC4302486.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33005831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Reality of dental implant surface modification: a short literature review. 种植体表面修饰的现状:一个简短的文献综述。

Open Biomedical Engineering Journal Pub Date : 2014-10-31 eCollection Date: 2014-01-01 DOI: 10.2174/1874120701408010114

In-Sung Yeo

{"title":"Reality of dental implant surface modification: a short literature review.","authors":"In-Sung Yeo","doi":"10.2174/1874120701408010114","DOIUrl":"https://doi.org/10.2174/1874120701408010114","url":null,"abstract":"Screw-shaped endosseous implants that have a turned surface of commercially pure titanium have a disadvantage of requiring a long time for osseointegration while those implants have shown long-term clinical success in single and multiple restorations. Titanium implant surfaces have been modified in various ways to improve biocompatibility and accelerate osseointegration, which results in a shorter edentulous period for a patient. This article reviewed some important modified titanium surfaces, exploring the in vitro, in vivo and clinical results that numerous comparison studies reported. Several methods are widely used to modify the topography or chemistry of titanium surface, including blasting, acid etching, anodic oxidation, fluoride treatment, and calcium phosphate coating. Such modified surfaces demonstrate faster and stronger osseointegration than the turned commercially pure titanium surface. However, there have been many studies finding no significant differences in in vivo bone responses among the modified surfaces. Considering those in vivo results, physical properties like roughening by sandblasting and acid etching may be major contributors to favorable bone response in biological environments over chemical properties obtained from various modifications including fluoride treatment and calcium phosphate application. Recently, hydrophilic properties added to the roughened surfaces or some osteogenic peptides coated on the surfaces have shown higher biocompatibility and have induced faster osseointegration, compared to the existing modified surfaces. However, the long-term clinical studies about those innovative surfaces are still lacking. ","PeriodicalId":39121,"journal":{"name":"Open Biomedical Engineering Journal","volume":"8 ","pages":"114-9"},"PeriodicalIF":0.0,"publicationDate":"2014-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874120701408010114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32816737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 66