Open Urology and Nephrology Journal最新文献_第10页

Editorial Pediatric Nephrology: an Update 儿科肾脏病学:最新进展

Open Urology and Nephrology Journal Pub Date : 2015-01-01 DOI: 10.2174/1874303x01508010090

A. Barakat

引用次数: 156

Progress in Pediatric Kidney Transplantation 儿童肾移植研究进展

Open Urology and Nephrology Journal Pub Date : 2014-12-31 DOI: 10.2174/1874303X014070100115

Jodi M. Smith, V. Dharnidharka

引用次数: 5

Efficacy of Extended Valganciclovir Prophylaxis in Preventing Cytomegalovirus Infection in Pediatric Kidney Transplantation. 延长缬更昔洛韦预防儿童肾移植巨细胞病毒感染的疗效观察。

Open Urology and Nephrology Journal Pub Date : 2014-12-31 eCollection Date: 2014-01-01 DOI: 10.2174/1874303X01407010152

Faris Hashim, Jon A Gregg, Vikas R Dharnidharka

{"title":"Efficacy of Extended Valganciclovir Prophylaxis in Preventing Cytomegalovirus Infection in Pediatric Kidney Transplantation.","authors":"Faris Hashim, Jon A Gregg, Vikas R Dharnidharka","doi":"10.2174/1874303X01407010152","DOIUrl":"https://doi.org/10.2174/1874303X01407010152","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) is one of the most frequent opportunistic infection in renal transplant (RTx) recipients. Valganciclovir (VGC) has been showed to be safe and highly effective in prophylaxis of CMV infection in RTx recipients. Recently, an increase in delayed onset CMV disease has been noted with some arguing that longer prophylaxis may decrease the late-onset disease. We retrospectively tested the hypothesis that extended term prophylaxis (ETP) of VGC for 12 months is more effective than short term prophylaxis (STP) of 6 months in preventing CMV infection and disease in pediatric RTx performed at the University of Florida from July 2003 to December 2010. In this period, all recipients underwent prospective CMV PCR (Polymerase Chain Reaction) monitoring and were maintained on similar immunosuppression. Eighty six patients received RTx during that period. All eligible subjects had to have at least 12 months of graft survival and 18 months of follow up, leaving 73 eligible subjects in final study group. CMV infection or disease occurred in 6/29 (20%) in the STP group vs 6/44 (14%) in the ETP group with no statistical significant difference (P= 0.42). Donor positive/recipients negative CMV serology status (D+/R-) were associated with a higher risk of CMV infection in both univariate and multivariate analysis (P=0.01). Anemia and Leucopenia directly associated with VGC were similar in both groups (P=0.58 and P=0.2 respectively). Biopsy-proven acute rejection was also non-significant in both groups (P=0.39). Although ETP for CMV from 6 months to 12 months is safe and has minimal adverse effect, it did not reduce CMV infection or disease. Further controlled studies in pediatrics age group are considered to compare longer versus shorter periods of prophylaxis and their impact on prevention of CMV infection, resistance, cost, and toxicity.</p>","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"7 Suppl 2 M7","pages":"152-157"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33047064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Intravenous Immunoglobulin in BK Virus Nephropathy 静脉注射免疫球蛋白治疗BK病毒肾病

Open Urology and Nephrology Journal Pub Date : 2014-12-31 DOI: 10.2174/1874303X014070100129

E. Anyaegbu, S. Hmiel

引用次数: 1

Adherence in Adolescent and Young Adult Kidney Transplant Recipients 青少年和青年肾移植受者的依从性

Open Urology and Nephrology Journal Pub Date : 2014-12-31 DOI: 10.2174/1874303X014070100133

J. Bethany, L. H. P. Ahna

引用次数: 17

Advances in Pediatric Renal Transplantation 儿童肾移植研究进展

Open Urology and Nephrology Journal Pub Date : 2014-12-31 DOI: 10.2174/1874303X014070100113

R. Vikas

引用次数: 0

Significance of Asymptomatic Persistent Epstein-Barr Viral Load in Pediatric Renal Transplant Recipients: North American Pediatric Renal Trials and Collaborative Studies Report 儿童肾移植受者无症状持续性Epstein-Barr病毒载量的意义:北美儿童肾脏试验和合作研究报告

Open Urology and Nephrology Journal Pub Date : 2014-12-31 DOI: 10.2174/1874303X014070100123

A. Moudgil, K. Martz, Therese Moore, W. Harmon, V. Dharnidharka

{"title":"Significance of Asymptomatic Persistent Epstein-Barr Viral Load in Pediatric Renal Transplant Recipients: North American Pediatric Renal Trials and Collaborative Studies Report","authors":"A. Moudgil, K. Martz, Therese Moore, W. Harmon, V. Dharnidharka","doi":"10.2174/1874303X014070100123","DOIUrl":"https://doi.org/10.2174/1874303X014070100123","url":null,"abstract":"Background: Many pediatric transplant (TX) centers routinely monitor Epstein-Barr (EB) viral load (VL) by real time quantitative PCR and intervene to prevent post-transplant lymphoproliferative disorder (PTLD). Some children develop asymptomatic persistent VL (PVL). Outcome of different interventions in preventing PTLD and other undesired effects on acute rejection (AR), graft failure (GF) and function amongst children with asymptomatic PVL is not known. Methods: NAPRTCS centers invited to enter data on children with asymptomatic PVL (≥ 6 months) into the EB VL registry. Comparison group included children into the NAPRTCS TX arm during the same period without PVL or VL monitoring. EB VL were arbitrarily divided into low (1-10), medium (>10-100) and high (>100times detection limit for the center) ratio. Results: Of 645 children (18 centers), 85 (13.2%) developed onset of PVL at a mean of 6.4 ± 6.3 months post-TX. PVL children were more likely to be younger (< 5 years) at TX and less likely to be African-American and majority (75.3%) was mismatched for EBV (donor EBV IgG positive and recipient negative). Thymoglobulin induction was used in 29.4% children with PVL versus 37% in controls (p=ns). PTLD developed in 7/85 (8.2%) children with PVL versus 5/560 (0.9%) controls (p < 0.0001). EB VL ratios were not different in those with and without PTLD. EB PVL as time varying covariate did not affect patient survival, GF and AR (HR, 0.85, 0.53 and 0.99). The change in GFR overtime in children with PVL was comparable to controls. Conclusion: Children with PVL (actual load not predictive) are at increased risk for PTLD, but not for AR, death, GF or loss of graft function.","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"7 1","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68065535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Sexuality and Reproductive Health Counseling in Adolescent Renal Transplant Recipients 青少年肾移植受者的性与生殖健康咨询

Open Urology and Nephrology Journal Pub Date : 2014-12-31 DOI: 10.2174/1874303X014070100144

I. Ashoor, Ryan H. Pasternak

{"title":"Sexuality and Reproductive Health Counseling in Adolescent Renal Transplant Recipients","authors":"I. Ashoor, Ryan H. Pasternak","doi":"10.2174/1874303X014070100144","DOIUrl":"https://doi.org/10.2174/1874303X014070100144","url":null,"abstract":"Normal adolescence marks a period of significant physical, cognitive and psychosocial change. It is characterized by transition from concrete to abstract thought processes and concern for risk taking behaviors. Adolescents and young adults with chronic conditions are at a particular disadvantage and tend to be more vulnerable to risky behavior than their healthy peers. While there currently exists no information on the burden of sexually transmitted infections (STIs) in adolescent renal transplant recipients, they present a particularly worrisome population as they are likely to engage in risk taking behavior when they feel \"normal\" following transplantation to compensate for poor quality of life endured on dialysis. This is further compounded by adolescents' false perception that they are unlikely to acquire such infections, and the likely improvement in libido and sexual functioning after transplantation. The potential for acquiring a sexually transmitted infection is concerning given their immunocompromised status, and complex treatment regimens which might have unfavorable interactions with STI treatments. Also, unintentional pregnancy is likely to have a significant impact on their overall medical condition and social functioning thereby impacting their long term allograft outcomes. As the pediatric nephrologist assumes a primary care provider role for these patients following their renal transplant, it becomes increasingly important to be familiar with basic reproductive health counseling techniques and available contraceptive methods on the market. Until consensus guidelines and specific recommendations for reproductive health counseling are developed for adolescent renal transplant recipients, this review provides a brief summary of available knowledge in those areas.","PeriodicalId":38952,"journal":{"name":"Open Urology and Nephrology Journal","volume":"7 1","pages":"144-151"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68065621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial Advances in Pediatric Renal Transplantation 儿科肾移植的编辑进展

Open Urology and Nephrology Journal Pub Date : 2014-12-16 DOI: 10.2174/1874303X01407010113

V. Dharnidharka

引用次数: 0

Management of End Stage Renal Disease-Bangladesh Perspective 终末期肾病的管理——孟加拉国观点

Open Urology and Nephrology Journal Pub Date : 2014-10-31 DOI: 10.2174/1874303X01407010108

H. Rashid

引用次数: 21