Climacteric : the journal of the International Menopause Society最新文献

{"title":"In search of a well-balanced narrative of the menopause momentum.","authors":"R. E. Nappi, N. Panay, S. R. Davis","doi":"10.1080/13697137.2024.2339129","DOIUrl":"https://doi.org/10.1080/13697137.2024.2339129","url":null,"abstract":"","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":" 13","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informal Invitation from Climacteric.","authors":"Tim Hillard, Nigel Crowther, N. Jaff","doi":"10.1080/13697137.2024.2343612","DOIUrl":"https://doi.org/10.1080/13697137.2024.2343612","url":null,"abstract":"","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":" 35","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fezolinetant for the treatment of vasomotor symptoms associated with menopause: a meta-analysis.","authors":"M. Chavez, E. Pasqualotto, R. Ferreira, Alexandre Hohl, Francisco Cezar Aquino de Moraes, P. Schmidt, A. Rodrigues, Joao Roberto de Sa","doi":"10.1080/13697137.2024.2334083","DOIUrl":"https://doi.org/10.1080/13697137.2024.2334083","url":null,"abstract":"This systematic review and meta-analysis investigated the efficacy and safety of fezolinetant for the treatment of moderate-to-severe vasomotor symptoms (VMS) associated with menopause. PubMed, Cochrane Library, Embase and Web of Science were searched for randomized controlled trials (RCTs) published from inception to June 2023, comparing fezolinetant to placebo in postmenopausal women suffering from moderate-to-severe VMS. The mean difference and risk ratio were calculated for continuous and binary outcomes, respectively. R software was used for the statistical analysis, and RoB-2 (Cochrane) to assess the risk of bias. We performed subgroup analysis based on different dosing regimens. Five RCTs comprising 3302 patients were included. Compared with placebo, at 12-week follow-up, fezolinetant significantly reduced the daily frequency of moderate-to-severe VMS (weighted mean difference [WMD] - 2.36; 95% confidence interval [CI] - 2.92, -1.81) and daily severity of moderate-to-severe VMS (WMD -0.22; 95% CI -0.31, -0.13). Also, fezolinetant significantly improved the quality of life (WMD -0.42; 95% CI -0.58, -0.26) and sleep disturbance (WMD -1.10; 95% CI -1.96, -0.24). There were no significant differences between groups in adverse events. These findings support the efficacy and safety of fezolinetant for the treatment of VMS related to menopause.","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":"19 3","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-affirming hormone therapy and cardiovascular health in transgender adults.","authors":"Caroline Ong, Monique Monita, Minghao Liu","doi":"10.1080/13697137.2024.2310518","DOIUrl":"https://doi.org/10.1080/13697137.2024.2310518","url":null,"abstract":"A growing number of people identify as transgender and gender non-binary in the USA and worldwide. Concomitantly, an increasing number of patients are receiving gender-affirming hormone therapy (GAHT) to achieve gender congruence. GAHT has far-ranging effects on clinical and subclinical markers of cardiovascular risk. Transgender patients also appear to be at higher risk for cardiovascular diseases compared to their cisgender peers and the impact of gender-affirming therapy on cardiovascular health is unclear. Studies on the effect of GAHT on cardiovascular outcomes are confounded by differences in GAHT regimens and methodological challenges in a diverse and historically hard-to-reach population. Current cardiovascular guidelines do not incorporate gender identity and hormone status into risk stratification and clinical decision-making. In this review, we provide an overview on the cardiometabolic impact and clinical considerations of GAHT for cardiovascular risk in transgender patients.","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":"11 9","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"My dream.","authors":"M. Neves-e-Castro","doi":"10.1525/9780520942202-099","DOIUrl":"https://doi.org/10.1525/9780520942202-099","url":null,"abstract":"","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128314319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of body mass index in women around menopause attending menopause clinics in Italy.","authors":"F. Parazzini, D. Aloysio, P. Donato, N. Giulini, A. Modena, G. Cicchetti, G. Comitini, G. Gentile, P. Cristiani, A. Careccia, E. Esposito, F. Gualdi, S. Golinelli, E. Bergamini, G. Masellis, S. Rastelli, C. Gigli, A. Elia, D. Marchesoni, F. Sticotti, G. D. Frate, C. Zompicchiatti, L. Marino, Mauro Costa, P. Pinto, D. Dodero, A. Storace, G. Spinelli, S. Quaranta, C. Bossi, A. Ollago, U. Omodei, M. Vaccari, M. Luerti, F. Repetti, G. Zandonini, F. Raspagliesi, F. Dolci, G. Gambarino, B. Pasquale, G. Polizzotti, G. Borsellino, P. Alpinelli, N. Natale, D. Colombo, C. Belloni, A. Viani, G. Cecchini, G. Vinci, B. Samaja, E. Pasinetti, M. Penotti, F. Ognissanti, P. Pesando, C. Malanetto, M. Gallo, G. Dolfin, P. Tartaglino, D. Mossotto, A. Pistoni, A. Tarani, P. Rattazzi, D. Rossaro, M. Campanella, E. Arisi, M. Gamper, D. Salvatores, E. Bocchin, G. Stellin, G. Meli, V. Azzini, F. Tirozzi, G. Buoso, R. Fraioli, V. Marsoni, C. Cetera, R. Sposetti, E. Candiotto, R. Pignalosa, L. D. Pup, U. Bellati, C. Angeloni, M. Bu","doi":"10.1080/713605344","DOIUrl":"https://doi.org/10.1080/713605344","url":null,"abstract":"OBJECTIVE\u0000To analyze determinants of body mass index (BMI, kg/m2) in women attending menopause clinics in Italy.\u0000\u0000\u0000METHODS\u0000Eligible for the study were women attending a network of first-level outpatient menopause clinics in Italy for general counselling about the menopause or treatment of menopausal symptoms. Women observed consecutively during the study period were eligible. A total of 49 122 women (mean age 54 years) entered the study.\u0000\u0000\u0000RESULTS AND CONCLUSIONS\u0000The mean BMI increased slightly with age, being 25.8 (standard deviation, SD 4.8) in women aged < 50 years and 26.3 (SD 4.6) in those aged 57 years or more. This trend was statistically significant also after taking into account the potential confounding effect of menopausal status. The mean BMI was higher in less educated women (27.2, SD 5.1) than in those with high-school education or a university degree (25.0, SD 4.5) (p < 0.05), in non-smokers (26.4, SD 4.9) than in smokers (25.4, SD 4.5), in never-users of hormone replacement therapy (HRT) (26.3, SD 4.9) than in ever-users of HRT (25.4, SD 4.4) and in women self-reporting no physical activity (26.5, SD 4.9) than in those reporting regular physical activity (24.9, SD 4.2). The BMI was higher in women following a surgical menopause than if it was spontaneous (p < 0.05), but there was no difference between the mean BMIs of premenopausal women and those with a spontaneous menopause. Women with diabetes and hypertension had a higher BMI. There was no relation between history of osteoporosis/osteopenia and BMI.","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116930353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WISDOM: history and early demise - was it inevitable?","authors":"M. Vickers, T. Meade, J. Darbyshire","doi":"10.1080/713605309","DOIUrl":"https://doi.org/10.1080/713605309","url":null,"abstract":"In 1989, the UK Medical Research Council (MRC) agreed that, if feasible, a randomized controlled trial to assess the long-term risks and benefits of hormone replacement therapy (HRT) was a priority. Feasibility work began in 1990 and demonstrated that a large-scale multicenter trial was possible. An application for funding for a main trial was submitted to MRC in 1993 and, after extensive review, funding was released in late 1996. Set-up work for the trial - the Women's International Study of long Duration Oestrogen after Menopause (WISDOM) - began in 1997 with recruitment in 1999. In October 2002, following the early discontinuation of one arm of the US Women's Health Initiative HRT trial, the MRC decided to stop the WISDOM trial. This article, by the principal UK investigators of WISDOM, sets out the background and history of the trial.","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126613445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective estrogen receptor modulators: tissue selectivity and differential uterine effects.","authors":"S. Silfen, A. Ciaccia, H. Bryant","doi":"10.3109/13697139909038087","DOIUrl":"https://doi.org/10.3109/13697139909038087","url":null,"abstract":"Selective estrogen receptor modulators (SERMs) are compounds that bind to estrogen receptors and produce estrogen-like (agonist) effects in some tissues and estrogen-blocking (antagonist) effects in other tissues. One of the goals of SERM research has been to develop compounds that provide the potential benefits of estrogen in the skeleton and cardiovascular system, but avoid the negative effects of estrogen in other tissues. Estrogen therapy has been consistently associated with endometrial stimulation, including glandular proliferation, hyperplasia and cancer. In contrast, the presence or degree of endometrial stimulation observed with SERMs varies by compound. The purpose of this review is to differentiate the endometrial effects of compounds that display a SERM-like profile. Molecular mechanisms involving SERM binding to estrogen receptors, preclinical uterine effects in both tissue culture and animal models, and endometrial findings in clinical experience are discussed. There are several SERMs commercially available or in development. The favorable safety profile of raloxifene in the uterus differentiates it from the others. Future SERM development will continue to focus on finding compounds that exhibit minimal endometrial stimulation.","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122099527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting sexual functioning of women in the mid-life years.","authors":"L. Dennerstein, P. Lehert, H. Burger, E. Dudley","doi":"10.3109/13697139909038085","DOIUrl":"https://doi.org/10.3109/13697139909038085","url":null,"abstract":"OBJECTIVE\u0000To model the interaction of hormones, symptoms and psychosocial factors on women's sexuality during the menopausal transition.\u0000\u0000\u0000DESIGN AND METHODS\u0000A prospective, observational study was carried out of a community-based sample of 438 Australian-born women aged 45-55 years at baseline. The study comprised six annual assessments in the women's own homes utilizing a core questionnaire, with rating scales for well-being and daily hassles, and a Personal Experiences Questionnaire as a measure of sexual functioning. Levels of follicle stimulating hormone (FSH), estradiol and inhibin were measured annually. Statistical analysis was performed by structural equation modelling.\u0000\u0000\u0000RESULTS\u0000The retention rate was 90% (final sample size after exclusions, n = 354). The normal fit index for the global model obtained was 0.92. There is a significant direct effect of menopausal status on vaginal dryness/dyspareunia, and an indirect effect on sexual responsivity via a direct effect of menopausal status on symptoms, which then affect well-being. Menopausal status reflects hormonal status. Feelings for the partner and the partner's sexual problems have direct effects on different aspects of sexual functioning. Other social variables such as paid work, interpersonal stress, daily hassles and educational level affect sexual functioning indirectly via effects on symptoms and well-being.\u0000\u0000\u0000CONCLUSIONS\u0000Psychosocial factors, symptoms and the menopausal transition affect women's sexual functioning during the mid-life years.","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132040163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Out-patient hysteroscopy in asymptomatic postmenopausal women.","authors":"T. Fay, N. Khanem, D. Hosking","doi":"10.3109/13697139909038086","DOIUrl":"https://doi.org/10.3109/13697139909038086","url":null,"abstract":"OBJECTIVE\u0000To determine the prevalence of uterine and endometrial abnormalities in normal postmenopausal women and assess the accuracy of subjective hysteroscopic appearances and endometrial histology following 12 weeks of hormonal treatment.\u0000\u0000\u0000DESIGN\u0000A multicentered randomized double-blind placebo-controlled trial in which the volunteers received conjugated equine estrogen 0.625 mg, selective estrogen receptor modulator (in one of two doses) or placebo.\u0000\u0000\u0000SETTING\u0000Out-patient endoscopy unit in a large teaching hospital.\u0000\u0000\u0000METHODS\u0000Out-patient hysteroscopy and endometrial biopsy.\u0000\u0000\u0000RESULTS\u0000Forty-eight women had a hysteroscopy and endometrial biopsy: eight (16.6%; 95% confidence interval, CI 6-27%) women had intrauterine polyps and 38 (79.2%) women had normal hysteroscopies. Thirty-five women had a repeat endometrial assessment with hysteroscopy and, for the detection of proliferative endometrium (prevalence 22.8%), a sensitivity of 87.5%, a specificity of 74%, a negative predictive value of 95% and a positive predictive value of 50% were observed. There was a good proportion of agreement, 0.77 (95% CI 0.63-0.91), but a kappa score of 0.486 revealed only a moderate level of agreement. The likelihood ratios for proliferative endometrium were: LHR+ = 3.38 (fair), and LHR- = 0.17 (moderate).\u0000\u0000\u0000CONCLUSIONS\u0000Hysteroscopic assessment of the uterine cavity is efficient in the detection of pathological intrauterine lesions, but is only moderately successful in determining physiological changes in the endometrium. This study defines a standard of observational statistics for out-patient hysteroscopy in relation to normal endometrial histology in postmenopausal women who may have been ingesting exogenous estrogens.","PeriodicalId":389387,"journal":{"name":"Climacteric : the journal of the International Menopause Society","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128763969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}