Turkiye Klinikleri Cardiovascular Sciences最新文献_第2页

Cardiac Involvement is the Reason for Persistent Dyspnea in Post COVID-19 Patients without Pulmonary Sequelae: A Retrospective Study 心脏受累是COVID-19后无肺后遗症患者持续呼吸困难的原因:一项回顾性研究

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2022-01-01 DOI: 10.5336/cardiosci.2022-88692

Tuğçe Çöllüoğlu, M. Acat, Ömer Özsaraç, Y. Akin, O. Önalan

{"title":"Cardiac Involvement is the Reason for Persistent Dyspnea in Post COVID-19 Patients without Pulmonary Sequelae: A Retrospective Study","authors":"Tuğçe Çöllüoğlu, M. Acat, Ömer Özsaraç, Y. Akin, O. Önalan","doi":"10.5336/cardiosci.2022-88692","DOIUrl":"https://doi.org/10.5336/cardiosci.2022-88692","url":null,"abstract":"Objective: Several forms of cardiovascular involvement have been described in acute coronavirus disease-2019 (COVID-19) infection and also it has been shown that acute infection is responsible for cardiac symptoms. However, the data on cardiac involvement and associated symptoms in chronic phase remains unclear. Recent evidence have shown that the reason for persistent dyspnea can be persistent cardiac dysfunction in post COVID-19 infection. The aim of our study was to investigate the relationship between persistent dyspnea and cardiac involvement in post COVID-19 patients without pulmonary sequelae. Material(s) and Method(s): In our study, we recruited 30 post COVID-19 patients with dyspnea between January 2021 and July 2021. In all patients, the absence of pulmonary sequelae was detected with PFT and chest- CT. 2D-TTE, 2D-STE and MPS were performed for each case. Result(s): Left ventricular dysfunction was detected in 63.3% of patients and also 93.3% of patients had extensive abnormal GLS at 3 month follow-up. Of the patients, 33.3% had myocardial perfusion defect (MPD) and all MPDs were observed to be reversible defects. MPD was obviously seen in anterior wall (60%) and mid (20%) to apical (70%) segments. As compared with patients without MPD, patients with MPD had higher CK-MB (p: 0.016) and troponin I (p: 0.011), lesser PW thickness (p:0.020) and lower peak systolic strain rate at A2C view (p:0.031). Patients with NYHA III had more impaired GLS than patients with NYHA II (p:0.035). Conclusion(s): Our study suggests ischemic or non-ischemic cardiac dysfunction may be associated with persistent dyspnea in post- COVID- 19 patients without lung sequelae. Copyright © 2022 by Turkiye Klinikleri.","PeriodicalId":39118,"journal":{"name":"Turkiye Klinikleri Cardiovascular Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85082793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Long Intergenic Non-Coding RNA LINC01538 as Potential Novel Biomarker for Acute Myocardial Infarction: Prospective Cohort Study 循环长基因间非编码RNA LINC01538作为急性心肌梗死潜在的新型生物标志物:前瞻性队列研究

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2022-01-01 DOI: 10.5336/cardiosci.2022-90615

C. Soliman, S. Agwa, S. Fathy, M. Emam, Ahmed M. Elshazly, D. Ibrahim

{"title":"Circulating Long Intergenic Non-Coding RNA LINC01538 as Potential Novel Biomarker for Acute Myocardial Infarction: Prospective Cohort Study","authors":"C. Soliman, S. Agwa, S. Fathy, M. Emam, Ahmed M. Elshazly, D. Ibrahim","doi":"10.5336/cardiosci.2022-90615","DOIUrl":"https://doi.org/10.5336/cardiosci.2022-90615","url":null,"abstract":"ABS TRACT Objective: Non-coding RNAs are the RNAs with no pro- tein coding function, long non-coding RNAs (LncRNAs) are the non-co-ding RNAs with more than 200 nucleotides. During the journey of discovering novel biomarkers for diagnosis of myocardial infarction (MI), the principle of studying the LncRNA as a potential would be al- ways attractive, as it needs easy sample collection, has high detection sensitivity and high myocardial tissue specificity. Our main objective was to investigate the potential of LINC01538 as a novel diagnostic biomarker for MI. Material and Methods: Quantitative real-time poly- merase chain reaction (RT-qPCR) was used to assess the expression of the serum LINC01538 in 50 ST Elevation MI (STEMI) patients and 48 controls. Results: The study showed a significant increase in serum level expression of LINC01538 in MI patients compared to controls [12 (6.6- 21.8) vs. 0.07 (0.01-0.2), p<0.001]. LINC01538 expression level in MI group was positively correlated with creatine kinase MB and high sen- sitive cardiac troponin I (hs-cTnI) (r=0.39, p=0.006 and r=0.22, p=0.007, respectively). Hs-cTnI found to have diagnostic value for MI with an area under curve (AUC) 0.917 [95% confidence interval (CI): 0.855-0.979, p<0.001] at an optimal cutoff point of 1.45 ng/L, 90% sensitivity and 91% specificity. However, LINC01538 showed the highest diagnostic value with an AUC 0.980 (95% CI: 0.942- 1, p<0.001) at an op- timal cut-off point of 1.76, 100% sensitivity and 98% specificity. Conclusion: Our findings have, for the first time, demonstrated that cir- culating LINC01538 are highly expressed in patients with MI, functioning as potential novel biomarker for diagnosis.","PeriodicalId":39118,"journal":{"name":"Turkiye Klinikleri Cardiovascular Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76375726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship of In-Hospital Mortality with Cardiac Injury in COVID-19 Patients: A Retrospective Cohort Study COVID-19患者住院死亡率与心脏损伤的关系:一项回顾性队列研究

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2022-01-01 DOI: 10.5336/cardiosci.2022-93884

Sevil Gülaştı, Ferdi Gülaştı

{"title":"The Relationship of In-Hospital Mortality with Cardiac Injury in COVID-19 Patients: A Retrospective Cohort Study","authors":"Sevil Gülaştı, Ferdi Gülaştı","doi":"10.5336/cardiosci.2022-93884","DOIUrl":"https://doi.org/10.5336/cardiosci.2022-93884","url":null,"abstract":"Objective: Coronavirus disease-2019 (COVID-19) emerged in late 2019 and has caused a pandemic, resulting in significant morbidity and mortality. However, the clinical significance of cardiac injury in patients affected by COVID-19 is still unknown. Therefore, our objective was to explore the association between cardiac injury and mortality in hospitalized patients with COVID-19. Material(s) and Method(s): The study included four hundred forty-three patients with laboratory values for troponin and follow-up. The mean age was 57.3+/-16.0 years. The male to female ratio was 1.53. Fever (45.6%) and cough (42.7%) were the most frequent sign and symptom at admission. Hypertension was the most common comorbidity, identified in 140 patients (31.6%). Result(s): In 143 (32.2%) patients, we determined cardiac injury. The median length of hospital stay was ten days. The mortality rate was 14.4%. The median length of hospital stay was longer in patients with cardiac injury (14 days vs. 9 days, respectively) (p<0.001). The mortality rate was 3.7% in the patients without cardiac injury, whereas the mortality rate was significantly higher among the patients with cardiac injury (37.7%, p<0.001). The multivariable model showed that cardiac injury was the only independent risk factor for death. There was a higher risk of death in patients with cardiac injury than in those without cardiac injury [hazard ratio, 4.01 (95% confidence interval, 1.85-8.72, p<0.001)]. Conclusion(s): In conclusion, cardiac injury is a common condition among hospitalized patients with COVID-19 and is associated with an elevated risk of in-hospital mortality. In addition, it is significantly more common in patients with known heart disease, complicating the treatment process.Copyright © 2022 by Turkiye Klinikleri.","PeriodicalId":39118,"journal":{"name":"Turkiye Klinikleri Cardiovascular Sciences","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89350619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemoglobin A1c is a Predictor of Poor Collateral Development in Non-Diabetic Patients with Coronary Chronic Total Occlusion: Retrospective Clinical Trial 糖化血红蛋白是非糖尿病冠状动脉慢性全闭塞患者侧支不良发展的预测指标:回顾性临床试验

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2022-01-01 DOI: 10.5336/cardiosci.2022-92530

M. Kış, Tuncay Güzel

引用次数: 0

Fibrosis-4 Index for Prediction of the Severity of Acute Pulmary Embolism: Cross-sectional Research 预测急性肺栓塞严重程度的纤维化-4指数:横断面研究

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2021-01-01 DOI: 10.5336/cardiosci.2020-78435

T. Karabağ, F. Mutlu, S. Efe

引用次数: 1

The Effect of Vitamin D Deficiency on the Risk and Time of Stent Restenosis After Percutaneous Coronary Angioplasty: Case-Control Study 维生素D缺乏对经皮冠状动脉血管成形术后支架再狭窄风险和时间的影响:病例-对照研究

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2021-01-01 DOI: 10.5336/cardiosci.2021-84366

Aysun Erdem Yaman, U. S. Ceylan

引用次数: 1

Impact of Adding Favipiravir to Hydroxychloroquine and Azithromycin Treatment on QTc Interval in COVID-19 法匹拉韦联合羟氯喹和阿奇霉素治疗对COVID-19患者QTc间期的影响

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2021-01-01 DOI: 10.5336/CARDIOSCI.2020-80082

I. Cerik, Hatun Öztürk Çerik, A. Dogan, S. Dereli, O. Bektaş, Y. Kaya

{"title":"Impact of Adding Favipiravir to Hydroxychloroquine and Azithromycin Treatment on QTc Interval in COVID-19","authors":"I. Cerik, Hatun Öztürk Çerik, A. Dogan, S. Dereli, O. Bektaş, Y. Kaya","doi":"10.5336/CARDIOSCI.2020-80082","DOIUrl":"https://doi.org/10.5336/CARDIOSCI.2020-80082","url":null,"abstract":"Objective: The Coronavirus disease-2019 (COVID-19) pandemic has caused the death of many people worldwide. Treatment protocol had to be developed as soon as possible so drug combinations, whose reliability has not been fully disclosed, have started to be used. In this study, we aimed to evaluate the effect of azithromycin (AZT), hydroxychloroquine (HCQ), and favipiravir (FVR) combination on the corrected QT (QTc) interval. Material and Methods: Eighty-four consecutive COVID 19 patients were enrolled in the study. All patients received AZT and HCQ, however, FVR was added to the combination in 32 patients with severe pneumonia at the beginning. ECG characteristics of all patients before treatment and on the fifth day of treatment were compared. Results: There was no significant difference between the HCQ+AZT group (n=52) and HCQ+AZT+FVR groups (n=32) in terms of baseline clinical characteristics. QTc interval significantly prolonged on the fifth day of treatment in the HCQ+AZT group (413,75±30,13;440,27±36,11 p<0.001) and in the HCQ+AZT+FVR group (426,65±32,83;468,22±42,13 p<0.001). When both groups were compared in terms of ΔQTc, a significant increase was observed in the HCQ+AZT+FVR group compared to the HCQ+AZT group (40(-14/175), 23(-28/213) respectively, p=0.042). In seven of the patients, QTc> 500 ms was detected after the treatment, four patients in the HCQ+AZT+FVR group and three patients in the HCQ+AZT group. Conclusion: We observed that FVR caused more prolongation in the QTc interval when used with the combination of HCQ+AZT. We recommend that patients who receive this treatment be monitored more closely for QTc.","PeriodicalId":39118,"journal":{"name":"Turkiye Klinikleri Cardiovascular Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74082104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diagnostic Considerations and Analytical Characteristics of Methods for the Determination of Cardiac Troponins: Traditional Review 心脏肌钙蛋白测定方法的诊断考虑和分析特点:传统综述

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2021-01-01 DOI: 10.5336/cardiosci.2021-84307

Aleksey Michailovich Chaulin

引用次数: 3

Femoral Artery Stenosis Due to Perivascular Mass: Endovascular Treatment of an Intraoperatively Detected Condition 股动脉狭窄由血管周围肿块引起:术中发现情况的血管内治疗

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2021-01-01 DOI: 10.5336/cardiosci.2021-82604

H. S. Başbuğ, V. Kızılgöz

引用次数: 0

P Wave and QT Dispersion in Patients with Subclinical Hypothyroidism: Case-control Research 亚临床甲状腺功能减退患者的P波和QT离散度:病例对照研究

Turkiye Klinikleri Cardiovascular Sciences Pub Date : 2021-01-01 DOI: 10.5336/cardiosci.2021-83346

C. Yıldız, A. Karakurt

引用次数: 0