Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)最新文献

{"title":"Pengaruh Ekstrak Benalu Mangga Terhadap Kadar Malondealdehid (MDA) pada Tikus Hipertensi yang Dipapar DOCA- Garam","authors":"R. Lestari, Nour Athiroh Abdoes Sjakoer, N. Mubarakati","doi":"10.33474/e-jbst.v8i2.402","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.402","url":null,"abstract":"Hypertension is a chronic disease that is most often found in society. Hypertension is associated with increased production of superoxide radicals and endothelial dysfunction, which causes oxidative stress characterized by increased levels of MDA. Mango mistletoe contains secondary metabolic compounds such as flavonoids which act as natural antioxidants. The use of antioxidants from manga parasites is an alternative to neutralize the increase in MDA in the body and neutralize free radicals. This study aims to determine the levels of MDA in hypertensive rats (DOCA-Salt) exposed to Mango mistletoe Methanolic Extract (EMBM) for 14 days. This study used the true experimental design method with completely randomized design on 50 male Wistar rats, differentiated into 5 treatments, namely control (-), control (+), treatment 1 dose 50 mg / KgBB, treatment 2 doses of 100 mg / KgBB and treatment 3 doses 200 mg / KgBW. Each treatment had 5 replications. Data analysis used oneway ANOVA and post hoc tests, namely JAMOVI version 1.1.9.0 which was used to determine differences in pulmonary MDA levels between groups and pulmonarymalondialdehyde (MDA) were analyzed by spectrophotometry. The results of this study indicated that pulmonary MDA levels in hypertensive rats (Doca salt) exposed to EMBM showed very significant differences between all groups. This is evidenced by the p value analysis that is <0.05, namely <0.001 so that it can be concluded that EMBM can reduce MDA levels in rats Hypertension. This effect is controlled by EMBM at a dose of 50 mg / KgBB which is the optimum dose in reducing pulmonarymalondialdehyd. \u0000Keywords : Hypertension, Mango mistletoe, MDA \u0000ABSTRAK \u0000Hipertensi merupakan penyakit kronik yang paling kerap ditemukan di masyarakat. Hipertensi berkaitan dengan peningkatan produksi radikal superoksida dan disfungsi endotel, yang menyebabkan stress oksidatif ditandai dengan meningkatnya kadar MDA. Benalu mangga mengandung senyawa metabolic sekunder seperti flavanoid yang berperan sebagai antioksidan alami. Penggunaan antioksidan dari benalu mangga menjadi salah satu alternatif untuk menetralisir terjadinya peningkatan MDA dalam tubuh dan menetralkan radikal bebas. Penelitian ini bertujuan untuk mengetahui kadar MDA pada tikus hipertensi (DOCA-Garam) yang dipapar Ekstrak Metanolik Benalu Mangga (EMBM) selama 14 hari. Penelitian ini menggunakan metode true eksperimental design dengan Rancangan Acak Lengkap pada 50 ekor tikus wistar jantan, dibedakan menjadi 5 perlakuan yaitru control (-), control (+), perlakuan 1 dosis 50 mg/KgBB, perlakuan 2 dosis 100 mg/KgBB dan perlakuan 3 dosis 200 mg/KgBB. Setiap perlakuan terdapat 5 kali ulangan. Analisis data menggunakan uji ANOVA one way dan post hoc yaitu JAMOVI dengan versi 1.1.9.0 yang digunakan untuk mengetahui perbedaan kadar MDA paru antar kelompok dan pulmonarymalondialdehyde (MDA) dianalisis dengan spektrofotometri. Hasil penelitian ini menunjukan bahwa kadar MDA paru pada tikus hipertensi (Doca","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121090081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uji Angka Lempeng Total (ALT) dan PH pada Produk Inovasi Minuman Probiotik Jalembi (Jambu Merah, Lemon, Melon, Bit) dengan Starter Lactobacillus plantarum","authors":"Reza Anindita, Afrinia Eka Sari","doi":"10.33474/e-jbst.v8i2.515","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.515","url":null,"abstract":"One of the causes of the failure of anemia prevention therapy in pregnant women with the potential for stunting is the side effects of nausea and vomiting from Blood Supplement Tablets so most pregnant women choose not to consume iron supplements given by the government for free. This has opened up opportunities for the discovery of product innovations for probiotic drinks from jalembi juice (red guava, lemon, melon, beetroot) with a starter Lactobacillus plantarum to be developed as a candidate for a health drink to replace anti-anemia anemia for pregnant women. The purpose of this study was to test the total lactic acid bacteria (LAB), pH, and temperature of jalembi juice probiotic drink with L. plantarum starter. This research method was carried out by calculating the total amount of LAB of L. plantarum using the Total Plate Count (TPC), pH, and temperature of the jalembi juice probiotic drink. Data analysis was carried out using a quantitative descriptive approach. The results of this study indicated that the total LAB of L. plantarum contained in the jalembi juice probiotic drink was 1.7 x 108 CFU/ml with an average pH and temperature of 3.38 and 22.4 ºC respectively. This study concludes that the total LAB in the jalembi juice probiotic drink with L.plantarum starter according to the recommended standards can have an effect on body health, which is around 108 -109 CFU/ml.","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134916208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fermentasi Bunga Telang (Clitoria ternatea L) Dengan Penambahan Madu Baduy Produk SR12 Sebagai Inovasi Bioteknologi Kombucha","authors":"Mu’jijah Mu’jijah, Nurullah Asep Abdilah, Firman Rezaldi, Kusumiyati Kusumiyati, Diyan Yunanto Setyaji, M. Fadillah","doi":"10.33474/e-jbst.v8i2.496","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.496","url":null,"abstract":"Gram positive and negative bacteria have always been a problem for the survival of living things in a high threshold as normal flora. Telang flower contains anthocyanins which are efficacious as antioxidants and antibacterials so that kombucha has a high potential to be fermented by kombucha as the latest biotechnology product innovation in improving the immune system with the addition of a concentration of Baduy honey Product SR12 which has the potential to inhibit the growth of pathogens. This study aims to produce information regarding the concentration of Baduy honey product SR12 which has the potential as a gram-positive and gram-negative antibacterial. The research design used was a randomized block design which was divided into 2 factors. Factor I is the Concentration of Telang Flower Kombucha Sugar (Clitoria ternatea L) solution in the first fermentation (20%, 30%, and 40%) and factor II is the concentration of baduy honey product SR12, namely (20%, 30%, and 40%). Each treatment was repeated 3 times. The results obtained were processed using statistical analysis using one-way ANOVA at the 95% level. If the data from the research results have significant differences, ideally it can be followed up using a post hoc test. The results obtained in this study were the concentration of Baduy honey Product SR12 was positively correlated in preventing the growth of pathogens in both gram-positive and gram-negative bacteria. The conclusion in this study is that kombucha flower telang has the ability as a gram positive and negative antibacterial and can also be developed as the latest biotechnology product innovation. Telang  flower kombucha fermentation with a concentration of Baduy honey Product SR12 of 40% had the highest antibacterial activity when compared to fermented telang flower kombucha at concentrations of Baduy honey Product SR12 with a concentration of 20% and 30%. The average diameter of the inhibition zone produced by Staphylococcus aureus bacteria is 20.08 mm in the strong category, Staphylococcus epidermidis 17.98 mm in the strong category, Pseudomonas aeruginosa 17.27 mm in the strong category, and Escherichia coli 16.59 mm strong category.","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114954920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potensi Ekstrak Daun Kirinyuh (Chromolaena odorata) dalam Menghambat Bakteri Patogen (E. sakazakii, S. typi, dan L. monocytogenes)","authors":"L. Wulandari, Khotibul Umam","doi":"10.33474/e-jbst.v8i2.497","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.497","url":null,"abstract":"Kirinyuh (Chromolaena odorata) is one of the wild plants found that is difficult to eradicate because it has a high defense, so this plants is considered a weed plant that is detrimental to farmers and planters. However, the kirinyuh plant has the potential to be developed as an antibacterial. One of the natural ingredients that show pharmacological effects is flavonoids. This study aims to determine the antibacterial activity, and the effective concentration of kirinyuh extract in inhibiting the growth of Enterobacter sakazakii, Salmonellla typi, and Listeria monocytogenes bacteria.  To get the extract used extraction method by maceration of immersion using 96% ethanol as solvent. The concentration of kirinyuh extract used was 20%, 40%, 60%, 80%, and 100%. While the positive control was used Ampicillin and negative control was used ethanol 96%, and for testing the antibacterial activity was carried out using the well difsusion method. The results of the antibacterial activity test were analyzed using ANOVA with a 95% confidance level and continued with Duncan’s Multiple Range Test (DMRT). The results showed that the extract concentrations of 20%, 40%, 60%, 80%, and 100% had given inhibitory activity to the growth of the test bacteria.  At a concentration of 100%, kirinyuh extract was more effective as an antibacterial against bacteria Enterobacter sakazakii, Salmonella typi, and Listeria monocytogenes bacteria compared to other concentrations. The increase in the concentration of kirinyuh extract showed the larger the diameter of the inhibition zone for bacterial growth. The results of the inhibitory power test of kirinyuh extract against bacteria Enterobacter sakazakii with an average value of the inhibition zone of 6,66 mm, and against Salmonella typi the average value of the inhibition xone was 4,83 mm, and Listeria moncytogenes with an average value of 5, 60 mm.","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126083220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serangga Entomofagus Sebagai Biological Control di Areal Persawahan Fafibola Kabupaten Timor Tengah Utara","authors":"Blasius Atini, Yoseph Nahak Seran, Lusia Naimnule","doi":"10.33474/e-jbst.v8i2.510","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.510","url":null,"abstract":"Tubuhue Village is a village located in North Central Timor Regency with a large rice field area. This large rice field area was used as a research location to determine the level of distribution and the role of entomophagous insects as a biological control in the agroecosystem. The benefits of the value of entomophagous insects as a biological control for life encourage humans to maintain their sustainability and diversity. However, there is a possibility that the balance of entomophagous insects' ecosystem as a biological control in the area is disturbed because chemical pesticides damage the habitat they occupy. Knowing the diversity of entomophagous insects as biological controllers in rice fields is the aim of the study. Fafibola North Central Timor Regency and environmental aspects that affect it. This research took place in April – June 2022 in the Fafibola rice field area of North Central Timor Regency. The data collection technique in this study is insect nets. Data analysis used the Shannon Wiener Diversity Formula to measure entomophagous insects' types and levels of diversity. The diversity index of all species is in the medium category.","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122534171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peningkatan Kadar Protein Terlarut pada Larutan Tepung Jagung Menggunakan Saccharomyces cerevisiae","authors":"S. Tridesianti","doi":"10.33474/e-jbst.v8i2.521","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.521","url":null,"abstract":"Poultry livestock are generally given feed in the form of corn kernels where the corn kernels contain high carbohydrates but have deficiencies of several amino acids. Amino acid deficiency can be overcome by increasing the protein content in the corn kernels. One way to increase the protein content in corn kernels is to carry out a fermentation process in corn flour solution. Therefore, this study aims to determine the effect of corn starch solution to increase dissolved protein levels in Saccharomyces cerevisiae biomass through a fermentation process. This study used a completely randomized design consisting of 8 treatments and 3 replications. The treatment volumes of corn flour solution were 0 mL, 5 mL, 10 mL, 15 mL, 20 mL, 25 mL, 30 mL and 35 mL. Data analysis used the calculation of variance and the BJND test. The results showed that the highest average dissolved protein content and total cell biomass of S. cerevisiae in the 15 ml treatment were 13.52%/g and 15.63 x 107 CFU/mL, the lowest average was in the 35 ml corn flour solution treatment, namely 0. 90%/gr and 3.01 x 107 CFU/mL. Based on the research, it can be concluded that corn flour solution can increase the dissolved protein content in S. cerevisiae biomass up to volume 15 mL/2 mL fermenter through the fermentation process. Based on the results of this study, it can be used as a basis for considering the use of S. cerevisiae fermenters to increase the nutritional value of corn seed-based animal feed.","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131178638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persepsi Mahasiswa MIPA Terhadap Pengelolaan Sampah Padat Berbasis 3R Di Kampus Universitas Islam Malang","authors":"Ahmad Taufiq Rohman, Ari Hayati, Ratna Djuniwati Lisminingsih","doi":"10.33474/e-jbst.v8i2.312","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.312","url":null,"abstract":"According to the republic of indonesia no undang-undang 18 years 2008, about waste management waste matter especially in kota-kota throughout the country right now this has been an issue that is always discussed the need to get the attention of all parties, no exception to the environment, poor islamic university campus how students perception about waste management 3r, based how about the model student perception of the trash can exist at community college islamic university, poor how are the awareness of student participation environmental quality to maintain a healthy and clean through waste management 3r, based this research use descriptive quantitative research methods and surveys in a field. directly A survey is data collection techniques specific techniques, than the other the percentage of perception student who answered a questionnaire in rata-rata show high marks, Student perception about waste management 3r based in college islamic university shows poor perception is very high obtained the results of ( 83-86 % ), a student knowing and perceiving a model that dumpster in the islamic university campus menunujuk very high percentage of poor showing the perception is very high obtained the results of ( 83-85 % ), the awareness of the students faculty mipa against participation menunujuk very high percentage of these things that indicated the result of ( 80-89 % )","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"231 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132474615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efek Pemberian Suspensi Buah Zuriat (Hyphaene thebaica) terhadap Morfometri Ovarium Mencit (Mus musculus L.) yang Terpapar Asap Rokok","authors":"Nofri Zayani, B. Susanto, Solihati Solihati","doi":"10.33474/e-jbst.v8i2.514","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.514","url":null,"abstract":"Optimizing ovarian function is an indicator of fertility in women. Cigarette smoke exposure can inhibit the work of the ovarian. Cigarette smoke containeds the main components of nicotine, tar, carbon monoxide, inorganic gases, heavy metals, nitrosamines, phenols, carbonyl formaldehydes, and polynuclear aromatic hydrocarbons that affect reproductive hormone levels and reduce fertility. Nutrients rich in antioxidants and proper nutrition can be consumed to prevent the risk of cigarette smoke exposure, one of which comes from Zuriat fruit (Hyphaene thebaica). Substances containeds in Zuriat fruit such as proteins, flavonoids, phenols, saponins, tannins, terpenoids, steroids and glycosides. This study aimed to examine the effect of Zuriat fruit suspension on ovarian morphometry of mices exposed to cigarette smoke. The method used is a total experiment with a completely randomized factorial design (CRF). Experimental animals in the form of healthy female mices, aged 10-12 weeks, and 20-30 grams weight as many as 24 animals. Zuriat fruit suspension was given at a dose of 0; 0.5; 1.0; and 2.5 g/kg1 BW. Mices were exposed to 1 cigarette smoke on days 1-20 and treated with Zuriat fruit suspensions on days 21-40. Mice were mated on days 40. Observations on ovarian morphometry (length, width, weight, and number of corpus luteum) were performed on days 18 of gestations. Data analysis used ANOVA and DMRT at = 1%. The results showed that there was an increase in the length, width, and weight of the ovarian and the number of corpus luteum mices exposed to cigarette smoke after being given Zuriat fruit suspension treatment (α = 1%). In conclusion, Zuriat fruit suspension had a good effect on repairing fertility by increasing of mouse ovarian morphometry (length, width","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128548957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efek Perendaman Biji dalam PGPR terhadap Pertumbuhan Semai Cabai Rawit (Capsicum frutescens L.)","authors":"Hesti Kurniahu","doi":"10.33474/e-jbst.v8i2.516","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.516","url":null,"abstract":"The process of cayenne pepper seedling begins with soaking the seeds in liquid to break the dormancy of the seeds. The effect of soaking cayenne pepper seeds using PGPR solution obtained from the root system of cultivated plants, namely cayenne pepper (Capsicum frutescens L.), maize (Zea mays L.), peanuts (Arachys hypogaea L.), and rice (Oryza sativa L.) which had been harvested was the purpose of this study. Cayenne pepper seeds were soaked overnight using PGPR, then the seeds were sown in a planting medium mixed with soil, manure, compost and husk charcoal in a ratio of 2:1:1:1. Cayenne pepper seedling plantations were observed for 4 WAP. Using one-way ANOVA test for research data. Soaking cayenne pepper seeds using PGPR had a significant effect on seedling growth in terms of height, number of leaves, and stem diameter parameters with optimal treatment of 50% concentration. Meanwhile, PGPR immersion for seedling root length parameters did not have a significant effect.","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125963718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika","authors":"Nugroho Wibisono, Yoyon Arif Martino","doi":"10.33474/e-jbst.v8i2.511","DOIUrl":"https://doi.org/10.33474/e-jbst.v8i2.511","url":null,"abstract":"Alstonia scholaris is a medicinal plant from the Apocynaceae family. Alstonia scholaris stem bark have some medicinal properties, but their effect on antidiabetics mechanisms is still unclear. Alstonia scholaris stem bark have some active compounds such as Echitamine, Beta Sitosterol, Lupeol, Alpha Amyrin Acetate, and Betulinic Acid. Present study was designed to find out the best active compounds of A. scholaris as a potential therapeutics agent against diabetes mellitus. This study involved the molecular docking of 3D structures of those active compounds into GLUT-1 receptor protein, visualized their result using Biovia Discovery Studio and pharmacokinetics profile prediction analysis using pkCSM web page. The molecular docking result show that Echitamine (-8,7 kcal/mol) have the lower energy compared to glibenclamide (-9,6 kcal/mol). Based on pkCSM web page, Echitamine were have a good pharmacokinetics profile.","PeriodicalId":388660,"journal":{"name":"Jurnal Ilmiah Biosaintropis (Bioscience-Tropic)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123007590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}